Pharmacology

Action Mechanism of Action Reference
INHIBITOR Tubulin inhibitor PubMed PubMed DailyMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Lymphoma, Large-Cell, Anaplastic 4 D017728 ClinicalTrials
Hodgkin Disease 4 D006689 ClinicalTrials
Mycosis Fungoides 3 D009182 ClinicalTrials
Lymphoma, Large B-Cell, Diffuse 3 D016403 ClinicalTrials
Lymphoma, Non-Hodgkin 3 D008228 ClinicalTrials
Lymphoma, Follicular 2 D008224 ClinicalTrials
Neoplasms, Germ Cell and Embryonal 2 D009373 ClinicalTrials
Graft vs Host Disease 2 D006086 ClinicalTrials
Lymphoma 2 D008223 ClinicalTrials
Lupus Erythematosus, Systemic 2 D008180 ClinicalTrials
Leukemia, Mast-Cell 2 D007946 ClinicalTrials
Graft vs Host Disease 2 D006086 ClinicalTrials
Leukemia-Lymphoma, Adult T-Cell 2 D015459 ClinicalTrials
Enteropathy-Associated T-Cell Lymphoma 2 D058527 ClinicalTrials
Scleroderma, Diffuse 2 D045743 ClinicalTrials
Sezary Syndrome 2 D012751 ClinicalTrials
Lymphoma, T-Cell, Peripheral 2 D016411 ClinicalTrials
Mesothelioma 2 D008654 ClinicalTrials
Leukemia, Lymphocytic, Chronic, B-Cell 2 D015451 ClinicalTrials
Lymphoma, Follicular 2 D008224 ClinicalTrials
Leukemia, Myeloid, Acute 1 D015470 ClinicalTrials
Leukemia 1 D007938 ClinicalTrials
Lymphoma, T-Cell, Cutaneous 1 D016410 ClinicalTrials
Hematologic Neoplasms 1 D019337 ClinicalTrials

Adverse Reactions

System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
12.91
Blood and lymphatic system disorders
9.92
Infections and infestations
8.22
Gastrointestinal disorders
7.83
Investigations
7.8
Nervous system disorders
7.78
Respiratory, thoracic and mediastinal disorders
7.42
Injury, poisoning and procedural complications
5.46
Vascular disorders
4.36
Skin and subcutaneous tissue disorders
4.22
Metabolism and nutrition disorders
4.14
Cardiac disorders
3.64
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
3.44
Immune system disorders
2.75
Musculoskeletal and connective tissue disorders
2.18

Cross References

Resources Reference
CAS NUMBER 914088-09-8
ChEMBL CHEMBL1742994
FDA SRS 7XL5ISS668
Guide to Pharmacology 6772