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Total: 139
Small molecule
Approved
OTHER
TOPICAL
Osteomyelitis; Amyotrophic Lateral Sclerosis; Eye Infections; Leishmaniasis; Trypanosomiasis
DNA inhibitor
Small molecule
Approved
OTHER
ORAL
Epilepsy
Voltage-gated T-type calcium channel blocker
Small molecule
Approved
DIABETES DRUGS & ENDOCRINOLOGY; OTHER; RHEUMATOLOGY
ORAL
Osteomyelitis; Glioblastoma; Hypertension, Pulmonary; Intestinal Obstruction; Nausea; Cholangitis, Sclerosing; Peripheral Nervous System Diseases; Spondylitis, Ankylosing; Arthritis, Psoriatic; Arthritis, Juvenile; Arthritis, Rheumatoid; Colitis, Ulcerative
Arachidonate 5-lipoxygenase inhibitor
Small molecule
Approved
OTHER
INJECTION; ORAL
Osteomyelitis; Melanoma; Acquired Immunodeficiency Syndrome; Diabetic Foot; Tuberculosis, Multidrug-Resistant; Ulcer; HIV Infections; Silicosis; Tuberculosis; Tuberculosis, Pulmonary
Enoyl-[acyl-carrier-protein] reductase inhibitor
Small molecule
Approved
OTHER
INJECTION; SUBCUTANEOUS
Muscular Dystrophy, Facioscapulohumeral; HIV Wasting Syndrome; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Pulmonary Disease, Chronic Obstructive; Weight Loss; Hypogonadism
Androgen Receptor agonist
Small molecule
Approved
OTHER
ORAL
Astrocytoma; Brain Neoplasms; Colitis; Glioblastoma; Glioma; Leukemia, Lymphoid; Oligodendroglioma; Colitis, Ulcerative; Crohn Disease; Histiocytosis, Langerhans-Cell; Leukemia; Leukemia, Biphenotypic, Acute; Leukemia, Myeloid, Acute; Leukemia, Promyelocytic, Acute; Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma
Amidophosphoribosyltransferase inhibitor
Small molecule
Approved
OTHER
ORAL
Unknown
Bacterial dihydropteroate synthase inhibitor
Small molecule
Approved
OTHER
INJECTION; ORAL
Lymphoma, B-Cell, Marginal Zone; Anemia; Breast Carcinoma In Situ; Carcinoma, Medullary; Carcinoma, Pancreatic Ductal; Chordoma; Desmoplastic Small Round Cell Tumor; Diffuse Intrinsic Pontine Glioma; Glioblastoma; Glomerulosclerosis, Focal Segmental; Head and Neck Neoplasms; Hepatoblastoma; HIV Infections; Leukemia, Plasma Cell; Liposarcoma; Lymphoma, B-Cell; Mesothelioma; Muscular Diseases; Myasthenia Gravis; Mycosis Fungoides; Nasopharyngeal Neoplasms; Nausea; Neoplasm Metastasis; Osteogenesis Imperfecta; Renal Insufficiency; Sarcoma, Synovial; Sezary Syndrome; Stiff-Person Syndrome; Thymoma; Urinary Bladder Neoplasms; Acquired Immunodeficiency Syndrome; Anemia, Sickle Cell; Arthritis, Rheumatoid; Blast Crisis; Breast Neoplasms, Male; Carcinoma, Merkel Cell; Castleman Disease; Colorectal Neoplasms; Crohn Disease; Endometrial Neoplasms; Epidermolysis Bullosa; Esophageal Neoplasms; Fallopian Tube Neoplasms; Fanconi Anemia; Fucosidosis; Gangliosidosis, GM1; Gaucher Disease; Glioma; Gliosarcoma; Granulomatous Disease, Chronic; Hematologic Diseases; Hematologic Neoplasms; Hereditary Breast and Ovarian Cancer Syndrome; Histiocytosis, Langerhans-Cell; Immune System Diseases; Immunologic Deficiency Syndromes; Leukemia, Lymphoid; Leukemia, Myelomonocytic, Juvenile; Leukemia, Prolymphocytic; Leukodystrophy, Globoid Cell; Leukodystrophy, Metachromatic; Liver Neoplasms; Lupus Erythematosus, Systemic; Lymphohistiocytosis, Hemophagocytic; Lymphoma, AIDS-Related; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell; Lymphoproliferative Disorders; Mouth Neoplasms; Myelodysplastic-Myeloproliferative Diseases; Myeloproliferative Disorders; Neuroectodermal Tumors, Primitive, Peripheral; Neuroendocrine Tumors; Neuromyelitis Optica; Neuronal Ceroid-Lipofuscinoses; Niemann-Pick Diseases; Osteopetrosis; Osteosarcoma; Pancreatic Neoplasms; Peritoneal Neoplasms; Plasmacytoma; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Primary Myelofibrosis; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Purpura, Schoenlein-Henoch; Purpura, Thrombocytopenic, Idiopathic; Rectal Neoplasms; Sandhoff Disease; Sarcoidosis; Skin Neoplasms; Squamous Intraepithelial Lesions; Takayasu Arteritis; Tay-Sachs Disease; Thalassemia; Thyroid Neoplasms; Tuberculosis; Uterine Cervical Neoplasms; Vasculitis; Wolman Disease; Adenocarcinoma; Amyloidosis; Amyloidosis, Familial; Anemia, Aplastic; Anemia, Refractory; Anemia, Refractory, with Excess of Blasts; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Behcet Syndrome; Bone Marrow Failure Disorders; Brain Neoplasms; Burkitt Lymphoma; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Central Nervous System Neoplasms; Choroid Plexus Neoplasms; Condylomata Acuminata; Ependymoma; Ganglioneuroblastoma; Gestational Trophoblastic Disease; Glomerulonephritis, IGA; Glomerulonephritis, Membranous; Graft vs Host Disease; Granuloma, Lethal Midline; Granulomatosis with Polyangiitis; Idiopathic Pulmonary Fibrosis; Immunoblastic Lymphadenopathy; Infertility; Inflammatory Breast Neoplasms; Kidney Diseases; Kidney Neoplasms; Leukemia; Leukemia, Biphenotypic, Acute; Leukemia, Erythroblastic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Megakaryoblastic, Acute; Leukemia, Monocytic, Acute; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Acute; Leukemia, Myelomonocytic, Chronic; Lung Neoplasms; Lupus Nephritis; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Peripheral; Medulloblastoma; Melanoma; Menopause; Mesenchymoma; Microscopic Polyangiitis; Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Myelodysplastic Syndromes; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Neuroectodermal Tumors, Primitive; Neutropenia; Ovarian Neoplasms; Pemphigus; Postoperative Nausea and Vomiting; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Pulmonary Fibrosis; Red-Cell Aplasia, Pure; Renal Insufficiency, Chronic; Retinoblastoma; Rhabdomyosarcoma; Rhabdomyosarcoma, Alveolar; Rhabdomyosarcoma, Embryonal; Sarcoma; Sarcoma, Ewing; Scleritis; Scleroderma, Localized; Scleroderma, Systemic; Small Cell Lung Carcinoma; Squamous Cell Carcinoma of Head and Neck; Testicular Neoplasms; Thrombocytopenia; Triple Negative Breast Neoplasms; Waldenstrom Macroglobulinemia; Wilms Tumor; Breast Neoplasms; Hodgkin Disease; Lymphoma; Multiple Myeloma; Neoplasms; Nephrotic Syndrome
DNA inhibitor
Small molecule
Approved
OTHER
ORAL
Osteomyelitis; Tuberculosis, Multidrug-Resistant; Tuberculosis
Enoyl-[acyl-carrier-protein] reductase inhibitor
Small molecule
Approved
OTHER
ORAL
Myocardial Infarction; Myocardial Ischemia; Cardiovascular Diseases
Peroxisome proliferator-activated receptor alpha agonist
Small molecule
Approved
OTHER
ORAL
Osteomyelitis; Infections; Urinary Tract Infections
DNA inhibitor
Small molecule
Approved
OTHER
ORAL
Inflammatory Bowel Diseases; Mucopolysaccharidoses; Myelodysplastic Syndromes; Urticaria; Anemia, Sickle Cell; Gout; Hepatitis, Autoimmune; Idiopathic Pulmonary Fibrosis; Infertility; Leukemia, Myeloid, Acute; Lung Diseases; Lung Diseases, Interstitial; Pemphigoid, Bullous; Pemphigus; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Carcinoma, Hepatocellular; Cardiomyopathies; Churg-Strauss Syndrome; Colitis, Ulcerative; Crohn Disease; Eczema; Glomerulonephritis, IGA; Granulomatosis with Polyangiitis; Lupus Erythematosus, Systemic; Lupus Nephritis; Microscopic Polyangiitis; Myasthenia Gravis; Neuromyelitis Optica; Pulmonary Fibrosis; Renal Insufficiency, Chronic; Takayasu Arteritis; Thrombocytopenia; Vasculitis; Arthritis, Rheumatoid; Immune System Diseases
Amidophosphoribosyltransferase inhibitor
Small molecule
Approved
OTHER
INJECTION; INTRAVENOUS; ORAL; RECTAL
Ankle Fractures; Brain Concussion; Delirium; Glaucoma; Tooth Diseases; Anemia, Hemolytic, Autoimmune; Arrhythmias, Cardiac; Crohn Disease; Diabetes Mellitus, Type 2; Glycogen Storage Disease Type II; Hepatitis B, Chronic; Immune System Diseases; Intervertebral Disc Degeneration; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Neoplasms; Nervous System Diseases; Obesity, Morbid; Parkinson Disease; Pruritus; Purpura, Thrombocytopenic, Idiopathic; Anxiety; Arthritis, Rheumatoid; Borderline Personality Disorder; Brain Injuries; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cleft Palate; Diabetes Mellitus, Type 1; Digestive System Diseases; Fractures, Bone; Glioma; Graft vs Host Disease; Hypertension; Hypertrophy; Immunoglobulin G4-Related Disease; Leukemia, Mast-Cell; Leukemia, T-Cell; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Melanoma; Mucositis; Neck Pain; Neuralgia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Pre-Eclampsia; Pulpitis; Renal Colic; Rotator Cuff Injuries; Sinusitis; Tension-Type Headache; Tonsillitis; Abdominal Pain; Chronic Pain; Diabetic Neuropathies; Ductus Arteriosus, Patent; Hemorrhage; HIV Infections; Hypospadias; Infections; Kidney Calculi; Kidney Diseases; Low Back Pain; Lupus Erythematosus, Systemic; Lupus Nephritis; Malaria; Meningitis, Bacterial; Multiple Myeloma; Multiple Sclerosis; Myopia; Nausea; Obesity; Osteoarthritis; Osteoarthritis, Hip; Osteoarthritis, Knee; Paget Disease, Extramammary; Pemphigus; Postoperative Nausea and Vomiting; Respiratory Tract Infections; Scoliosis; Sepsis; Severe Acute Respiratory Syndrome; Streptococcal Infections; Vomiting; Wounds and Injuries; Acute Pain; Arthritis; Back Pain; Common Cold; Dysmenorrhea; Fever; Headache; Influenza, Human; Migraine Disorders; Muscle Cramp; Pain; Pharyngitis; Toothache
Anandamide amidohydrolase inhibitor
Small molecule
Approved
OTHER
INJECTION
Arthritis, Rheumatoid; Pain; Eye Diseases; Hemorrhoids; Lung Diseases, Obstructive; Nasal Obstruction; Osteoarthritis
Glucocorticoid receptor agonist
Small molecule
Approved
OTHER
ORAL
Unknown
Unknown
Small molecule
Approved
Unknown
Unknown
Glioblastoma; Central Nervous System Neoplasms; Hodgkin Disease; Lymphoma; Neoplasms
Unknown
Small molecule
Approved
OTHER
ORAL
Astrocytoma; Carcinoma, Hepatocellular; Colorectal Neoplasms; Gliosarcoma; Neoplasms; Oligodendroglioma; Intracranial Hypertension; Meningitis, Cryptococcal; Candidiasis; Infections; Meningitis
Thymidylate synthase inhibitor
Small molecule
Approved
OTHER
ORAL
Osteomyelitis; HIV Infections; Acquired Immunodeficiency Syndrome; Tuberculosis, Multidrug-Resistant; Tuberculosis; Tuberculosis, Pulmonary
70S ribosome inhibitor
Small molecule
Approved
DERMATOLOGY; OTHER
TOPICAL
Dermatitis, Atopic; Eye Diseases; Skin Diseases
Glucocorticoid receptor agonist
Small molecule
Approved
OTHER
ORAL
Anxiety; Anxiety Disorders; Seizures
GABA-A receptor; anion channel positive allosteric modulator
Small molecule
Approved
OTHER
INJECTION
Psoriasis; Psychotic Disorders
Dopamine D2 receptor antagonist
Small molecule
Approved
OTHER
INJECTION
Atrophic Vaginitis
Androgen Receptor agonist
Small molecule
Approved
OTHER
TOPICAL
Dermatitis, Atopic; Lichen Planus, Oral; Periarthritis; Eye Diseases; Hemorrhoids; Infections; Lung Diseases, Obstructive; Nasal Obstruction; Psoriasis; Skin Diseases
Glucocorticoid receptor agonist
Small molecule
Approved
Unknown
Unknown
Breast Neoplasms; Neoplasms
Unknown
Small molecule
Approved
OTHER
INJECTION
Sexual Dysfunction, Physiological; Diabetic Neuropathies; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Hypogonadism; Neoplasms; Orchitis
Androgen Receptor agonist
Small molecule
Approved
OTHER
ORAL
Breast Neoplasms; Carcinoma, Squamous Cell; Fibromatosis, Aggressive; Fragile X Syndrome; Leukemia, Myeloid, Acute; Melanoma; Adenomatous Polyposis Coli; Colorectal Neoplasms; Precancerous Conditions; Arthritis, Rheumatoid; Osteoarthritis; Rheumatic Diseases; Spondylitis
Cyclooxygenase inhibitor
Small molecule
Approved
OTHER
TOPICAL
Unknown
Glucocorticoid receptor agonist
Small molecule
Approved
DERMATOLOGY; OTHER
ORAL; TOPICAL
Alopecia; Hypertension; Hypotrichosis
Sulfonylurea receptor 2, Kir6.2 opener
Small molecule
Approved
OTHER
ORAL
Arrhythmias, Cardiac
Sodium channel alpha subunit blocker
Small molecule
Approved
DERMATOLOGY; IMMUNE SYSTEM; OTHER
BUCCAL; OPHTHALMIC; ORAL; TOPICAL
Cytomegalovirus Infections; HIV Infections; Chickenpox; Eye Infections; Herpes Genitalis; Herpes Labialis; Herpes Simplex; Herpes Zoster; Virus Diseases
Human herpesvirus 1 DNA polymerase inhibitor
Small molecule
Approved
OTHER
TOPICAL
Carcinoma, Non-Small-Cell Lung; Eye Diseases; Skin Diseases
Glucocorticoid receptor agonist
Small molecule
Approved
OTHER
ORAL
Alzheimer Disease; Astrocytoma; Burkitt Lymphoma; Carcinoma, Renal Cell; Epidermolysis Bullosa; Glioblastoma; Glioma; Gliosarcoma; Hodgkin Disease; Infections; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Leukemia, Promyelocytic, Acute; Lymphoma, Large B-Cell, Diffuse; Myelodysplastic Syndromes; Neoplasms; Oligodendroglioma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Azoospermia; Emphysema; Ganglioneuroblastoma; Glomerulosclerosis, Focal Segmental; HIV Infections; Ichthyosis; Keratosis, Actinic; Klinefelter Syndrome; Leukemia; Leukemia, Myelomonocytic, Juvenile; Multiple Myeloma; Mycosis Fungoides; Prostatic Neoplasms, Castration-Resistant; Tinea Pedis; Uterine Cervical Neoplasms; Brain Neoplasms; Central Nervous System Neoplasms; Head and Neck Neoplasms; Kidney Neoplasms; Lung Neoplasms; Medulloblastoma; Neuroblastoma; Rosacea; Severe Acute Respiratory Syndrome; Uterine Cervical Dysplasia; Acne Vulgaris
Retinoic acid receptor agonist
Small molecule
Approved
OTHER
TOPICAL
Unknown
Glucocorticoid receptor agonist
Small molecule
Approved
OTHER
ORAL
Bacterial Infections
Penicillin-binding protein inhibitor
Small molecule
Approved
OTHER
ORAL
Liver Neoplasms; Carcinoma, Hepatocellular
Estrogen receptor beta modulator