BORTEZOMIB

Search structure
Trade Names:
Synonyms:
Status: Approved (2003)
Entry Type: Small molecule
Molecule Category: UNKNOWN
ATC: L01XG01
UNII: 69G8BD63PP

Structure
InChI Key GXJABQQUPOEUTA-RDJZCZTQSA-N
Smile CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O
InChI
InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C19H25BN4O4
Molecular Weight 384.25
AlogP None
Hydrogen Bond Acceptor None
Hydrogen Bond Donor None
Number of Rotational Bond None
Polar Surface Area None
Molecular species None
Aromatic Rings None
Heavy Atoms None

Pharmacology

Action Mechanism of Action Reference
INHIBITOR 26S proteosome inhibitor PubMed DailyMed
Primary Target
proteasome 20S subunit beta 5
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Lyase
- - - 1160-1160 -
Enzyme Protease Aspartic protease Aspartic protease AA clan Aspartic protease A1A subfamily
- - - -
Enzyme Protease Cysteine protease Cysteine protease CA clan Cysteine protease C1A family
- - - - 27
Enzyme Protease Cysteine protease Cysteine protease CA clan Cysteine protease C2 family
- - - - 0
Enzyme Protease Cysteine protease Cysteine protease CD clan Cysteine protease C14 family
- - - - 2-3
Enzyme Protease Cysteine protease Cysteine protease PAC clan Cysteine protease C3A subfamily
- - - -
Enzyme Protease Metallo protease Metallo protease MAE clan Metallo protease M13 family
- - - - 26
Enzyme Protease Metallo protease Metallo protease MAM clan Metallo protease M10A subfamily
- - - - -7-3
Enzyme Protease Metallo protease Metallo protease MAM clan Metallo protease M12B subfamily
- - - - 2
Enzyme Protease Metallo protease Metallo protease MP clan Metallo protease M67 family Metallo protease M67A subfamily
- 3-2000 - - -
Enzyme Protease Serine protease Serine protease PA clan Serine protease S1A subfamily
- 520-3100 - 13000 -1-17
Enzyme Protease Serine protease Serine protease SC clan Serine protease S10 family
- 9200 - - -
Enzyme Protease Serine protease Serine protease SC clan Serine protease S9B subfamily
- - - - 1-21
Enzyme Protease Serine protease Serine protease SK clan Serine protease S14 family
23500 5300 - - -
Enzyme Protease Threonine protease Threonine protease PBT clan Threonine protease T1A subfamily
- 1-2100 - 1-10 51-100
Enzyme Protease Threonine protease Threonine protease PBT clan Threonine protease T1B subfamily
- 3-2000 - - -
Enzyme
23500 1-2100 - 1-10 51-100
Epigenetic regulator Eraser Histone deacetylase HDAC class I
- 1180 - - -
Epigenetic regulator Eraser Histone deacetylase HDAC class IIb
- 69440 - - -
Epigenetic regulator Writer Protein methyltransferase SET domain
- - - - 18-24
Other cytosolic protein
- 3-2000 - - -
Transcription factor
- 10 - - -
Unclassified protein
- 3-2000 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Neoplasms 4 D009369 ClinicalTrials
Multiple Myeloma 4 D009101 ClinicalTrials
Cholangiocarcinoma 3 D018281 ClinicalTrials
Amyloidosis, Familial 3 D028226 ClinicalTrials
Amyloidosis 3 D000686 ClinicalTrials
Sarcoma, Myeloid 3 D023981 ClinicalTrials
Precursor Cell Lymphoblastic Leukemia-Lymphoma 3 D054198 ClinicalTrials
Purpura, Thrombocytopenic, Idiopathic 3 D016553 ClinicalTrials
Plasmacytoma 3 D010954 ClinicalTrials
Renal Insufficiency, Chronic 3 D051436 ClinicalTrials
Lymphoma, Large B-Cell, Diffuse 3 D016403 ClinicalTrials
Lymphoma, Non-Hodgkin 3 D008228 ClinicalTrials
Waldenstrom Macroglobulinemia 3 D008258 ClinicalTrials
Precursor Cell Lymphoblastic Leukemia-Lymphoma 3 D054198 ClinicalTrials
Amyloidosis 3 D000686 ClinicalTrials
Lymphoma 3 D008223 ClinicalTrials
Lymphoma, T-Cell, Peripheral 2 D016411 ClinicalTrials
Carcinoma, Adenoid Cystic 2 D003528 ClinicalTrials
Urinary Bladder Neoplasms 2 D001749 ClinicalTrials
Adenocarcinoma, Bronchiolo-Alveolar 2 D002282 ClinicalTrials
Glioma 2 D005910 ClinicalTrials
Leukemia, Myelogenous, Chronic, BCR-ABL Positive 2 D015464 ClinicalTrials
Adenocarcinoma, Follicular 2 D018263 ClinicalTrials
Immune System Diseases 2 D007154 ClinicalTrials
Thyroid Neoplasms 2 D013964 ClinicalTrials
Prostatic Neoplasms 2 D011471 ClinicalTrials
Sarcoma 2 D012509 ClinicalTrials
Hematologic Neoplasms 2 D019337 ClinicalTrials
Prostatic Neoplasms 2 D011471 ClinicalTrials
Carcinoma, Pancreatic Ductal 2 D021441 ClinicalTrials
Pancreatic Neoplasms 2 D010190 ClinicalTrials
Nasopharyngeal Neoplasms 2 D009303 ClinicalTrials
Leukemia, Plasma Cell 2 D007952 ClinicalTrials
Red-Cell Aplasia, Pure 2 D012010 ClinicalTrials
Leukemia 2 D007938 ClinicalTrials
Graft vs Host Disease 2 D006086 ClinicalTrials
Melanoma 2 D008545 ClinicalTrials
Leukemia, Promyelocytic, Acute 2 D015473 ClinicalTrials
Myelodysplastic Syndromes 2 D009190 ClinicalTrials
Lymphoma, Follicular 2 D008224 ClinicalTrials
Leukemia, Myeloid, Acute 2 D015470 ClinicalTrials
Mesothelioma 2 D008654 ClinicalTrials
Carcinoma, Hepatocellular 2 D006528 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 2 D002289 ClinicalTrials
Neuromyelitis Optica 2 D009471 ClinicalTrials
Bronchiolitis Obliterans 2 D001989 ClinicalTrials
Leukemia, Biphenotypic, Acute 2 D015456 ClinicalTrials
Leukemia, Lymphocytic, Chronic, B-Cell 2 D015451 ClinicalTrials
Hodgkin Disease 2 D006689 ClinicalTrials
Lymphoma, B-Cell, Marginal Zone 2 D018442 ClinicalTrials
Leukemia, Biphenotypic, Acute 2 D015456 ClinicalTrials
Sarcoma 2 D012509 ClinicalTrials
Stomach Neoplasms 2 D013274 ClinicalTrials
Urinary Bladder Neoplasms 2 D001749 ClinicalTrials
Kidney Neoplasms 2 D007680 ClinicalTrials
Uterine Cervical Neoplasms 2 D002583 ClinicalTrials
Carcinoma, Adenoid Cystic 2 D003528 ClinicalTrials
Urethral Neoplasms 2 D014523 ClinicalTrials
Breast Neoplasms 2 D001943 ClinicalTrials
Esophageal Neoplasms 2 D004938 ClinicalTrials
Ovarian Neoplasms 2 D010051 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 2 D064129 ClinicalTrials
Ureteral Neoplasms 2 D014516 ClinicalTrials
Lung Neoplasms 2 D008175 ClinicalTrials
Hodgkin Disease 2 D006689 ClinicalTrials
Graft vs Host Disease 2 D006086 ClinicalTrials
Castleman Disease 2 D005871 ClinicalTrials
Lymphoma, Follicular 2 D008224 ClinicalTrials
Leukemia, Biphenotypic, Acute 2 D015456 ClinicalTrials
Hematologic Neoplasms 2 D019337 ClinicalTrials
Lymphoproliferative Disorders 2 D008232 ClinicalTrials
Breast Neoplasms 2 D001943 ClinicalTrials
Head and Neck Neoplasms 2 D006258 ClinicalTrials
Gliosarcoma 2 D018316 ClinicalTrials
Colorectal Neoplasms 2 D015179 ClinicalTrials
Adenocarcinoma of Lung 2 D000077192 ClinicalTrials
Encephalitis, Japanese 2 D004672 ClinicalTrials
Central Nervous System Neoplasms 2 D016543 ClinicalTrials
Lymphoma, AIDS-Related 1 D016483 ClinicalTrials
Carcinoma, Medullary 1 D018276 ClinicalTrials
Smoldering Multiple Myeloma 1 D000075122 ClinicalTrials
Oligodendroglioma 1 D009837 ClinicalTrials
Muscular Dystrophies 1 D009136 ClinicalTrials
Astrocytoma 1 D001254 ClinicalTrials
Neuroblastoma 1 D009447 ClinicalTrials
Carcinoma, Squamous Cell 1 D002294 ClinicalTrials
Carcinoma, Renal Cell 1 D002292 ClinicalTrials
Leukemia-Lymphoma, Adult T-Cell 1 D015459 ClinicalTrials
Peritoneal Neoplasms 1 D010534 ClinicalTrials
Glioblastoma 1 D005909 ClinicalTrials
Immunoblastic Lymphadenopathy 1 D007119 ClinicalTrials
Burkitt Lymphoma 1 D002051 ClinicalTrials
Anemia, Refractory, with Excess of Blasts 1 D000754 ClinicalTrials
Lymphoma, Large-Cell, Anaplastic 1 D017728 ClinicalTrials
Fallopian Tube Neoplasms 1 D005185 ClinicalTrials
Sezary Syndrome 1 D012751 ClinicalTrials
Mycosis Fungoides 1 D009182 ClinicalTrials
Uremia 1 D014511 ClinicalTrials
Myeloproliferative Disorders 0 D009196 ClinicalTrials

Related Entries

Scaffolds

Side Effects from Label

Side effects Relative Frequency (%) Labels
Gastrointestinal disorders Nausea 64.0
Gastrointestinal disorders Nausea 63.6
Gastrointestinal disorders Diarrhoea 57.4
Gastrointestinal disorders Nausea 57.4
Blood and lymphatic system disorders Plasma cell myeloma 57.0
Blood and lymphatic system disorders Plasmacytoma 57.0
Gastrointestinal disorders Nausea 56.7
Blood and lymphatic system disorders Mantle cell lymphoma 55.0
Gastrointestinal disorders Nausea 55.0
Blood and lymphatic system disorders Thrombocytopenia 55.0
Nervous system disorders Neuropathy peripheral 54.8
Blood and lymphatic system disorders Mantle cell lymphoma 54.0
Gastrointestinal disorders Diarrhoea 52.7
Gastrointestinal disorders Diarrhoea 52.0
Gastrointestinal disorders Nausea 52.0
Gastrointestinal disorders Diarrhoea 51.9
Gastrointestinal disorders Diarrhoea 51.0
Blood and lymphatic system disorders Plasma cell myeloma 51.0
Blood and lymphatic system disorders Plasmacytoma 51.0
Gastrointestinal disorders Diarrhoea 50.9
Gastrointestinal disorders Constipation 49.7
Psychiatric disorders Mental disorder 49.1
Psychiatric disorders Mental disorder 49.0
Gastrointestinal disorders Nausea 49.0
Gastrointestinal disorders Diarrhoea 47.1
Gastrointestinal disorders Diarrhoea 46.0
Blood and lymphatic system disorders Mantle cell lymphoma 44.0
Gastrointestinal disorders Nausea 43.9
General disorders and administration site conditions Decreased appetite 43.4
Gastrointestinal disorders Constipation 43.0
Blood and lymphatic system disorders Thrombocytopenia 43.0
Gastrointestinal disorders Constipation 42.5
Blood and lymphatic system disorders Thrombocytopenia 42.5
Gastrointestinal disorders Constipation 42.3
Gastrointestinal disorders Constipation 42.0
Gastrointestinal disorders Constipation 41.4
General disorders and administration site conditions Asthenia 41.0
Gastrointestinal disorders Constipation 41.0
General disorders and administration site conditions Fatigue 41.0
Gastrointestinal disorders Constipation 40.1
Nervous system disorders Neuropathy peripheral 40.0
Nervous system disorders Neuropathy peripheral 39.3
General disorders and administration site conditions Asthenia 39.0
General disorders and administration site conditions Fatigue 39.0
General disorders and administration site conditions Decreased appetite 38.7
Blood and lymphatic system disorders Thrombocytopenia 38.5
Nervous system disorders Neuropathy peripheral 38.0
Blood and lymphatic system disorders Plasma cell myeloma 38.0
Blood and lymphatic system disorders Plasmacytoma 38.0
Blood and lymphatic system disorders Anaemia 37.0
Blood and lymphatic system disorders Plasma cell myeloma 37.0
Blood and lymphatic system disorders Plasmacytoma 37.0
Nervous system disorders Neuropathy peripheral 36.9
Investigations Body temperature increased 36.8
Nervous system disorders Neuropathy peripheral 36.8
Nervous system disorders Neuropathy peripheral 36.3
Blood and lymphatic system disorders Thrombocytopenia 36.2
Investigations Body temperature increased 36.0
Blood and lymphatic system disorders Mantle cell lymphoma 36.0
Blood and lymphatic system disorders Plasma cell myeloma 36.0
Blood and lymphatic system disorders Plasmacytoma 36.0
Gastrointestinal disorders Vomiting 36.0
General disorders and administration site conditions Decreased appetite 35.9
General disorders and administration site conditions Decreased appetite 35.4
Psychiatric disorders Mental disorder 35.3
Gastrointestinal disorders Vomiting 35.3
Investigations Body temperature increased 35.0
Gastrointestinal disorders Diarrhoea 35.0
Nervous system disorders Neuropathy peripheral 35.0
Blood and lymphatic system disorders Thrombocytopenia 34.7
Investigations Body temperature increased 34.5
Investigations Body temperature increased 34.0
General disorders and administration site conditions Decreased appetite 34.0
Blood and lymphatic system disorders Plasma cell myeloma 34.0
Blood and lymphatic system disorders Plasmacytoma 34.0
Gastrointestinal disorders Vomiting 34.0
General disorders and administration site conditions Decreased appetite 33.8
Gastrointestinal disorders Vomiting 33.1
Blood and lymphatic system disorders Thrombocytopenia 33.0
Gastrointestinal disorders Vomiting 33.0
Blood and lymphatic system disorders Anaemia 32.5
Blood and lymphatic system disorders Anaemia 32.0
Blood and lymphatic system disorders Plasma cell myeloma 32.0
Blood and lymphatic system disorders Plasmacytoma 32.0
Blood and lymphatic system disorders Thrombocytopenia 32.0
Blood and lymphatic system disorders Thrombocytopenia 31.7
Blood and lymphatic system disorders Anaemia 30.4
Gastrointestinal disorders Constipation 30.0
Blood and lymphatic system disorders Anaemia 29.0
Blood and lymphatic system disorders Thrombocytopenia 29.0
Gastrointestinal disorders Vomiting 29.0
Blood and lymphatic system disorders Anaemia 28.6
General disorders and administration site conditions Oedema 28.4
Gastrointestinal disorders Constipation 28.0
Blood and lymphatic system disorders Plasma cell myeloma 28.0
Blood and lymphatic system disorders Plasmacytoma 28.0
Gastrointestinal disorders Vomiting 28.0
Skin and subcutaneous tissue disorders Dermatitis 27.7
Skin and subcutaneous tissue disorders Rash 27.7
Nervous system disorders Headache 27.6
Nervous system disorders Dysaesthesia 27.5
Nervous system disorders Paraesthesia 27.5
Nervous system disorders Insomnia 27.2
Nervous system disorders Insomnia 27.1
Gastrointestinal disorders Vomiting 27.1
Nervous system disorders Dysaesthesia 27.0
Nervous system disorders Insomnia 27.0
Blood and lymphatic system disorders Thrombocytopenia 26.8
Blood and lymphatic system disorders Anaemia 26.3
Musculoskeletal and connective tissue disorders Arthralgia 26.3
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 26.3
Musculoskeletal and connective tissue disorders Pain in extremity 25.9
Nervous system disorders Headache 25.7
Blood and lymphatic system disorders Thrombocytopenia 25.7
General disorders and administration site conditions Oedema 25.4
General disorders and administration site conditions Asthenia 25.0
Gastrointestinal disorders Constipation 25.0
General disorders and administration site conditions Fatigue 25.0
Blood and lymphatic system disorders Neutropenia 24.1
Musculoskeletal and connective tissue disorders Muscle spasms 24.0
Nervous system disorders Dysaesthesia 23.8
Nervous system disorders Paraesthesia 23.8
Cardiac disorders Dizziness 23.2
Nervous system disorders Dysaesthesia 23.2
Nervous system disorders Paraesthesia 23.2
Blood and lymphatic system disorders Plasma cell myeloma 23.0
Blood and lymphatic system disorders Plasmacytoma 23.0
Cardiac disorders Dyspnoea 22.6
Nervous system disorders Headache 22.5
General disorders and administration site conditions Oedema 22.5
Blood and lymphatic system disorders Anaemia 22.3
Blood and lymphatic system disorders Anaemia 22.0
Cardiac disorders Dyspnoea 21.9
Nervous system disorders Dysaesthesia 21.8
Nervous system disorders Headache 21.8
Nervous system disorders Paraesthesia 21.8
General disorders and administration site conditions Oedema 21.6
Nervous system disorders Insomnia 21.3
Blood and lymphatic system disorders Thrombocytopenia 21.3
Respiratory, thoracic and mediastinal disorders Cough 21.1
Cardiac disorders Dizziness 21.1
Ear and labyrinth disorders Vertigo 21.1
Investigations Body temperature increased 21.0
Respiratory, thoracic and mediastinal disorders Cough 21.0
General disorders and administration site conditions Decreased appetite 21.0
Cardiac disorders Dyspnoea 21.0
Blood and lymphatic system disorders Mantle cell lymphoma 21.0
Gastrointestinal disorders Diarrhoea 20.8
Infections and infestations Infection 20.8
Cardiac disorders Dyspnoea 20.7
Skin and subcutaneous tissue disorders Dermatitis 20.6
Skin and subcutaneous tissue disorders Rash 20.6
Respiratory, thoracic and mediastinal disorders Cough 20.0
Respiratory, thoracic and mediastinal disorders Cough 19.9
Nervous system disorders Insomnia 19.9
Nervous system disorders Insomnia 19.7
Cardiac disorders Dyspnoea 19.6
Investigations Body temperature increased 19.4
Respiratory, thoracic and mediastinal disorders Cough 19.4
Blood and lymphatic system disorders Mantle cell lymphoma 19.0
Blood and lymphatic system disorders Neutropenia 18.7
Metabolism and nutrition disorders Dehydration 18.4
Skin and subcutaneous tissue disorders Dermatitis 18.4
Blood and lymphatic system disorders Neutropenia 18.4
Skin and subcutaneous tissue disorders Rash 18.4
Skin and subcutaneous tissue disorders Dermatitis 18.3
Skin and subcutaneous tissue disorders Rash 18.3
Nervous system disorders Insomnia 18.1
Nervous system disorders Insomnia 18.0
Blood and lymphatic system disorders Plasma cell myeloma 18.0
Blood and lymphatic system disorders Plasmacytoma 18.0
Infections and infestations Upper respiratory tract infection 18.0
Musculoskeletal and connective tissue disorders Arthralgia 17.8
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 17.8
Cardiac disorders Dyspnoea 17.5
Blood and lymphatic system disorders Anaemia 17.4
Musculoskeletal and connective tissue disorders Arthralgia 17.1
Respiratory, thoracic and mediastinal disorders Cough 17.1
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 17.1
Musculoskeletal and connective tissue disorders Pain in extremity 17.1
Skin and subcutaneous tissue disorders Dermatitis 16.9
Skin and subcutaneous tissue disorders Rash 16.9
Cardiac disorders Dizziness 16.8
Nervous system disorders Headache 16.8
Blood and lymphatic system disorders Neutropenia 16.8
Investigations Body temperature increased 16.3
Musculoskeletal and connective tissue disorders Bone pain 16.2
Gastrointestinal disorders Abdominal pain 16.0
Gastrointestinal disorders Gastrointestinal pain 16.0
Blood and lymphatic system disorders Mantle cell lymphoma 16.0
Blood and lymphatic system disorders Plasma cell myeloma 16.0
Blood and lymphatic system disorders Plasmacytoma 16.0
Cardiac disorders Dizziness 15.8
Musculoskeletal and connective tissue disorders Bone pain 15.7
Gastrointestinal disorders Abdominal pain 15.5
Gastrointestinal disorders Gastrointestinal pain 15.5
Musculoskeletal and connective tissue disorders Pain in extremity 15.4
Musculoskeletal and connective tissue disorders Bone pain 15.1
Musculoskeletal and connective tissue disorders Muscle spasms 15.1
Musculoskeletal and connective tissue disorders Pain in extremity 15.1
Blood and lymphatic system disorders Mantle cell lymphoma 15.0
Musculoskeletal and connective tissue disorders Back pain 14.9
Gastrointestinal disorders Constipation 14.8
Vascular disorders Hypotension 14.8
Gastrointestinal disorders Abdominal pain 14.6
Gastrointestinal disorders Gastrointestinal pain 14.6
Gastrointestinal disorders Abdominal pain 14.5
Musculoskeletal and connective tissue disorders Bone pain 14.5
Gastrointestinal disorders Gastrointestinal pain 14.5
Infections and infestations Infection 14.5
Musculoskeletal and connective tissue disorders Bone pain 14.3
Psychiatric disorders Anxiety 14.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 14.0
Musculoskeletal and connective tissue disorders Myalgia 14.0
Infections and infestations Nasopharyngitis 14.0
Blood and lymphatic system disorders Plasma cell myeloma 14.0
Blood and lymphatic system disorders Plasmacytoma 14.0
Musculoskeletal and connective tissue disorders Back pain 13.9
Gastrointestinal disorders Nausea 13.9
Musculoskeletal and connective tissue disorders Arthralgia 13.6
Musculoskeletal and connective tissue disorders Back pain 13.6
Cardiac disorders Dizziness 13.6
Musculoskeletal and connective tissue disorders Muscle spasms 13.6
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 13.6
Infections and infestations Nasopharyngitis 13.6
Nervous system disorders Neuropathy peripheral 13.6
Blood and lymphatic system disorders Neutropenia 13.6
Ear and labyrinth disorders Vertigo 13.6
Gastrointestinal disorders Dyspepsia 13.2
Blood and lymphatic system disorders Neutropenia 13.2
Musculoskeletal and connective tissue disorders Back pain 13.0
Gastrointestinal disorders Dysgeusia 13.0
Nervous system disorders Headache 13.0
Infections and infestations Herpes zoster 13.0
Cardiac disorders Oedema peripheral 13.0
Musculoskeletal and connective tissue disorders Arthralgia 12.9
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 12.9
Nervous system disorders Neuropathy peripheral 12.9
Gastrointestinal disorders Abdominal pain 12.7
Gastrointestinal disorders Dysgeusia 12.7
Gastrointestinal disorders Gastrointestinal pain 12.7
Infections and infestations Herpes zoster 12.7
Vascular disorders Hypotension 12.6
Infections and infestations Herpes zoster 12.5
Infections and infestations Nasopharyngitis 12.5
Musculoskeletal and connective tissue disorders Muscle spasms 12.4
Vascular disorders Hypotension 12.3
Blood and lymphatic system disorders Neutropenia 12.3
Blood and lymphatic system disorders Neutropenia 12.1
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 12.0
Musculoskeletal and connective tissue disorders Myalgia 12.0
Infections and infestations Nasopharyngitis 12.0
Blood and lymphatic system disorders Plasma cell myeloma 12.0
Blood and lymphatic system disorders Plasmacytoma 12.0
Skin and subcutaneous tissue disorders Pruritus 12.0
Blood and lymphatic system disorders Anaemia 11.9
Infections and infestations Pneumonia 11.9
General disorders and administration site conditions Chills 11.8
Vascular disorders Hypotension 11.8
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 11.8
Musculoskeletal and connective tissue disorders Myalgia 11.8
Musculoskeletal and connective tissue disorders Muscle spasms 11.7
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 11.7
Musculoskeletal and connective tissue disorders Myalgia 11.7
Nervous system disorders Neuropathy peripheral 11.5
Infections and infestations Pneumonia 11.5
Nervous system disorders Dysaesthesia 11.4
Infections and infestations Herpes zoster 11.4
Nervous system disorders Paraesthesia 11.4
Skin and subcutaneous tissue disorders Pruritus 11.4
Nervous system disorders Neuropathy peripheral 11.3
General disorders and administration site conditions Chills 11.2
Psychiatric disorders Anxiety 11.0
General disorders and administration site conditions Asthenia 11.0
Nervous system disorders Hypoaesthesia 11.0
Blood and lymphatic system disorders Mantle cell lymphoma 11.0
Blood and lymphatic system disorders Thrombocytopenia 11.0
Eye disorders Vision blurred 11.0
Metabolism and nutrition disorders Dehydration 10.8
Blood and lymphatic system disorders Thrombocytopenia 10.8
Blood and lymphatic system disorders Anaemia 10.7
Musculoskeletal and connective tissue disorders Muscle spasms 10.7
Cardiac disorders Oedema peripheral 10.6
Musculoskeletal and connective tissue disorders Arthralgia 10.5
Respiratory, thoracic and mediastinal disorders Cough 10.5
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 10.5
Metabolism and nutrition disorders Dehydration 10.3
Cardiac disorders Dizziness 10.2
Ear and labyrinth disorders Vertigo 10.2
Psychiatric disorders Anxiety 10.1
Infections and infestations Pneumonia 10.1
Respiratory, thoracic and mediastinal disorders Epistaxis 10.0
Blood and lymphatic system disorders Mantle cell lymphoma 10.0
Musculoskeletal and connective tissue disorders Musculoskeletal pain 10.0
Musculoskeletal and connective tissue disorders Back pain 9.94
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 9.68
Musculoskeletal and connective tissue disorders Myalgia 9.68
Blood and lymphatic system disorders Anaemia 9.64
Blood and lymphatic system disorders Anaemia 9.37
General disorders and administration site conditions Decreased appetite 9.34
Blood and lymphatic system disorders Anaemia 9.21
Nervous system disorders Dysaesthesia 9.03
Infections and infestations Herpes zoster 9.03
Nervous system disorders Paraesthesia 9.03
Infections and infestations Pneumonia 9.03
Blood and lymphatic system disorders Mantle cell lymphoma 9.0
Nervous system disorders Neuralgia 9.0
Nervous system disorders Peripheral sensory neuropathy 9.0
Nervous system disorders Neuropathy peripheral 8.73
Gastrointestinal disorders Diarrhoea 8.43
Infections and infestations Nasopharyngitis 8.39
Gastrointestinal disorders Diarrhoea 8.25
Blood and lymphatic system disorders Mantle cell lymphoma 8.0
Nervous system disorders Neuropathy peripheral 8.0
Blood and lymphatic system disorders Plasma cell myeloma 8.0
Blood and lymphatic system disorders Plasmacytoma 8.0
Psychiatric disorders Mental disorder 7.83
Gastrointestinal disorders Diarrhoea 7.25
Nervous system disorders Neuropathy peripheral 7.25
Infections and infestations Infection 7.23
Musculoskeletal and connective tissue disorders Pain in extremity 7.23
Metabolism and nutrition disorders Dehydration 7.1
Gastrointestinal disorders Diarrhoea 7.1
Gastrointestinal disorders Diarrhoea 7.02
Musculoskeletal and connective tissue disorders Pain in extremity 7.02
Gastrointestinal disorders Vomiting 7.02
Investigations Body temperature increased 7.0
Infections and infestations Pneumonia 7.0
Infections and infestations Nasopharyngitis 6.63
Metabolism and nutrition disorders Dehydration 6.58
Blood and lymphatic system disorders Neutropenia 6.45
Infections and infestations Pneumonia 6.45
Infections and infestations Pneumonia 6.19
Skin and subcutaneous tissue disorders Dermatitis 6.02
Skin and subcutaneous tissue disorders Rash 6.02
Gastrointestinal disorders Vomiting 6.02
Investigations Body temperature increased 6.0
Gastrointestinal disorders Diarrhoea 6.0
Blood and lymphatic system disorders Mantle cell lymphoma 6.0
Gastrointestinal disorders Nausea 5.7
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 5.42
Musculoskeletal and connective tissue disorders Myalgia 5.42
Blood and lymphatic system disorders Thrombocytopenia 5.42
Infections and infestations Pneumonia 5.26
Gastrointestinal disorders Vomiting 5.26
Gastrointestinal disorders Abdominal pain 5.16
Cardiac disorders Dyspnoea 5.16
Gastrointestinal disorders Gastrointestinal pain 5.16
Cardiac disorders Dyspnoea 5.07
Metabolism and nutrition disorders Dehydration 5.0
Gastrointestinal disorders Diarrhoea 5.0
Blood and lymphatic system disorders Mantle cell lymphoma 5.0
Nervous system disorders Neuralgia 5.0
Nervous system disorders Neuropathy peripheral 5.0
Nervous system disorders Peripheral sensory neuropathy 5.0
Blood and lymphatic system disorders Thrombocytopenia 5.0
Gastrointestinal disorders Vomiting 5.0
Gastrointestinal disorders Vomiting 4.9
Cardiac disorders Dyspnoea 4.83
Musculoskeletal and connective tissue disorders Arthralgia 4.82
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 4.82
Psychiatric disorders Anxiety 4.52
Metabolism and nutrition disorders Dehydration 4.52
Cardiac disorders Dyspnoea 4.52
Infections and infestations Herpes zoster 4.52
Musculoskeletal and connective tissue disorders Muscle spasms 4.52
Musculoskeletal and connective tissue disorders Pain in extremity 4.52
Infections and infestations Pneumonia 4.52
Investigations Body temperature increased 4.0
Blood and lymphatic system disorders Mantle cell lymphoma 4.0
Gastrointestinal disorders Nausea 4.0
Infections and infestations Pneumonia 4.0
Blood and lymphatic system disorders Thrombocytopenia 4.0
Gastrointestinal disorders Vomiting 4.0
Musculoskeletal and connective tissue disorders Back pain 3.95
Investigations Body temperature increased 3.95
Musculoskeletal and connective tissue disorders Back pain 3.87
Gastrointestinal disorders Nausea 3.87
Blood and lymphatic system disorders Neutropenia 3.87
Blood and lymphatic system disorders Thrombocytopenia 3.8
Gastrointestinal disorders Nausea 3.7
Musculoskeletal and connective tissue disorders Bone pain 3.67
Musculoskeletal and connective tissue disorders Bone pain 3.63
Infections and infestations Infection 3.63
Blood and lymphatic system disorders Thrombocytopenia 3.63
Gastrointestinal disorders Abdominal pain 3.61
Gastrointestinal disorders Gastrointestinal pain 3.61
Musculoskeletal and connective tissue disorders Pain in extremity 3.57
Nervous system disorders Headache 3.51
Vascular disorders Hypotension 3.51
Metabolism and nutrition disorders Dehydration 3.44
Investigations Body temperature increased 3.37
Musculoskeletal and connective tissue disorders Back pain 3.35
Gastrointestinal disorders Vomiting 3.32
Metabolism and nutrition disorders Dehydration 3.27
General disorders and administration site conditions Decreased appetite 3.23
Cardiac disorders Dizziness 3.23
Vascular disorders Hypotension 3.23
Musculoskeletal and connective tissue disorders Bone pain 3.18
Vascular disorders Hypotension 3.18
Vascular disorders Hypotension 3.17
Investigations Body temperature increased 3.1
Musculoskeletal and connective tissue disorders Pain in extremity 3.1
Cardiac disorders Dyspnoea 3.07
Blood and lymphatic system disorders Thrombocytopenia 3.07
Musculoskeletal and connective tissue disorders Back pain 3.02
Gastrointestinal disorders Diarrhoea 3.0
Endocrine disorders Hyperglycaemia 3.0
Blood and lymphatic system disorders Mantle cell lymphoma 3.0
Blood and lymphatic system disorders Neutropenia 3.0
Blood and lymphatic system disorders Thrombocytopenia 3.0
Gastrointestinal disorders Vomiting 3.0
General disorders and administration site conditions Decreased appetite 2.72
Psychiatric disorders Mental disorder 2.72
Musculoskeletal and connective tissue disorders Bone pain 2.71
Cardiac disorders Dyspnoea 2.71
General disorders and administration site conditions Decreased appetite 2.63
Nervous system disorders Dysaesthesia 2.63
Blood and lymphatic system disorders Neutropenia 2.63
Nervous system disorders Paraesthesia 2.63
Gastrointestinal disorders Abdominal pain 2.58
Blood and lymphatic system disorders Anaemia 2.58
Gastrointestinal disorders Constipation 2.58
General disorders and administration site conditions Decreased appetite 2.58
Skin and subcutaneous tissue disorders Dermatitis 2.58
Gastrointestinal disorders Gastrointestinal pain 2.58
Gastrointestinal disorders Nausea 2.58
General disorders and administration site conditions Oedema 2.58
Skin and subcutaneous tissue disorders Rash 2.58
Gastrointestinal disorders Vomiting 2.58
Musculoskeletal and connective tissue disorders Arthralgia 2.48
General disorders and administration site conditions Decreased appetite 2.48
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 2.48
Gastrointestinal disorders Nausea 2.42
Blood and lymphatic system disorders Neutropenia 2.42
General disorders and administration site conditions Chills 2.41
Musculoskeletal and connective tissue disorders Arthralgia 2.32
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 2.32
Gastrointestinal disorders Diarrhoea 2.3
Gastrointestinal disorders Constipation 2.24
Gastrointestinal disorders Abdominal pain 2.19
Musculoskeletal and connective tissue disorders Bone pain 2.19
Gastrointestinal disorders Constipation 2.19
Gastrointestinal disorders Gastrointestinal pain 2.19
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 2.19
Musculoskeletal and connective tissue disorders Myalgia 2.19
Gastrointestinal disorders Abdominal pain 2.18
Gastrointestinal disorders Constipation 2.18
Gastrointestinal disorders Gastrointestinal pain 2.18
Gastrointestinal disorders Constipation 2.11
Infections and infestations Herpes zoster 2.08
General disorders and administration site conditions Asthenia 2.0
Gastrointestinal disorders Diarrhoea 2.0
General disorders and administration site conditions Fatigue 2.0
Endocrine disorders Hypercalcaemia 2.0
Endocrine disorders Hyperglycaemia 2.0
Blood and lymphatic system disorders Neutropenia 2.0
Musculoskeletal and connective tissue disorders Bone pain 1.94
Infections and infestations Herpes zoster 1.89
Gastrointestinal disorders Abdominal pain 1.81
Investigations Body temperature increased 1.81
Gastrointestinal disorders Diarrhoea 1.81
Nervous system disorders Dysaesthesia 1.81
Gastrointestinal disorders Gastrointestinal pain 1.81
Infections and infestations Herpes zoster 1.81
Nervous system disorders Paraesthesia 1.81
Nervous system disorders Headache 1.69
Cardiac disorders Dizziness 1.55
Musculoskeletal and connective tissue disorders Arthralgia 1.51
Nervous system disorders Insomnia 1.51
Psychiatric disorders Mental disorder 1.51
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 1.51
Blood and lymphatic system disorders Neutropenia 1.51
Musculoskeletal and connective tissue disorders Pain in extremity 1.51
Nervous system disorders Headache 1.46
Nervous system disorders Dysaesthesia 1.39
Nervous system disorders Paraesthesia 1.39
Nervous system disorders Dysaesthesia 1.38
Nervous system disorders Paraesthesia 1.38
Cardiac disorders Dizziness 1.32
Nervous system disorders Insomnia 1.32
General disorders and administration site conditions Oedema 1.32
Ear and labyrinth disorders Vertigo 1.32
Musculoskeletal and connective tissue disorders Arthralgia 1.29
Investigations Body temperature increased 1.29
Cardiac disorders Dizziness 1.29
Nervous system disorders Dysaesthesia 1.29
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 1.29
Nervous system disorders Paraesthesia 1.29
Skin and subcutaneous tissue disorders Dermatitis 1.21
Skin and subcutaneous tissue disorders Rash 1.21
Musculoskeletal and connective tissue disorders Back pain 1.2
Investigations Body temperature increased 1.2
Gastrointestinal disorders Constipation 1.2
Infections and infestations Herpes zoster 1.2
Blood and lymphatic system disorders Neutropenia 1.2
Blood and lymphatic system disorders Thrombocytopenia 1.2
Gastrointestinal disorders Vomiting 1.2
Blood and lymphatic system disorders Acute febrile neutrophilic dermatosis 1.0
Cardiac disorders Angina pectoris 1.0
Cardiac disorders Arrhythmia 1.0
Convulsion 1.0
Ear and labyrinth disorders Deafness 1.0
Eye disorders Diplopia 1.0
Blood and lymphatic system disorders Disseminated intravascular coagulation 1.0
Investigations Ejection fraction decreased 1.0
Nervous system disorders Encephalopathy 1.0
Gastrointestinal disorders Enteritis 1.0
Blood and lymphatic system disorders Febrile neutropenia 1.0
Investigations Haemoglobin 1.0
Vascular disorders Haemorrhage 1.0
Hearing impaired 1.0
Hepatobiliary disorders Hepatic failure 1.0
Blood and lymphatic system disorders Hyperbilirubinaemia 1.0
Immune system disorders Hypersensitivity 1.0
Gastrointestinal disorders Pancreatitis acute 1.0
Psychiatric disorders Psychotic disorder 1.0
Respiratory, thoracic and mediastinal disorders Pulmonary hypertension 1.0
Renal and urinary disorders Renal failure 1.0
Metabolism and nutrition disorders Respiratory failure 1.0
Infections and infestations Sepsis 1.0
Gastrointestinal disorders Stomatitis 1.0
Metabolism and nutrition disorders Tumour lysis syndrome 1.0
Musculoskeletal and connective tissue disorders Arthralgia 0.906
Cardiac disorders Dizziness 0.906
Nervous system disorders Headache 0.906
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 0.906
Ear and labyrinth disorders Vertigo 0.906
Blood and lymphatic system disorders Anaemia 0.904
Infections and infestations Infection 0.904
Psychiatric disorders Mental disorder 0.904
Musculoskeletal and connective tissue disorders Muscle spasms 0.904
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 0.893
Musculoskeletal and connective tissue disorders Myalgia 0.893
Gastrointestinal disorders Diarrhoea 0.877
Infections and infestations Herpes zoster 0.877
Skin and subcutaneous tissue disorders Dermatitis 0.86
General disorders and administration site conditions Oedema 0.86
Skin and subcutaneous tissue disorders Rash 0.86
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 0.774
Musculoskeletal and connective tissue disorders Myalgia 0.774
Musculoskeletal and connective tissue disorders Back pain 0.645
Infections and infestations Herpes zoster 0.645
Nervous system disorders Insomnia 0.645
Blood and lymphatic system disorders Anaemia 0.604
Respiratory, thoracic and mediastinal disorders Cough 0.604
Infections and infestations Infection 0.604
Psychiatric disorders Mental disorder 0.604
Nervous system disorders Neuropathy peripheral 0.604
Cardiac disorders Dyspnoea 0.602
Nervous system disorders Headache 0.602
Nervous system disorders Insomnia 0.602
Musculoskeletal and connective tissue disorders Pain in extremity 0.602
Psychiatric disorders Anxiety 0.595
Skin and subcutaneous tissue disorders Dermatitis 0.595
Nervous system disorders Insomnia 0.595
General disorders and administration site conditions Oedema 0.595
Skin and subcutaneous tissue disorders Rash 0.595
Psychiatric disorders Anxiety 0.516
Respiratory, thoracic and mediastinal disorders Cough 0.496
General disorders and administration site conditions Chills 0.439
Respiratory, thoracic and mediastinal disorders Cough 0.439
Skin and subcutaneous tissue disorders Dermatitis 0.439
Gastrointestinal disorders Dysgeusia 0.439
Cardiac disorders Dyspnoea 0.439
Musculoskeletal and connective tissue disorders Muscle spasms 0.439
Skin and subcutaneous tissue disorders Rash 0.439
Eye disorders Vision blurred 0.439
Gastrointestinal disorders Vomiting 0.439
Respiratory, thoracic and mediastinal disorders Cough 0.43
Cardiac disorders Dyspnoea 0.302
Nervous system disorders Insomnia 0.302
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 0.302
Musculoskeletal and connective tissue disorders Myalgia 0.302
Infections and infestations Nasopharyngitis 0.302
Gastrointestinal disorders Abdominal pain 0.301
Investigations Body temperature increased 0.301
Respiratory, thoracic and mediastinal disorders Cough 0.301
General disorders and administration site conditions Decreased appetite 0.301
Nervous system disorders Dysaesthesia 0.301
Gastrointestinal disorders Gastrointestinal pain 0.301
Infections and infestations Herpes zoster 0.301
Infections and infestations Infection 0.301
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 0.301
Musculoskeletal and connective tissue disorders Myalgia 0.301
Nervous system disorders Neuropathy peripheral 0.301
Cardiac disorders Oedema peripheral 0.301
Nervous system disorders Paraesthesia 0.301
Infections and infestations Nasopharyngitis 0.198
Infections and infestations Nasopharyngitis 0.172
Musculoskeletal and connective tissue disorders Muscle spasms 0.0992
Musculoskeletal and connective tissue disorders Muscle spasms 0.086

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
13.68
Nervous system disorders
9.73
Gastrointestinal disorders
8.28
Infections and infestations
7.67
Injury, poisoning and procedural complications
7.4
Blood and lymphatic system disorders
7.29
Respiratory, thoracic and mediastinal disorders
6.55
Skin and subcutaneous tissue disorders
5.24
Cardiac disorders
5.08
Vascular disorders
4.69
Investigations
4.58
Metabolism and nutrition disorders
3.79
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
3.46
Musculoskeletal and connective tissue disorders
3.23
Renal and urinary disorders
2.2

Cross References

Resources Reference
CAS NUMBER 179324-69-7
ChEBI 52717
ChEMBL CHEMBL325041
DrugBank DB00188
DrugCentral 391
EPA CompTox DTXSID3040980
FDA SRS 69G8BD63PP
Human Metabolome Database HMDB0014334
Guide to Pharmacology 6391
KEGG D03150
PDB BO2
PubChem 387447
SureChEMBL SCHEMBL192129
ZINC ZINC000169746649
CONTENTS