Trade Names:
Synonyms:
Status: Approved (2018)
Entry Type: Small molecule
Molecule Category: Salt
UNII: 8HF8FIN815
Parent Compound: AMIFAMPRIDINE

Structure

InChI Key KAICRBBQCRKMPO-UHFFFAOYSA-N
Smile Nc1ccncc1N.O=P(O)(O)O
InChI
InChI=1S/C5H7N3.H3O4P/c6-4-1-2-8-3-5(4)7;1-5(2,3)4/h1-3H,7H2,(H2,6,8);(H3,1,2,3,4)

Physicochemical Descriptors

Property Name Value
Molecular Formula C5H10N3O4P
Molecular Weight 207.13
AlogP 0.25
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 0.0
Polar Surface Area 64.93
Molecular species BASE
Aromatic Rings 1.0
Heavy Atoms 8.0

Pharmacology

Action Mechanism of Action Reference
BLOCKER Voltage-gated potassium channel blocker FDA Other

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Lambert-Eaton Myasthenic Syndrome 4 D015624 FDA
Myasthenia Gravis 3 D009157 ClinicalTrials
Brugada Syndrome 3 D053840 ClinicalTrials
Muscular Atrophy, Spinal 2 D009134 ClinicalTrials
Muscular Atrophy 2 D009133 ClinicalTrials

Related Entries

Parent

Adverse Reactions

System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
19.97
Nervous system disorders
18.59
Gastrointestinal disorders
10.62
Respiratory, thoracic and mediastinal disorders
6.87
Injury, poisoning and procedural complications
5.92
Musculoskeletal and connective tissue disorders
5.76
Psychiatric disorders
4.49
Skin and subcutaneous tissue disorders
4.38
Cardiac disorders
3.96
Infections and infestations
3.75
Investigations
2.96
Eye disorders
2.8
Vascular disorders
2.59
Renal and urinary disorders
2.01

Cross References

Resources Reference
ChEMBL CHEMBL3301611
EPA CompTox DTXSID40196254
FDA SRS 8HF8FIN815
PubChem 9920716
SureChEMBL SCHEMBL3958357