DrugMapper


Display Options: Drug type Therapeutic Area Route of administration Mechanism of Action Indication Status		Total: 92


Small molecule Approved OTHER ORAL Amphetamine-Related Disorders; Fatigue; HIV Infections; Multiple Myeloma; Neoplasms; Obesity; Prostatic Neoplasms, Castration-Resistant; Retinal Dystrophies; Sarcoma; Alcohol-Related Disorders; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cocaine-Related Disorders; Glioblastoma; Melanoma; Neoplasms, Germ Cell and Embryonal; Opioid-Related Disorders; Pancreatic Neoplasms; Paraganglioma; Severe Acute Respiratory Syndrome; Alcoholism; Ectoparasitic Infestations Aldehyde dehydrogenase inhibitor

Small molecule

Approved

OTHER

ORAL

Amphetamine-Related Disorders; Fatigue; HIV Infections; Multiple Myeloma; Neoplasms; Obesity; Prostatic Neoplasms, Castration-Resistant; Retinal Dystrophies; Sarcoma; Alcohol-Related Disorders; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cocaine-Related Disorders; Glioblastoma; Melanoma; Neoplasms, Germ Cell and Embryonal; Opioid-Related Disorders; Pancreatic Neoplasms; Paraganglioma; Severe Acute Respiratory Syndrome; Alcoholism; Ectoparasitic Infestations

Aldehyde dehydrogenase inhibitor


Small molecule Approved OTHER ORAL Anemia; Cocaine-Related Disorders; Immune System Diseases; Leukemia; Lymphoma; Neuroblastoma; Anemia, Sickle Cell; Optic Neuritis; Pancreatic Neoplasms; Polyneuropathies; Thalassemia; Wounds and Injuries; Anxiety; Dementia; Depressive Disorder; Schizophrenia; Epilepsy; Seizures Sodium channel alpha subunit blocker


Small molecule Approved OTHER ORAL Stroke; Epilepsy; Seizures GABA-A receptor; anion channel positive allosteric modulator


Small molecule Approved OTHER ORAL; TRANSDERMAL Alcoholism; Hypotension, Orthostatic; Opioid-Related Disorders; Postoperative Complications; Amphetamine-Related Disorders; Brain Injuries; Chronic Pain; Cocaine-Related Disorders; Feeding and Eating Disorders; Parkinson Disease; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Stress Disorders, Post-Traumatic; Substance-Related Disorders; Alzheimer Disease; Anemia, Sickle Cell; Asthenia; Bipolar Disorder; Brain Neoplasms; Delirium; Dementia; Depressive Disorder; Depressive Disorder, Major; Fatigue; Hematologic Neoplasms; Multiple Sclerosis; Neoplasms; Tobacco Use Disorder; Attention Deficit Disorder with Hyperactivity; Narcolepsy Dopamine transporter inhibitor

Small molecule

Approved

OTHER

ORAL; TRANSDERMAL

Alcoholism; Hypotension, Orthostatic; Opioid-Related Disorders; Postoperative Complications; Amphetamine-Related Disorders; Brain Injuries; Chronic Pain; Cocaine-Related Disorders; Feeding and Eating Disorders; Parkinson Disease; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Stress Disorders, Post-Traumatic; Substance-Related Disorders; Alzheimer Disease; Anemia, Sickle Cell; Asthenia; Bipolar Disorder; Brain Neoplasms; Delirium; Dementia; Depressive Disorder; Depressive Disorder, Major; Fatigue; Hematologic Neoplasms; Multiple Sclerosis; Neoplasms; Tobacco Use Disorder; Attention Deficit Disorder with Hyperactivity; Narcolepsy

Dopamine transporter inhibitor


Small molecule Approved OTHER RECTAL Cardiotoxicity; Multiple Myeloma; Genital Neoplasms, Female; Headache; Migraine Disorders; Nausea; Anxiety; Postoperative Nausea and Vomiting; Psychotic Disorders; Schizophrenia Dopamine D2 receptor antagonist


Small molecule Approved OTHER IM-IV; INJECTION; ORAL Liver Cirrhosis; Pain Carbonic anhydrase I inhibitor


Small molecule Approved OTHER INJECTION; ORAL Cocaine-Related Disorders; Ischemic Stroke; Anxiety; Dementia; Depressive Disorder; Psychomotor Agitation; Postoperative Nausea and Vomiting; Psychotic Disorders; Schizophrenia Dopamine D2 receptor antagonist


Small molecule Approved OTHER ORAL Unknown Intermediate conductance calcium-activated potassium channel protein 4 opener


Small molecule Approved OTHER ORAL Low Back Pain; Pain; Spasm Unknown


Small molecule Approved OTHER ORAL Depressive Disorder; Migraine Disorders; Complex Regional Pain Syndromes; Neuralgia; Epilepsy, Absence; Irritable Bowel Syndrome; Seizures; Epilepsy Voltage-gated T-type calcium channel blocker


Small molecule Approved OTHER ORAL Unknown Unknown


Small molecule Approved OTHER INJECTION; ORAL; RECTAL Landau-Kleffner Syndrome; Low Back Pain; Rotator Cuff Injuries; Wounds and Injuries; Dementia; Depressive Disorder; Epilepsy, Complex Partial; Pain; Schizophrenia; Seizures; Status Epilepticus; Vertigo; Anxiety; Anxiety Disorders; Cerebral Palsy; Epilepsy; Mental Disorders; Psychomotor Agitation; Stiff-Person Syndrome GABA-A receptor; anion channel positive allosteric modulator

Small molecule

Approved

OTHER

INJECTION; ORAL; RECTAL

Landau-Kleffner Syndrome; Low Back Pain; Rotator Cuff Injuries; Wounds and Injuries; Dementia; Depressive Disorder; Epilepsy, Complex Partial; Pain; Schizophrenia; Seizures; Status Epilepticus; Vertigo; Anxiety; Anxiety Disorders; Cerebral Palsy; Epilepsy; Mental Disorders; Psychomotor Agitation; Stiff-Person Syndrome

GABA-A receptor; anion channel positive allosteric modulator


Small molecule Approved OTHER ORAL HIV Infections; Tobacco Use Disorder; Dementia; Depressive Disorder; Schizophrenia; Anxiety; Anxiety Disorders; Mental Disorders GABA-A receptor; anion channel positive allosteric modulator


Small molecule Approved OTHER ORAL Diabetes Mellitus; Pain; Hemorrhage; Dysmenorrhea; Rheumatic Diseases Cyclooxygenase inhibitor


Small molecule Approved OTHER ORAL Psychotic Disorders; Schizophrenia Dopamine D2 receptor antagonist


Small molecule Approved OTHER INJECTION; ORAL Huntington Disease; Tobacco Use Disorder; Aggression; Amphetamine-Related Disorders; Mood Disorders; Pain; Alzheimer Disease; Anxiety; Bipolar Disorder; Delirium; Dementia; Depressive Disorder; Emergence Delirium; Nausea; Postoperative Complications; Psychomotor Agitation; Conduct Disorder; Psychotic Disorders; Schizophrenia; Tics; Tourette Syndrome D2-like dopamine receptor inverse agonist

Small molecule

Approved

OTHER

INJECTION; ORAL

Huntington Disease; Tobacco Use Disorder; Aggression; Amphetamine-Related Disorders; Mood Disorders; Pain; Alzheimer Disease; Anxiety; Bipolar Disorder; Delirium; Dementia; Depressive Disorder; Emergence Delirium; Nausea; Postoperative Complications; Psychomotor Agitation; Conduct Disorder; Psychotic Disorders; Schizophrenia; Tics; Tourette Syndrome

D2-like dopamine receptor inverse agonist


Small molecule Approved OTHER INJECTION; INTRAVENOUS; ORAL; RECTAL Ankle Fractures; Arrhythmias, Cardiac; Brain Concussion; Cognition; Crohn Disease; Diabetes Mellitus; Diabetes Mellitus, Type 2; Drug-Related Side Effects and Adverse Reactions; Esophageal Neoplasms; Glaucoma; Glycogen Storage Disease Type II; Glycogen Storage Disease Type III; Hepatitis; Hepatitis B, Chronic; Immune System Diseases; Intervertebral Disc Degeneration; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mesothelioma; Nervous System Diseases; Obesity, Morbid; Parkinson Disease; Prostatic Neoplasms, Castration-Resistant; Pruritus; Purpura, Thrombocytopenic, Idiopathic; Tooth Diseases; Urinary Bladder Neoplasms; Anxiety; Arthritis, Rheumatoid; Borderline Personality Disorder; Brain Injuries; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cleft Palate; Diabetes Mellitus, Type 1; Digestive System Diseases; Fractures, Bone; Glioma; Graft vs Host Disease; Hypertension; Hypertrophy; Immunoglobulin G4-Related Disease; Kidney Neoplasms; Leukemia; Leukemia, Hairy Cell; Leukemia, Mast-Cell; Leukemia, Myeloid, Acute; Leukemia, T-Cell; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Melanoma; Mucositis; Myelodysplastic Syndromes; Neck Pain; Neuralgia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Pre-Eclampsia; Pulpitis; Rotator Cuff Injuries; Sinusitis; Tension-Type Headache; Tonsillitis; Abdominal Pain; Cancer Pain; Chronic Pain; Delirium; Diabetic Neuropathies; Ductus Arteriosus, Patent; Hemorrhage; HIV Infections; Hypospadias; Infections; Kidney Calculi; Kidney Diseases; Low Back Pain; Lupus Erythematosus, Systemic; Lupus Nephritis; Malaria; Malaria, Falciparum; Meningitis, Bacterial; Mucopolysaccharidosis I; Multiple Myeloma; Multiple Sclerosis; Myopia; Nausea; Neoplasms; Obesity; Osteoarthritis; Osteoarthritis, Hip; Osteoarthritis, Knee; Paget Disease, Extramammary; Pemphigus; Postoperative Nausea and Vomiting; Renal Colic; Respiratory Tract Infections; Scoliosis; Sepsis; Severe Acute Respiratory Syndrome; Streptococcal Infections; Vomiting; Wounds and Injuries; Acute Pain; Arthritis; Back Pain; Common Cold; Dysmenorrhea; Fever; Headache; Influenza, Human; Migraine Disorders; Muscle Cramp; Pain; Pharyngitis; Toothache Anandamide amidohydrolase inhibitor

Small molecule

Approved

OTHER

INJECTION; INTRAVENOUS; ORAL; RECTAL

Ankle Fractures; Arrhythmias, Cardiac; Brain Concussion; Cognition; Crohn Disease; Diabetes Mellitus; Diabetes Mellitus, Type 2; Drug-Related Side Effects and Adverse Reactions; Esophageal Neoplasms; Glaucoma; Glycogen Storage Disease Type II; Glycogen Storage Disease Type III; Hepatitis; Hepatitis B, Chronic; Immune System Diseases; Intervertebral Disc Degeneration; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mesothelioma; Nervous System Diseases; Obesity, Morbid; Parkinson Disease; Prostatic Neoplasms, Castration-Resistant; Pruritus; Purpura, Thrombocytopenic, Idiopathic; Tooth Diseases; Urinary Bladder Neoplasms; Anxiety; Arthritis, Rheumatoid; Borderline Personality Disorder; Brain Injuries; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cleft Palate; Diabetes Mellitus, Type 1; Digestive System Diseases; Fractures, Bone; Glioma; Graft vs Host Disease; Hypertension; Hypertrophy; Immunoglobulin G4-Related Disease; Kidney Neoplasms; Leukemia; Leukemia, Hairy Cell; Leukemia, Mast-Cell; Leukemia, Myeloid, Acute; Leukemia, T-Cell; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Melanoma; Mucositis; Myelodysplastic Syndromes; Neck Pain; Neuralgia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Pre-Eclampsia; Pulpitis; Rotator Cuff Injuries; Sinusitis; Tension-Type Headache; Tonsillitis; Abdominal Pain; Cancer Pain; Chronic Pain; Delirium; Diabetic Neuropathies; Ductus Arteriosus, Patent; Hemorrhage; HIV Infections; Hypospadias; Infections; Kidney Calculi; Kidney Diseases; Low Back Pain; Lupus Erythematosus, Systemic; Lupus Nephritis; Malaria; Malaria, Falciparum; Meningitis, Bacterial; Mucopolysaccharidosis I; Multiple Myeloma; Multiple Sclerosis; Myopia; Nausea; Neoplasms; Obesity; Osteoarthritis; Osteoarthritis, Hip; Osteoarthritis, Knee; Paget Disease, Extramammary; Pemphigus; Postoperative Nausea and Vomiting; Renal Colic; Respiratory Tract Infections; Scoliosis; Sepsis; Severe Acute Respiratory Syndrome; Streptococcal Infections; Vomiting; Wounds and Injuries; Acute Pain; Arthritis; Back Pain; Common Cold; Dysmenorrhea; Fever; Headache; Influenza, Human; Migraine Disorders; Muscle Cramp; Pain; Pharyngitis; Toothache

Anandamide amidohydrolase inhibitor


Small molecule Approved CANCER; NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER BUCCAL; SUBLINGUAL; TRANSDERMAL Burns; Opioid-Related Disorders; Respiratory Distress Syndrome; Brain Injuries; Breast Neoplasms; Delirium; Fractures, Bone; Hypospadias; Hypotension; Irritable Bowel Syndrome; Pregnancy; Pulpitis; Scoliosis; Subarachnoid Hemorrhage; Abscess; Adenoma; Aortic Coarctation; Diabetic Neuropathies; Liver Diseases; Low Back Pain; Lung Diseases; Migraine Disorders; Neoplasm Metastasis; Obesity; Obesity, Morbid; Osteoarthritis; Pancreatic Neoplasms; Renal Insufficiency, Chronic; Respiratory Insufficiency; Severe Acute Respiratory Syndrome; Sleep Apnea, Obstructive; Stomach Neoplasms; Acute Pain; Cancer Pain; Chronic Pain; Neoplasms; Pain Mu opioid receptor agonist

Small molecule

Approved

CANCER; NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER

BUCCAL; SUBLINGUAL; TRANSDERMAL

Burns; Opioid-Related Disorders; Respiratory Distress Syndrome; Brain Injuries; Breast Neoplasms; Delirium; Fractures, Bone; Hypospadias; Hypotension; Irritable Bowel Syndrome; Pregnancy; Pulpitis; Scoliosis; Subarachnoid Hemorrhage; Abscess; Adenoma; Aortic Coarctation; Diabetic Neuropathies; Liver Diseases; Low Back Pain; Lung Diseases; Migraine Disorders; Neoplasm Metastasis; Obesity; Obesity, Morbid; Osteoarthritis; Pancreatic Neoplasms; Renal Insufficiency, Chronic; Respiratory Insufficiency; Severe Acute Respiratory Syndrome; Sleep Apnea, Obstructive; Stomach Neoplasms; Acute Pain; Cancer Pain; Chronic Pain; Neoplasms; Pain

Mu opioid receptor agonist


Small molecule Approved NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER; PEDIATRICS INTRAVENOUS; ORAL Hepatitis B, Chronic; Parkinson Disease; Severe Acute Respiratory Syndrome; Cocaine-Related Disorders; Epilepsy, Reflex; HIV Infections; Nausea; Substance-Related Disorders; Anxiety; Dementia; Depressive Disorder; Schizophrenia; Bipolar Disorder; Epilepsies, Partial; Epilepsy; Glossopharyngeal Nerve Diseases; Seizures; Trigeminal Neuralgia Sodium channel alpha subunit blocker

Small molecule

Approved

NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER; PEDIATRICS

INTRAVENOUS; ORAL

Hepatitis B, Chronic; Parkinson Disease; Severe Acute Respiratory Syndrome; Cocaine-Related Disorders; Epilepsy, Reflex; HIV Infections; Nausea; Substance-Related Disorders; Anxiety; Dementia; Depressive Disorder; Schizophrenia; Bipolar Disorder; Epilepsies, Partial; Epilepsy; Glossopharyngeal Nerve Diseases; Seizures; Trigeminal Neuralgia

Sodium channel alpha subunit blocker


Small molecule Approved OTHER ORAL; TRANSDERMAL Brain Ischemia; Cocaine-Related Disorders; Dermatitis, Atopic; Hemorrhage; Heroin Dependence; Hypotension, Orthostatic; Orthostatic Intolerance; Anxiety; Back Pain; Brain Injuries; Breast Neoplasms; Child Development Disorders, Pervasive; Diabetic Neuropathies; Low Back Pain; Marijuana Abuse; Musculoskeletal Diseases; Opioid-Related Disorders; Sialorrhea; Stomatitis; Substance-Related Disorders; Attention Deficit Disorder with Hyperactivity; Cardiovascular Diseases; Delirium; Dwarfism, Pituitary; Fecal Incontinence; Genital Neoplasms, Male; Hyperemesis Gravidarum; Neonatal Abstinence Syndrome; Pain; Postoperative Complications; Pregnancy; Scoliosis; Stress Disorders, Post-Traumatic; Glaucoma; Hypertension; Migraine Disorders; Neoplasms; Neuralgia Adrenergic receptor alpha-2 agonist

Small molecule

Approved

OTHER

ORAL; TRANSDERMAL

Brain Ischemia; Cocaine-Related Disorders; Dermatitis, Atopic; Hemorrhage; Heroin Dependence; Hypotension, Orthostatic; Orthostatic Intolerance; Anxiety; Back Pain; Brain Injuries; Breast Neoplasms; Child Development Disorders, Pervasive; Diabetic Neuropathies; Low Back Pain; Marijuana Abuse; Musculoskeletal Diseases; Opioid-Related Disorders; Sialorrhea; Stomatitis; Substance-Related Disorders; Attention Deficit Disorder with Hyperactivity; Cardiovascular Diseases; Delirium; Dwarfism, Pituitary; Fecal Incontinence; Genital Neoplasms, Male; Hyperemesis Gravidarum; Neonatal Abstinence Syndrome; Pain; Postoperative Complications; Pregnancy; Scoliosis; Stress Disorders, Post-Traumatic; Glaucoma; Hypertension; Migraine Disorders; Neoplasms; Neuralgia

Adrenergic receptor alpha-2 agonist


Small molecule Approved OTHER INTRAVENOUS; ORAL Acute Kidney Injury; Alzheimer Disease; Ankle Fractures; Bipolar Disorder; Glycogen Storage Disease Type III; Hypotension, Orthostatic; Malaria; Muscular Dystrophy, Duchenne; Osteoarthritis, Knee; Premature Birth; Rhinitis, Allergic, Seasonal; Uveal Melanoma; Brachial Plexus Neuritis; Bronchopulmonary Dysplasia; Cognitive Dysfunction; Depressive Disorder, Major; Diabetes Mellitus, Type 1; Emphysema; Enuresis; Epilepsies, Partial; Epilepsy; Glioma; Granulomatous Disease, Chronic; Hemorrhage; Hypertension; Kidney Neoplasms; Muscular Diseases; Pancreatitis; Periodontitis; Pre-Eclampsia; Retinopathy of Prematurity; Sinusitis; Spondylarthropathies; Spondylosis; Stomatitis, Aphthous; Sunburn; Temporomandibular Joint Disorders; Tension-Type Headache; Tooth Diseases; Tuberculosis; Wounds and Injuries; Altitude Sickness; Breast Neoplasms; Burns; Causalgia; Cerebral Palsy; Chronic Pain; Fractures, Bone; HIV Infections; Hypospadias; Infections; Low Back Pain; Mucopolysaccharidosis I; Multiple Sclerosis; Neck Pain; Peptic Ulcer; Pulpitis; Respiratory Distress Syndrome; Shock, Septic; Sleep Apnea, Obstructive; Sprains and Strains; Tibial Fractures; Vasculitis; Acute Pain; Arthralgia; Arthritis; Arthritis, Juvenile; Arthritis, Rheumatoid; Back Pain; Cardiovascular Diseases; Common Cold; Ductus Arteriosus, Patent; Dysmenorrhea; Fever; Headache; Influenza, Human; Migraine Disorders; Muscle Cramp; Myalgia; Osteoarthritis; Pain; Pharyngitis; Rheumatic Diseases; Toothache; Vaginitis Cyclooxygenase inhibitor

Small molecule

Approved

OTHER

INTRAVENOUS; ORAL

Acute Kidney Injury; Alzheimer Disease; Ankle Fractures; Bipolar Disorder; Glycogen Storage Disease Type III; Hypotension, Orthostatic; Malaria; Muscular Dystrophy, Duchenne; Osteoarthritis, Knee; Premature Birth; Rhinitis, Allergic, Seasonal; Uveal Melanoma; Brachial Plexus Neuritis; Bronchopulmonary Dysplasia; Cognitive Dysfunction; Depressive Disorder, Major; Diabetes Mellitus, Type 1; Emphysema; Enuresis; Epilepsies, Partial; Epilepsy; Glioma; Granulomatous Disease, Chronic; Hemorrhage; Hypertension; Kidney Neoplasms; Muscular Diseases; Pancreatitis; Periodontitis; Pre-Eclampsia; Retinopathy of Prematurity; Sinusitis; Spondylarthropathies; Spondylosis; Stomatitis, Aphthous; Sunburn; Temporomandibular Joint Disorders; Tension-Type Headache; Tooth Diseases; Tuberculosis; Wounds and Injuries; Altitude Sickness; Breast Neoplasms; Burns; Causalgia; Cerebral Palsy; Chronic Pain; Fractures, Bone; HIV Infections; Hypospadias; Infections; Low Back Pain; Mucopolysaccharidosis I; Multiple Sclerosis; Neck Pain; Peptic Ulcer; Pulpitis; Respiratory Distress Syndrome; Shock, Septic; Sleep Apnea, Obstructive; Sprains and Strains; Tibial Fractures; Vasculitis; Acute Pain; Arthralgia; Arthritis; Arthritis, Juvenile; Arthritis, Rheumatoid; Back Pain; Cardiovascular Diseases; Common Cold; Ductus Arteriosus, Patent; Dysmenorrhea; Fever; Headache; Influenza, Human; Migraine Disorders; Muscle Cramp; Myalgia; Osteoarthritis; Pain; Pharyngitis; Rheumatic Diseases; Toothache; Vaginitis

Cyclooxygenase inhibitor


Small molecule Approved NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER ORAL Burning Mouth Syndrome; Neuralgia; Marijuana Abuse; REM Sleep Behavior Disorder; Anxiety; Dementia; Depressive Disorder; Epilepsia Partialis Continua; Epilepsy, Tonic-Clonic; Pain; Schizophrenia; Status Epilepticus; Epilepsy; Panic Disorder; Seizures GABA-A receptor; anion channel positive allosteric modulator


Small molecule Approved OTHER; UROLOGY AND KIDNEY TRANSDERMAL Paget Disease, Extramammary; Rhinitis, Allergic, Seasonal; Sialorrhea; Sleep Apnea, Obstructive; Sleep Apnea Syndromes; Breast Neoplasms; Enuresis; Hyperhidrosis; Polyneuropathies; Urinary Bladder, Neurogenic; Polyuria; Urinary Bladder, Overactive; Urinary Incontinence; Urinary Incontinence, Urge Muscarinic acetylcholine receptor M2 antagonist

Small molecule

Approved

OTHER; UROLOGY AND KIDNEY

TRANSDERMAL

Paget Disease, Extramammary; Rhinitis, Allergic, Seasonal; Sialorrhea; Sleep Apnea, Obstructive; Sleep Apnea Syndromes; Breast Neoplasms; Enuresis; Hyperhidrosis; Polyneuropathies; Urinary Bladder, Neurogenic; Polyuria; Urinary Bladder, Overactive; Urinary Incontinence; Urinary Incontinence, Urge

Muscarinic acetylcholine receptor M2 antagonist


Small molecule Approved OTHER ORAL Amyotrophic Lateral Sclerosis; Angelman Syndrome; Asthma; Diabetic Retinopathy; Hypertension; Hypotension, Orthostatic; Tobacco Use Disorder; Albinism; Albinism, Oculocutaneous; Aphasia; Attention Deficit Disorder with Hyperactivity; Back Pain; Chronic Pain; Cocaine-Related Disorders; Fibromyalgia; Macular Degeneration; Multiple Sclerosis; Pain; Retinitis Pigmentosa; Schizophrenia; Spinal Cord Injuries; Amblyopia; Dysautonomia, Familial; Stroke; Parkinson Disease; Parkinson Disease, Postencephalitic; Parkinson Disease, Secondary; Wounds and Injuries DOPA decarboxylase inhibitor

Small molecule

Approved

OTHER

ORAL

Amyotrophic Lateral Sclerosis; Angelman Syndrome; Asthma; Diabetic Retinopathy; Hypertension; Hypotension, Orthostatic; Tobacco Use Disorder; Albinism; Albinism, Oculocutaneous; Aphasia; Attention Deficit Disorder with Hyperactivity; Back Pain; Chronic Pain; Cocaine-Related Disorders; Fibromyalgia; Macular Degeneration; Multiple Sclerosis; Pain; Retinitis Pigmentosa; Schizophrenia; Spinal Cord Injuries; Amblyopia; Dysautonomia, Familial; Stroke; Parkinson Disease; Parkinson Disease, Postencephalitic; Parkinson Disease, Secondary; Wounds and Injuries

DOPA decarboxylase inhibitor


Small molecule Approved OTHER ORAL Colorectal Neoplasms, Hereditary Nonpolyposis; Inflammation; Alzheimer Disease; Breast Neoplasms; Duodenal Ulcer; Neuralgia; Pleural Effusion; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Wounds and Injuries; Low Back Pain; Migraine Disorders; Multiple Sclerosis; Osteoarthritis, Hip; Osteoarthritis, Knee; Peptic Ulcer; Severe Acute Respiratory Syndrome; Acute Pain; Arthralgia; Arthritis; Arthritis, Gouty; Arthritis, Juvenile; Arthritis, Rheumatoid; Back Pain; Bursitis; Common Cold; Dysmenorrhea; Fever; Gout; Headache; Muscle Cramp; Myalgia; Osteoarthritis; Pain; Rheumatic Diseases; Spondylitis; Spondylitis, Ankylosing; Stomach Ulcer; Tendinopathy; Toothache; Vaginitis Cyclooxygenase inhibitor

Small molecule

Approved

OTHER

ORAL

Colorectal Neoplasms, Hereditary Nonpolyposis; Inflammation; Alzheimer Disease; Breast Neoplasms; Duodenal Ulcer; Neuralgia; Pleural Effusion; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Wounds and Injuries; Low Back Pain; Migraine Disorders; Multiple Sclerosis; Osteoarthritis, Hip; Osteoarthritis, Knee; Peptic Ulcer; Severe Acute Respiratory Syndrome; Acute Pain; Arthralgia; Arthritis; Arthritis, Gouty; Arthritis, Juvenile; Arthritis, Rheumatoid; Back Pain; Bursitis; Common Cold; Dysmenorrhea; Fever; Gout; Headache; Muscle Cramp; Myalgia; Osteoarthritis; Pain; Rheumatic Diseases; Spondylitis; Spondylitis, Ankylosing; Stomach Ulcer; Tendinopathy; Toothache; Vaginitis

Cyclooxygenase inhibitor

Small molecule

Approved

OTHER

INTRATHECAL; ORAL

Ataxia Telangiectasia; Autistic Disorder; Liver Cirrhosis, Alcoholic; Obesity; Carcinoma, Hepatocellular; Cocaine-Related Disorders; Fragile X Syndrome; Marijuana Abuse; Paget Disease, Extramammary; Substance-Related Disorders; Tobacco Use Disorder; Alcoholism; Charcot-Marie-Tooth Disease; Gastroesophageal Reflux; Pain; Substance Withdrawal Syndrome; Brain Injuries; Brain Injuries, Traumatic; Cerebral Palsy; Multiple Sclerosis; Muscle Rigidity; Muscle Spasticity; Spinal Cord Diseases; Spinal Cord Injuries

GABA-B receptor agonist

Small molecule

Approved

OTHER

INJECTION; ORAL

Alzheimer Disease; Epidermolysis Bullosa; Obsessive-Compulsive Disorder; Substance-Related Disorders; Voice Disorders; Alcoholism; Amphetamine-Related Disorders; Cocaine-Related Disorders; Delirium; Down Syndrome; Epilepsy, Reflex; Pain; Seizures; Substance Withdrawal Syndrome; Dementia; Depressive Disorder; Epilepsia Partialis Continua; Epilepsy; Psychomotor Agitation; Psychotic Disorders; Schizophrenia; Vertigo; Anxiety; Anxiety Disorders; Depression; Status Epilepticus

GABA-A receptor; anion channel positive allosteric modulator

Small molecule

Approved

NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER

ORAL

Astrocytoma; Brain Injuries; Burkitt Lymphoma; Carcinoma, Non-Small-Cell Lung; Central Nervous System Neoplasms; Colorectal Neoplasms; Epilepsies, Partial; Lung Neoplasms; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Medulloblastoma; Melanoma; Nasopharyngeal Carcinoma; Neoplasms; Ovarian Neoplasms; Paraganglioma; Sarcoma; Shock; Urinary Bladder Neoplasms; Wounds and Injuries; Alopecia; Brain Neoplasms; Breast Neoplasms; Carcinoma, Squamous Cell; Ependymoma; Glioblastoma; Glioma; Head and Neck Neoplasms; HIV Infections; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Lymphoma; Myelodysplastic Syndromes; Neuralgia; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Retinitis Pigmentosa; Small Cell Lung Carcinoma; Supranuclear Palsy, Progressive; Thyroid Neoplasms; Uveal Melanoma; Alcoholism; Alzheimer Disease; Anxiety; Autistic Disorder; Dementia; Depressive Disorder; Migraine Disorders; Muscular Atrophy, Spinal; Paraparesis, Tropical Spastic; Psychomotor Agitation; Schizophrenia; Status Epilepticus; Bipolar Disorder; Epilepsy; Epilepsy, Absence; Epilepsy, Complex Partial; Mitochondrial Diseases; Seizures

Succinate semialdehyde dehydrogenase inhibitor


Small molecule Approved OTHER ORAL Breast Neoplasms; Carcinoma, Squamous Cell; Desmoid Tumors; Fragile X Syndrome; Leukemia, Myeloid, Acute; Melanoma; Adenomatous Polyposis Coli; Colorectal Neoplasms; Precancerous Conditions; Arthritis, Rheumatoid; Osteoarthritis; Rheumatic Diseases; Spondylitis Cyclooxygenase inhibitor


Small molecule Approved OTHER ORAL Substance-Related Disorders; Anxiety; Dementia; Depressive Disorder; Schizophrenia; Sleep Initiation and Maintenance Disorders GABA-A receptor; anion channel positive allosteric modulator


Small molecule Approved OTHER ORAL Depressive Disorder Dopamine receptor antagonist


Small molecule Approved OTHER ORAL Asthma; Diabetes Mellitus, Type 1; Migraine Disorders; Phobia, Social; Substance-Related Disorders; Dental Anxiety; Epilepsy; Stress Disorders, Post-Traumatic; Dementia; Depressive Disorder; Schizophrenia; Seizures; Anxiety; Anxiety Disorders; Panic Disorder GABA-A receptor; anion channel positive allosteric modulator

Small molecule

Approved

OTHER

INJECTION; INTRAMUSCULAR; INTRAVENOUS

Chronic Pain; Head and Neck Neoplasms; Heart Arrest; Hypertension; Hypotension; Ischemic Stroke; Osteoporosis; Peripheral Nervous System Diseases; Persistent Fetal Circulation Syndrome; Psoriasis; Status Asthmaticus; Temporomandibular Joint Disorders; Bronchiolitis; Hand, Foot and Mouth Disease; Headache; Hearing Loss, Noise-Induced; Hip Fractures; Mesothelioma; Muscle Cramp; Muscular Diseases; Neoplasms; Neuralgia; Osteoporosis, Postmenopausal; Pancreatic Neoplasms; Renal Colic; Renal Insufficiency, Chronic; Scoliosis; Abruptio Placentae; Anemia, Sickle Cell; Asthma; Atrial Fibrillation; Brain Injuries; Brain Ischemia; Brain Neoplasms; Cardiovascular Diseases; Cerebral Palsy; Colorectal Neoplasms; Coronary Disease; Craniocerebral Trauma; Delirium; Glioma; Heart Diseases; Hemorrhage; Hypoxia-Ischemia, Brain; Leukomalacia, Periventricular; Meningioma; Myocardial Infarction; Myocardial Ischemia; Pain; Pancreatitis; Pharyngitis; Placenta Previa; Poisoning; Premature Birth; Pulmonary Disease, Chronic Obstructive; Pulmonary Edema; Stroke; Subarachnoid Hemorrhage; Substance Withdrawal Syndrome; Tinnitus; Anemia; Anemia, Iron-Deficiency; Constipation; Eclampsia; Folic Acid Deficiency; Magnesium Deficiency; Pre-Eclampsia; Seizures; Toxemia

Unknown


Small molecule Approved OTHER ORAL Anxiety; Dementia; Depressive Disorder; Pulmonary Disease, Chronic Obstructive; Schizophrenia; Sleep Initiation and Maintenance Disorders GABA-A receptor; anion channel positive allosteric modulator


Small molecule Approved OTHER ORAL Pain; Osteoarthritis, Knee; Tennis Elbow; Renal Colic; Wounds and Injuries; Arthralgia; Arthritis, Rheumatoid; Eye Diseases; Myalgia; Osteoarthritis; Rheumatic Diseases Cyclooxygenase inhibitor