ANASTROZOLE

Search structure
Trade Names:
Synonyms:
Status: Approved (1995)
Entry Type: Small molecule
Molecule Category: UNKNOWN
ATC: L02BG03
UNII: 2Z07MYW1AZ

Structure
InChI Key YBBLVLTVTVSKRW-UHFFFAOYSA-N
Smile CC(C)(C#N)c1cc(Cn2cncn2)cc(C(C)(C)C#N)c1
InChI
InChI=1S/C17H19N5/c1-16(2,9-18)14-5-13(8-22-12-20-11-21-22)6-15(7-14)17(3,4)10-19/h5-7,11-12H,8H2,1-4H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C17H19N5
Molecular Weight 293.37
AlogP 2.93
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 4.0
Polar Surface Area 78.29
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 22.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Cytochrome P450 19A1 inhibitor DailyMed
Primary Target
CYP19A1
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 19 Cytochrome P450 family 19A Cytochrome P450 19A1
- 2-600 - 0 -
Enzyme Oxidoreductase
- - - - 0-7
Enzyme Transferase
- 4720 - - 65-90

Metabolites

visNetwork

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Neoplasms 4 D009369 ClinicalTrials
Neoplasms 4 D009369 ClinicalTrials
Breast Neoplasms 4 D001943 ClinicalTrials
Breast Neoplasms 4 D001943 ClinicalTrials
Carcinoma, Lobular 3 D018275 ClinicalTrials
Carcinoma, Intraductal, Noninfiltrating 3 D002285 ClinicalTrials
Gynecomastia 3 D006177 ClinicalTrials
Peritoneal Neoplasms 2 D010534 ClinicalTrials
Breast Neoplasms, Male 2 D018567 ClinicalTrials
Hypertension, Pulmonary 2 D006976 ClinicalTrials
Fibrous Dysplasia, Polyostotic 2 D005359 ClinicalTrials
Carcinoma 2 D002277 ClinicalTrials
Endometriosis 2 D004715 ClinicalTrials
Metabolic Syndrome 2 D024821 ClinicalTrials
Hypopituitarism 2 D007018 ClinicalTrials
Triple Negative Breast Neoplasms 2 D064726 ClinicalTrials
Puberty, Precocious 2 D011629 ClinicalTrials
Hypogonadism 2 D007006 ClinicalTrials
Anovulation 2 D000858 ClinicalTrials
Ovarian Neoplasms 2 D010051 ClinicalTrials
Endometrial Neoplasms 1 D016889 ClinicalTrials
Aging 1 D000375 ClinicalTrials
Endometrial Neoplasms 1 D016889 ClinicalTrials
Kallmann Syndrome 1 D017436 ClinicalTrials
Hypertension 0 D006973 ClinicalTrials

Side Effects from Label

Side effects Relative Frequency (%) Labels
General disorders and administration site conditions Hot flush 40.9
Reproductive system and breast disorders Menopausal symptoms 40.9
Gastrointestinal disorders Dyspepsia 38.4
Gastrointestinal disorders Gastrointestinal disorder 38.4
Musculoskeletal and connective tissue disorders Arthralgia 35.9
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 35.9
Musculoskeletal and connective tissue disorders Musculoskeletal stiffness 35.9
General disorders and administration site conditions Hot flush 35.7
Reproductive system and breast disorders Menopausal symptoms 35.7
Gastrointestinal disorders Dyspepsia 33.6
Gastrointestinal disorders Gastrointestinal disorder 33.6
Gastrointestinal disorders Dyspepsia 33.0
Gastrointestinal disorders Gastrointestinal disorder 33.0
Gastrointestinal disorders Dyspepsia 32.9
Gastrointestinal disorders Gastrointestinal disorder 32.9
Musculoskeletal and connective tissue disorders Arthralgia 29.8
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 29.8
Musculoskeletal and connective tissue disorders Musculoskeletal stiffness 29.8
Gastrointestinal disorders Dyspepsia 29.4
Gastrointestinal disorders Gastrointestinal disorder 29.4
Gastrointestinal disorders Dyspepsia 29.0
Gastrointestinal disorders Gastrointestinal disorder 29.0
General disorders and administration site conditions Hot flush 26.5
Reproductive system and breast disorders Menopausal symptoms 26.5
Surgical and medical procedures Vasodilation procedure 25.3
General disorders and administration site conditions Hot flush 23.1
Reproductive system and breast disorders Menopausal symptoms 23.1
Gastrointestinal disorders Dyspepsia 21.3
Gastrointestinal disorders Gastrointestinal disorder 21.3
Gastrointestinal disorders Dyspepsia 21.0
Cardiac disorders Dyspnoea 21.0
Gastrointestinal disorders Gastrointestinal disorder 21.0
Cardiac disorders Dyspnoea 20.9
Gastrointestinal disorders Nausea 20.7
Surgical and medical procedures Vasodilation procedure 20.7
Gastrointestinal disorders Nausea 20.0
Gastrointestinal disorders Nausea 19.5
Psychiatric disorders Mood swings 19.4
Psychiatric disorders Mood swings 19.3
General disorders and administration site conditions Asthenia 19.0
General disorders and administration site conditions Fatigue 19.0
General disorders and administration site conditions Asthenia 18.7
General disorders and administration site conditions Fatigue 18.7
General disorders and administration site conditions Asthenia 18.6
General disorders and administration site conditions Fatigue 18.6
Gastrointestinal disorders Nausea 18.6
Nervous system disorders Headache 18.0
Psychiatric disorders Mood swings 18.0
Nervous system disorders Headache 17.9
Psychiatric disorders Mood swings 17.9
General disorders and administration site conditions Asthenia 17.6
General disorders and administration site conditions Fatigue 17.6
General disorders and administration site conditions Pain 17.2
Musculoskeletal and connective tissue disorders Arthritis 16.6
General disorders and administration site conditions Asthenia 16.4
General disorders and administration site conditions Asthenia 16.0
Gastrointestinal disorders Nausea 16.0
General disorders and administration site conditions Asthenia 15.9
General disorders and administration site conditions Pain 15.7
Gastrointestinal disorders Nausea 15.6
General disorders and administration site conditions Pain 15.4
Musculoskeletal and connective tissue disorders Arthralgia 15.1
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 15.1
General disorders and administration site conditions Pain 15.0
Musculoskeletal and connective tissue disorders Arthritis 14.4
General disorders and administration site conditions Pain 14.3
Gastrointestinal disorders Pharyngitis 14.3
Musculoskeletal and connective tissue disorders Arthritis 14.0
General disorders and administration site conditions Hot flush 14.0
Reproductive system and breast disorders Menopausal symptoms 14.0
General disorders and administration site conditions Oedema 14.0
General disorders and administration site conditions Hot flush 13.8
Reproductive system and breast disorders Menopausal symptoms 13.8
General disorders and administration site conditions Oedema 13.8
General disorders and administration site conditions Pain 13.8
Gastrointestinal disorders Pharyngitis 13.6
General disorders and administration site conditions Asthenia 13.4
Psychiatric disorders Depression 13.4
Musculoskeletal and connective tissue disorders Back pain 13.3
Gastrointestinal disorders Pharyngitis 13.3
Reproductive system and breast disorders Vaginal discharge 13.2
General disorders and administration site conditions Asthenia 13.0
Nervous system disorders Headache 13.0
General disorders and administration site conditions Hot flush 13.0
Vascular disorders Hypertension 13.0
Reproductive system and breast disorders Menopausal symptoms 13.0
Investigations Weight increased 13.0
Gastrointestinal disorders Constipation 12.9
Gastrointestinal disorders Nausea 12.8
Gastrointestinal disorders Vomiting 12.8
Gastrointestinal disorders Nausea 12.7
Gastrointestinal disorders Vomiting 12.7
General disorders and administration site conditions Hot flush 12.6
Reproductive system and breast disorders Menopausal symptoms 12.6
Skin and subcutaneous tissue disorders Dermatitis 12.5
Skin and subcutaneous tissue disorders Rash 12.5
Gastrointestinal disorders Nausea 12.4
Gastrointestinal disorders Vomiting 12.4
Psychiatric disorders Depression 12.3
General disorders and administration site conditions Hot flush 12.2
Reproductive system and breast disorders Menopausal symptoms 12.2
Musculoskeletal and connective tissue disorders Bone pain 12.0
General disorders and administration site conditions Hot flush 12.0
Reproductive system and breast disorders Menopausal symptoms 12.0
Investigations Weight increased 12.0
Musculoskeletal and connective tissue disorders Back pain 11.9
Investigations Weight increased 11.9
General disorders and administration site conditions Hot flush 11.8
Reproductive system and breast disorders Menopausal symptoms 11.8
General disorders and administration site conditions Pain 11.5
General disorders and administration site conditions Oedema 11.4
Vascular disorders Hypertension 11.3
Musculoskeletal and connective tissue disorders Arthralgia 11.1
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 11.1
Gastrointestinal disorders Nausea 11.1
Cardiac disorders Oedema peripheral 11.1
Musculoskeletal and connective tissue disorders Back pain 11.0
Cardiac disorders Dyspnoea 11.0
Musculoskeletal and connective tissue disorders Fracture 11.0
General disorders and administration site conditions Hot flush 11.0
Blood and lymphatic system disorders Lymphoedema 11.0
Reproductive system and breast disorders Menopausal symptoms 11.0
Injury, poisoning and procedural complications Multiple fractures 11.0
Gastrointestinal disorders Nausea 11.0
General disorders and administration site conditions Oedema 11.0
Cardiac disorders Oedema peripheral 11.0
General disorders and administration site conditions Pain 11.0
Gastrointestinal disorders Vomiting 11.0
Respiratory, thoracic and mediastinal disorders Cough 10.9
Skin and subcutaneous tissue disorders Dermatitis 10.8
Gastrointestinal disorders Nausea 10.8
Skin and subcutaneous tissue disorders Rash 10.8
Musculoskeletal and connective tissue disorders Back pain 10.7
Musculoskeletal and connective tissue disorders Bone pain 10.7
General disorders and administration site conditions Pain 10.7
Musculoskeletal and connective tissue disorders Back pain 10.6
Gastrointestinal disorders Vomiting 10.6
Metabolism and nutrition disorders Osteoporosis 10.5
Musculoskeletal and connective tissue disorders Back pain 10.4
Reproductive system and breast disorders Vaginal haemorrhage 10.4
Musculoskeletal and connective tissue disorders Bone pain 10.2
Respiratory, thoracic and mediastinal disorders Cough 10.2
Musculoskeletal and connective tissue disorders Fracture 10.2
Nervous system disorders Headache 10.2
Injury, poisoning and procedural complications Multiple fractures 10.2
Reproductive system and breast disorders Vaginal haemorrhage 10.2
Cardiac disorders Dyspnoea 10.1
Injury, poisoning and procedural complications Injury 10.1
Cardiac disorders Oedema peripheral 10.1
Infections and infestations Urinary tract infection 10.1
Cardiac disorders Dyspnoea 10.0
Musculoskeletal and connective tissue disorders Back pain 9.99
Nervous system disorders Insomnia 9.99
Blood and lymphatic system disorders Lymphoedema 9.83
Injury, poisoning and procedural complications Injury 9.79
Gastrointestinal disorders Pharyngitis 9.68
Nervous system disorders Headache 9.49
Gastrointestinal disorders Pharyngitis 9.35
Gastrointestinal disorders Constipation 9.29
Nervous system disorders Headache 9.29
Respiratory, thoracic and mediastinal disorders Cough 9.28
Reproductive system and breast disorders Vaginal discharge 9.24
Infections and infestations Infection 9.22
Investigations Weight increased 9.22
Cardiac disorders Dyspnoea 9.2
Cardiac disorders Dyspnoea 9.16
Gastrointestinal disorders Vomiting 9.16
Nervous system disorders Insomnia 9.08
Gastrointestinal disorders Constipation 9.0
General disorders and administration site conditions Decreased appetite 9.0
Cardiac disorders Dyspnoea 9.0
Nervous system disorders Headache 9.0
Blood and lymphatic system disorders Lymphoedema 9.0
Cardiac disorders Oedema peripheral 9.0
Gastrointestinal disorders Pharyngitis 9.0
Gastrointestinal disorders Vomiting 9.0
Metabolism and nutrition disorders Hypercholesterolaemia 8.99
Gastrointestinal disorders Abdominal pain 8.92
Gastrointestinal disorders Gastrointestinal pain 8.92
Infections and infestations Infection 8.92
Investigations Weight increased 8.86
Gastrointestinal disorders Abdominal pain 8.76
Gastrointestinal disorders Gastrointestinal pain 8.76
Gastrointestinal disorders Diarrhoea 8.57
Cardiac disorders Oedema peripheral 8.54
Respiratory, thoracic and mediastinal disorders Cough 8.44
Respiratory, thoracic and mediastinal disorders Cough 8.4
Gastrointestinal disorders Diarrhoea 8.4
Gastrointestinal disorders Constipation 8.3
General disorders and administration site conditions Hot flush 8.3
Reproductive system and breast disorders Menopausal symptoms 8.3
Gastrointestinal disorders Constipation 8.14
Reproductive system and breast disorders Breast pain 8.12
Gastrointestinal disorders Constipation 8.05
Nervous system disorders Headache 8.05
Cardiac disorders Oedema peripheral 8.02
Gastrointestinal disorders Abdominal pain 8.0
Musculoskeletal and connective tissue disorders Back pain 8.0
Musculoskeletal and connective tissue disorders Bone pain 8.0
Gastrointestinal disorders Constipation 8.0
Respiratory, thoracic and mediastinal disorders Cough 8.0
General disorders and administration site conditions Decreased appetite 8.0
Skin and subcutaneous tissue disorders Dermatitis 8.0
Gastrointestinal disorders Diarrhoea 8.0
Gastrointestinal disorders Gastrointestinal pain 8.0
General disorders and administration site conditions Hot flush 8.0
Reproductive system and breast disorders Menopausal symptoms 8.0
Skin and subcutaneous tissue disorders Rash 8.0
Gastrointestinal disorders Abdominal pain 7.91
Gastrointestinal disorders Diarrhoea 7.91
Gastrointestinal disorders Gastrointestinal pain 7.91
Infections and infestations Urinary tract infection 7.89
Nervous system disorders Headache 7.83
General disorders and administration site conditions Decreased appetite 7.72
Musculoskeletal and connective tissue disorders Fracture 7.69
Injury, poisoning and procedural complications Multiple fractures 7.69
Cardiac disorders Dyspnoea 7.66
Cardiac disorders Dizziness 7.63
Cardiac disorders Dyspnoea 7.57
Cardiac disorders Dizziness 7.56
Musculoskeletal and connective tissue disorders Back pain 7.51
Musculoskeletal and connective tissue disorders Bone pain 7.51
Respiratory, thoracic and mediastinal disorders Cough 7.51
Skin and subcutaneous tissue disorders Dermatitis 7.51
Skin and subcutaneous tissue disorders Rash 7.51
Gastrointestinal disorders Vomiting 7.51
Gastrointestinal disorders Abdominal pain 7.44
Gastrointestinal disorders Gastrointestinal pain 7.44
Nervous system disorders Insomnia 7.44
Cardiac disorders Chest pain 7.32
Gastrointestinal disorders Constipation 7.32
Respiratory, thoracic and mediastinal disorders Cough 7.32
Gastrointestinal disorders Diarrhoea 7.32
Cardiac disorders Chest pain 7.31
Metabolism and nutrition disorders Osteoporosis 7.3
General disorders and administration site conditions Oedema 7.25
Cardiac disorders Chest pain 7.24
Gastrointestinal disorders Abdominal pain 7.11
Gastrointestinal disorders Gastrointestinal pain 7.11
Eye disorders Cataract 7.08
Vascular disorders Hypertension 7.05
Gastrointestinal disorders Vomiting 7.05
Gastrointestinal disorders Abdominal pain 7.0
Reproductive system and breast disorders Breast tenderness 7.0
Cardiac disorders Chest pain 7.0
Gastrointestinal disorders Constipation 7.0
Respiratory, thoracic and mediastinal disorders Cough 7.0
General disorders and administration site conditions Decreased appetite 7.0
Gastrointestinal disorders Diarrhoea 7.0
Gastrointestinal disorders Gastrointestinal pain 7.0
Metabolism and nutrition disorders Hypercholesterolaemia 7.0
General disorders and administration site conditions Influenza like illness 7.0
General disorders and administration site conditions Oedema 7.0
Metabolism and nutrition disorders Osteoporosis 7.0
Gastrointestinal disorders Pelvic pain 7.0
Gastrointestinal disorders Diarrhoea 6.98
Nervous system disorders Paraesthesia 6.95
Infections and infestations Influenza 6.92
Gastrointestinal disorders Pelvic pain 6.91
Eye disorders Cataract 6.88
Gastrointestinal disorders Abdominal pain 6.87
Gastrointestinal disorders Constipation 6.87
General disorders and administration site conditions Decreased appetite 6.87
Gastrointestinal disorders Gastrointestinal pain 6.87
Gastrointestinal disorders Gastrointestinal disorder 6.79
Musculoskeletal and connective tissue disorders Fracture 6.76
Injury, poisoning and procedural complications Multiple fractures 6.76
Musculoskeletal and connective tissue disorders Arthropathy 6.69
Musculoskeletal and connective tissue disorders Osteoarthritis 6.69
Gastrointestinal disorders Dyspepsia 6.66
Musculoskeletal and connective tissue disorders Bone pain 6.5
Musculoskeletal and connective tissue disorders Bone pain 6.49
Cardiac disorders Chest pain 6.47
Gastrointestinal disorders Diarrhoea 6.46
Vascular disorders Embolism 6.46
Vascular disorders Embolism venous 6.46
General disorders and administration site conditions Hyperhidrosis 6.32
Gastrointestinal disorders Vomiting 6.32
Psychiatric disorders Anxiety 6.31
Infections and infestations Influenza 6.3
Infections and infestations Vulvovaginitis 6.27
Psychiatric disorders Depression 6.26
Eye disorders Cataract 6.18
Cardiac disorders Dizziness 6.11
Gastrointestinal disorders Pharyngitis 6.11
Skin and subcutaneous tissue disorders Dermatitis 6.1
Nervous system disorders Paraesthesia 6.1
Skin and subcutaneous tissue disorders Rash 6.1
Reproductive system and breast disorders Vaginal discharge 6.07
Gastrointestinal disorders Abdominal pain 6.0
Musculoskeletal and connective tissue disorders Arthropathy 6.0
Musculoskeletal and connective tissue disorders Bone pain 6.0
Skin and subcutaneous tissue disorders Dermatitis 6.0
Cardiac disorders Dizziness 6.0
Gastrointestinal disorders Dry mouth 6.0
Gastrointestinal disorders Gastrointestinal pain 6.0
General disorders and administration site conditions Hyperhidrosis 6.0
Musculoskeletal and connective tissue disorders Osteoarthritis 6.0
Nervous system disorders Paraesthesia 6.0
Gastrointestinal disorders Pharyngitis 6.0
Skin and subcutaneous tissue disorders Rash 6.0
Gastrointestinal disorders Vomiting 6.0
Infections and infestations Vulvovaginitis 6.0
Musculoskeletal and connective tissue disorders Bone pain 5.98
Eye disorders Cataract 5.98
Musculoskeletal and connective tissue disorders Arthropathy 5.95
Musculoskeletal and connective tissue disorders Osteoarthritis 5.95
Infections and infestations Sinusitis 5.95
Cardiac disorders Dizziness 5.93
Nervous system disorders Insomnia 5.93
Gastrointestinal disorders Pharyngitis 5.93
Eye disorders Cataract 5.89
Infections and infestations Influenza 5.87
Gastrointestinal disorders Pelvic pain 5.87
Psychiatric disorders Anxiety 5.82
Reproductive system and breast disorders Vaginal haemorrhage 5.82
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 5.79
Musculoskeletal and connective tissue disorders Myalgia 5.79
Skin and subcutaneous tissue disorders Dermatitis 5.73
Gastrointestinal disorders Dry mouth 5.73
Skin and subcutaneous tissue disorders Rash 5.73
General disorders and administration site conditions Hyperhidrosis 5.72
Gastrointestinal disorders Abdominal pain 5.69
Gastrointestinal disorders Gastrointestinal pain 5.69
Infections and infestations Influenza 5.66
Reproductive system and breast disorders Vaginal haemorrhage 5.53
Reproductive system and breast disorders Breast pain 5.46
Gastrointestinal disorders Dyspepsia 5.46
Infections and infestations Bronchitis 5.4
Reproductive system and breast disorders Vaginal haemorrhage 5.4
Psychiatric disorders Depression 5.34
Cardiac disorders Oedema peripheral 5.34
Gastrointestinal disorders Pelvic pain 5.34
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Breast neoplasm 5.3
General disorders and administration site conditions Cyst 5.24
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Neoplasm 5.24
Musculoskeletal and connective tissue disorders Arthropathy 5.17
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 5.17
Musculoskeletal and connective tissue disorders Myalgia 5.17
Musculoskeletal and connective tissue disorders Osteoarthritis 5.17
Blood and lymphatic system disorders Anaemia 5.14
Cardiac disorders Chest pain 5.14
General disorders and administration site conditions Decreased appetite 5.14
Gastrointestinal disorders Dry mouth 5.14
General disorders and administration site conditions Increased appetite 5.14
Gastrointestinal disorders Pelvic pain 5.14
Infections and infestations Sinusitis 5.14
Reproductive system and breast disorders Vaginal haemorrhage 5.14
Gastrointestinal disorders Gastrointestinal disorder 5.11
Infections and infestations Vaginal infection 5.11
Vaginal inflammation 5.11
Musculoskeletal and connective tissue disorders Hypertonia 5.09
Musculoskeletal and connective tissue disorders Arthropathy 5.04
Musculoskeletal and connective tissue disorders Osteoarthritis 5.04
Psychiatric disorders Anxiety 5.0
Cardiac disorders Chest pain 5.0
Psychiatric disorders Depression 5.0
Cardiac disorders Dizziness 5.0
Gastrointestinal disorders Dry mouth 5.0
Vascular disorders Embolism 5.0
Vascular disorders Embolism venous 5.0
General disorders and administration site conditions Increased appetite 5.0
Cardiac disorders Oedema peripheral 5.0
Nervous system disorders Paraesthesia 5.0
Gastrointestinal disorders Pelvic pain 5.0
Reproductive system and breast disorders Vaginal haemorrhage 5.0
Cardiac disorders Chest pain 4.96
Infections and infestations Bronchitis 4.95
Vascular disorders Hypertension 4.94
Cardiac disorders Dizziness 4.88
Vascular disorders Embolism 4.88
Cardiac disorders Chest pain 4.85
Infections and infestations Vulvovaginitis 4.85
Musculoskeletal and connective tissue disorders Fracture 4.79
Injury, poisoning and procedural complications Multiple fractures 4.79
Vascular disorders Embolism 4.74
Vascular disorders Embolism venous 4.74
General disorders and administration site conditions Hyperhidrosis 4.69
Nervous system disorders Paraesthesia 4.69
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Neoplasm 4.65
Nervous system disorders Paraesthesia 4.58
Psychiatric disorders Depression 4.55
Gastrointestinal disorders Pelvic pain 4.55
Vascular disorders Embolism 4.52
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Breast neoplasm 4.49
Gastrointestinal disorders Dry mouth 4.47
General disorders and administration site conditions Cyst 4.46
Cardiac disorders Cardiovascular disorder 4.43
General disorders and administration site conditions Decreased appetite 4.35
Cardiac disorders Dizziness 4.31
Musculoskeletal and connective tissue disorders Fracture 4.3
Injury, poisoning and procedural complications Multiple fractures 4.3
Cardiac disorders Cardiovascular disorder 4.11
Investigations Weight increased 4.07
Infections and infestations Vaginal infection 4.04
Vaginal inflammation 4.04
General disorders and administration site conditions Decreased appetite 4.0
Gastrointestinal disorders Dry mouth 4.0
Nervous system disorders Paraesthesia 4.0
Investigations Weight increased 4.0
Reproductive system and breast disorders Vaginal haemorrhage 3.95
Cardiac disorders Cardiovascular disorder 3.85
Investigations Weight increased 3.66
Blood and lymphatic system disorders Anaemia 3.65
Musculoskeletal and connective tissue disorders Fracture 3.62
Injury, poisoning and procedural complications Multiple fractures 3.62
Reproductive system and breast disorders Vaginal discharge 3.59
Vascular disorders Embolism 3.56
Vascular disorders Embolism venous 3.56
Nervous system disorders Paraesthesia 3.56
Reproductive system and breast disorders Vaginal discharge 3.53
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Tumour flare 3.52
Metabolism and nutrition disorders Hypercholesterolaemia 3.49
Vascular disorders Embolism 3.44
Vascular disorders Embolism venous 3.44
Cardiac disorders Cardiovascular disorder 3.36
Musculoskeletal and connective tissue disorders Hypertonia 3.16
Vascular disorders Embolism 3.07
Gastrointestinal disorders Diarrhoea 3.0
Vascular disorders Embolism 3.0
Vascular disorders Embolism venous 3.0
Musculoskeletal and connective tissue disorders Hypertonia 3.0
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Tumour flare 3.0
Reproductive system and breast disorders Vulvovaginal dryness 3.0
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Tumour flare 2.96
Musculoskeletal and connective tissue disorders Fracture 2.94
General disorders and administration site conditions Lethargy 2.94
Injury, poisoning and procedural complications Multiple fractures 2.94
Vascular disorders Embolism 2.81
Reproductive system and breast disorders Vaginal discharge 2.78
Gastrointestinal disorders Diarrhoea 2.77
Vascular disorders Embolism 2.68
Psychiatric disorders Depression 2.44
Cardiac disorders Angina pectoris 2.43
Vascular disorders Embolism 2.39
Reproductive system and breast disorders Vaginal haemorrhage 2.29
Musculoskeletal and connective tissue disorders Fracture 2.17
Injury, poisoning and procedural complications Multiple fractures 2.17
Investigations Weight increased 2.17
Reproductive system and breast disorders Vaginal haemorrhage 2.15
Psychiatric disorders Depression 2.0
Vascular disorders Embolism 2.0
Vascular disorders Embolism venous 2.0
General disorders and administration site conditions Hyperhidrosis 2.0
Reproductive system and breast disorders Vaginal haemorrhage 2.0
Reproductive system and breast disorders Vulvovaginal dryness 2.0
Investigations Weight increased 2.0
Psychiatric disorders Depression 1.98
Reproductive system and breast disorders Vulvovaginal dryness 1.91
Vascular disorders Embolism 1.84
Cardiac disorders Angina pectoris 1.81
Reproductive system and breast disorders Vaginal discharge 1.78
Reproductive system and breast disorders Vulvovaginal dryness 1.78
Vascular disorders Embolism 1.63
Vascular disorders Embolism venous 1.63
Reproductive system and breast disorders Vaginal haemorrhage 1.63
Musculoskeletal and connective tissue disorders Fracture 1.62
Injury, poisoning and procedural complications Multiple fractures 1.62
Musculoskeletal and connective tissue disorders Fracture 1.57
Injury, poisoning and procedural complications Multiple fractures 1.57
Investigations Weight increased 1.57
Vascular disorders Embolism 1.55
General disorders and administration site conditions Hyperhidrosis 1.53
Investigations Weight increased 1.53
Musculoskeletal and connective tissue disorders Fracture 1.48
Injury, poisoning and procedural complications Multiple fractures 1.48
Musculoskeletal and connective tissue disorders Fracture 1.39
Injury, poisoning and procedural complications Multiple fractures 1.39
Cardiac disorders Acute coronary syndrome 1.36
Cardiac disorders Myocardial infarction 1.36
Musculoskeletal and connective tissue disorders Fracture 1.34
Injury, poisoning and procedural complications Multiple fractures 1.34
Musculoskeletal and connective tissue disorders Arthralgia 1.32
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 1.32
Musculoskeletal and connective tissue disorders Musculoskeletal stiffness 1.32
Cardiac disorders Acute coronary syndrome 1.29
Cardiac disorders Myocardial infarction 1.29
Cardiac disorders Cardiovascular disorder 1.23
General disorders and administration site conditions Hyperhidrosis 1.22
Reproductive system and breast disorders Vulvovaginal dryness 1.22
General disorders and administration site conditions Lethargy 1.19
Cardiac disorders Cardiovascular disorder 1.16
Psychiatric disorders Mood swings 1.1
General disorders and administration site conditions Asthenia 1.08
General disorders and administration site conditions Fatigue 1.08
General disorders and administration site conditions Asthenia 1.07
General disorders and administration site conditions Fatigue 1.07
Gastrointestinal disorders Nausea 1.03
Gastrointestinal disorders Vomiting 1.03
General disorders and administration site conditions Hyperhidrosis 1.0
Reproductive system and breast disorders Vulvovaginal dryness 1.0
Reproductive system and breast disorders Vaginal haemorrhage 0.988
Musculoskeletal and connective tissue disorders Hip fracture 0.906
Cardiac disorders Coronary artery disease 0.873
Eye disorders Cataract 0.86
Eye disorders Cataract 0.85
Cardiac disorders Coronary artery disease 0.841
Musculoskeletal and connective tissue disorders Hip fracture 0.84
General disorders and administration site conditions Hot flush 0.8
Reproductive system and breast disorders Menopausal symptoms 0.8
Reproductive system and breast disorders Vulvovaginal dryness 0.791
Cardiac disorders Myocardial ischaemia 0.776
Musculoskeletal and connective tissue disorders Fracture 0.711
Injury, poisoning and procedural complications Multiple fractures 0.711
Gastrointestinal disorders Nausea 0.7
Gastrointestinal disorders Vomiting 0.7
Vascular disorders Embolism 0.68
Vascular disorders Embolism 0.64
Vascular disorders Embolism 0.62
Vascular disorders Embolism 0.61
Reproductive system and breast disorders Vulvovaginal dryness 0.587
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Endometrial cancer 0.549
Cardiac disorders Myocardial ischaemia 0.517
Reproductive system and breast disorders Vaginal haemorrhage 0.5
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Endometrial cancer 0.42
General disorders and administration site conditions Increased appetite 0.407
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Endometrial cancer 0.31
General disorders and administration site conditions Asthenia 0.3
General disorders and administration site conditions Fatigue 0.3
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Endometrial cancer 0.29
Reproductive system and breast disorders Vaginal discharge 0.25
Reproductive system and breast disorders Vaginal discharge 0.24
Cardiac disorders Cardiovascular disorder 0.2
Eye disorders Cataract 0.2
Psychiatric disorders Mood swings 0.2
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Endometrial cancer 0.162
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Endometrial cancer 0.129
Vascular disorders Embolism 0.03
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Endometrial cancer 0.02
Musculoskeletal and connective tissue disorders Fracture 0.02
Injury, poisoning and procedural complications Multiple fractures 0.02
Vascular disorders Embolism 0.0003
Musculoskeletal and connective tissue disorders Arthralgia 0.0001
Musculoskeletal and connective tissue disorders Fracture 0.0001
General disorders and administration site conditions Hot flush 0.0001
Reproductive system and breast disorders Menopausal symptoms 0.0001
Injury, poisoning and procedural complications Multiple fractures 0.0001
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 0.0001
Musculoskeletal and connective tissue disorders Musculoskeletal stiffness 0.0001
Reproductive system and breast disorders Vaginal discharge 0.0001
Reproductive system and breast disorders Vaginal haemorrhage 0.0001

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Musculoskeletal and connective tissue disorders
12.84
General disorders and administration site conditions
11.97
Nervous system disorders
10.28
Gastrointestinal disorders
6.95
Psychiatric disorders
6.51
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
5.54
Skin and subcutaneous tissue disorders
5.49
Vascular disorders
4.88
Investigations
4.34
Injury, poisoning and procedural complications
4.3
Respiratory, thoracic and mediastinal disorders
4.18
Reproductive system and breast disorders
4.0
Cardiac disorders
3.23
Metabolism and nutrition disorders
2.58
Immune system disorders
2.27

Cross References

Resources Reference
CAS NUMBER 120511-73-1
ChEBI 2704
ChEMBL CHEMBL1399
DrugBank DB01217
DrugCentral 210
EPA CompTox DTXSID9022607
FDA SRS 2Z07MYW1AZ
Human Metabolome Database HMDB0015348
Guide to Pharmacology 5137
KEGG C08159
PharmGKB PA448432
PubChem 2187
SureChEMBL SCHEMBL9726
ZINC ZINC000000000941
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