BEVACIZUMAB

Search structure
Trade Names:
Synonyms:
Status: Approved (2004)
Entry Type: Antibody
Molecule Category: UNKNOWN
ATC: L01XC07
UNII: 2S9ZZM9Q9V

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Vascular endothelial growth factor A inhibitor PubMed DailyMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Neoplasms 4 D009369 ClinicalTrials
Colorectal Neoplasms 4 D015179 ClinicalTrials
Carcinoma, Renal Cell 4 D002292 ClinicalTrials
Uterine Cervical Neoplasms 4 D002583 ClinicalTrials
Uterine Cervical Neoplasms 4 D002583 ClinicalTrials
Colonic Neoplasms 4 D003110 ClinicalTrials
Carcinoma, Renal Cell 4 D002292 ClinicalTrials
Colorectal Neoplasms 4 D015179 ClinicalTrials
Neoplasms 4 D009369 ClinicalTrials
Carcinoma, Renal Cell 4 D002292 ClinicalTrials
Colorectal Neoplasms 4 D015179 ClinicalTrials
Glioblastoma 4 D005909 ClinicalTrials
Colorectal Neoplasms 4 D015179 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 4 D002289 ClinicalTrials
Carcinoma, Renal Cell 4 D002292 ClinicalTrials
Peritoneal Neoplasms 3 D010534 ClinicalTrials
Pancreatic Neoplasms 3 D010190 ClinicalTrials
Inflammation 3 D007249 ClinicalTrials
Lung Neoplasms 3 D008175 ClinicalTrials
Uveomeningoencephalitic Syndrome 3 D014607 ClinicalTrials
Ovarian Neoplasms 3 D010051 ClinicalTrials
Gastrointestinal Stromal Tumors 3 D046152 ClinicalTrials
Ovarian Neoplasms 3 D010051 ClinicalTrials
Breast Neoplasms 3 D001943 ClinicalTrials
Pterygium 3 D011625 ClinicalTrials
Carcinoma, Endometrioid 3 D018269 ClinicalTrials
Stomach Neoplasms 3 D013274 ClinicalTrials
Adenocarcinoma of Lung 3 D000077192 ClinicalTrials
Mesothelioma 3 D008654 ClinicalTrials
Macular Edema 3 D008269 ClinicalTrials
Wet Macular Degeneration 3 D057135 ClinicalTrials
Myopia 3 D009216 ClinicalTrials
Mesothelioma 3 D008654 ClinicalTrials
Macular Degeneration 3 D008268 ClinicalTrials
Pleural Effusion 3 D010996 ClinicalTrials
Fallopian Tube Neoplasms 3 D005185 ClinicalTrials
Retinal Diseases 3 D012164 ClinicalTrials
Ovarian Neoplasms 3 D010051 ClinicalTrials
Kidney Neoplasms 3 D007680 ClinicalTrials
Diabetic Retinopathy 3 D003930 ClinicalTrials
Breast Neoplasms 3 D001943 ClinicalTrials
Fallopian Tube Neoplasms 3 D005185 ClinicalTrials
Prostatic Neoplasms 3 D011471 ClinicalTrials
Peritoneal Neoplasms 3 D010534 ClinicalTrials
Macular Degeneration 3 D008268 ClinicalTrials
Corneal Neovascularization 3 D016510 ClinicalTrials
Telangiectasis 3 D013684 ClinicalTrials
Choroiditis 3 D002833 ClinicalTrials
Carcinoma, Signet Ring Cell 3 D018279 ClinicalTrials
Pulmonary Disease, Chronic Obstructive 3 D029424 ClinicalTrials
Stomach Neoplasms 3 D013274 ClinicalTrials
Retinal Vein Occlusion 3 D012170 ClinicalTrials
Gliosarcoma 3 D018316 ClinicalTrials
Rectal Neoplasms 3 D012004 ClinicalTrials
Colorectal Neoplasms, Hereditary Nonpolyposis 3 D003123 ClinicalTrials
Carcinoma, Hepatocellular 3 D006528 ClinicalTrials
Pancreatic Neoplasms 3 D010190 ClinicalTrials
Breast Neoplasms 3 D001943 ClinicalTrials
Retinopathy of Prematurity 3 D012178 ClinicalTrials
Lymphoma, Follicular 3 D008224 ClinicalTrials
Uveitis 3 D014605 ClinicalTrials
Glaucoma 3 D005901 ClinicalTrials
Lymphoma, Follicular 3 D008224 ClinicalTrials
Retinal Detachment 3 D012163 ClinicalTrials
Stomach Neoplasms 3 D013274 ClinicalTrials
Telangiectasia, Hereditary Hemorrhagic 3 D013683 ClinicalTrials
Ovarian Neoplasms 3 D010051 ClinicalTrials
Prostatic Neoplasms 3 D011471 ClinicalTrials
Adenocarcinoma 3 D000230 ClinicalTrials
Rectal Neoplasms 3 D012004 ClinicalTrials
Pneumonia 2 D011014 ClinicalTrials
Central Serous Chorioretinopathy 2 D056833 ClinicalTrials
Digestive System Diseases 2 D004066 ClinicalTrials
Diffuse Intrinsic Pontine Glioma 2 D000080443 ClinicalTrials
Central Nervous System Neoplasms 2 D016543 ClinicalTrials
Retroviridae Infections 2 D012192 ClinicalTrials
Trophoblastic Tumor, Placental Site 2 D018245 ClinicalTrials
Urinary Bladder Neoplasms 2 D001749 ClinicalTrials
Thyroid Neoplasms 2 D013964 ClinicalTrials
Brain Neoplasms 2 D001932 ClinicalTrials
Carcinoma 2 D002277 ClinicalTrials
Esophageal Neoplasms 2 D004938 ClinicalTrials
Ascites 2 D001201 ClinicalTrials
Leukemia, Lymphocytic, Chronic, B-Cell 2 D015451 ClinicalTrials
Glioma 2 D005910 ClinicalTrials
Sarcoma, Kaposi 2 D012514 ClinicalTrials
Head and Neck Neoplasms 2 D006258 ClinicalTrials
Myelodysplastic Syndromes 2 D009190 ClinicalTrials
Neurilemmoma 2 D009442 ClinicalTrials
Hemorrhage 2 D006470 ClinicalTrials
Melanoma 2 D008545 ClinicalTrials
Multiple Myeloma 2 D009101 ClinicalTrials
Sarcoma 2 D012509 ClinicalTrials
Small Cell Lung Carcinoma 2 D055752 ClinicalTrials
Neoplasms, Germ Cell and Embryonal 2 D009373 ClinicalTrials
Keloid 2 D007627 ClinicalTrials
Carcinoid Tumor 2 D002276 ClinicalTrials
Melanoma 2 D008545 ClinicalTrials
Optic Neuropathy, Ischemic 2 D018917 ClinicalTrials
Meningioma 2 D008579 ClinicalTrials
Sarcoma, Ewing 2 D012512 ClinicalTrials
Carcinoma, Squamous Cell 2 D002294 ClinicalTrials
Hodgkin Disease 2 D006689 ClinicalTrials
Rhabdomyosarcoma, Alveolar 2 D018232 ClinicalTrials
Astrocytoma 2 D001254 ClinicalTrials
Leukemia, Myelogenous, Chronic, BCR-ABL Positive 2 D015464 ClinicalTrials
Lymphoma, Large B-Cell, Diffuse 2 D016403 ClinicalTrials
Leiomyosarcoma 2 D007890 ClinicalTrials
Leukemia 2 D007938 ClinicalTrials
Liposarcoma 2 D008080 ClinicalTrials
Lymphoma 2 D008223 ClinicalTrials
Neuroblastoma 2 D009447 ClinicalTrials
Oligodendroglioma 2 D009837 ClinicalTrials
Oligodendroglioma 2 D009837 ClinicalTrials
Carcinoma, Squamous Cell 2 D002294 ClinicalTrials
Melanoma 2 D008545 ClinicalTrials
Sarcoma, Synovial 2 D013584 ClinicalTrials
Fibrosarcoma 2 D005354 ClinicalTrials
Astrocytoma 2 D001254 ClinicalTrials
Oligodendroglioma 2 D009837 ClinicalTrials
Choriocarcinoma 2 D002822 ClinicalTrials
Rhabdomyosarcoma 2 D012208 ClinicalTrials
Medulloblastoma 2 D008527 ClinicalTrials
Carcinoma, Large Cell 2 D018287 ClinicalTrials
Spinal Cord Neoplasms 2 D013120 ClinicalTrials
Hemangiosarcoma 2 D006394 ClinicalTrials
Nasopharyngeal Neoplasms 2 D009303 ClinicalTrials
Vascular Diseases 2 D014652 ClinicalTrials
Cholangiocarcinoma 2 D018281 ClinicalTrials
Triple Negative Breast Neoplasms 2 D064726 ClinicalTrials
Lymphoma, Non-Hodgkin 2 D008228 ClinicalTrials
Head and Neck Neoplasms 2 D006258 ClinicalTrials
Breast Neoplasms, Male 2 D018567 ClinicalTrials
Sex Cord-Gonadal Stromal Tumors 2 D018312 ClinicalTrials
Ependymoma 2 D004806 ClinicalTrials
Pinealoma 2 D010871 ClinicalTrials
Thymoma 2 D013945 ClinicalTrials
Lymphoma, Mantle-Cell 2 D020522 ClinicalTrials
Endometrial Neoplasms 2 D016889 ClinicalTrials
Sarcoma 2 D012509 ClinicalTrials
Adenoma 2 D000236 ClinicalTrials
Carcinoma 2 D002277 ClinicalTrials
Carcinoma, Islet Cell 2 D018273 ClinicalTrials
Urinary Bladder Neoplasms 2 D001749 ClinicalTrials
Vitreous Hemorrhage 2 D014823 ClinicalTrials
Pulmonary Fibrosis 2 D011658 ClinicalTrials
Adrenal Cortex Neoplasms 2 D000306 ClinicalTrials
Somatostatinoma 2 D013005 ClinicalTrials
Neuroendocrine Tumors 2 D018358 ClinicalTrials
Liver Neoplasms 2 D008113 ClinicalTrials
Neurilemmoma 2 D009442 ClinicalTrials
Esophageal Neoplasms 2 D004938 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 2 D064129 ClinicalTrials
Endometrial Neoplasms 2 D016889 ClinicalTrials
Ependymoma 2 D004806 ClinicalTrials
Neuroectodermal Tumors, Primitive, Peripheral 2 D018241 ClinicalTrials
Granuloma, Lethal Midline 2 D006103 ClinicalTrials
Meningioma 2 D008579 ClinicalTrials
Brain Neoplasms 2 D001932 ClinicalTrials
Insulinoma 2 D007340 ClinicalTrials
Primary Myelofibrosis 2 D055728 ClinicalTrials
Adenocarcinoma, Clear Cell 2 D018262 ClinicalTrials
Sarcoma, Alveolar Soft Part 2 D018234 ClinicalTrials
Liver Neoplasms 2 D008113 ClinicalTrials
Severe Acute Respiratory Syndrome 2 D045169 ClinicalTrials
Glioma 2 D005910 ClinicalTrials
Severe Acute Respiratory Syndrome 2 D045169 ClinicalTrials
Brain Neoplasms 2 D001932 ClinicalTrials
Thyroid Neoplasms 2 D013964 ClinicalTrials
Carcinoma, Neuroendocrine 2 D018278 ClinicalTrials
Papilloma 2 D010212 ClinicalTrials
Histiocytoma, Benign Fibrous 2 D018219 ClinicalTrials
Biliary Tract Neoplasms 2 D001661 ClinicalTrials
Glioma 2 D005910 ClinicalTrials
Lymphedema 1 D008209 ClinicalTrials
Meningitis, Aseptic 1 D008582 ClinicalTrials
Endometriosis 1 D004715 ClinicalTrials
Cystadenoma, Serous 1 D018293 ClinicalTrials
Pulmonary Veno-Occlusive Disease 1 D011668 ClinicalTrials
Diabetic Neuropathies 1 D003929 ClinicalTrials
Inflammatory Breast Neoplasms 1 D058922 ClinicalTrials
Myeloproliferative Disorders 1 D009196 ClinicalTrials
Carcinoma, Pancreatic Ductal 1 D021441 ClinicalTrials
Carcinoma, Merkel Cell 1 D015266 ClinicalTrials
Neuromyelitis Optica 1 D009471 ClinicalTrials
Neoplasm Metastasis 1 D009362 ClinicalTrials
Pharyngeal Neoplasms 0 D010610 ClinicalTrials
von Hippel-Lindau Disease 0 D006623 ClinicalTrials
Renal Insufficiency, Chronic 0 D051436 ClinicalTrials
Desmoplastic Small Round Cell Tumor 0 D058405 ClinicalTrials

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
14.73
Gastrointestinal disorders
11.04
Nervous system disorders
8.26
Vascular disorders
7.87
Investigations
6.85
Injury, poisoning and procedural complications
5.76
Respiratory, thoracic and mediastinal disorders
5.62
Eye disorders
4.86
Blood and lymphatic system disorders
4.14
Skin and subcutaneous tissue disorders
4.07
Metabolism and nutrition disorders
3.82
Cardiac disorders
3.78
Musculoskeletal and connective tissue disorders
3.61
Infections and infestations
3.52
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
2.66
Renal and urinary disorders
2.54
Psychiatric disorders
2.16

Cross References

Resources Reference
CAS NUMBER 216974-75-3
ChEMBL CHEMBL1201583
FDA SRS 2S9ZZM9Q9V
Guide to Pharmacology 6771
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