ALEMTUZUMAB

Search structure
Trade Names:
Synonyms:
Status: Approved (2001)
Entry Type: Antibody
Molecule Category: UNKNOWN
ATC: L04AA34
UNII: 3A189DH42V

Pharmacology

Action Mechanism of Action Reference
INHIBITOR CAMPATH-1 antigen inhibitor DailyMed
Primary Target
CD52

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Multiple Sclerosis 4 D009103 ClinicalTrials
Multiple Sclerosis, Relapsing-Remitting 3 D020529 ClinicalTrials
Granuloma, Lethal Midline 3 D006103 ClinicalTrials
Lymphoma, T-Cell, Peripheral 3 D016411 ClinicalTrials
Leukemia 3 D007938 ClinicalTrials
Myelodysplastic Syndromes 3 D009190 ClinicalTrials
Leukemia, Myeloid, Acute 3 D015470 ClinicalTrials
Anemia, Sickle Cell 3 D000755 ClinicalTrials
Immunoblastic Lymphadenopathy 3 D007119 ClinicalTrials
Lymphoma 3 D008223 ClinicalTrials
Hematologic Neoplasms 2 D019337 ClinicalTrials
Leukemia, Prolymphocytic 2 D015463 ClinicalTrials
Graft vs Host Disease 2 D006086 ClinicalTrials
Precursor Cell Lymphoblastic Leukemia-Lymphoma 2 D054198 ClinicalTrials
Hodgkin Disease 2 D006689 ClinicalTrials
Leukemia, Biphenotypic, Acute 2 D015456 ClinicalTrials
Anemia, Aplastic 2 D000741 ClinicalTrials
Neoplasms 2 D009369 ClinicalTrials
Crohn Disease 2 D003424 ClinicalTrials
Lymphoma, Large B-Cell, Diffuse 2 D016403 ClinicalTrials
Neoplasms 2 D009369 ClinicalTrials
Diabetes Mellitus, Type 1 2 D003922 ClinicalTrials
Liver Diseases 2 D008107 ClinicalTrials
Osteopetrosis 2 D010022 ClinicalTrials
Granulomatous Disease, Chronic 2 D006105 ClinicalTrials
beta-Thalassemia 2 D017086 ClinicalTrials
Renal Insufficiency, Chronic 2 D051436 ClinicalTrials
Waldenstrom Macroglobulinemia 2 D008258 ClinicalTrials
Myeloproliferative Disorders 2 D009196 ClinicalTrials
Purpura, Thrombocytopenic, Idiopathic 2 D016553 ClinicalTrials
Anemia, Hemolytic, Autoimmune 2 D000744 ClinicalTrials
Precursor Cell Lymphoblastic Leukemia-Lymphoma 2 D054198 ClinicalTrials
Kidney Neoplasms 2 D007680 ClinicalTrials
Graft vs Host Disease 2 D006086 ClinicalTrials
Leukemia, Large Granular Lymphocytic 2 D054066 ClinicalTrials
Hematologic Neoplasms 2 D019337 ClinicalTrials
Hemoglobinopathies 2 D006453 ClinicalTrials
Leukemia, Biphenotypic, Acute 2 D015456 ClinicalTrials
Leukemia, Lymphoid 2 D007945 ClinicalTrials
Anemia, Aplastic 2 D000741 ClinicalTrials
Myositis, Inclusion Body 2 D018979 ClinicalTrials
Sezary Syndrome 2 D012751 ClinicalTrials
Mycosis Fungoides 2 D009182 ClinicalTrials
Leukemia, Erythroblastic, Acute 2 D004915 ClinicalTrials
Thalassemia 2 D013789 ClinicalTrials
Histiocytosis 2 D015614 ClinicalTrials
Severe Combined Immunodeficiency 2 D016511 ClinicalTrials
Fanconi Anemia 1 D005199 ClinicalTrials
Lymphohistiocytosis, Hemophagocytic 1 D051359 ClinicalTrials
Lymphoma, Non-Hodgkin 1 D008228 ClinicalTrials
Arthritis, Rheumatoid 1 D001172 ClinicalTrials
Peritoneal Neoplasms 1 D010534 ClinicalTrials
Vasculitis 1 D014657 ClinicalTrials
Fallopian Tube Neoplasms 1 D005185 ClinicalTrials
Leukemia, Prolymphocytic, T-Cell 1 D015461 ClinicalTrials
Renal Insufficiency 1 D051437 ClinicalTrials
Multiple Myeloma 1 D009101 ClinicalTrials
Anemia 1 D000740 ClinicalTrials
Kidney Diseases 1 D007674 ClinicalTrials
Ovarian Neoplasms 1 D010051 ClinicalTrials
Neuroblastoma 1 D009447 ClinicalTrials
Neoplasms, Neuroepithelial 0 D018302 ClinicalTrials

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
12.81
Investigations
12.15
Nervous system disorders
12.11
Skin and subcutaneous tissue disorders
7.09
Respiratory, thoracic and mediastinal disorders
6.39
Musculoskeletal and connective tissue disorders
6.04
Infections and infestations
5.59
Gastrointestinal disorders
5.45
Vascular disorders
4.65
Cardiac disorders
4.01
Psychiatric disorders
3.61
Renal and urinary disorders
3.19
Injury, poisoning and procedural complications
3.16
Blood and lymphatic system disorders
2.97
Immune system disorders
2.77

Cross References

Resources Reference
CAS NUMBER 216503-57-0
ChEMBL CHEMBL1201587
FDA SRS 3A189DH42V
Guide to Pharmacology 6770
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