DrugMapper


Display Options: Drug type Therapeutic Area Route of administration Mechanism of Action Indication Status		Total: 23


Small molecule Approved HEMATOLOGY; OTHER ORAL Hypertension, Pulmonary; Lung Neoplasms; beta-Thalassemia; Central Nervous System Neoplasms; Esophageal Neoplasms; Fibromatosis, Aggressive; Gliosarcoma; Head and Neck Neoplasms; Hemoglobin SC Disease; Leukemia, Myeloid, Acute; Lymphoma; Meningioma; Multiple Sclerosis; Muscular Atrophy, Spinal; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stomach Neoplasms; Carcinoma; Glioblastoma; Hematologic Diseases; Hemochromatosis; HIV Infections; Laryngeal Neoplasms; Leukemia; Leukemia, Promyelocytic, Acute; Mouth Neoplasms; Myelodysplastic Syndromes; Myeloproliferative Disorders; Paranasal Sinus Neoplasms; Pharyngeal Neoplasms; Polycythemia Vera; Primary Myelofibrosis; Stroke; Thrombocythemia, Essential; Anemia, Sickle Cell; Carcinoma, Squamous Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Melanoma; Neoplasms Ribonucleoside-diphosphate reductase RR1 inhibitor

Small molecule

Approved

HEMATOLOGY; OTHER

ORAL

Hypertension, Pulmonary; Lung Neoplasms; beta-Thalassemia; Central Nervous System Neoplasms; Esophageal Neoplasms; Fibromatosis, Aggressive; Gliosarcoma; Head and Neck Neoplasms; Hemoglobin SC Disease; Leukemia, Myeloid, Acute; Lymphoma; Meningioma; Multiple Sclerosis; Muscular Atrophy, Spinal; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stomach Neoplasms; Carcinoma; Glioblastoma; Hematologic Diseases; Hemochromatosis; HIV Infections; Laryngeal Neoplasms; Leukemia; Leukemia, Promyelocytic, Acute; Mouth Neoplasms; Myelodysplastic Syndromes; Myeloproliferative Disorders; Paranasal Sinus Neoplasms; Pharyngeal Neoplasms; Polycythemia Vera; Primary Myelofibrosis; Stroke; Thrombocythemia, Essential; Anemia, Sickle Cell; Carcinoma, Squamous Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Melanoma; Neoplasms

Ribonucleoside-diphosphate reductase RR1 inhibitor


Small molecule Approved DIABETES DRUGS & ENDOCRINOLOGY; HEMATOLOGY; OTHER ORAL Angina, Stable; Ischemic Stroke; Spinal Cord Injuries; Brain Injuries; Diabetes Mellitus, Type 1; Stroke; Diabetes, Gestational; Diabetes Mellitus; Diabetes Mellitus, Type 2 Sulfonylurea receptor 1, Kir6.2 blocker


Protein Approved CANCER; HEMATOLOGY; OTHER UNKNOWN Peripheral Vascular Diseases; Alzheimer Disease; Blast Crisis; Carcinoma, Endometrioid; Chordoma; Coronary Disease; Cystadenoma, Serous; Enterocolitis, Necrotizing; Gliosarcoma; Leukemia, Plasma Cell; Leukemia, Promyelocytic, Acute; Liver Neoplasms; Lymphoma, B-Cell, Marginal Zone; Menopause; Multiple Sclerosis; Muscular Diseases; Myasthenia Gravis; Neoplasm Metastasis; Neurilemmoma; Peripheral Arterial Disease; Primary Myelofibrosis; Sarcoma, Synovial; Severe Combined Immunodeficiency; Stiff-Person Syndrome; Vasculitis; Waldenstrom Macroglobulinemia; Amyotrophic Lateral Sclerosis; Anemia, Sickle Cell; Biliary Atresia; Breast Neoplasms, Male; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Cardiomyopathy, Dilated; Cerebral Palsy; Colorectal Neoplasms; Crohn Disease; Diabetes Mellitus, Type 1; Epidermolysis Bullosa Dystrophica; Esophageal Neoplasms; Fallopian Tube Neoplasms; Fanconi Anemia; Hematologic Diseases; Hematologic Neoplasms; Histiocytosis, Langerhans-Cell; HIV Infections; Infertility; Inflammatory Breast Neoplasms; Ischemic Stroke; Leukemia, Mast-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid; Lupus Erythematosus, Systemic; Lymphoma, AIDS-Related; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell; Lymphoma, T-Cell, Peripheral; Lymphopenia; Myelodysplastic-Myeloproliferative Diseases; Nasopharyngeal Neoplasms; Neuromyelitis Optica; Osteosarcoma; Pancreatic Neoplasms; Parkinson Disease; Pemphigus; Peritoneal Neoplasms; Prostatic Neoplasms; Red-Cell Aplasia, Pure; Sarcoma, Ewing; Small Cell Lung Carcinoma; Stomach Neoplasms; Stroke; Urethral Neoplasms; Uterine Cervical Neoplasms; Wilms Tumor; Adrenal Cortex Neoplasms; Amyloidosis, Familial; Anemia; Anemia, Aplastic; Anemia, Refractory; Anemia, Refractory, with Excess of Blasts; Brain Neoplasms; Breast Neoplasms; Burkitt Lymphoma; Carcinoma, Non-Small-Cell Lung; Central Nervous System Neoplasms; Chagas Cardiomyopathy; Endometrial Neoplasms; Fever; Graft vs Host Disease; Head and Neck Neoplasms; Hepatitis, Alcoholic; Hodgkin Disease; Hot Flashes; Kidney Neoplasms; Leukemia; Leukemia, Basophilic, Acute; Leukemia, Biphenotypic, Acute; Leukemia, Erythroblastic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Megakaryoblastic, Acute; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Acute; Leukemia, Myelomonocytic, Chronic; Liver Cirrhosis; Liver Diseases; Liver Failure; Lung Neoplasms; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Mediastinal Neoplasms; Medulloblastoma; Melanoma; Mesenchymoma; Multiple Myeloma; Multiple Sclerosis, Relapsing-Remitting; Myelodysplastic Syndromes; Myeloproliferative Disorders; Myocardial Infarction; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Neuroectodermal Tumors, Primitive; Ovarian Neoplasms; Pheochromocytoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Ovarian Insufficiency; Prostatic Neoplasms, Castration-Resistant; Retinoblastoma; Rhabdomyosarcoma; Sarcoma; Scleroderma, Systemic; Testicular Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Uterine Neoplasms; Infections; Neoplasms; Neutropenia Granulocyte colony stimulating factor receptor agonist

Protein

Approved

CANCER; HEMATOLOGY; OTHER

UNKNOWN

Peripheral Vascular Diseases; Alzheimer Disease; Blast Crisis; Carcinoma, Endometrioid; Chordoma; Coronary Disease; Cystadenoma, Serous; Enterocolitis, Necrotizing; Gliosarcoma; Leukemia, Plasma Cell; Leukemia, Promyelocytic, Acute; Liver Neoplasms; Lymphoma, B-Cell, Marginal Zone; Menopause; Multiple Sclerosis; Muscular Diseases; Myasthenia Gravis; Neoplasm Metastasis; Neurilemmoma; Peripheral Arterial Disease; Primary Myelofibrosis; Sarcoma, Synovial; Severe Combined Immunodeficiency; Stiff-Person Syndrome; Vasculitis; Waldenstrom Macroglobulinemia; Amyotrophic Lateral Sclerosis; Anemia, Sickle Cell; Biliary Atresia; Breast Neoplasms, Male; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Cardiomyopathy, Dilated; Cerebral Palsy; Colorectal Neoplasms; Crohn Disease; Diabetes Mellitus, Type 1; Epidermolysis Bullosa Dystrophica; Esophageal Neoplasms; Fallopian Tube Neoplasms; Fanconi Anemia; Hematologic Diseases; Hematologic Neoplasms; Histiocytosis, Langerhans-Cell; HIV Infections; Infertility; Inflammatory Breast Neoplasms; Ischemic Stroke; Leukemia, Mast-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid; Lupus Erythematosus, Systemic; Lymphoma, AIDS-Related; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell; Lymphoma, T-Cell, Peripheral; Lymphopenia; Myelodysplastic-Myeloproliferative Diseases; Nasopharyngeal Neoplasms; Neuromyelitis Optica; Osteosarcoma; Pancreatic Neoplasms; Parkinson Disease; Pemphigus; Peritoneal Neoplasms; Prostatic Neoplasms; Red-Cell Aplasia, Pure; Sarcoma, Ewing; Small Cell Lung Carcinoma; Stomach Neoplasms; Stroke; Urethral Neoplasms; Uterine Cervical Neoplasms; Wilms Tumor; Adrenal Cortex Neoplasms; Amyloidosis, Familial; Anemia; Anemia, Aplastic; Anemia, Refractory; Anemia, Refractory, with Excess of Blasts; Brain Neoplasms; Breast Neoplasms; Burkitt Lymphoma; Carcinoma, Non-Small-Cell Lung; Central Nervous System Neoplasms; Chagas Cardiomyopathy; Endometrial Neoplasms; Fever; Graft vs Host Disease; Head and Neck Neoplasms; Hepatitis, Alcoholic; Hodgkin Disease; Hot Flashes; Kidney Neoplasms; Leukemia; Leukemia, Basophilic, Acute; Leukemia, Biphenotypic, Acute; Leukemia, Erythroblastic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Megakaryoblastic, Acute; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Acute; Leukemia, Myelomonocytic, Chronic; Liver Cirrhosis; Liver Diseases; Liver Failure; Lung Neoplasms; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Mediastinal Neoplasms; Medulloblastoma; Melanoma; Mesenchymoma; Multiple Myeloma; Multiple Sclerosis, Relapsing-Remitting; Myelodysplastic Syndromes; Myeloproliferative Disorders; Myocardial Infarction; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Neuroectodermal Tumors, Primitive; Ovarian Neoplasms; Pheochromocytoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Ovarian Insufficiency; Prostatic Neoplasms, Castration-Resistant; Retinoblastoma; Rhabdomyosarcoma; Sarcoma; Scleroderma, Systemic; Testicular Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Uterine Neoplasms; Infections; Neoplasms; Neutropenia

Granulocyte colony stimulating factor receptor agonist


Protein Approved DIABETES DRUGS & ENDOCRINOLOGY; HEMATOLOGY; OTHER UNKNOWN Myasthenia Gravis; Adenocarcinoma; Anemia, Refractory, with Excess of Blasts; Arthritis, Rheumatoid; Carcinoma, Hepatocellular; Endometrial Neoplasms; Glioma; Hepatitis B, Chronic; Leukemia, Plasma Cell; Liver Neoplasms; Lung Neoplasms; Neoplasm Metastasis; Parkinson Disease; Periodontitis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Triple Negative Breast Neoplasms; Alzheimer Disease; Biliary Tract Neoplasms; Brain Neoplasms; Breast Neoplasms, Male; Burkitt Lymphoma; Carcinoma, Endometrioid; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Non-Small-Cell Lung; Central Nervous System Neoplasms; Colonic Neoplasms; Colorectal Neoplasms; Cystadenoma, Serous; Esophageal Neoplasms; Fallopian Tube Neoplasms; Gallbladder Neoplasms; Ganglioneuroblastoma; Glioblastoma; Gliosarcoma; Hematologic Neoplasms; HIV Infections; Hodgkin Disease; Inflammatory Breast Neoplasms; Kidney Diseases; Kidney Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Myelodysplastic-Myeloproliferative Diseases; Myeloproliferative Disorders; Neoplasms; Osteosarcoma; Ovarian Neoplasms; Peripheral Arterial Disease; Peritoneal Neoplasms; Prostatic Neoplasms; Pulmonary Alveolar Proteinosis; Rectal Neoplasms; Respiratory Distress Syndrome; Severe Acute Respiratory Syndrome; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Breast Neoplasms; Carcinoma, Renal Cell; Crohn Disease; Cytomegalovirus Retinitis; Fever; Graft vs Host Disease; Hematologic Diseases; Infections; Leishmaniasis, Cutaneous; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphoma; Lymphoma, Non-Hodgkin; Melanoma; Mesenchymoma; Multiple Myeloma; Myelodysplastic Syndromes; Neuroblastoma; Neutropenia; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rhabdomyosarcoma; Sarcoma; Sepsis; Urinary Bladder Neoplasms; Leukemia, Myeloid, Acute Granulocyte-macrophage colony-stimulating factor receptor agonist

Protein

Approved

DIABETES DRUGS & ENDOCRINOLOGY; HEMATOLOGY; OTHER

UNKNOWN

Myasthenia Gravis; Adenocarcinoma; Anemia, Refractory, with Excess of Blasts; Arthritis, Rheumatoid; Carcinoma, Hepatocellular; Endometrial Neoplasms; Glioma; Hepatitis B, Chronic; Leukemia, Plasma Cell; Liver Neoplasms; Lung Neoplasms; Neoplasm Metastasis; Parkinson Disease; Periodontitis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Triple Negative Breast Neoplasms; Alzheimer Disease; Biliary Tract Neoplasms; Brain Neoplasms; Breast Neoplasms, Male; Burkitt Lymphoma; Carcinoma, Endometrioid; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Non-Small-Cell Lung; Central Nervous System Neoplasms; Colonic Neoplasms; Colorectal Neoplasms; Cystadenoma, Serous; Esophageal Neoplasms; Fallopian Tube Neoplasms; Gallbladder Neoplasms; Ganglioneuroblastoma; Glioblastoma; Gliosarcoma; Hematologic Neoplasms; HIV Infections; Hodgkin Disease; Inflammatory Breast Neoplasms; Kidney Diseases; Kidney Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Myelodysplastic-Myeloproliferative Diseases; Myeloproliferative Disorders; Neoplasms; Osteosarcoma; Ovarian Neoplasms; Peripheral Arterial Disease; Peritoneal Neoplasms; Prostatic Neoplasms; Pulmonary Alveolar Proteinosis; Rectal Neoplasms; Respiratory Distress Syndrome; Severe Acute Respiratory Syndrome; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Breast Neoplasms; Carcinoma, Renal Cell; Crohn Disease; Cytomegalovirus Retinitis; Fever; Graft vs Host Disease; Hematologic Diseases; Infections; Leishmaniasis, Cutaneous; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphoma; Lymphoma, Non-Hodgkin; Melanoma; Mesenchymoma; Multiple Myeloma; Myelodysplastic Syndromes; Neuroblastoma; Neutropenia; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rhabdomyosarcoma; Sarcoma; Sepsis; Urinary Bladder Neoplasms; Leukemia, Myeloid, Acute

Granulocyte-macrophage colony-stimulating factor receptor agonist


Antibody Approved HEMATOLOGY; OTHER UNKNOWN Neuroblastoma; Prostatic Neoplasms, Castration-Resistant; Arthritis, Psoriatic; Autoimmune Diseases; Candidiasis, Chronic Mucocutaneous; Carcinoma, Squamous Cell; Crohn Disease; Encephalomyelitis; Fanconi Anemia; Frontotemporal Dementia; Gangliosidoses; Glycogen Storage Disease Type II; Hematologic Diseases; Hematologic Neoplasms; Liver Cirrhosis, Biliary; Lymphoma, B-Cell; Lymphoma, T-Cell; Macular Degeneration; Muscular Diseases; Mycosis Fungoides; Opsoclonus-Myoclonus Syndrome; Parkinson Disease; Pemphigoid, Benign Mucous Membrane; Schizophrenia; Scleritis; Urticaria; Acquired Immunodeficiency Syndrome; Anemia, Aplastic; Anemia, Hemolytic, Autoimmune; Anemia, Sickle Cell; Antiphospholipid Syndrome; Behcet Syndrome; Blast Crisis; Breast Neoplasms; Castleman Disease; Churg-Strauss Syndrome; Colitis, Ulcerative; Colonic Neoplasms; Dermatomyositis; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Encephalitis, Japanese; Glomerulonephritis; Glomerulosclerosis, Focal Segmental; Graves Ophthalmopathy; Heart Failure; Hemolytic-Uremic Syndrome; Hemophilia A; Histiocytosis, Langerhans-Cell; Idiopathic Pulmonary Fibrosis; Immunoblastic Lymphadenopathy; Leukemia, Biphenotypic, Acute; Leukemia, Hairy Cell; Leukemia, Mast-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Leukemia, Prolymphocytic; Lung Neoplasms; Lymphoma, AIDS-Related; Lymphoma, Large-Cell, Anaplastic; Lymphoproliferative Disorders; Melanoma; Multiple Myeloma; Multiple Sclerosis, Chronic Progressive; Multiple System Atrophy; Myelodysplastic Syndromes; Neuromyelitis Optica; Pancreatic Neoplasms; Peripheral Nervous System Diseases; Pneumococcal Infections; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Pulmonary Alveolar Proteinosis; Renal Insufficiency; Renal Insufficiency, Chronic; Sarcoidosis; Scleroderma, Systemic; Sjogren's Syndrome; Spondylitis, Ankylosing; Stiff-Person Syndrome; Stomach Neoplasms; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Burkitt Lymphoma; Fatigue Syndrome, Chronic; Glomerulonephritis, Membranous; Graft vs Host Disease; Hodgkin Disease; Immune System Diseases; Kidney Diseases; Leukemia; Leukemia, Lymphoid; Lung Diseases, Interstitial; Lupus Erythematosus, Systemic; Lupus Nephritis; Lymphoma; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Myasthenia Gravis; Nephrotic Syndrome; Pemphigoid, Bullous; Pemphigus; Polyneuropathies; Proteinuria; Purpura, Thrombocytopenic, Idiopathic; Purpura, Thrombotic Thrombocytopenic; Waldenstrom Macroglobulinemia; Arthritis, Rheumatoid; Granulomatosis with Polyangiitis; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Non-Hodgkin; Microscopic Polyangiitis; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Systemic Vasculitis B-lymphocyte antigen CD20 binding agent

Antibody

Approved

HEMATOLOGY; OTHER

UNKNOWN

Neuroblastoma; Prostatic Neoplasms, Castration-Resistant; Arthritis, Psoriatic; Autoimmune Diseases; Candidiasis, Chronic Mucocutaneous; Carcinoma, Squamous Cell; Crohn Disease; Encephalomyelitis; Fanconi Anemia; Frontotemporal Dementia; Gangliosidoses; Glycogen Storage Disease Type II; Hematologic Diseases; Hematologic Neoplasms; Liver Cirrhosis, Biliary; Lymphoma, B-Cell; Lymphoma, T-Cell; Macular Degeneration; Muscular Diseases; Mycosis Fungoides; Opsoclonus-Myoclonus Syndrome; Parkinson Disease; Pemphigoid, Benign Mucous Membrane; Schizophrenia; Scleritis; Urticaria; Acquired Immunodeficiency Syndrome; Anemia, Aplastic; Anemia, Hemolytic, Autoimmune; Anemia, Sickle Cell; Antiphospholipid Syndrome; Behcet Syndrome; Blast Crisis; Breast Neoplasms; Castleman Disease; Churg-Strauss Syndrome; Colitis, Ulcerative; Colonic Neoplasms; Dermatomyositis; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Encephalitis, Japanese; Glomerulonephritis; Glomerulosclerosis, Focal Segmental; Graves Ophthalmopathy; Heart Failure; Hemolytic-Uremic Syndrome; Hemophilia A; Histiocytosis, Langerhans-Cell; Idiopathic Pulmonary Fibrosis; Immunoblastic Lymphadenopathy; Leukemia, Biphenotypic, Acute; Leukemia, Hairy Cell; Leukemia, Mast-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Leukemia, Prolymphocytic; Lung Neoplasms; Lymphoma, AIDS-Related; Lymphoma, Large-Cell, Anaplastic; Lymphoproliferative Disorders; Melanoma; Multiple Myeloma; Multiple Sclerosis, Chronic Progressive; Multiple System Atrophy; Myelodysplastic Syndromes; Neuromyelitis Optica; Pancreatic Neoplasms; Peripheral Nervous System Diseases; Pneumococcal Infections; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Pulmonary Alveolar Proteinosis; Renal Insufficiency; Renal Insufficiency, Chronic; Sarcoidosis; Scleroderma, Systemic; Sjogren's Syndrome; Spondylitis, Ankylosing; Stiff-Person Syndrome; Stomach Neoplasms; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Burkitt Lymphoma; Fatigue Syndrome, Chronic; Glomerulonephritis, Membranous; Graft vs Host Disease; Hodgkin Disease; Immune System Diseases; Kidney Diseases; Leukemia; Leukemia, Lymphoid; Lung Diseases, Interstitial; Lupus Erythematosus, Systemic; Lupus Nephritis; Lymphoma; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Myasthenia Gravis; Nephrotic Syndrome; Pemphigoid, Bullous; Pemphigus; Polyneuropathies; Proteinuria; Purpura, Thrombocytopenic, Idiopathic; Purpura, Thrombotic Thrombocytopenic; Waldenstrom Macroglobulinemia; Arthritis, Rheumatoid; Granulomatosis with Polyangiitis; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Non-Hodgkin; Microscopic Polyangiitis; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Systemic Vasculitis

B-lymphocyte antigen CD20 binding agent


Small molecule Approved HEMATOLOGY ORAL Cognitive Dysfunction; HIV Infections; Amyotrophic Lateral Sclerosis; beta-Thalassemia; Dementia; Friedreich Ataxia; Parkinson Disease; Acute Kidney Injury; Hemochromatosis; Pantothenate Kinase-Associated Neurodegeneration; Anemia, Sickle Cell; Thalassemia Unknown


Small molecule Approved HEMATOLOGY; OTHER; UROLOGY AND KIDNEY INTRAVENOUS Renal Insufficiency; Hematologic Neoplasms; Hypertension, Pulmonary; Anemia; Anemia, Iron-Deficiency; Renal Insufficiency, Chronic Unknown


Small molecule Approved CARDIOVASCULAR; HEMATOLOGY; OTHER INJECTION; INTRAVENOUS Angina, Unstable; Ischemic Stroke; Thrombocytopenia; Thrombosis Thrombin inhibitor


Small molecule Approved HEMATOLOGY; OTHER INTRAVENOUS; SUBCUTANEOUS Brain Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colorectal Neoplasms; Ependymoma; Esophageal Neoplasms; Head and Neck Neoplasms; Hodgkin Disease; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liposarcoma; Lymphoma, Non-Hodgkin; Myelodysplastic-Myeloproliferative Diseases; Osteosarcoma; Ovarian Neoplasms; Tuberculosis; beta-Thalassemia; Breast Neoplasms; Breast Neoplasms, Male; Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Glioma; Hematologic Neoplasms; Leukemia, Erythroblastic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Follicular; Lymphoma, T-Cell, Peripheral; Melanoma; Multiple Myeloma; Pancreatic Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Immunoblastic Lymphadenopathy; Leukemia; Leukemia, Myeloid, Acute; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Anemia; Anemia, Refractory, with Excess of Blasts; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Neoplasms; Thrombocytopenia DNA (cytosine-5)-methyltransferase 1 inhibitor

Small molecule

Approved

HEMATOLOGY; OTHER

INTRAVENOUS; SUBCUTANEOUS

Brain Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colorectal Neoplasms; Ependymoma; Esophageal Neoplasms; Head and Neck Neoplasms; Hodgkin Disease; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liposarcoma; Lymphoma, Non-Hodgkin; Myelodysplastic-Myeloproliferative Diseases; Osteosarcoma; Ovarian Neoplasms; Tuberculosis; beta-Thalassemia; Breast Neoplasms; Breast Neoplasms, Male; Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Glioma; Hematologic Neoplasms; Leukemia, Erythroblastic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Follicular; Lymphoma, T-Cell, Peripheral; Melanoma; Multiple Myeloma; Pancreatic Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Immunoblastic Lymphadenopathy; Leukemia; Leukemia, Myeloid, Acute; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Anemia; Anemia, Refractory, with Excess of Blasts; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Neoplasms; Thrombocytopenia

DNA (cytosine-5)-methyltransferase 1 inhibitor


Small molecule Approved CANCER; HEMATOLOGY; OTHER ORAL Astrocytoma; Burkitt Lymphoma; Cachexia; Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Central Nervous System Neoplasms; Colonic Neoplasms; Diffuse Intrinsic Pontine Glioma; Fallopian Tube Neoplasms; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphoma, B-Cell; Neoplasms; Neuroblastoma; Ovarian Neoplasms; Peritoneal Neoplasms; Rectal Neoplasms; Sarcoma, Kaposi; Urethral Neoplasms; Amyloidosis; Autistic Disorder; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Colorectal Neoplasms; Complex Regional Pain Syndromes; Crohn Disease; Glioma; Gliosarcoma; Graft vs Host Disease; Hematologic Diseases; Hematologic Neoplasms; Histiocytosis, Sinus; HIV Infections; Hodgkin Disease; Kidney Neoplasms; Leukemia; Leukemia, Biphenotypic, Acute; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Plasma Cell; Leukemia, Prolymphocytic; Liver Neoplasms; Lymphoma, B-Cell, Marginal Zone; Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Myeloproliferative Disorders; Pancreatic Neoplasms; POEMS Syndrome; Polycythemia Vera; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Prostatic Neoplasms; Radiculopathy; Thrombocythemia, Essential; Thyroid Neoplasms; Urinary Bladder Neoplasms; Waldenstrom Macroglobulinemia; Amyloidosis, Familial; Epstein-Barr Virus Infections; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Melanoma; Neoplasm Metastasis; Plasmacytoma; Prostatic Neoplasms, Castration-Resistant; Smoldering Multiple Myeloma; Anemia; Immune System Diseases; Lymphoma, Mantle-Cell; Multiple Myeloma; Myelodysplastic Syndromes CRL4(CRBN) E3 ubiquitin ligase inhibitor

Small molecule

Approved

CANCER; HEMATOLOGY; OTHER

ORAL

Astrocytoma; Burkitt Lymphoma; Cachexia; Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Central Nervous System Neoplasms; Colonic Neoplasms; Diffuse Intrinsic Pontine Glioma; Fallopian Tube Neoplasms; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphoma, B-Cell; Neoplasms; Neuroblastoma; Ovarian Neoplasms; Peritoneal Neoplasms; Rectal Neoplasms; Sarcoma, Kaposi; Urethral Neoplasms; Amyloidosis; Autistic Disorder; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Colorectal Neoplasms; Complex Regional Pain Syndromes; Crohn Disease; Glioma; Gliosarcoma; Graft vs Host Disease; Hematologic Diseases; Hematologic Neoplasms; Histiocytosis, Sinus; HIV Infections; Hodgkin Disease; Kidney Neoplasms; Leukemia; Leukemia, Biphenotypic, Acute; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Plasma Cell; Leukemia, Prolymphocytic; Liver Neoplasms; Lymphoma, B-Cell, Marginal Zone; Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Myeloproliferative Disorders; Pancreatic Neoplasms; POEMS Syndrome; Polycythemia Vera; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Prostatic Neoplasms; Radiculopathy; Thrombocythemia, Essential; Thyroid Neoplasms; Urinary Bladder Neoplasms; Waldenstrom Macroglobulinemia; Amyloidosis, Familial; Epstein-Barr Virus Infections; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Melanoma; Neoplasm Metastasis; Plasmacytoma; Prostatic Neoplasms, Castration-Resistant; Smoldering Multiple Myeloma; Anemia; Immune System Diseases; Lymphoma, Mantle-Cell; Multiple Myeloma; Myelodysplastic Syndromes

CRL4(CRBN) E3 ubiquitin ligase inhibitor


Small molecule Approved HEMATOLOGY; OTHER INTRAVENOUS Lymphoma, Follicular; Anemia, Sickle Cell; Burkitt Lymphoma; Glioma; Head and Neck Neoplasms; Hematologic Neoplasms; Leukemia, Promyelocytic, Acute; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Cutaneous; Medulloblastoma; Multiple Myeloma; Neuroblastoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Adenocarcinoma, Follicular; Anemia, Aplastic; Blast Crisis; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Fallopian Tube Neoplasms; Granuloma, Lethal Midline; Hodgkin Disease; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Melanoma; Ovarian Neoplasms; Peritoneal Neoplasms; Severe Acute Respiratory Syndrome; Thalassemia; Thyroid Neoplasms; Graft vs Host Disease; Leukemia; Leukemia, Myeloid, Acute; Lymphoma, T-Cell, Peripheral; Myeloproliferative Disorders; Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia; Anemia; Anemia, Refractory, with Excess of Blasts; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Neoplasms DNA (cytosine-5)-methyltransferase 1 inhibitor

Small molecule

Approved

HEMATOLOGY; OTHER

INTRAVENOUS

Lymphoma, Follicular; Anemia, Sickle Cell; Burkitt Lymphoma; Glioma; Head and Neck Neoplasms; Hematologic Neoplasms; Leukemia, Promyelocytic, Acute; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Cutaneous; Medulloblastoma; Multiple Myeloma; Neuroblastoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Adenocarcinoma, Follicular; Anemia, Aplastic; Blast Crisis; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Fallopian Tube Neoplasms; Granuloma, Lethal Midline; Hodgkin Disease; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Melanoma; Ovarian Neoplasms; Peritoneal Neoplasms; Severe Acute Respiratory Syndrome; Thalassemia; Thyroid Neoplasms; Graft vs Host Disease; Leukemia; Leukemia, Myeloid, Acute; Lymphoma, T-Cell, Peripheral; Myeloproliferative Disorders; Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia; Anemia; Anemia, Refractory, with Excess of Blasts; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Neoplasms

DNA (cytosine-5)-methyltransferase 1 inhibitor


Antibody Approved HEMATOLOGY IV (INFUSION) End Stage Liver Disease; Glomerulonephritis, Membranoproliferative; Graft vs Host Disease; Hemolysis; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Dermatomyositis; Diabetes Mellitus; Macular Degeneration; Renal Insufficiency, Chronic; Severe Acute Respiratory Syndrome; Thrombocytopenia; Guillain-Barre Syndrome; Hemolytic-Uremic Syndrome; Leukemia; Myasthenia Gravis; Neuromyelitis Optica; Atypical Hemolytic Uremic Syndrome; Hemoglobinuria; Hemoglobinuria, Paroxysmal; Immune System Diseases Complement C5 inhibitor

Antibody

Approved

HEMATOLOGY

IV (INFUSION)

End Stage Liver Disease; Glomerulonephritis, Membranoproliferative; Graft vs Host Disease; Hemolysis; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Dermatomyositis; Diabetes Mellitus; Macular Degeneration; Renal Insufficiency, Chronic; Severe Acute Respiratory Syndrome; Thrombocytopenia; Guillain-Barre Syndrome; Hemolytic-Uremic Syndrome; Leukemia; Myasthenia Gravis; Neuromyelitis Optica; Atypical Hemolytic Uremic Syndrome; Hemoglobinuria; Hemoglobinuria, Paroxysmal; Immune System Diseases

Complement C5 inhibitor


Small molecule Approved HEMATOLOGY; OTHER ORAL Myelodysplastic Syndromes; Anemia, Aplastic; Hepatitis C, Chronic; Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia Thrombopoietin receptor agonist


Protein Approved HEMATOLOGY SUBCUTANEOUS Lymphoma; Neoplasms; Purpura, Thrombocytopenic; Anemia, Aplastic; Carcinoma; Glioblastoma; Lymphoma, Non-Hodgkin; Myelodysplastic Syndromes; Ovarian Neoplasms; Purpura, Thrombotic Thrombocytopenic; Wiskott-Aldrich Syndrome; Hemorrhage; Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia Thrombopoietin receptor agonist


Small molecule Approved HEMATOLOGY; OTHER ORAL Kidney Calculi; Carcinoma; Kidney Diseases; Renal Insufficiency, Chronic; Dyspnea; Edema, Cardiac; Inappropriate ADH Syndrome; Liver Cirrhosis; Polycystic Kidney, Autosomal Dominant; Cardiovascular Diseases; Heart Failure; Hyponatremia; Polycystic Kidney Diseases Vasopressin V2 receptor antagonist


Protein Approved HEMATOLOGY INTRAVENOUS Astrocytoma; Carcinoma, Pancreatic Ductal; Gliosarcoma; Hodgkin Disease; Inflammatory Breast Neoplasms; Leukemia; Liposarcoma; Lymphoma, Non-Hodgkin; Mycosis Fungoides; Oligodendroglioma; Pancreatic Neoplasms; Sezary Syndrome; Triple Negative Breast Neoplasms; Adenocarcinoma, Follicular; Breast Neoplasms, Male; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; HIV Infections; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Promyelocytic, Acute; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Mantle-Cell; Melanoma; Multiple Myeloma; Ovarian Neoplasms; Prostatic Neoplasms, Castration-Resistant; Small Cell Lung Carcinoma; Stomach Neoplasms; Thyroid Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Immunoblastic Lymphadenopathy; Lymphoma; Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Neoplasms Histone deacetylase inhibitor

Protein

Approved

HEMATOLOGY

INTRAVENOUS

Astrocytoma; Carcinoma, Pancreatic Ductal; Gliosarcoma; Hodgkin Disease; Inflammatory Breast Neoplasms; Leukemia; Liposarcoma; Lymphoma, Non-Hodgkin; Mycosis Fungoides; Oligodendroglioma; Pancreatic Neoplasms; Sezary Syndrome; Triple Negative Breast Neoplasms; Adenocarcinoma, Follicular; Breast Neoplasms, Male; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; HIV Infections; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Promyelocytic, Acute; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Mantle-Cell; Melanoma; Multiple Myeloma; Ovarian Neoplasms; Prostatic Neoplasms, Castration-Resistant; Small Cell Lung Carcinoma; Stomach Neoplasms; Thyroid Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Immunoblastic Lymphadenopathy; Lymphoma; Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Neoplasms

Histone deacetylase inhibitor


Small molecule Approved CARDIOVASCULAR; HEMATOLOGY; OTHER ORAL Obesity, Morbid; Renal Insufficiency, Chronic; Acute Coronary Syndrome; Anemia, Sickle Cell; Aortic Valve Disease; Heart Diseases; Hemorrhage; Ischemia; Multiple Myeloma; Thromboembolism; Antiphospholipid Syndrome; Coronary Disease; Diabetes Mellitus, Type 2; Hematoma; Ischemic Stroke; Liver Cirrhosis; Myocardial Infarction; Neoplasms; Peripheral Arterial Disease; Renal Insufficiency; Rheumatic Heart Disease; Severe Acute Respiratory Syndrome; Stroke; Thrombocytopenia; Venous Thromboembolism; Atrial Fibrillation; Pulmonary Embolism; Thrombosis; Venous Thrombosis Coagulation factor X inhibitor

Small molecule

Approved

CARDIOVASCULAR; HEMATOLOGY; OTHER

ORAL

Obesity, Morbid; Renal Insufficiency, Chronic; Acute Coronary Syndrome; Anemia, Sickle Cell; Aortic Valve Disease; Heart Diseases; Hemorrhage; Ischemia; Multiple Myeloma; Thromboembolism; Antiphospholipid Syndrome; Coronary Disease; Diabetes Mellitus, Type 2; Hematoma; Ischemic Stroke; Liver Cirrhosis; Myocardial Infarction; Neoplasms; Peripheral Arterial Disease; Renal Insufficiency; Rheumatic Heart Disease; Severe Acute Respiratory Syndrome; Stroke; Thrombocytopenia; Venous Thromboembolism; Atrial Fibrillation; Pulmonary Embolism; Thrombosis; Venous Thrombosis

Coagulation factor X inhibitor


Enzyme Approved HEMATOLOGY INTRAVENOUS Gaucher Disease Glucocerebroside hydrolytic enzyme


Small molecule Approved HEMATOLOGY ORAL Breast Neoplasms; Carcinoma, Renal Cell; Colonic Neoplasms; Colorectal Neoplasms; Glioblastoma; Hematologic Neoplasms; Leukemia, Lymphoid; Liver Diseases; Lung Neoplasms; Myelodysplastic Syndromes; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms, Castration-Resistant; Amyloidosis; Anemia, Hemolytic, Autoimmune; Burkitt Lymphoma; Carcinoid Tumor; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Esophageal Neoplasms; Food Hypersensitivity; Hodgkin Disease; Leukemia; Leukemia, Hairy Cell; Leukemia, Mast-Cell; Leukemia, Myeloid, Acute; Leukemia, Prolymphocytic; Leukemia, Prolymphocytic, T-Cell; Lymphoma, B-Cell, Marginal Zone; Melanoma; Multiple Myeloma; Severe Acute Respiratory Syndrome; Graft vs Host Disease; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Mantle-Cell; Waldenstrom Macroglobulinemia Tyrosine-protein kinase BTK inhibitor

Small molecule

Approved

HEMATOLOGY

ORAL

Breast Neoplasms; Carcinoma, Renal Cell; Colonic Neoplasms; Colorectal Neoplasms; Glioblastoma; Hematologic Neoplasms; Leukemia, Lymphoid; Liver Diseases; Lung Neoplasms; Myelodysplastic Syndromes; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms, Castration-Resistant; Amyloidosis; Anemia, Hemolytic, Autoimmune; Burkitt Lymphoma; Carcinoid Tumor; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Esophageal Neoplasms; Food Hypersensitivity; Hodgkin Disease; Leukemia; Leukemia, Hairy Cell; Leukemia, Mast-Cell; Leukemia, Myeloid, Acute; Leukemia, Prolymphocytic; Leukemia, Prolymphocytic, T-Cell; Lymphoma, B-Cell, Marginal Zone; Melanoma; Multiple Myeloma; Severe Acute Respiratory Syndrome; Graft vs Host Disease; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Mantle-Cell; Waldenstrom Macroglobulinemia

Tyrosine-protein kinase BTK inhibitor


Small molecule Approved CANCER; HEMATOLOGY; OTHER ORAL Amyloidosis; Anemia, Sickle Cell; Castleman Disease; Hodgkin Disease; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Neoplasms; Pancreatic Neoplasms; Small Cell Lung Carcinoma; Waldenstrom Macroglobulinemia; Amyloidosis, Familial; Graft vs Host Disease; Leukemia, Plasma Cell; Lung Diseases, Interstitial; Medulloblastoma; Myeloproliferative Disorders; Plasmacytoma; Polycythemia Vera; Prostatic Neoplasms, Castration-Resistant; Pulmonary Fibrosis; Sarcoma; Sarcoma, Kaposi; Scleroderma, Systemic; Telangiectasia, Hereditary Hemorrhagic; Primary Myelofibrosis; Immune System Diseases; Multiple Myeloma CRL4(CRBN) E3 ubiquitin ligase inhibitor

Small molecule

Approved

CANCER; HEMATOLOGY; OTHER

ORAL

Amyloidosis; Anemia, Sickle Cell; Castleman Disease; Hodgkin Disease; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Neoplasms; Pancreatic Neoplasms; Small Cell Lung Carcinoma; Waldenstrom Macroglobulinemia; Amyloidosis, Familial; Graft vs Host Disease; Leukemia, Plasma Cell; Lung Diseases, Interstitial; Medulloblastoma; Myeloproliferative Disorders; Plasmacytoma; Polycythemia Vera; Prostatic Neoplasms, Castration-Resistant; Pulmonary Fibrosis; Sarcoma; Sarcoma, Kaposi; Scleroderma, Systemic; Telangiectasia, Hereditary Hemorrhagic; Primary Myelofibrosis; Immune System Diseases; Multiple Myeloma

CRL4(CRBN) E3 ubiquitin ligase inhibitor


Small molecule Approved HEMATOLOGY INTRAVENOUS Adenocarcinoma; Blast Crisis; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Hematologic Neoplasms; Hodgkin Disease; Lymphoma; Lymphoma, Follicular; Mycosis Fungoides; Sarcoma; Small Cell Lung Carcinoma; Burkitt Lymphoma; Carcinoma; Carcinoma, Endometrioid; Cystadenoma, Serous; Fallopian Tube Neoplasms; Glioblastoma; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Myeloid, Acute; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Cutaneous; Mesothelioma; Multiple Myeloma; Myelodysplastic Syndromes; Peritoneal Neoplasms; Thymoma; Lymphoma, T-Cell; Lymphoma, T-Cell, Peripheral; Neoplasms Histone deacetylase inhibitor

Small molecule

Approved

HEMATOLOGY

INTRAVENOUS

Adenocarcinoma; Blast Crisis; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Hematologic Neoplasms; Hodgkin Disease; Lymphoma; Lymphoma, Follicular; Mycosis Fungoides; Sarcoma; Small Cell Lung Carcinoma; Burkitt Lymphoma; Carcinoma; Carcinoma, Endometrioid; Cystadenoma, Serous; Fallopian Tube Neoplasms; Glioblastoma; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Myeloid, Acute; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Cutaneous; Mesothelioma; Multiple Myeloma; Myelodysplastic Syndromes; Peritoneal Neoplasms; Thymoma; Lymphoma, T-Cell; Lymphoma, T-Cell, Peripheral; Neoplasms

Histone deacetylase inhibitor


Small molecule Approved CANCER; HEMATOLOGY; OTHER ORAL Carcinoma, Pancreatic Ductal; Leukemia, Myeloid, Acute; Multiple Myeloma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Rhinitis, Allergic, Seasonal; Amyloidosis; Hodgkin Disease; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Waldenstrom Macroglobulinemia; Lymphoma; Lymphoma, Follicular; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Non-Hodgkin; Neoplasms PI3-kinase p110-delta subunit inhibitor

Small molecule

Approved

CANCER; HEMATOLOGY; OTHER

ORAL

Carcinoma, Pancreatic Ductal; Leukemia, Myeloid, Acute; Multiple Myeloma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Rhinitis, Allergic, Seasonal; Amyloidosis; Hodgkin Disease; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Waldenstrom Macroglobulinemia; Lymphoma; Lymphoma, Follicular; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Non-Hodgkin; Neoplasms

PI3-kinase p110-delta subunit inhibitor


Small molecule Approved CANCER; HEMATOLOGY; OTHER ORAL Unknown Unknown