ANAKINRA

Search structure
Trade Names:
Synonyms:
Status: Approved (2001)
Entry Type: Protein
Molecule Category: UNKNOWN
ATC: L04AC03
UNII: 9013DUQ28K

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Interleukin-1 receptor antagonist DailyMed
Primary Target
Interleukin-1 receptor, type I

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Immune System Diseases 4 D007154 ClinicalTrials
Cryopyrin-Associated Periodic Syndromes 4 D056587 ClinicalTrials
Severe Acute Respiratory Syndrome 3 D045169 ClinicalTrials
Severe Acute Respiratory Syndrome 3 D045169 ClinicalTrials
Metabolic Syndrome 3 D024821 ClinicalTrials
Giant Cell Arteritis 3 D013700 ClinicalTrials
Familial Mediterranean Fever 3 D010505 ClinicalTrials
Myocardial Infarction 3 D009203 ClinicalTrials
Mucocutaneous Lymph Node Syndrome 3 D009080 ClinicalTrials
Dermatomyositis 2 D003882 ClinicalTrials
Multiple Myeloma 2 D009101 ClinicalTrials
Lymphoma, Follicular 2 D008224 ClinicalTrials
Diabetes Mellitus, Type 1 2 D003922 ClinicalTrials
Osteoarthritis 2 D010003 ClinicalTrials
Heart Failure 2 D006333 ClinicalTrials
Arthritis, Juvenile 2 D001171 ClinicalTrials
Renal Insufficiency, Chronic 2 D051436 ClinicalTrials
Fatigue Syndrome, Chronic 2 D015673 ClinicalTrials
Hidradenitis Suppurativa 2 D017497 ClinicalTrials
Uveitis 2 D014605 ClinicalTrials
Pericarditis 2 D010493 ClinicalTrials
Amyotrophic Lateral Sclerosis 2 D000690 ClinicalTrials
Gout 2 D006073 ClinicalTrials
Still's Disease, Adult-Onset 2 D016706 ClinicalTrials
Myositis, Inclusion Body 2 D018979 ClinicalTrials
Hepatitis, Alcoholic 2 D006519 ClinicalTrials
Macrophage Activation Syndrome 2 D055501 ClinicalTrials
Polycystic Ovary Syndrome 2 D011085 ClinicalTrials
Myocarditis 2 D009205 ClinicalTrials
Labyrinth Diseases 2 D007759 ClinicalTrials
Sarcoidosis 2 D012507 ClinicalTrials
Diabetes Mellitus 2 D003920 ClinicalTrials
Infections 2 D007239 ClinicalTrials
Brain Injuries 2 D001930 ClinicalTrials
Cerebral Hemorrhage 2 D002543 ClinicalTrials
Blepharitis 1 D001762 ClinicalTrials
Knee Injuries 1 D007718 ClinicalTrials
HIV Infections 1 D015658 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 1 D064129 ClinicalTrials
Hearing Loss 1 D034381 ClinicalTrials
Neoplasms 1 D009369 ClinicalTrials
Rectal Neoplasms 1 D012004 ClinicalTrials
Hypertension, Pulmonary 1 D006976 ClinicalTrials
Smoldering Multiple Myeloma 1 D000075122 ClinicalTrials
Breast Neoplasms 1 D001943 ClinicalTrials
Hypertension, Pulmonary 1 D006976 ClinicalTrials
Pancreatic Neoplasms 1 D010190 ClinicalTrials
Asthma 1 D001249 ClinicalTrials
Leukemia, Lymphocytic, Chronic, B-Cell 1 D015451 ClinicalTrials
Multiple Sclerosis 1 D009103 ClinicalTrials
Endometriosis 0 D004715 ClinicalTrials
Granulomatous Disease, Chronic 0 D006105 ClinicalTrials

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
21.14
Injury, poisoning and procedural complications
15.15
Skin and subcutaneous tissue disorders
12.81
Respiratory, thoracic and mediastinal disorders
6.65
Immune system disorders
5.09
Infections and infestations
4.73
Vascular disorders
4.51
Gastrointestinal disorders
4.01
Nervous system disorders
3.99
Musculoskeletal and connective tissue disorders
3.46
Investigations
2.89
Cardiac disorders
2.64
Blood and lymphatic system disorders
2.09

Cross References

Resources Reference
CAS NUMBER 143090-92-0
ChEMBL CHEMBL1201570
FDA SRS 9013DUQ28K
Guide to Pharmacology 6972
PubChem 90470007
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