CARIPRAZINE HYDROCHLORIDE

Search structure
Trade Names:
Synonyms:
Status: Approved (2015)
Entry Type: Small molecule
Molecule Category: Salt
UNII: KQD7C255YG
Parent Compound: CARIPRAZINE

Structure
InChI Key GPPJWWMREQHLQT-BHQIMSFRSA-N
Smile CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1.Cl
InChI
InChI=1S/C21H32Cl2N4O.ClH/c1-25(2)21(28)24-17-8-6-16(7-9-17)10-11-26-12-14-27(15-13-26)19-5-3-4-18(22)20(19)23;/h3-5,16-17H,6-15H2,1-2H3,(H,24,28);1H/t16-,17-;

Physicochemical Descriptors

Property Name Value
Molecular Formula C21H33Cl3N4O
Molecular Weight 463.88
AlogP 4.34
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 5.0
Polar Surface Area 38.82
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 28.0

Pharmacology

Action Mechanism of Action Reference
MODULATOR Dopamine D2 receptor modulator PubMed DailyMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor
- - - 214 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor
- 16 - 1-6 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference

Related Entries

Scaffolds

Parent

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Nervous system disorders
21.4
Psychiatric disorders
20.33
General disorders and administration site conditions
10.67
Injury, poisoning and procedural complications
9.19
Gastrointestinal disorders
6.69
Musculoskeletal and connective tissue disorders
5.25
Investigations
4.11
Eye disorders
4.01
Skin and subcutaneous tissue disorders
2.98
Cardiac disorders
2.84
Vascular disorders
2.44

Cross References

Resources Reference
ChEBI 90932
ChEMBL CHEMBL2024517
FDA SRS KQD7C255YG
PubChem 25096873
SureChEMBL SCHEMBL183804
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