DrugMapper


Display Options: Drug type Therapeutic Area Route of administration Mechanism of Action Indication Status		Total: 45


Small molecule Approved CARDIOVASCULAR; DIABETES DRUGS & ENDOCRINOLOGY; OTHER BUCCAL; IMPLANTATION; INJECTION; NASAL; TRANSDERMAL Aging; Cerebral Arterial Diseases; Dyspareunia; Insulin Resistance; Kallmann Syndrome; Pain; Penile Induration; Polycystic Ovary Syndrome; Acquired Immunodeficiency Syndrome; Anorexia Nervosa; Carcinoma, Intraductal, Noninfiltrating; Dwarfism; Heart Failure; Hereditary Breast and Ovarian Cancer Syndrome; Multiple Sclerosis; Muscle Weakness; Obesity; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sarcopenia; Spinal Cord Injuries; Testicular Neoplasms; Coronary Disease; Disorders of Sex Development; Erectile Dysfunction; Hip Fractures; Infertility; Kidney Failure, Chronic; Menopause; Metabolic Syndrome; Hypogonadism; Klinefelter Syndrome; Neoplasms; Orchitis; Sexual Dysfunctions, Psychological Androgen Receptor agonist

Small molecule

Approved

CARDIOVASCULAR; DIABETES DRUGS & ENDOCRINOLOGY; OTHER

BUCCAL; IMPLANTATION; INJECTION; NASAL; TRANSDERMAL

Aging; Cerebral Arterial Diseases; Dyspareunia; Insulin Resistance; Kallmann Syndrome; Pain; Penile Induration; Polycystic Ovary Syndrome; Acquired Immunodeficiency Syndrome; Anorexia Nervosa; Carcinoma, Intraductal, Noninfiltrating; Dwarfism; Heart Failure; Hereditary Breast and Ovarian Cancer Syndrome; Multiple Sclerosis; Muscle Weakness; Obesity; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sarcopenia; Spinal Cord Injuries; Testicular Neoplasms; Coronary Disease; Disorders of Sex Development; Erectile Dysfunction; Hip Fractures; Infertility; Kidney Failure, Chronic; Menopause; Metabolic Syndrome; Hypogonadism; Klinefelter Syndrome; Neoplasms; Orchitis; Sexual Dysfunctions, Psychological

Androgen Receptor agonist


Small molecule Approved CARDIOVASCULAR; GASTROINTESTINAL; OTHER INJECTION; INTRA-ANAL; SUBLINGUAL; TRANSDERMAL Colorectal Neoplasms; Hypertension, Pulmonary; Hypotension; Infections; Inflammation; Peripheral Arterial Disease; Phlebitis; Rectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Diabetic Neuropathies; Erectile Dysfunction; Hot Flashes; Lung Neoplasms; Pulmonary Edema; Shock; Tendinopathy; Anus Diseases; Arthritis, Rheumatoid; Bone Diseases, Metabolic; Heart Diseases; Muscle Cramp; Myocardial Ischemia; Osteoporosis; Raynaud Disease; Reperfusion Injury; Scleroderma, Localized; Stroke; Wounds and Injuries; Angina Pectoris; Cardiovascular Diseases; Coronary Artery Disease; Heart Failure; Hemorrhoids; Hypertension; Myocardial Infarction; Pain Soluble guanylate cyclase activator

Small molecule

Approved

CARDIOVASCULAR; GASTROINTESTINAL; OTHER

INJECTION; INTRA-ANAL; SUBLINGUAL; TRANSDERMAL

Colorectal Neoplasms; Hypertension, Pulmonary; Hypotension; Infections; Inflammation; Peripheral Arterial Disease; Phlebitis; Rectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Diabetic Neuropathies; Erectile Dysfunction; Hot Flashes; Lung Neoplasms; Pulmonary Edema; Shock; Tendinopathy; Anus Diseases; Arthritis, Rheumatoid; Bone Diseases, Metabolic; Heart Diseases; Muscle Cramp; Myocardial Ischemia; Osteoporosis; Raynaud Disease; Reperfusion Injury; Scleroderma, Localized; Stroke; Wounds and Injuries; Angina Pectoris; Cardiovascular Diseases; Coronary Artery Disease; Heart Failure; Hemorrhoids; Hypertension; Myocardial Infarction; Pain

Soluble guanylate cyclase activator


Small molecule Approved CARDIOVASCULAR; DIABETES DRUGS & ENDOCRINOLOGY; OTHER ORAL Diabetes Mellitus, Type 2; Glioblastoma; Hypertension, Pulmonary; Neoplasms; Primary Myelofibrosis; Heart Diseases; Pneumonia; Diabetes Mellitus, Type 1; Essential Hypertension; Severe Acute Respiratory Syndrome; Cardiovascular Diseases; Collagen Diseases; Diabetic Nephropathies; Diabetic Retinopathy; Heart Failure; Hypertension; Myocardial Infarction; Renal Insufficiency; Ventricular Dysfunction, Left Angiotensin-converting enzyme inhibitor

Small molecule

Approved

CARDIOVASCULAR; DIABETES DRUGS & ENDOCRINOLOGY; OTHER

ORAL

Diabetes Mellitus, Type 2; Glioblastoma; Hypertension, Pulmonary; Neoplasms; Primary Myelofibrosis; Heart Diseases; Pneumonia; Diabetes Mellitus, Type 1; Essential Hypertension; Severe Acute Respiratory Syndrome; Cardiovascular Diseases; Collagen Diseases; Diabetic Nephropathies; Diabetic Retinopathy; Heart Failure; Hypertension; Myocardial Infarction; Renal Insufficiency; Ventricular Dysfunction, Left

Angiotensin-converting enzyme inhibitor


Small molecule Approved CARDIOVASCULAR; OTHER; UROLOGY AND KIDNEY INJECTION; URETHRAL Acute Kidney Injury; Arteriosclerosis Obliterans; Optic Neuropathy, Ischemic; Peripheral Arterial Disease; Peripheral Vascular Diseases; Respiratory Distress Syndrome; Severe Acute Respiratory Syndrome; Sexual Dysfunction, Physiological; Heart Failure; Macular Degeneration; Prostatic Neoplasms, Castration-Resistant; Cardiovascular Diseases; Ductus Arteriosus, Patent; Erectile Dysfunction Prostanoid EP1 receptor agonist

Small molecule

Approved

CARDIOVASCULAR; OTHER; UROLOGY AND KIDNEY

INJECTION; URETHRAL

Acute Kidney Injury; Arteriosclerosis Obliterans; Optic Neuropathy, Ischemic; Peripheral Arterial Disease; Peripheral Vascular Diseases; Respiratory Distress Syndrome; Severe Acute Respiratory Syndrome; Sexual Dysfunction, Physiological; Heart Failure; Macular Degeneration; Prostatic Neoplasms, Castration-Resistant; Cardiovascular Diseases; Ductus Arteriosus, Patent; Erectile Dysfunction

Prostanoid EP1 receptor agonist


Small molecule Approved CARDIOVASCULAR; DIABETES DRUGS & ENDOCRINOLOGY; OTHER ORAL Depressive Disorder; Depressive Disorder, Major; Cardiovascular Diseases Beta-1 adrenergic receptor partial agonist


Small molecule Approved CARDIOVASCULAR; OTHER ORAL Alopecia Areata; Anemia; Bipolar Disorder; Central Nervous System Neoplasms; Cognitive Dysfunction; Crohn Disease; Hermanski-Pudlak Syndrome; HIV Infections; Infertility; Muscular Dystrophy, Duchenne; Oral Submucous Fibrosis; Pancreatitis; Schizophrenia; Severe Acute Respiratory Syndrome; Acute Coronary Syndrome; Acute Kidney Injury; Behcet Syndrome; Biliary Atresia; Brain Diseases; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Coronary Disease; Depressive Disorder; Depressive Disorder, Major; Diabetic Nephropathies; Ductus Arteriosus, Patent; Epilepsy; Fatty Liver; Fibrosis; Head and Neck Neoplasms; Heart Diseases; Inflammatory Bowel Diseases; Leishmaniasis; Leishmaniasis, Cutaneous; Liver Cirrhosis, Biliary; Liver Diseases; Malaria, Falciparum; Neoplasms; Non-alcoholic Fatty Liver Disease; Parkinson Disease; Post-Acute COVID-19 Syndrome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sarcoidosis, Pulmonary; Sexually Transmitted Diseases; Wounds and Injuries; Brachial Plexus Neuropathies; Endometriosis; Enterocolitis, Necrotizing; Glomerulonephritis; Hepatitis, Alcoholic; Jaundice; Kidney Failure, Chronic; Liver Cirrhosis; Liver Failure; Neonatal Sepsis; Nephrotic Syndrome; Osteonecrosis; Renal Insufficiency, Chronic; Cardiovascular Diseases 3',5'-cyclic phosphodiesterase inhibitor

Small molecule

Approved

CARDIOVASCULAR; OTHER

ORAL

Alopecia Areata; Anemia; Bipolar Disorder; Central Nervous System Neoplasms; Cognitive Dysfunction; Crohn Disease; Hermanski-Pudlak Syndrome; HIV Infections; Infertility; Muscular Dystrophy, Duchenne; Oral Submucous Fibrosis; Pancreatitis; Schizophrenia; Severe Acute Respiratory Syndrome; Acute Coronary Syndrome; Acute Kidney Injury; Behcet Syndrome; Biliary Atresia; Brain Diseases; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Coronary Disease; Depressive Disorder; Depressive Disorder, Major; Diabetic Nephropathies; Ductus Arteriosus, Patent; Epilepsy; Fatty Liver; Fibrosis; Head and Neck Neoplasms; Heart Diseases; Inflammatory Bowel Diseases; Leishmaniasis; Leishmaniasis, Cutaneous; Liver Cirrhosis, Biliary; Liver Diseases; Malaria, Falciparum; Neoplasms; Non-alcoholic Fatty Liver Disease; Parkinson Disease; Post-Acute COVID-19 Syndrome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sarcoidosis, Pulmonary; Sexually Transmitted Diseases; Wounds and Injuries; Brachial Plexus Neuropathies; Endometriosis; Enterocolitis, Necrotizing; Glomerulonephritis; Hepatitis, Alcoholic; Jaundice; Kidney Failure, Chronic; Liver Cirrhosis; Liver Failure; Neonatal Sepsis; Nephrotic Syndrome; Osteonecrosis; Renal Insufficiency, Chronic; Cardiovascular Diseases

3',5'-cyclic phosphodiesterase inhibitor


Small molecule Approved CARDIOVASCULAR; OTHER ORAL Asthma; Inflammation; Leukemia, Myeloid, Acute; Metabolic Diseases; Porokeratosis; Stroke; Arthritis, Rheumatoid; Breast Neoplasms; Carotid Stenosis; Cerebrovascular Disorders; Cognitive Dysfunction; Fragile X Syndrome; HIV Infections; Intracranial Arteriosclerosis; Intracranial Arteriovenous Malformations; Learning Disabilities; Melanoma; Neurofibromatosis 1; Ovarian Neoplasms; Parkinson Disease; Prostatic Neoplasms, Castration-Resistant; Pulmonary Disease, Chronic Obstructive; Rett Syndrome; Xanthomatosis, Cerebrotendinous; Heart Diseases; Intermittent Claudication; Lipid Metabolism Disorders; Myocardial Ischemia; Peripheral Vascular Diseases; Atherosclerosis; Cardiovascular Diseases; Coronary Artery Disease; Coronary Disease; Hypercholesterolemia HMG-CoA reductase inhibitor

Small molecule

Approved

CARDIOVASCULAR; OTHER

ORAL

Asthma; Inflammation; Leukemia, Myeloid, Acute; Metabolic Diseases; Porokeratosis; Stroke; Arthritis, Rheumatoid; Breast Neoplasms; Carotid Stenosis; Cerebrovascular Disorders; Cognitive Dysfunction; Fragile X Syndrome; HIV Infections; Intracranial Arteriosclerosis; Intracranial Arteriovenous Malformations; Learning Disabilities; Melanoma; Neurofibromatosis 1; Ovarian Neoplasms; Parkinson Disease; Prostatic Neoplasms, Castration-Resistant; Pulmonary Disease, Chronic Obstructive; Rett Syndrome; Xanthomatosis, Cerebrotendinous; Heart Diseases; Intermittent Claudication; Lipid Metabolism Disorders; Myocardial Ischemia; Peripheral Vascular Diseases; Atherosclerosis; Cardiovascular Diseases; Coronary Artery Disease; Coronary Disease; Hypercholesterolemia

HMG-CoA reductase inhibitor


Small molecule Approved CARDIOVASCULAR; OTHER ORAL Cerebrovascular Disorders; Intracranial Aneurysm; Schizophrenia; Cocaine-Related Disorders; Infertility; Muscle Cramp; Neuroma, Acoustic; Stroke; Poisoning; Subarachnoid Hemorrhage; Cardiovascular Diseases Mineralocorticoid receptor antagonist


Small molecule Approved CARDIOVASCULAR; OTHER ORAL Opioid-Related Disorders; Smoking Cessation; Substance-Related Disorders; Tobacco Use Disorder; Bipolar Disorder; Parkinson Disease; Cardiovascular Diseases; Hypertension Voltage-gated L-type calcium channel blocker


Small molecule Approved CARDIOVASCULAR; OTHER ORAL Alopecia Areata; Arthritis, Rheumatoid; Choroideremia; Chronic Pain; Cystic Fibrosis; Dental Caries; Dental Pulp Exposure; Endotoxemia; Epilepsy; Heart Failure; Hemangioma; Hemangioma, Cavernous, Central Nervous System; Hepatitis B, Chronic; HIV Infections; Leukemia, Lymphocytic, Chronic, B-Cell; Lupus Erythematosus, Systemic; Lymphoma; Neoplasms; Obesity; Ovarian Neoplasms; Pancreatitis, Chronic; Sleep Wake Disorders; Vascular Diseases; Anemia, Sickle Cell; Atrial Fibrillation; Bipolar Disorder; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Cardiomyopathy, Dilated; Carotid Artery Diseases; Cerebral Hemorrhage; Diabetes Mellitus, Type 1; Hypertension, Pulmonary; Intermittent Claudication; Leiomyoma; Lung Neoplasms; Migraine Disorders; Mucositis; Multiple Myeloma; Pancreatic Neoplasms; Pancreatitis; Parkinson Disease; Periodontitis; Peripheral Arterial Disease; Prediabetic State; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Sepsis; Shock, Septic; Sinusitis; Small Cell Lung Carcinoma; Smith-Lemli-Opitz Syndrome; Smoking Cessation; Urinary Bladder Neoplasms; Uveitis; Vitiligo; Waldenstrom Macroglobulinemia; Acute Coronary Syndrome; Alzheimer Disease; Aortic Valve Stenosis; Asthma; Atherosclerosis; Cholangitis, Sclerosing; Colorectal Neoplasms; Depressive Disorder, Treatment-Resistant; Diabetes Mellitus; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diabetic Retinopathy; Essential Hypertension; Graves Ophthalmopathy; Hyperlipidemia, Familial Combined; Hypertension; Hypertension, Portal; Hypertriglyceridemia; Inflammation; Influenza, Human; Intestinal Neoplasms; Ischemic Stroke; Lipid Metabolism Disorders; Liver Cirrhosis; Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Myocardial Ischemia; Noonan Syndrome; Optic Neuritis; Pneumonia; Polycystic Ovary Syndrome; Pulmonary Disease, Chronic Obstructive; Renal Insufficiency, Chronic; Severe Acute Respiratory Syndrome; Stomach Neoplasms; Subarachnoid Hemorrhage; Cardiovascular Diseases; Coronary Artery Disease; Coronary Disease; Dyslipidemias; Hypercholesterolemia; Hyperlipidemias; Hyperlipoproteinemia Type II; Myocardial Infarction; Stroke HMG-CoA reductase inhibitor

Small molecule

Approved

CARDIOVASCULAR; OTHER

ORAL

Alopecia Areata; Arthritis, Rheumatoid; Choroideremia; Chronic Pain; Cystic Fibrosis; Dental Caries; Dental Pulp Exposure; Endotoxemia; Epilepsy; Heart Failure; Hemangioma; Hemangioma, Cavernous, Central Nervous System; Hepatitis B, Chronic; HIV Infections; Leukemia, Lymphocytic, Chronic, B-Cell; Lupus Erythematosus, Systemic; Lymphoma; Neoplasms; Obesity; Ovarian Neoplasms; Pancreatitis, Chronic; Sleep Wake Disorders; Vascular Diseases; Anemia, Sickle Cell; Atrial Fibrillation; Bipolar Disorder; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Cardiomyopathy, Dilated; Carotid Artery Diseases; Cerebral Hemorrhage; Diabetes Mellitus, Type 1; Hypertension, Pulmonary; Intermittent Claudication; Leiomyoma; Lung Neoplasms; Migraine Disorders; Mucositis; Multiple Myeloma; Pancreatic Neoplasms; Pancreatitis; Parkinson Disease; Periodontitis; Peripheral Arterial Disease; Prediabetic State; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Sepsis; Shock, Septic; Sinusitis; Small Cell Lung Carcinoma; Smith-Lemli-Opitz Syndrome; Smoking Cessation; Urinary Bladder Neoplasms; Uveitis; Vitiligo; Waldenstrom Macroglobulinemia; Acute Coronary Syndrome; Alzheimer Disease; Aortic Valve Stenosis; Asthma; Atherosclerosis; Cholangitis, Sclerosing; Colorectal Neoplasms; Depressive Disorder, Treatment-Resistant; Diabetes Mellitus; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diabetic Retinopathy; Essential Hypertension; Graves Ophthalmopathy; Hyperlipidemia, Familial Combined; Hypertension; Hypertension, Portal; Hypertriglyceridemia; Inflammation; Influenza, Human; Intestinal Neoplasms; Ischemic Stroke; Lipid Metabolism Disorders; Liver Cirrhosis; Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Myocardial Ischemia; Noonan Syndrome; Optic Neuritis; Pneumonia; Polycystic Ovary Syndrome; Pulmonary Disease, Chronic Obstructive; Renal Insufficiency, Chronic; Severe Acute Respiratory Syndrome; Stomach Neoplasms; Subarachnoid Hemorrhage; Cardiovascular Diseases; Coronary Artery Disease; Coronary Disease; Dyslipidemias; Hypercholesterolemia; Hyperlipidemias; Hyperlipoproteinemia Type II; Myocardial Infarction; Stroke

HMG-CoA reductase inhibitor


Small molecule Approved CARDIOVASCULAR ORAL Bronchopulmonary Dysplasia Unknown


Antibody Approved CARDIOVASCULAR INJECTION Carotid Stenosis; Angina, Stable; Acute Disease; Brain Ischemia; Myocardial Infarction; ST Elevation Myocardial Infarction; Stroke; Angina, Unstable; Thrombosis Integrin alpha-IIb/beta-3 inhibitor


Small molecule Approved CARDIOVASCULAR; DIABETES DRUGS & ENDOCRINOLOGY; OTHER ORAL Cholangitis, Sclerosing; Alcoholism; Burns; Diabetic Nephropathies; HIV Infections; Huntington Disease; Inflammatory Bowel Diseases; Metabolic Syndrome; Multiple Myeloma; Non-alcoholic Fatty Liver Disease; Obesity; Atherosclerosis; Coronary Disease; Diabetic Retinopathy; Hyperlipidemia, Familial Combined; Hyperlipidemias; Hyperlipoproteinemias; Hyperlipoproteinemia Type III; Hypertension; Hypertriglyceridemia; Lipid Metabolism Disorders; Lipodystrophy; Liver Cirrhosis, Biliary; Metabolic Diseases; Cardiovascular Diseases; Diabetes Mellitus; Diabetes Mellitus, Type 2; Dyslipidemias; Hypercholesterolemia; Hypothyroidism Peroxisome proliferator-activated receptor alpha agonist

Small molecule

Approved

CARDIOVASCULAR; DIABETES DRUGS & ENDOCRINOLOGY; OTHER

ORAL

Cholangitis, Sclerosing; Alcoholism; Burns; Diabetic Nephropathies; HIV Infections; Huntington Disease; Inflammatory Bowel Diseases; Metabolic Syndrome; Multiple Myeloma; Non-alcoholic Fatty Liver Disease; Obesity; Atherosclerosis; Coronary Disease; Diabetic Retinopathy; Hyperlipidemia, Familial Combined; Hyperlipidemias; Hyperlipoproteinemias; Hyperlipoproteinemia Type III; Hypertension; Hypertriglyceridemia; Lipid Metabolism Disorders; Lipodystrophy; Liver Cirrhosis, Biliary; Metabolic Diseases; Cardiovascular Diseases; Diabetes Mellitus; Diabetes Mellitus, Type 2; Dyslipidemias; Hypercholesterolemia; Hypothyroidism

Peroxisome proliferator-activated receptor alpha agonist


Small molecule Approved CARDIOVASCULAR; OTHER INJECTION Unknown HERG blocker


Small molecule Approved CARDIOVASCULAR; IMMUNE SYSTEM; OTHER ORAL Arthritis, Rheumatoid; beta-Thalassemia; Carcinoma, Renal Cell; DiGeorge Syndrome; Glioblastoma; Gliosarcoma; Hypertension; Lecithin Cholesterol Acyltransferase Deficiency; Leukemia, Lymphoid; Leukemia, Myeloid; Neoplasms, Neuroepithelial; Pancreatic Neoplasms; Small Cell Lung Carcinoma; Amyotrophic Lateral Sclerosis; Anemia, Aplastic; Anemia, Diamond-Blackfan; Anemia, Sickle Cell; Autoimmune Diseases; Bronchiolitis Obliterans Syndrome; Burkitt Lymphoma; Cardiomyopathies; Chemical and Drug Induced Liver Injury; Crohn Disease; Epidermolysis Bullosa; Fanconi Anemia; Gout; Granuloma, Lethal Midline; Graves Disease; Hematologic Diseases; Hematologic Neoplasms; Hemoglobinuria; Hepatitis, Alcoholic; Histiocytosis, Langerhans-Cell; HIV Infections; Hyperlipoproteinemia Type I; IgA Vasculitis; Immunoblastic Lymphadenopathy; Immunologic Deficiency Syndromes; Kidney Neoplasms; Leukemia, Large Granular Lymphocytic; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Mast-Cell; Leukemia, Myelomonocytic, Chronic; Leukemia, Myelomonocytic, Juvenile; Leukemia, Prolymphocytic, B-Cell; Leukemia, Prolymphocytic, T-Cell; Liver Diseases; Lymphoma; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell, Peripheral; Macular Degeneration; Melanoma; Multiple Sclerosis; Mycosis Fungoides; Myeloproliferative Disorders; Neoplasms, Plasma Cell; Neuroblastoma; Neuronal Ceroid-Lipofuscinoses; Pemphigoid, Benign Mucous Membrane; Pemphigoid, Bullous; Polycythemia Vera; Primary Myelofibrosis; Psoriasis; Renal Insufficiency, Chronic; Scleroderma, Diffuse; Scleroderma, Limited; Scleroderma, Systemic; Severe Combined Immunodeficiency; Sezary Syndrome; Shwachman-Diamond Syndrome; Sjogren's Syndrome; Vasculitis; Wiskott-Aldrich Syndrome; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Carcinoma, Hepatocellular; Cardiovascular Diseases; Cystitis, Interstitial; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Glomerulonephritis, IGA; Glomerulonephritis, Membranous; Glomerulosclerosis, Focal Segmental; Graft vs Host Disease; Granulomatosis with Polyangiitis; Heart Diseases; Hepatitis C; Hodgkin Disease; Kidney Diseases; Kidney Failure, Chronic; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Lung Diseases, Interstitial; Lupus Erythematosus, Systemic; Lupus Nephritis; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Microscopic Polyangiitis; Multiple Myeloma; Myasthenia Gravis; Myelodysplastic Syndromes; Neoplasms; Nephrotic Syndrome; Neuromyelitis Optica; Pemphigus; Polyradiculopathy; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purpura, Thrombocytopenic, Idiopathic; Red-Cell Aplasia, Pure; Renal Insufficiency; Takayasu Arteritis; Uveitis; Waldenstrom Macroglobulinemia; Delayed Graft Function Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor

Small molecule

Approved

CARDIOVASCULAR; IMMUNE SYSTEM; OTHER

ORAL

Arthritis, Rheumatoid; beta-Thalassemia; Carcinoma, Renal Cell; DiGeorge Syndrome; Glioblastoma; Gliosarcoma; Hypertension; Lecithin Cholesterol Acyltransferase Deficiency; Leukemia, Lymphoid; Leukemia, Myeloid; Neoplasms, Neuroepithelial; Pancreatic Neoplasms; Small Cell Lung Carcinoma; Amyotrophic Lateral Sclerosis; Anemia, Aplastic; Anemia, Diamond-Blackfan; Anemia, Sickle Cell; Autoimmune Diseases; Bronchiolitis Obliterans Syndrome; Burkitt Lymphoma; Cardiomyopathies; Chemical and Drug Induced Liver Injury; Crohn Disease; Epidermolysis Bullosa; Fanconi Anemia; Gout; Granuloma, Lethal Midline; Graves Disease; Hematologic Diseases; Hematologic Neoplasms; Hemoglobinuria; Hepatitis, Alcoholic; Histiocytosis, Langerhans-Cell; HIV Infections; Hyperlipoproteinemia Type I; IgA Vasculitis; Immunoblastic Lymphadenopathy; Immunologic Deficiency Syndromes; Kidney Neoplasms; Leukemia, Large Granular Lymphocytic; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Mast-Cell; Leukemia, Myelomonocytic, Chronic; Leukemia, Myelomonocytic, Juvenile; Leukemia, Prolymphocytic, B-Cell; Leukemia, Prolymphocytic, T-Cell; Liver Diseases; Lymphoma; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell, Peripheral; Macular Degeneration; Melanoma; Multiple Sclerosis; Mycosis Fungoides; Myeloproliferative Disorders; Neoplasms, Plasma Cell; Neuroblastoma; Neuronal Ceroid-Lipofuscinoses; Pemphigoid, Benign Mucous Membrane; Pemphigoid, Bullous; Polycythemia Vera; Primary Myelofibrosis; Psoriasis; Renal Insufficiency, Chronic; Scleroderma, Diffuse; Scleroderma, Limited; Scleroderma, Systemic; Severe Combined Immunodeficiency; Sezary Syndrome; Shwachman-Diamond Syndrome; Sjogren's Syndrome; Vasculitis; Wiskott-Aldrich Syndrome; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Carcinoma, Hepatocellular; Cardiovascular Diseases; Cystitis, Interstitial; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Glomerulonephritis, IGA; Glomerulonephritis, Membranous; Glomerulosclerosis, Focal Segmental; Graft vs Host Disease; Granulomatosis with Polyangiitis; Heart Diseases; Hepatitis C; Hodgkin Disease; Kidney Diseases; Kidney Failure, Chronic; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Lung Diseases, Interstitial; Lupus Erythematosus, Systemic; Lupus Nephritis; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Microscopic Polyangiitis; Multiple Myeloma; Myasthenia Gravis; Myelodysplastic Syndromes; Neoplasms; Nephrotic Syndrome; Neuromyelitis Optica; Pemphigus; Polyradiculopathy; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purpura, Thrombocytopenic, Idiopathic; Red-Cell Aplasia, Pure; Renal Insufficiency; Takayasu Arteritis; Uveitis; Waldenstrom Macroglobulinemia; Delayed Graft Function

Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor


Small molecule Approved CARDIOVASCULAR; DIABETES DRUGS & ENDOCRINOLOGY; OTHER ORAL Acute Coronary Syndrome; Aortic Valve Insufficiency; Cardiomyopathy, Hypertrophic; Diabetic Nephropathies; Nephritis, Hereditary; Peripheral Arterial Disease; Renal Insufficiency, Chronic; Atherosclerosis; Atrial Fibrillation; Chagas Cardiomyopathy; Coronary Disease; Diabetes Mellitus, Type 2; Essential Hypertension; Hypercholesterolemia; Hypertension, Pulmonary; Kidney Diseases; Lipid Metabolism Disorders; Metabolic Syndrome; Non-ST Elevated Myocardial Infarction; Severe Acute Respiratory Syndrome; ST Elevation Myocardial Infarction; Cardiovascular Diseases; Diabetes Mellitus; Heart Failure; Hypertension; Myocardial Infarction; Stroke; Ventricular Dysfunction, Left Type-1 angiotensin II receptor antagonist

Small molecule

Approved

CARDIOVASCULAR; DIABETES DRUGS & ENDOCRINOLOGY; OTHER

ORAL

Acute Coronary Syndrome; Aortic Valve Insufficiency; Cardiomyopathy, Hypertrophic; Diabetic Nephropathies; Nephritis, Hereditary; Peripheral Arterial Disease; Renal Insufficiency, Chronic; Atherosclerosis; Atrial Fibrillation; Chagas Cardiomyopathy; Coronary Disease; Diabetes Mellitus, Type 2; Essential Hypertension; Hypercholesterolemia; Hypertension, Pulmonary; Kidney Diseases; Lipid Metabolism Disorders; Metabolic Syndrome; Non-ST Elevated Myocardial Infarction; Severe Acute Respiratory Syndrome; ST Elevation Myocardial Infarction; Cardiovascular Diseases; Diabetes Mellitus; Heart Failure; Hypertension; Myocardial Infarction; Stroke; Ventricular Dysfunction, Left

Type-1 angiotensin II receptor antagonist


Enzyme Approved CARDIOVASCULAR UNKNOWN Ischemic Stroke; Stroke; Heart Failure; Myocardial Infarction; ST Elevation Myocardial Infarction; Thrombosis Tissue-type plasminogen activator exogenous protein


Oligosaccharide Approved CARDIOVASCULAR; OTHER INJECTION Unknown Antithrombin-III activator


Small molecule Approved CARDIOVASCULAR; DIABETES DRUGS & ENDOCRINOLOGY; OTHER ORAL Cardiovascular Diseases; Brain Injuries; Pain; Severe Acute Respiratory Syndrome; Atherosclerosis; Breast Neoplasms; Coronary Disease; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Essential Hypertension; Hypercholesterolemia; Hypertension, Renovascular; Proteinuria; Renal Artery Obstruction; Angina Pectoris; Diabetes Mellitus; Heart Failure; Hypertension; Myocardial Infarction; Stroke Type-1 angiotensin II receptor antagonist

Small molecule

Approved

CARDIOVASCULAR; DIABETES DRUGS & ENDOCRINOLOGY; OTHER

ORAL

Cardiovascular Diseases; Brain Injuries; Pain; Severe Acute Respiratory Syndrome; Atherosclerosis; Breast Neoplasms; Coronary Disease; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Essential Hypertension; Hypercholesterolemia; Hypertension, Renovascular; Proteinuria; Renal Artery Obstruction; Angina Pectoris; Diabetes Mellitus; Heart Failure; Hypertension; Myocardial Infarction; Stroke

Type-1 angiotensin II receptor antagonist


Protein Approved CARDIOVASCULAR; OTHER INJECTION; INTRAVENOUS Venous Thrombosis; Acute Disease; Aortic Valve Stenosis; Cardiovascular Diseases; Coronary Disease; Heart Diseases; Hematologic Diseases; Hemorrhage; Myocardial Infarction; Subarachnoid Hemorrhage; Acute Coronary Syndrome; Angina, Unstable; Syndrome; Thrombocytopenia; Thrombosis Thrombin inhibitor


Small molecule Approved CARDIOVASCULAR; HEMATOLOGY; OTHER INJECTION; INTRAVENOUS Angina, Unstable; Coronary Disease; Hemorrhagic Disorders; Ischemic Stroke; Thrombocytopenia; Thrombosis Thrombin inhibitor


Small molecule Approved CARDIOVASCULAR; OTHER ORAL Diabetes Mellitus, Type 2; Atrial Fibrillation; Breast Neoplasms; Central Serous Chorioretinopathy; Diabetic Nephropathies; Hyperparathyroidism, Primary; Cardiomyopathies; Essential Hypertension; Muscular Dystrophy, Duchenne; Renal Insufficiency, Chronic; Cardiovascular Diseases; Heart Failure; Hypertension; Myocardial Infarction; Stroke Mineralocorticoid receptor antagonist

Small molecule

Approved

CARDIOVASCULAR; OTHER

ORAL

Diabetes Mellitus, Type 2; Atrial Fibrillation; Breast Neoplasms; Central Serous Chorioretinopathy; Diabetic Nephropathies; Hyperparathyroidism, Primary; Cardiomyopathies; Essential Hypertension; Muscular Dystrophy, Duchenne; Renal Insufficiency, Chronic; Cardiovascular Diseases; Heart Failure; Hypertension; Myocardial Infarction; Stroke

Mineralocorticoid receptor antagonist


Small molecule Approved CARDIOVASCULAR; OTHER; RESPIRATORY INHALATION; INTRAVENOUS; IV (INFUSION); SUBCUTANEOUS Diabetes Mellitus, Type 1; Diabetic Foot; Raynaud Disease; Reperfusion Injury; Scleroderma, Systemic; Hernias, Diaphragmatic, Congenital; Ischemia; Peripheral Vascular Diseases; Persistent Fetal Circulation Syndrome; Pulmonary Disease, Chronic Obstructive; Respiratory Distress Syndrome; Familial Primary Pulmonary Hypertension; Idiopathic Pulmonary Fibrosis; Lung Diseases, Interstitial; Pulmonary Fibrosis; Hypertension, Pulmonary; Pulmonary Arterial Hypertension; Thrombosis Prostanoid IP receptor agonist

Small molecule

Approved

CARDIOVASCULAR; OTHER; RESPIRATORY

INHALATION; INTRAVENOUS; IV (INFUSION); SUBCUTANEOUS

Diabetes Mellitus, Type 1; Diabetic Foot; Raynaud Disease; Reperfusion Injury; Scleroderma, Systemic; Hernias, Diaphragmatic, Congenital; Ischemia; Peripheral Vascular Diseases; Persistent Fetal Circulation Syndrome; Pulmonary Disease, Chronic Obstructive; Respiratory Distress Syndrome; Familial Primary Pulmonary Hypertension; Idiopathic Pulmonary Fibrosis; Lung Diseases, Interstitial; Pulmonary Fibrosis; Hypertension, Pulmonary; Pulmonary Arterial Hypertension; Thrombosis

Prostanoid IP receptor agonist


Small molecule Approved CARDIOVASCULAR; OTHER ORAL Hypertension, Pulmonary; Kidney Diseases; Myotonic Disorders; Acute Coronary Syndrome; Amyotrophic Lateral Sclerosis; Cardiomyopathy, Dilated; Crohn Disease; Heart Failure, Diastolic; Irritable Bowel Syndrome; Romano-Ward Syndrome; Vascular Diseases; Atrial Fibrillation; Coronary Disease; Diabetes Mellitus, Type 2; Myocardial Ischemia; Angina Pectoris; Cardiovascular Diseases Sodium channel protein type IV alpha subunit blocker

Small molecule

Approved

CARDIOVASCULAR; OTHER

ORAL

Hypertension, Pulmonary; Kidney Diseases; Myotonic Disorders; Acute Coronary Syndrome; Amyotrophic Lateral Sclerosis; Cardiomyopathy, Dilated; Crohn Disease; Heart Failure, Diastolic; Irritable Bowel Syndrome; Romano-Ward Syndrome; Vascular Diseases; Atrial Fibrillation; Coronary Disease; Diabetes Mellitus, Type 2; Myocardial Ischemia; Angina Pectoris; Cardiovascular Diseases

Sodium channel protein type IV alpha subunit blocker


Small molecule Approved CARDIOVASCULAR; OTHER; RESPIRATORY ORAL Anemia, Sickle Cell; Altitude Sickness; Asthma; Hypoplastic Left Heart Syndrome; Severe Acute Respiratory Syndrome; Idiopathic Pulmonary Fibrosis; Vascular Diseases; Familial Primary Pulmonary Hypertension; Hypertension; Hypertension, Pulmonary; Pulmonary Arterial Hypertension Endothelin receptor, ET-A/ET-B antagonist


Small molecule Approved CARDIOVASCULAR; OTHER ORAL Coronary Disease; Hypercholesterolemia; Hyperlipidemia, Familial Combined; Lipid Metabolism Disorders; Cardiovascular Diseases Peroxisome proliferator-activated receptor alpha agonist


Small molecule Approved CARDIOVASCULAR; OTHER INTRAVENOUS Vascular Diseases; Scoliosis; Hypertension; Hypertension, Malignant; Stroke; Cardiovascular Diseases Voltage-gated L-type calcium channel blocker

Small molecule

Approved

CARDIOVASCULAR; HEMATOLOGY; OTHER

ORAL

Blood Coagulation Disorders; Obesity, Morbid; Renal Insufficiency, Chronic; Anemia, Sickle Cell; Aortic Valve Disease; Heart Diseases; Hemorrhage; Ischemia; Multiple Myeloma; Thromboembolism; Angina, Unstable; Aortic Valve Stenosis; Diabetes Mellitus, Type 2; Hematoma; Hip Fractures; Ischemic Stroke; Liver Cirrhosis; Myocardial Infarction; Neoplasms; Polyendocrinopathies, Autoimmune; Renal Insufficiency; Rheumatic Heart Disease; Severe Acute Respiratory Syndrome; Thrombocytopenia; Acute Coronary Syndrome; Arthroplasty, Replacement; Atrial Fibrillation; Coronary Artery Disease; Peripheral Arterial Disease; Pulmonary Embolism; Stroke; Thrombosis; Venous Thromboembolism; Venous Thrombosis

Coagulation factor X inhibitor

Small molecule

Approved

CARDIOVASCULAR

ORAL

Cardiovascular Diseases; Ischemia; Kidney Diseases; Kidney Failure, Chronic; Aortic Aneurysm, Abdominal; Carotid Stenosis; Pulmonary Disease, Chronic Obstructive; Anemia, Sickle Cell; Angina, Stable; Aortic Valve Stenosis; Atrial Fibrillation; Influenza, Human; Intracranial Aneurysm; Ischemic Stroke; Non-ST Elevated Myocardial Infarction; Peripheral Arterial Disease; Pneumonia; Renal Insufficiency, Chronic; Severe Acute Respiratory Syndrome; ST Elevation Myocardial Infarction; Acute Coronary Syndrome; Coronary Artery Disease; Diabetes Mellitus, Type 2; Myocardial Infarction; Peripheral Vascular Diseases; Stroke; Thrombosis

Purinergic receptor P2Y12 negative allosteric modulator


Small molecule Approved CARDIOVASCULAR; OTHER ORAL Hypertension; Stroke Type-1 angiotensin II receptor antagonist


Small molecule Approved CARDIOVASCULAR ORAL Breast Neoplasms; Lipid Metabolism Disorders; Adenoma; Alzheimer Disease; Colonic Neoplasms; Non-alcoholic Fatty Liver Disease; Cardiovascular Diseases; Severe Acute Respiratory Syndrome; Dyslipidemias; Hypertriglyceridemia; Pancreatitis Unknown


Small molecule Approved CARDIOVASCULAR; OTHER; RESPIRATORY ORAL HIV Infections; Anemia, Sickle Cell; Coronary Disease; Cystic Fibrosis; Ischemic Stroke; Raynaud Disease; Scleroderma, Localized; Scleroderma, Systemic; Ulcer; Familial Primary Pulmonary Hypertension; Hypertension; Hypertension, Pulmonary Soluble guanylate cyclase positive allosteric modulator


Small molecule Approved CARDIOVASCULAR ORAL Crohn Disease; Hypertriglyceridemia Unknown


Combination Approved CARDIOVASCULAR ORAL Unknown Unknown


Small molecule Approved CARDIOVASCULAR; OTHER ORAL Unknown Unknown