ALPRAZOLAM

Search structure
Trade Names:
Synonyms:
Status: Approved (1981)
Entry Type: Small molecule
Molecule Category: Parent
ATC: N05BA12
UNII: YU55MQ3IZY

Structure
InChI Key VREFGVBLTWBCJP-UHFFFAOYSA-N
Smile Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2
InChI
InChI=1S/C17H13ClN4/c1-11-20-21-16-10-19-17(12-5-3-2-4-6-12)14-9-13(18)7-8-15(14)22(11)16/h2-9H,10H2,1H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C17H13ClN4
Molecular Weight 308.77
AlogP 3.58
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 1.0
Polar Surface Area 43.07
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 22.0

Pharmacology

Action Mechanism of Action Reference
POSITIVE ALLOSTERIC MODULATOR GABA-A receptor; anion channel positive allosteric modulator PubMed PubMed Wikipedia
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Epigenetic regulator Reader Bromodomain
- - 2460 - -
Ion channel Ligand-gated ion channel GABA-A receptor
10 - - 3 -
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Short peptide receptor (family A GPCR) Cholecystokinin receptor
- 64000 - - -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Lipid-like ligand receptor (family A GPCR) PAF receptor
- 22000 - - -

Metabolites

visNetwork

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Schizophrenia 3 D012559 ClinicalTrials
Dementia 3 D003704 ClinicalTrials
Depressive Disorder 3 D003866 ClinicalTrials
Epilepsy 2 D004827 ClinicalTrials
Stress Disorders, Post-Traumatic 2 D013313 ClinicalTrials
Asthma 1 D001249 ClinicalTrials
Substance-Related Disorders 1 D019966 ClinicalTrials
Migraine Disorders 1 D008881 ClinicalTrials
Diabetes Mellitus, Type 1 1 D003922 ClinicalTrials
Phobia, Social 1 D000072861 ClinicalTrials

Related Entries

MCS

Scaffolds

Side Effects from Label

Side effects Relative Frequency (%) Labels
Nervous system disorders Somnolence 76.8
General disorders and administration site conditions Asthenia 49.0
General disorders and administration site conditions Fatigue 49.0
General disorders and administration site conditions Asthenia 48.6
General disorders and administration site conditions Fatigue 48.6
Nervous system disorders Somnolence
General disorders and administration site conditions Asthenia
General disorders and administration site conditions Fatigue
General disorders and administration site conditions Asthenia
General disorders and administration site conditions Fatigue
Nervous system disorders Insomnia
Nervous system disorders Somnolence 41.0
Nervous system disorders Coordination abnormal 40.1
Nervous system disorders Coordination abnormal 40.0
Cardiac disorders Dizziness
Nervous system disorders Headache
Gastrointestinal disorders Salivary hypersecretion
General disorders and administration site conditions Irritability 33.1
Nervous system disorders Memory impairment 33.1
General disorders and administration site conditions Increased appetite 33.0
General disorders and administration site conditions Irritability 33.0
Nervous system disorders Memory impairment 33.0
Gastrointestinal disorders Salivary hypersecretion 32.8
General disorders and administration site conditions Increased appetite 32.7
Gastrointestinal disorders Nausea
Gastrointestinal disorders Nausea 31.8
Gastrointestinal disorders Vomiting
Gastrointestinal disorders Vomiting 31.8
General disorders and administration site conditions Irritability
General disorders and administration site conditions Irritability
Cardiac disorders Dizziness 29.8
Nervous system disorders Insomnia 29.4
Nervous system disorders Headache 29.2
Nervous system disorders Cognitive disorder 29.0
Nervous system disorders Cognitive disorder 28.8
Nervous system disorders Tremor 28.2
General disorders and administration site conditions Decreased appetite 28.0
General disorders and administration site conditions Decreased appetite 27.8
Investigations Weight increased 27.2
Investigations Weight increased 27.0
Cardiac disorders Tachycardia
Cardiac disorders Tachycardia 26.8
Nervous system disorders Headache 26.5
Gastrointestinal disorders Constipation 26.2
Gastrointestinal disorders Constipation 26.0
Psychiatric disorders Anxiety
Nervous system disorders Insomnia 24.2
General disorders and administration site conditions Decreased appetite
General disorders and administration site conditions Decreased appetite 24.1
General disorders and administration site conditions Decreased appetite
General disorders and administration site conditions Hyperhidrosis
General disorders and administration site conditions Hyperhidrosis 23.5
Nervous system disorders Dysarthria 23.3
Musculoskeletal and connective tissue disorders Osteoarthritis 23.3
Nervous system disorders Dysarthria 23.0
General disorders and administration site conditions Increased appetite
Musculoskeletal and connective tissue disorders Osteoarthritis 23.0
Nervous system disorders Somnolence 23.0
Investigations Weight decreased 23.0
Gastrointestinal disorders Diarrhoea
Gastrointestinal disorders Diarrhoea 22.8
General disorders and administration site conditions Increased appetite
General disorders and administration site conditions Increased appetite 22.8
Investigations Weight decreased 22.6
Nervous system disorders Memory impairment
Nervous system disorders Memory impairment
Gastrointestinal disorders Nausea 22.0
Gastrointestinal disorders Vomiting 22.0
Psychiatric disorders Nervousness 21.8
Psychiatric disorders Tension 21.8
Nervous system disorders Somnolence
Gastrointestinal disorders Abdominal discomfort
Gastrointestinal disorders Abdominal discomfort 21.5
Ear and labyrinth disorders Tinnitus
Eye disorders Vision blurred
Eye disorders Vision blurred 21.4
Nervous system disorders Cognitive disorder
Cardiac disorders Dizziness 21.0
Nervous system disorders Dyskinesia
Ear and labyrinth disorders Tinnitus 21.0
Eye disorders Vision blurred 21.0
Cardiac disorders Dizziness 20.8
Gastrointestinal disorders Diarrhoea 20.6
Nervous system disorders Cognitive disorder
Nervous system disorders Headache
Cardiac disorders Dizziness
Cardiac disorders Dizziness
Nervous system disorders Insomnia
Gastrointestinal disorders Abdominal discomfort 18.3
Cardiac disorders Chest pain
Cardiac disorders Chest pain 18.1
Psychiatric disorders Depression
Nervous system disorders Coordination abnormal
Investigations Weight increased
Nervous system disorders Coordination abnormal
Investigations Weight increased
Investigations Weight increased 17.9
Respiratory, thoracic and mediastinal disorders Nasal congestion 17.4
Investigations Weight decreased
Psychiatric disorders Anxiety 16.6
Respiratory, thoracic and mediastinal disorders Nasal congestion
Investigations Weight decreased
Investigations Weight decreased 16.5
Cardiac disorders Palpitations
Cardiac disorders Tachycardia
Gastrointestinal disorders Constipation
Gastrointestinal disorders Constipation 15.4
Nervous system disorders Memory impairment 15.4
Cardiac disorders Tachycardia 15.4
General disorders and administration site conditions Hyperhidrosis 15.1
Nervous system disorders Somnolence 15.1
Gastrointestinal disorders Constipation
Gastrointestinal disorders Dry mouth 15.0
Nervous system disorders Dyskinesia 14.8
Gastrointestinal disorders Dry mouth 14.7
Psychiatric disorders Hyperventilation
Psychiatric disorders Hyperventilation 14.5
Psychiatric disorders Disturbance in sexual arousal 14.4
Psychiatric disorders Libido decreased 14.4
Psychiatric disorders Depression
Psychiatric disorders Disturbance in sexual arousal 14.0
Psychiatric disorders Libido decreased 14.0
General disorders and administration site conditions Asthenia 13.9
Psychiatric disorders Depression 13.9
General disorders and administration site conditions Fatigue 13.9
Psychiatric disorders Depression 13.8
Gastrointestinal disorders Dry mouth
Gastrointestinal disorders Dry mouth
Nervous system disorders Headache 12.9
Gastrointestinal disorders Nausea
Gastrointestinal disorders Vomiting
Nervous system disorders Headache
Renal and urinary disorders Dysuria 12.2
Renal and urinary disorders Strangury 12.2
Psychiatric disorders Depression 12.1
Gastrointestinal disorders Diarrhoea 12.1
Gastrointestinal disorders Gastrointestinal disorder 12.1
Renal and urinary disorders Dysuria 12.0
Renal and urinary disorders Strangury 12.0
Musculoskeletal and connective tissue disorders Muscle twitching
Gastrointestinal disorders Constipation
Skin and subcutaneous tissue disorders Dermatitis 11.0
Skin and subcutaneous tissue disorders Rash 11.0
Psychiatric disorders Depression 10.9
Nervous system disorders Dysarthria 10.9
Musculoskeletal and connective tissue disorders Osteoarthritis 10.9
Skin and subcutaneous tissue disorders Dermatitis 10.8
Skin and subcutaneous tissue disorders Rash 10.8
Nervous system disorders Tremor
Cardiac disorders Chest pain 10.6
Nervous system disorders Confusional state 10.4
Gastrointestinal disorders Constipation 10.4
General disorders and administration site conditions Feeling abnormal 10.4
Reproductive system and breast disorders Menstrual disorder 10.4
Ear and labyrinth disorders Tinnitus
Ear and labyrinth disorders Tinnitus 10.4
Gastrointestinal disorders Diarrhoea
Psychiatric disorders Nervousness
Psychiatric disorders Tension
Gastrointestinal disorders Dry mouth 10.2
Gastrointestinal disorders Diarrhoea 10.1
Nervous system disorders Confusional state
Nervous system disorders Confusional state 10.0
General disorders and administration site conditions Feeling abnormal
General disorders and administration site conditions Feeling abnormal 10.0
Reproductive system and breast disorders Menstrual disorder 10.0
Nervous system disorders Confusional state 9.9
General disorders and administration site conditions Feeling abnormal 9.9
General disorders and administration site conditions Decreased appetite
Gastrointestinal disorders Dry mouth
Psychiatric disorders Hyperventilation 9.7
Nervous system disorders Insomnia
Gastrointestinal disorders Nausea 9.6
Gastrointestinal disorders Vomiting 9.6
General disorders and administration site conditions Decreased appetite 9.5
Metabolism and nutrition disorders Malnutrition 9.5
Nervous system disorders Coordination abnormal 9.4
Respiratory, thoracic and mediastinal disorders Nasal congestion
General disorders and administration site conditions Asthenia
Psychiatric disorders Depression
General disorders and administration site conditions Fatigue
Renal and urinary disorders Dysuria
Reproductive system and breast disorders Menstrual disorder
Renal and urinary disorders Strangury
Nervous system disorders Insomnia 8.9
Psychiatric disorders Nervousness
Psychiatric disorders Tension
Nervous system disorders Tremor
Reproductive system and breast disorders Menstrual disorder
Reproductive system and breast disorders Menstrual disorder 8.7
Renal and urinary disorders Dysuria
Renal and urinary disorders Dysuria 8.6
Renal and urinary disorders Strangury
Renal and urinary disorders Strangury 8.6
Psychiatric disorders Hyperventilation 8.5
Respiratory, thoracic and mediastinal disorders Mediastinal disorder 8.5
General disorders and administration site conditions Asthenia
General disorders and administration site conditions Asthenia 8.4
Nervous system disorders Confusional state
General disorders and administration site conditions Feeling abnormal
Gastrointestinal disorders Constipation 8.1
Skin and subcutaneous tissue disorders Dermatitis
Skin and subcutaneous tissue disorders Dermatitis 8.1
Skin and subcutaneous tissue disorders Rash
Skin and subcutaneous tissue disorders Rash 8.1
Nervous system disorders Confusional state
Psychiatric disorders Derealisation 8.0
Skin and subcutaneous tissue disorders Dermatitis
Psychiatric disorders Disturbance in sexual arousal
Psychiatric disorders Disturbance in sexual arousal 8.0
General disorders and administration site conditions Feeling abnormal
Psychiatric disorders Libido decreased
Psychiatric disorders Libido increased 8.0
Skin and subcutaneous tissue disorders Rash
Musculoskeletal and connective tissue disorders Muscle twitching 7.9
Psychiatric disorders Anxiety 7.8
Nervous system disorders Hypoaesthesia 7.8
Psychiatric disorders Disturbance in sexual arousal 7.7
Psychiatric disorders Libido increased 7.7
Cardiac disorders Palpitations 7.7
Cardiac disorders Tachycardia 7.7
Musculoskeletal and connective tissue disorders Connective tissue disorder 7.4
Musculoskeletal and connective tissue disorders Muscle twitching 7.4
Psychiatric disorders Sexual dysfunction 7.4
General disorders and administration site conditions Decreased appetite 7.3
Respiratory, thoracic and mediastinal disorders Nasal congestion 7.3
Nervous system disorders Ataxia 7.2
General disorders and administration site conditions Decreased appetite
Social circumstances Mental disability 7.2
Mental retardation 7.2
General disorders and administration site conditions Asthenia 7.1
Nervous system disorders Paraesthesia 7.1
General disorders and administration site conditions Increased appetite 7.0
Psychiatric disorders Sexual dysfunction 7.0
Nervous system disorders Memory impairment
Ear and labyrinth disorders Tinnitus 6.6
Nervous system disorders Dysarthria
Musculoskeletal and connective tissue disorders Osteoarthritis
Eye disorders Vision blurred
Eye disorders Vision blurred 6.2
Psychiatric disorders Disturbance in sexual arousal 6.0
Nervous system disorders Dysarthria
General disorders and administration site conditions Increased appetite
Psychiatric disorders Libido decreased 6.0
Gastrointestinal disorders Nausea 6.0
Musculoskeletal and connective tissue disorders Osteoarthritis
Gastrointestinal disorders Salivary hypersecretion 6.0
Nervous system disorders Somnolence
Vascular disorders Angiopathy 5.9
General disorders and administration site conditions Hot flush 5.9
Reproductive system and breast disorders Menopausal symptoms 5.9
Depersonalisation 5.7
Social circumstances Mental disability
Mental retardation
General disorders and administration site conditions Oedema
General disorders and administration site conditions Oedema 5.6
Gastrointestinal disorders Salivary hypersecretion 5.6
Musculoskeletal and connective tissue disorders Muscle rigidity
Investigations Weight increased 5.1
Psychiatric disorders Depression
Vascular disorders Hypotension 5.0
General disorders and administration site conditions Oedema 4.9
Cardiac disorders Dizziness
Cardiac disorders Dizziness 4.8
Nervous system disorders Loss of consciousness
Nervous system disorders Loss of consciousness 4.8
Vascular disorders Shock
Vascular disorders Shock 4.8
Cardiac disorders Syncope
Cardiac disorders Syncope 4.8
Vascular disorders Hypotension 4.7
Gastrointestinal disorders Salivary hypersecretion
Nervous system disorders Akathisia
Nervous system disorders Akathisia 4.3
Gastrointestinal disorders Constipation
Infections and infestations Upper respiratory tract infection 4.3
Investigations Weight decreased 4.3
Investigations Weight increased
Musculoskeletal and connective tissue disorders Muscle rigidity 4.2
Gastrointestinal disorders Salivary hypersecretion 4.2
Psychiatric disorders Disturbance in sexual arousal
Psychiatric disorders Libido increased
Psychiatric disorders Nervousness 4.1
Psychiatric disorders Tension 4.1
Skin and subcutaneous tissue disorders Dermatitis 4.0
Psychiatric disorders Disturbance in sexual arousal
Cardiac disorders Dizziness
Immune system disorders Hypersensitivity 4.0
Psychiatric disorders Libido increased
Nervous system disorders Loss of consciousness
Gastrointestinal disorders Salivary hypersecretion
Gastrointestinal disorders Salivary hypersecretion 4.0
Psychiatric disorders Sexual dysfunction
Vascular disorders Shock
Cardiac disorders Syncope
Nervous system disorders Tremor 4.0
General disorders and administration site conditions Decreased appetite
Psychiatric disorders Derealisation
Skin and subcutaneous tissue disorders Dermatitis 3.8
Cardiac disorders Dizziness 3.8
Immune system disorders Hypersensitivity 3.8
Nervous system disorders Loss of consciousness 3.8
Metabolism and nutrition disorders Malnutrition
Vascular disorders Shock 3.8
Cardiac disorders Syncope 3.8
Psychiatric disorders Sexual dysfunction
Psychiatric disorders Sexual dysfunction 3.7
Infections and infestations Upper respiratory tract infection
Infections and infestations Upper respiratory tract infection 3.7
Investigations Weight decreased
Reproductive system and breast disorders Dysmenorrhoea 3.6
Musculoskeletal and connective tissue disorders Musculoskeletal stiffness
Musculoskeletal and connective tissue disorders Musculoskeletal stiffness 3.3
Nervous system disorders Ataxia
Nervous system disorders Disturbance in attention 3.2
Respiratory, thoracic and mediastinal disorders Laryngeal pain 3.2
Gastrointestinal disorders Nausea
Nervous system disorders Paraesthesia
Nervous system disorders Paraesthesia 3.2
Nervous system disorders Somnolence 3.2
Skin and subcutaneous tissue disorders Dermatitis
Gastrointestinal disorders Diarrhoea
Cardiac disorders Dizziness 3.1
Gastrointestinal disorders Gastrointestinal disorder
Immune system disorders Hypersensitivity
Nervous system disorders Loss of consciousness 3.1
Vascular disorders Shock 3.1
Cardiac disorders Syncope 3.1
Nervous system disorders Akathisia 3.0
Skin and subcutaneous tissue disorders Dermatitis
Psychiatric disorders Disinhibition 3.0
Immune system disorders Hypersensitivity
Investigations Weight decreased
Nervous system disorders Agitation 2.9
Reproductive system and breast disorders Dysmenorrhoea
Vascular disorders Angiopathy
Psychiatric disorders Anxiety
Musculoskeletal and connective tissue disorders Connective tissue disorder
Psychiatric disorders Disinhibition 2.7
General disorders and administration site conditions Hot flush
Psychiatric disorders Hyperventilation
Respiratory, thoracic and mediastinal disorders Mediastinal disorder
Reproductive system and breast disorders Menopausal symptoms
Musculoskeletal and connective tissue disorders Muscle twitching
Nervous system disorders Paraesthesia
Investigations Weight increased
Investigations Weight increased 2.7
Nervous system disorders Agitation
Nervous system disorders Agitation 2.6
Nervous system disorders Dysarthria
Respiratory, thoracic and mediastinal disorders Laryngeal pain
Musculoskeletal and connective tissue disorders Osteoarthritis
Psychiatric disorders Depression 2.5
Cardiac disorders Dizziness 2.5
Psychiatric disorders Mental disorder 2.5
Musculoskeletal and connective tissue disorders Arthralgia 2.4
Psychiatric disorders Depression 2.4
Infections and infestations Influenza 2.4
Musculoskeletal and connective tissue disorders Muscle spasms
Musculoskeletal and connective tissue disorders Muscle spasms 2.4
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 2.4
Nervous system disorders Paraesthesia 2.4
Gastrointestinal disorders Salivary hypersecretion
Psychiatric disorders Sexual dysfunction 2.4
Psychiatric disorders Disturbance in sexual arousal
Nervous system disorders Hypoaesthesia
Infections and infestations Influenza
Psychiatric disorders Libido decreased
Investigations Weight decreased 2.3
Vascular disorders Hypotension
Nervous system disorders Logorrhoea 2.2
Musculoskeletal and connective tissue disorders Musculoskeletal stiffness 2.2
Nervous system disorders Dysarthria 2.1
Musculoskeletal and connective tissue disorders Osteoarthritis 2.1
Nervous system disorders Akathisia 2.0
Psychiatric disorders Derealisation 2.0
Psychiatric disorders Disinhibition
Cardiac disorders Dizziness 2.0
Vascular disorders Hypotension
Gastrointestinal disorders Incontinence 2.0
Nervous system disorders Logorrhoea 2.0
Gastrointestinal disorders Salivary hypersecretion
Nervous system disorders Coordination abnormal 1.9
Depersonalisation
Psychiatric disorders Derealisation 1.9
Infections and infestations Infection 1.9
Infections and infestations Upper respiratory tract infection 1.9
General disorders and administration site conditions Asthenia 1.8
Cardiac disorders Dizziness 1.8
General disorders and administration site conditions Fatigue 1.8
Nervous system disorders Somnolence 1.8
General disorders and administration site conditions Asthenia 1.7
Nervous system disorders Dyskinesia 1.7
General disorders and administration site conditions Fatigue 1.7
Infections and infestations Infection
Infections and infestations Infection 1.7
General disorders and administration site conditions Lethargy 1.7
Gastrointestinal disorders Nausea 1.7
Nervous system disorders Paraesthesia
Psychiatric disorders Premenstrual syndrome 1.7
Infections and infestations Upper respiratory tract infection
Gastrointestinal disorders Vomiting 1.7
Nervous system disorders Akathisia 1.6
Vascular disorders Angiopathy 1.5
Nervous system disorders Confusional state 1.5
General disorders and administration site conditions Decreased appetite 1.5
Psychiatric disorders Disinhibition
Psychiatric disorders Disinhibition 1.5
Nervous system disorders Disorientation 1.5
Cardiac disorders Dyspnoea 1.5
General disorders and administration site conditions Feeling abnormal 1.5
General disorders and administration site conditions Hot flush 1.5
Gastrointestinal disorders Incontinence 1.5
Nervous system disorders Memory impairment 1.5
Reproductive system and breast disorders Menopausal symptoms 1.5
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 1.5
Musculoskeletal and connective tissue disorders Myalgia 1.5
Injury, poisoning and procedural complications Road traffic accident 1.5
Vascular disorders Angiopathy
Nervous system disorders Dyskinesia
Psychiatric disorders Fear 1.4
General disorders and administration site conditions Hot flush
Reproductive system and breast disorders Menopausal symptoms
Psychiatric disorders Depressed mood 1.3
Skin and subcutaneous tissue disorders Hyperaesthesia 1.3
Nervous system disorders Hypersomnia 1.3
Nervous system disorders Hypoaesthesia 1.3
Infections and infestations Infection 1.3
Nervous system disorders Insomnia 1.3
Nervous system disorders Akathisia
Psychiatric disorders Depression
Psychiatric disorders Derealisation
Psychiatric disorders Derealisation 1.2
Gastrointestinal disorders Diarrhoea 1.2
Cardiac disorders Dizziness 1.2
Psychiatric disorders Mental disorder
Psychiatric disorders Anxiety 1.1
Nervous system disorders Headache 1.1
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort
Musculoskeletal and connective tissue disorders Myalgia
Psychiatric disorders Nervousness 1.1
Musculoskeletal and connective tissue disorders Pain in extremity 1.1
Skin and subcutaneous tissue disorders Pruritus 1.1
Immune system disorders Rhinitis allergic 1.1
Psychiatric disorders Sexual dysfunction
Skin and subcutaneous tissue disorders Skin disorder 1.1
Psychiatric disorders Tension 1.1
Nervous system disorders Akathisia
Psychiatric disorders Derealisation
Cardiac disorders Dizziness
Psychiatric disorders Fear
Psychiatric disorders Fear 1.0
Gastrointestinal disorders Incontinence
Nervous system disorders Logorrhoea
Nervous system disorders Logorrhoea 1.0
Nervous system disorders Confusional state
Nervous system disorders Confusional state 0.9
Gastrointestinal disorders Constipation 0.9
Nervous system disorders Coordination abnormal
General disorders and administration site conditions Feeling abnormal
General disorders and administration site conditions Feeling abnormal 0.9
Skin and subcutaneous tissue disorders Pruritus
Skin and subcutaneous tissue disorders Skin disorder
Cardiac disorders Dizziness
Gastrointestinal disorders Dry mouth 0.7
Psychiatric disorders Anxiety
Musculoskeletal and connective tissue disorders Arthralgia
General disorders and administration site conditions Asthenia
Skin and subcutaneous tissue disorders Dermatitis 0.6
Nervous system disorders Disturbance in attention
General disorders and administration site conditions Fatigue
Immune system disorders Hypersensitivity 0.6
Gastrointestinal disorders Incontinence
Gastrointestinal disorders Incontinence 0.6
General disorders and administration site conditions Lethargy
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort
Psychiatric disorders Premenstrual syndrome
Immune system disorders Rhinitis allergic
Musculoskeletal and connective tissue disorders Muscle rigidity 0.4
Cardiac disorders Palpitations 0.4
Cardiac disorders Tachycardia 0.4
Nervous system disorders Tremor 0.4
Eye disorders Vision blurred 0.4
Nervous system disorders Coordination abnormal
Psychiatric disorders Depressed mood
Cardiac disorders Dyspnoea
Nervous system disorders Hypoaesthesia
Nervous system disorders Memory impairment
Musculoskeletal and connective tissue disorders Pain in extremity
Nervous system disorders Somnolence

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Psychiatric disorders
23.47
General disorders and administration site conditions
15.13
Nervous system disorders
15.0
Injury, poisoning and procedural complications
10.98
Cardiac disorders
5.01
Respiratory, thoracic and mediastinal disorders
4.75
Gastrointestinal disorders
4.06
Vascular disorders
3.28
Musculoskeletal and connective tissue disorders
2.93
Investigations
2.51
Skin and subcutaneous tissue disorders
2.02

Environmental Impact

Environmental Impact Map
Countries
Germany
Hungary
Romania
USA

Cross References

Resources Reference
CAS NUMBER 28981-97-7
ChEBI 2611
ChEMBL CHEMBL661
DrugBank DB00404
DrugCentral 136
EPA CompTox DTXSID4022577
FDA SRS YU55MQ3IZY
Human Metabolome Database HMDB0014548
Guide to Pharmacology 7111
KEGG C06817
PDB 08H
PharmGKB PA448333
PubChem 2118
SureChEMBL SCHEMBL8398
ZINC ZINC000000000903
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