Trade Names: | |
Synonyms: | |
Status: | Approved (1996) |
Entry Type: | Small molecule |
Molecule Category: | Salt |
UNII: | 0L591QR10I |
Parent Compound: | AZELASTINE |
InChI Key | YEJAJYAHJQIWNU-UHFFFAOYSA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C22H25Cl2N3O |
Molecular Weight | 418.37 |
AlogP | 4.3 |
Hydrogen Bond Acceptor | 4.0 |
Hydrogen Bond Donor | 0.0 |
Number of Rotational Bond | 3.0 |
Polar Surface Area | 38.13 |
Molecular species | BASE |
Aromatic Rings | 3.0 |
Heavy Atoms | 27.0 |
Action | Mechanism of Action | Reference |
---|---|---|
ANTAGONIST | Histamine H1 receptor antagonist | FDA |
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
---|---|---|---|---|---|---|
Transporter
Electrochemical transporter
SLC superfamily of solute carriers
SLC21/SLCO family of organic anion transporting polypeptides
|
- | - | - | - | 135 |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Rhinitis, Vasomotor | 4 | D012223 | ClinicalTrials |
Rhinitis, Allergic, Seasonal | 4 | D006255 | ClinicalTrials |
Common Cold | 3 | D003139 | ClinicalTrials |
Resources | Reference |
---|---|
ChEBI | 2951 |
ChEMBL | CHEMBL1200809 |
EPA CompTox | DTXSID2045945 |
FDA SRS | 0L591QR10I |
Guide to Pharmacology | 7121 |
KEGG | C07768 |
PubChem | 54360 |
SureChEMBL | SCHEMBL36770 |
ZINC | ZINC00897240 |