Trade Names: | |
Synonyms: | |
Status: | Approved (1972) |
Entry Type: | Small molecule |
Molecule Category: | Salt |
UNII: | AKA908P8J1 |
Parent Compound: | BUPIVACAINE |
InChI Key | SIEYLFHKZGLBNX-UHFFFAOYSA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C18H29ClN2O |
Molecular Weight | 324.9 |
AlogP | 3.9 |
Hydrogen Bond Acceptor | 2.0 |
Hydrogen Bond Donor | 1.0 |
Number of Rotational Bond | 5.0 |
Polar Surface Area | 32.34 |
Molecular species | NEUTRAL |
Aromatic Rings | 1.0 |
Heavy Atoms | 21.0 |
Action | Mechanism of Action | Reference |
---|---|---|
BLOCKER | Sodium channel protein type IV alpha subunit blocker | PubMed |
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
---|---|---|---|---|---|---|
Ion channel
Voltage-gated ion channel
Potassium channels
Voltage-gated potassium channel
|
- | 22000-95000 | - | - | - | |
Transporter
Electrochemical transporter
SLC superfamily of solute carriers
SLC21/SLCO family of organic anion transporting polypeptides
|
- | - | - | - | 94 |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Cleft Palate | 3 | D002972 | ClinicalTrials |
Osteoarthritis | 3 | D010003 | ClinicalTrials |
Hallux Valgus | 3 | D006215 | ClinicalTrials |
Radiculopathy | 3 | D011843 | ClinicalTrials |
Peritoneal Neoplasms | 3 | D010534 | ClinicalTrials |
Hemorrhoids | 3 | D006484 | ClinicalTrials |
Hernia, Inguinal | 2 | D006552 | ClinicalTrials |
Wounds and Injuries | 2 | D014947 | ClinicalTrials |
Neoplasms | 2 | D009369 | ClinicalTrials |
HIV Infections | 1 | D015658 | ClinicalTrials |
Hot Flashes | 0 | D019584 | ClinicalTrials |
Resources | Reference |
---|---|
ChEBI | 77441 |
ChEMBL | CHEMBL1200396 |
EPA CompTox | DTXSID0030877 |
FDA SRS | AKA908P8J1 |
PubChem | 5282419 |
SureChEMBL | SCHEMBL34374 |
ZINC | ZINC01530814 |