Pharmacology

Action Mechanism of Action Reference
INHIBITOR Subtilisin/kexin type 9 inhibitor DailyMed
Primary Target
proprotein convertase subtilisin/kexin type 9

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Cardiovascular Diseases 4 D002318 ClinicalTrials
Hyperlipoproteinemia Type II 4 D006938 ClinicalTrials
Coronary Disease 4 D003327 ClinicalTrials
Hyperlipoproteinemia Type II 4 D006938 ClinicalTrials
Diabetes Mellitus 3 D003920 ClinicalTrials
Hypercholesterolemia 3 D006937 ClinicalTrials
Lipid Metabolism Disorders 3 D052439 ClinicalTrials
Atherosclerosis 3 D050197 ClinicalTrials

Adverse Reactions

System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
19.39
Injury, poisoning and procedural complications
14.85
Musculoskeletal and connective tissue disorders
10.43
Skin and subcutaneous tissue disorders
8.58
Respiratory, thoracic and mediastinal disorders
7.04
Nervous system disorders
6.64
Vascular disorders
5.4
Gastrointestinal disorders
5.32
Investigations
4.3
Cardiac disorders
3.41
Psychiatric disorders
2.96
Infections and infestations
2.95

Cross References

Resources Reference
CAS NUMBER 1245916-14-6
ChEMBL CHEMBL2109540
FDA SRS PP0SHH6V16
Guide to Pharmacology 6744