Trade Names: | |
Synonyms: | |
Status: | Approved (2011) |
Entry Type: | Small molecule |
Molecule Category: | Parent |
ATC: | A10BK02 |
UNII: | 6S49DGR869 |
InChI Key | XTNGUQKDFGDXSJ-ZXGKGEBGSA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C24H27FO6S |
Molecular Weight | 462.54 |
AlogP | 2.97 |
Hydrogen Bond Acceptor | 6.0 |
Hydrogen Bond Donor | 4.0 |
Number of Rotational Bond | 5.0 |
Polar Surface Area | 90.15 |
Molecular species | NEUTRAL |
Aromatic Rings | 3.0 |
Heavy Atoms | 31.0 |
Action | Mechanism of Action | Reference |
---|---|---|
INHIBITOR | Sodium/glucose cotransporter 2 inhibitor | DailyMed |
Primary Target | |
---|---|
Sodium/glucose cotransporter 2 |
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
---|---|---|---|---|---|---|
Transporter
Electrochemical transporter
SLC superfamily of solute carriers
SLC05 family of sodium-dependent glucose transporters
|
2 | 2-7 | - | - | - |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Diabetes Mellitus | 4 | D003920 | ClinicalTrials |
Heart Failure | 3 | D006333 | ClinicalTrials |
Diabetic Nephropathies | 3 | D003928 | ClinicalTrials |
Obesity | 2 | D009765 | ClinicalTrials |
Diabetes Mellitus, Type 1 | 2 | D003922 | ClinicalTrials |
Renal Insufficiency | 1 | D051437 | ClinicalTrials |
Polycystic Ovary Syndrome | 1 | D011085 | ClinicalTrials |
Resources | Reference |
---|---|
ChEBI | 73274 |
ChEMBL | CHEMBL2048484 |
DrugBank | DB08907 |
DrugCentral | 4758 |
FDA SRS | 6S49DGR869 |
Guide to Pharmacology | 4582 |
SureChEMBL | SCHEMBL157162 |
ZINC | ZINC000043207238 |
ChEMBL | CHEMBL4594217 |
FDA SRS | B2L6AES9XQ |
SureChEMBL | SCHEMBL322059 |