CARVEDILOL

Search structure
Trade Names:
Synonyms:
Status: Approved (1995)
Entry Type: Small molecule
Molecule Category: Parent
ATC: C07AG02
UNII: 0K47UL67F2

Structure
InChI Key OGHNVEJMJSYVRP-UHFFFAOYSA-N
Smile COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12
InChI
InChI=1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C24H26N2O4
Molecular Weight 406.48
AlogP 3.74
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 10.0
Polar Surface Area 75.74
Molecular species BASE
Aromatic Rings 4.0
Heavy Atoms 30.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Adrenergic receptor alpha-1 antagonist FDA
Primary Target
β1-adrenoceptor
β2-adrenoceptor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Transferase
- 12000-27000 - - -
Ion channel Voltage-gated ion channel Potassium channels Two-pore domain potassium channel
- 1600-20300 - - -
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel
- 350-12589 - - -
Ion channel Voltage-gated ion channel Voltage-gated calcium channel
- 3590 - - -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor
- - 0 2-2 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor
- - - 3 -
Membrane receptor Toll-like and Il-1 receptors
- 32220 - - -
Membrane receptor
- 30000 0 2-2 -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters
- 3400 - - -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC47 family of multidrug and toxin extrusion transporters
- 92400 - - 21

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Leukemia, Lymphoid 3 D007945 ClinicalTrials
Essential Hypertension 3 D000075222 ClinicalTrials
Coronary Disease 3 D003327 ClinicalTrials
Hypercholesterolemia 3 D006937 ClinicalTrials
Leukemia, Myeloid, Acute 3 D015470 ClinicalTrials
Hypertension, Portal 3 D006975 ClinicalTrials
Diabetes Mellitus, Type 2 3 D003924 ClinicalTrials
Atherosclerosis 3 D050197 ClinicalTrials
Multiple Myeloma 3 D009101 ClinicalTrials
Hypertrophy, Left Ventricular 3 D017379 ClinicalTrials
Atrial Fibrillation 3 D001281 ClinicalTrials
Esophageal and Gastric Varices 2 D004932 ClinicalTrials
Stress Disorders, Post-Traumatic 2 D013313 ClinicalTrials
Cocaine-Related Disorders 2 D019970 ClinicalTrials
Tobacco Use Disorder 2 D014029 ClinicalTrials
Lymphoma 2 D008223 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 2 D064129 ClinicalTrials
Kidney Diseases 2 D007674 ClinicalTrials
Hypoglycemia 2 D007003 ClinicalTrials
Neoplasms 2 D009369 ClinicalTrials
Epilepsy 2 D004827 ClinicalTrials
Hypertension, Pulmonary 2 D006976 ClinicalTrials
Breast Neoplasms 2 D001943 ClinicalTrials
Hypertension, Pulmonary 2 D006976 ClinicalTrials
Vascular Diseases 1 D014652 ClinicalTrials
Glioblastoma 0 D005909 ClinicalTrials

Related Entries

Scaffolds

Salt

Side Effects from Label

Side effects Relative Frequency (%) Labels
Cardiac disorders Dizziness 32.4
Cardiac disorders Dizziness 32.0
Cardiac disorders Cardiac failure
Cardiac disorders Cardiac failure 31.5
Cardiac disorders Cardiac failure 26.0
Cardiac disorders Dizziness 24.1
General disorders and administration site conditions Asthenia 24.0
Cardiac disorders Dizziness 24.0
General disorders and administration site conditions Fatigue 24.0
General disorders and administration site conditions Asthenia 23.9
General disorders and administration site conditions Fatigue 23.9
General disorders and administration site conditions Asthenia
General disorders and administration site conditions Fatigue
General disorders and administration site conditions Asthenia
General disorders and administration site conditions Fatigue
Cardiac disorders Dyspnoea 21.3
Cardiac disorders Dizziness
Cardiac disorders Dizziness 19.2
Cardiac disorders Dizziness
Infections and infestations Upper respiratory tract infection 18.3
Infections and infestations Upper respiratory tract infection
Cardiac disorders Dizziness
Cardiac disorders Dizziness
Cardiac disorders Dizziness 16.8
Cardiac disorders Cardiac failure 15.3
Cardiac disorders Chest pain 14.4
Cardiac disorders Chest pain
Cardiac disorders Chest pain 14.2
Vascular disorders Hypotension 14.0
Vascular disorders Hypotension 13.9
Infections and infestations Upper respiratory tract infection 13.6
Infections and infestations Upper respiratory tract infection
Infections and infestations Upper respiratory tract infection 12.6
Endocrine disorders Hyperglycaemia 12.2
Gastrointestinal disorders Diarrhoea 12.0
Endocrine disorders Hyperglycaemia 12.0
Investigations Weight increased 12.0
Gastrointestinal disorders Diarrhoea 11.8
Investigations Weight increased 11.7
Cardiac disorders Dyspnoea 11.2
General disorders and administration site conditions Asthenia 11.0
Cardiac disorders Dyspnoea
Cardiac disorders Dyspnoea 11.0
Investigations Weight increased
General disorders and administration site conditions Asthenia 10.9
Investigations Weight increased
Investigations Weight increased 10.7
Cardiac disorders Bradycardia 10.3
Cardiac disorders Bradycardia 10.0
Investigations Weight increased 10.0
Investigations Weight increased 9.7
General disorders and administration site conditions Asthenia
General disorders and administration site conditions Asthenia 9.4
General disorders and administration site conditions Asthenia
Cardiac disorders Bradycardia 9.0
Respiratory, thoracic and mediastinal disorders Cough
Vascular disorders Hypotension 9.0
Gastrointestinal disorders Nausea 9.0
Cardiac disorders Bradycardia 8.8
General disorders and administration site conditions Pain 8.6
Vascular disorders Hypotension 8.5
Gastrointestinal disorders Nausea 8.5
Vascular disorders Hypotension
Vascular disorders Hypotension 8.2
Nervous system disorders Headache 8.1
Respiratory, thoracic and mediastinal disorders Cough 8.0
Cardiac disorders Dizziness 8.0
Nervous system disorders Headache 8.0
Endocrine disorders Hyperglycaemia
Vascular disorders Hypotension
Nervous system disorders Loss of consciousness 8.0
Vascular disorders Shock 8.0
Cardiac disorders Syncope 8.0
Endocrine disorders Hyperglycaemia
Cardiac disorders Chest pain
Cardiac disorders Chest pain 7.6
Cardiac disorders Dizziness 7.6
Nervous system disorders Loss of consciousness 7.6
General disorders and administration site conditions Pain
General disorders and administration site conditions Pain 7.6
Cardiac disorders Presyncope 7.6
Vascular disorders Shock 7.6
Cardiac disorders Syncope 7.6
Gastrointestinal disorders Abdominal pain 7.2
Gastrointestinal disorders Gastrointestinal pain 7.2
Gastrointestinal disorders Abdominal pain
Gastrointestinal disorders Abdominal pain 7.1
Gastrointestinal disorders Gastrointestinal pain
Gastrointestinal disorders Gastrointestinal pain 7.1
Nervous system disorders Headache
Nervous system disorders Headache 7.1
General disorders and administration site conditions Asthenia
General disorders and administration site conditions Asthenia 7.0
Nervous system disorders Headache
Cardiac disorders Oedema peripheral 7.0
Investigations Weight increased
Musculoskeletal and connective tissue disorders Back pain 6.9
Investigations Weight increased
Cardiac disorders Chest pain 6.8
Musculoskeletal and connective tissue disorders Back pain
Musculoskeletal and connective tissue disorders Arthralgia 6.4
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 6.4
Cardiac disorders Oedema peripheral
Cardiac disorders Oedema peripheral 6.4
Metabolism and nutrition disorders Gout 6.3
Gastrointestinal disorders Vomiting 6.3
Metabolism and nutrition disorders Gout
General disorders and administration site conditions Sudden death
General disorders and administration site conditions Sudden death 6.1
Cardiac disorders Angina pectoris 6.0
Musculoskeletal and connective tissue disorders Arthralgia 6.0
Investigations Blood urea increased 6.0
Gastrointestinal disorders Diarrhoea
Cardiac disorders Dizziness 6.0
Metabolism and nutrition disorders Fluid retention 6.0
General disorders and administration site conditions Generalised oedema 6.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 6.0
Cardiac disorders Oedema peripheral
Gastrointestinal disorders Vomiting 6.0
Gastrointestinal disorders Diarrhoea
Gastrointestinal disorders Diarrhoea 5.9
Investigations Blood urea increased 5.8
Cardiac disorders Cardiac failure 5.6
Cardiac disorders Angina pectoris 5.5
Infections and infestations Bronchitis 5.4
Infections and infestations Sinusitis 5.4
Infections and infestations Bronchitis 5.2
Investigations Drug level increased 5.1
Metabolism and nutrition disorders Fluid retention 5.1
General disorders and administration site conditions Generalised oedema 5.1
General disorders and administration site conditions Oedema 5.1
Musculoskeletal and connective tissue disorders Arthralgia
Investigations Blood urea increased
Investigations Cardioactive drug level increased 5.0
Respiratory, thoracic and mediastinal disorders Cough
Respiratory, thoracic and mediastinal disorders Cough 5.0
Gastrointestinal disorders Diarrhoea 5.0
Cardiac disorders Dizziness
Cardiac disorders Dizziness 5.0
Metabolism and nutrition disorders Fluid retention
Metabolism and nutrition disorders Fluid retention 5.0
General disorders and administration site conditions Generalised oedema
General disorders and administration site conditions Generalised oedema 5.0
Nervous system disorders Headache 5.0
Endocrine disorders Hyperglycaemia 5.0
Nervous system disorders Loss of consciousness
Nervous system disorders Loss of consciousness 5.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort
Gastrointestinal disorders Nausea
Cardiac disorders Presyncope
Cardiac disorders Presyncope 5.0
Vascular disorders Shock
Vascular disorders Shock 5.0
Cardiac disorders Syncope
Cardiac disorders Syncope 5.0
Eye disorders Visual impairment 5.0
Metabolism and nutrition disorders Fluid retention
Metabolism and nutrition disorders Fluid retention 4.9
General disorders and administration site conditions Generalised oedema
General disorders and administration site conditions Generalised oedema 4.9
Musculoskeletal and connective tissue disorders Arthralgia
Gastrointestinal disorders Diarrhoea 4.8
Nervous system disorders Headache 4.8
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort
Gastrointestinal disorders Nausea
Gastrointestinal disorders Nausea 4.8
Investigations Blood urea increased
Infections and infestations Bronchitis
Infections and infestations Bronchitis 4.5
Respiratory, thoracic and mediastinal disorders Cough 4.5
Endocrine disorders Hyperglycaemia 4.5
Cardiac disorders Atrial fibrillation
Cardiac disorders Atrial fibrillation 4.3
Infections and infestations Sinusitis
Gastrointestinal disorders Vomiting
Gastrointestinal disorders Vomiting 4.3
Respiratory, thoracic and mediastinal disorders Cough
Respiratory, thoracic and mediastinal disorders Cough 4.2
Cardiac disorders Angina pectoris
Cardiac disorders Angina pectoris 4.1
Metabolism and nutrition disorders Hypercholesterolaemia 4.1
Metabolism and nutrition disorders Hypocholesterolaemia 4.1
Cardiac disorders Pulmonary oedema
Cardiac disorders Pulmonary oedema 4.1
Cardiac disorders Angina pectoris
Investigations Cardioactive drug level increased
Respiratory, thoracic and mediastinal disorders Cough
Cardiac disorders Gravitational oedema 4.0
Metabolism and nutrition disorders Hypercholesterolaemia 4.0
Respiratory, thoracic and mediastinal disorders Lung disorder 4.0
Infections and infestations Nasopharyngitis 4.0
Gastrointestinal disorders Nausea 4.0
Respiratory, thoracic and mediastinal disorders Rales
Respiratory, thoracic and mediastinal disorders Rales 4.0
Gastrointestinal disorders Vomiting
Infections and infestations Pneumonia
Infections and infestations Pneumonia 3.9
General disorders and administration site conditions Sudden death 3.9
Cardiac disorders Ventricular tachycardia
Cardiac disorders Ventricular tachycardia 3.9
Gastrointestinal disorders Nausea 3.8
Investigations Drug level increased
Investigations Drug level increased 3.7
Cardiac disorders Gravitational oedema 3.7
General disorders and administration site conditions Oedema 3.7
Metabolism and nutrition disorders Gout 3.5
Cardiac disorders Pulmonary oedema 3.5
Infections and infestations Bronchitis
Cardiac disorders Dizziness 3.4
Metabolism and nutrition disorders Hypokalaemia
Metabolism and nutrition disorders Hypokalaemia 3.4
Vascular disorders Hypotension
Vascular disorders Hypotension 3.4
Nervous system disorders Loss of consciousness 3.4
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 3.4
Musculoskeletal and connective tissue disorders Myalgia 3.4
Vascular disorders Shock 3.4
Cardiac disorders Syncope 3.4
Endocrine disorders Hyperglycaemia
Endocrine disorders Hyperglycaemia 3.3
Metabolism and nutrition disorders Hyperkalaemia 3.3
Gastrointestinal disorders Nausea
Gastrointestinal disorders Nausea 3.3
Respiratory, thoracic and mediastinal disorders Lung disorder
Respiratory, thoracic and mediastinal disorders Lung disorder 3.2
Infections and infestations Pneumonia 3.2
Investigations Body temperature increased 3.1
Gastrointestinal disorders Diarrhoea
Gastrointestinal disorders Diarrhoea 3.1
Gastrointestinal disorders Pharyngitis 3.1
Infections and infestations Urinary tract infection 3.1
Gastrointestinal disorders Abdominal pain
Gastrointestinal disorders Abdominal pain 3.0
Cardiac disorders Angina pectoris
Cardiac disorders Bradycardia
Gastrointestinal disorders Diarrhoea
Cardiac disorders Dizziness
Cardiac disorders Dizziness 3.0
Metabolism and nutrition disorders Fluid retention
Gastrointestinal disorders Gastrointestinal pain
Gastrointestinal disorders Gastrointestinal pain 3.0
General disorders and administration site conditions Generalised oedema
Nervous system disorders Headache
Nervous system disorders Headache 3.0
Metabolism and nutrition disorders Hypercholesterolaemia
Endocrine disorders Hyperglycaemia
Vascular disorders Hypotension
Nervous system disorders Loss of consciousness
Nervous system disorders Loss of consciousness 3.0
Gastrointestinal disorders Nausea
Vascular disorders Shock
Vascular disorders Shock 3.0
Cardiac disorders Syncope
Cardiac disorders Syncope 3.0
Cardiac disorders Atrioventricular block 2.9
Musculoskeletal and connective tissue disorders Back pain 2.9
Investigations Blood creatinine increased 2.9
Cardiac disorders Cardiac failure 2.9
Renal and urinary disorders Haematuria 2.9
General disorders and administration site conditions Hyperhidrosis 2.9
Vascular disorders Hypertension 2.9
Eye disorders Vision blurred 2.8
Cardiac disorders Angina pectoris
Cardiac disorders Angina pectoris 2.7
Vascular disorders Angina unstable
Vascular disorders Angina unstable 2.7
Cardiac disorders Bradycardia
Cardiac disorders Bradycardia 2.7
Metabolism and nutrition disorders Gout
Metabolism and nutrition disorders Gout 2.7
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort
Musculoskeletal and connective tissue disorders Myalgia
Gastrointestinal disorders Pharyngitis
Infections and infestations Urinary tract infection
Vascular disorders Hypertension 2.6
Cardiac disorders Dizziness
Cardiac disorders Dizziness 2.5
Metabolism and nutrition disorders Fluid retention
General disorders and administration site conditions Generalised oedema
Metabolism and nutrition disorders Hypercholesterolaemia
Vascular disorders Hypertension
Vascular disorders Hypertension 2.5
Metabolism and nutrition disorders Hypocholesterolaemia
Metabolism and nutrition disorders Hypokalaemia 2.5
Infections and infestations Infection 2.5
Nervous system disorders Loss of consciousness
Nervous system disorders Loss of consciousness 2.5
General disorders and administration site conditions Oedema
General disorders and administration site conditions Oedema 2.5
Musculoskeletal and connective tissue disorders Pain in extremity
Musculoskeletal and connective tissue disorders Pain in extremity 2.5
Vascular disorders Shock
Vascular disorders Shock 2.5
Cardiac disorders Syncope
Cardiac disorders Syncope 2.5
Blood and lymphatic system disorders Anaemia 2.4
Infections and infestations Infection
Infections and infestations Infection 2.4
Vascular disorders Peripheral vascular disorder
Vascular disorders Peripheral vascular disorder 2.4
Infections and infestations Urinary tract infection
Infections and infestations Urinary tract infection 2.4
Cardiac disorders Atrioventricular block first degree 2.3
Investigations Body temperature increased
Investigations Body temperature increased 2.3
Renal and urinary disorders Renal impairment
Renal and urinary disorders Renal impairment 2.3
Gastrointestinal disorders Abdominal pain 2.2
Cardiac disorders Acute coronary syndrome
Cardiac disorders Acute coronary syndrome 2.2
General disorders and administration site conditions Asthenia 2.2
Cardiac disorders Atrial fibrillation 2.2
General disorders and administration site conditions Fatigue 2.2
Gastrointestinal disorders Gastrointestinal pain 2.2
Vascular disorders Hypertension
Vascular disorders Hypertension 2.2
Infections and infestations Infection 2.2
Cardiac disorders Myocardial infarction
Cardiac disorders Myocardial infarction 2.2
General disorders and administration site conditions Oedema 2.2
Cardiac disorders Oedema peripheral 2.2
Eye disorders Vision blurred
Eye disorders Vision blurred 2.2
Metabolism and nutrition disorders Dehydration 2.1
Renal and urinary disorders Haematuria
General disorders and administration site conditions Hyperhidrosis
Musculoskeletal and connective tissue disorders Pain in extremity 2.1
Renal and urinary disorders Renal impairment 2.1
Cardiac disorders Ventricular fibrillation
Cardiac disorders Ventricular fibrillation 2.1
Blood and lymphatic system disorders Anaemia
Blood and lymphatic system disorders Anaemia 2.0
Cardiac disorders Angina pectoris 2.0
Vascular disorders Angina unstable 2.0
Cardiac disorders Bradycardia 2.0
Investigations Cardioactive drug level increased 2.0
Endocrine disorders Diabetes mellitus 2.0
Gastrointestinal disorders Diarrhoea 2.0
Cardiac disorders Dizziness 2.0
Cardiac disorders Fluid overload 2.0
Cardiac disorders Gravitational oedema
Injury, poisoning and procedural complications Injury
Nervous system disorders Insomnia 2.0
Musculoskeletal and connective tissue disorders Muscle spasms 2.0
Gastrointestinal disorders Nausea 2.0
Cardiac disorders Oedema peripheral 2.0
Nervous system disorders Orthostatic hypotension 2.0
Nervous system disorders Paraesthesia 2.0
Respiratory, thoracic and mediastinal disorders Rales
Blood and lymphatic system disorders Thrombocytopenia 2.0
Eye disorders Visual impairment
Gastrointestinal disorders Vomiting
Metabolism and nutrition disorders Hyperkalaemia
Metabolism and nutrition disorders Hyperkalaemia 1.9
Investigations Blood uric acid increased 1.8
Cardiac disorders Dizziness 1.8
Cardiac disorders Dyspnoea 1.8
Cardiac disorders Gravitational oedema
Metabolism and nutrition disorders Hyperuricaemia 1.8
Nervous system disorders Loss of consciousness 1.8
General disorders and administration site conditions Oedema
General disorders and administration site conditions Oedema 1.8
Nervous system disorders Orthostatic hypotension 1.8
Nervous system disorders Paraesthesia
Nervous system disorders Paraesthesia 1.8
Vascular disorders Shock 1.8
Cardiac disorders Syncope 1.8
Eye disorders Visual impairment
Endocrine disorders Diabetes mellitus
Endocrine disorders Diabetes mellitus 1.7
Cardiac disorders Dizziness 1.7
Psychiatric disorders Erectile dysfunction 1.7
Cardiac disorders Fluid overload 1.7
Nervous system disorders Hypoaesthesia 1.7
Injury, poisoning and procedural complications Injury 1.7
Nervous system disorders Loss of consciousness 1.7
Nervous system disorders Paraesthesia 1.7
Renal and urinary disorders Renal impairment 1.7
Vascular disorders Shock 1.7
Cardiac disorders Sinus bradycardia 1.7
Cardiac disorders Syncope 1.7
Cardiac disorders Acute coronary syndrome 1.6
Renal and urinary disorders Albuminuria 1.6
Cardiac disorders Atrioventricular block first degree
Cardiac disorders Atrioventricular block first degree 1.6
Investigations Blood uric acid increased
Cardiac disorders Bradycardia 1.6
Metabolism and nutrition disorders Dehydration
Cardiac disorders Fluid overload
Gastrointestinal disorders Gastrointestinal disorder 1.6
Metabolism and nutrition disorders Hyperuricaemia
Endocrine disorders Hypoglycaemia 1.6
Cardiac disorders Myocardial infarction 1.6
Cardiac disorders Oedema peripheral 1.6
Cardiac disorders Palpitations 1.6
Vascular disorders Peripheral vascular disorder 1.6
Renal and urinary disorders Renal failure 1.6
Infections and infestations Sinusitis 1.6
Infections and infestations Urinary tract infection 1.6
Cardiac disorders Ventricular tachycardia 1.6
Cardiac disorders Palpitations
Investigations Alanine aminotransferase increased 1.4
Musculoskeletal and connective tissue disorders Back pain
Musculoskeletal and connective tissue disorders Back pain 1.4
Investigations Blood creatinine increased
Investigations Blood creatinine increased 1.4
Immune system disorders Hypersensitivity 1.4
Endocrine disorders Hypoglycaemia
Gastrointestinal disorders Melaena 1.4
Nervous system disorders Paraesthesia
Renal and urinary disorders Renal impairment
Ear and labyrinth disorders Vertigo 1.4
Investigations Weight decreased 1.4
Nervous system disorders Confusional state 1.3
General disorders and administration site conditions Discomfort 1.3
Cardiac disorders Dizziness 1.3
General disorders and administration site conditions Feeling abnormal 1.3
Metabolism and nutrition disorders Hyponatraemia 1.3
Vascular disorders Hypotension 1.3
General disorders and administration site conditions Ill-defined disorder 1.3
General disorders and administration site conditions Malaise 1.3
Gastrointestinal disorders Periodontitis 1.3
Investigations Prothrombin level decreased 1.3
Blood and lymphatic system disorders Purpura 1.3
Renal and urinary disorders Renal failure
General disorders and administration site conditions Sudden death 1.3
Blood and lymphatic system disorders Vascular purpura 1.3
Investigations Aspartate aminotransferase increased 1.2
Renal and urinary disorders Glycosuria 1.2
Metabolism and nutrition disorders Hypovolaemia 1.2
Musculoskeletal and connective tissue disorders Muscle spasms
Musculoskeletal and connective tissue disorders Muscle spasms 1.2
Nervous system disorders Orthostatic hypotension 1.2
Renal failure acute 1.2
Nervous system disorders Somnolence 1.2
Renal and urinary disorders Albuminuria
Cardiac disorders Angina pectoris
Cardiac disorders Angina pectoris 1.1
Gastrointestinal disorders Gastrointestinal disorder
Nervous system disorders Hypoaesthesia
Metabolism and nutrition disorders Hyponatraemia
Gastrointestinal disorders Melaena
Investigations Prothrombin level decreased
Infections and infestations Sinusitis
General disorders and administration site conditions Sudden death
Ear and labyrinth disorders Vertigo
Investigations Weight decreased
Musculoskeletal and connective tissue disorders Arthralgia
Musculoskeletal and connective tissue disorders Arthralgia 1.0
Investigations Blood triglycerides increased 1.0
Cardiac disorders Bradycardia
Investigations Cardioactive drug level increased
Gastrointestinal disorders Diarrhoea
Gastrointestinal disorders Diarrhoea 1.0
Cardiac disorders Dizziness
Metabolism and nutrition disorders Hypercholesterolaemia
Metabolism and nutrition disorders Hypercholesterolaemia 1.0
Metabolism and nutrition disorders Hypertriglyceridaemia 1.0
Nervous system disorders Insomnia
Nervous system disorders Insomnia 1.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 1.0
Respiratory, thoracic and mediastinal disorders Nasal congestion 1.0
Cardiac disorders Oedema peripheral
Cardiac disorders Oedema peripheral 1.0
Nervous system disorders Orthostatic hypotension
Nervous system disorders Paraesthesia 1.0
Respiratory, thoracic and mediastinal disorders Sinus congestion 1.0
Blood and lymphatic system disorders Thrombocytopenia 1.0
Cardiac disorders Ventricular fibrillation 1.0
Gastrointestinal disorders Vomiting 1.0
Cardiac disorders Acute coronary syndrome 0.9
Investigations Alanine aminotransferase increased
Investigations Aspartate aminotransferase increased
Cardiac disorders Bradycardia
Cardiac disorders Bradycardia 0.9
Nervous system disorders Confusional state
Psychiatric disorders Erectile dysfunction
General disorders and administration site conditions Feeling abnormal
Cardiac disorders Fluid overload
Infections and infestations Infection
Cardiac disorders Myocardial infarction 0.9
Nervous system disorders Somnolence
Cardiac disorders Bradycardia 0.8
Renal failure acute 0.8
General disorders and administration site conditions Asthenia
General disorders and administration site conditions Asthenia 0.7
Cardiac disorders Atrioventricular block 0.7
General disorders and administration site conditions Discomfort
General disorders and administration site conditions Fatigue
General disorders and administration site conditions Fatigue 0.7
General disorders and administration site conditions Feeling abnormal
Renal and urinary disorders Glycosuria
General disorders and administration site conditions Ill-defined disorder
General disorders and administration site conditions Malaise
Cardiac disorders Oedema peripheral
Gastrointestinal disorders Periodontitis
Cardiac disorders Bradycardia 0.6
Cardiac disorders Dizziness
Vascular disorders Hypotension 0.6
Cardiac disorders Atrioventricular block
Cardiac disorders Atrioventricular block 0.5
Cardiac disorders Dyspnoea 0.5
Renal failure acute
Blood and lymphatic system disorders Thrombocytopenia
Blood and lymphatic system disorders Thrombocytopenia 0.5
Investigations Weight increased
General disorders and administration site conditions Asthenia 0.4
Cardiac disorders Dizziness
Cardiac disorders Dizziness 0.4
Vascular disorders Hypotension
Vascular disorders Hypotension 0.4
Nervous system disorders Loss of consciousness
Nervous system disorders Loss of consciousness 0.4
Vascular disorders Shock
Vascular disorders Shock 0.4
Cardiac disorders Sinus bradycardia
Cardiac disorders Syncope
Cardiac disorders Syncope 0.4
Gastrointestinal disorders Abdominal pain 0.3
Investigations Blood urea increased 0.3
Gastrointestinal disorders Diarrhoea 0.3
Cardiac disorders Dizziness 0.3
Cardiac disorders Dyspnoea
Gastrointestinal disorders Gastrointestinal pain 0.3
Nervous system disorders Headache 0.3
Nervous system disorders Loss of consciousness 0.3
Renal failure acute 0.3
Renal and urinary disorders Renal impairment 0.3
Vascular disorders Shock 0.3
Cardiac disorders Syncope 0.3
Investigations Blood urea increased
Infections and infestations Bronchitis
Respiratory, thoracic and mediastinal disorders Cough
Cardiac disorders Dizziness
Investigations Drug level increased
Metabolism and nutrition disorders Fluid retention
Metabolism and nutrition disorders Fluid retention 0.2
General disorders and administration site conditions Generalised oedema
General disorders and administration site conditions Generalised oedema 0.2
Metabolism and nutrition disorders Hyperkalaemia 0.2
Immune system disorders Hypersensitivity
Vascular disorders Hypotension
Metabolism and nutrition disorders Hypovolaemia
Nervous system disorders Loss of consciousness
General disorders and administration site conditions Oedema
General disorders and administration site conditions Oedema 0.2
Cardiac disorders Oedema peripheral
Cardiac disorders Oedema peripheral 0.2
Nervous system disorders Orthostatic hypotension
General disorders and administration site conditions Pain
Blood and lymphatic system disorders Purpura
Vascular disorders Shock
Nervous system disorders Somnolence
Cardiac disorders Syncope
Blood and lymphatic system disorders Vascular purpura
Eye disorders Vision blurred 0.2
Cardiac disorders Angina pectoris
Cardiac disorders Angina pectoris 0.1
Investigations Blood creatinine increased
Infections and infestations Bronchitis 0.1
Cardiac disorders Chest pain 0.1
Respiratory, thoracic and mediastinal disorders Cough 0.1
Gastrointestinal disorders Gastrointestinal disorder
Gastrointestinal disorders Gastrointestinal disorder 0.1
Nervous system disorders Headache
Endocrine disorders Hyperglycaemia
Endocrine disorders Hyperglycaemia 0.1
Metabolism and nutrition disorders Hyperkalaemia
Vascular disorders Hypertension
Vascular disorders Hypertension 0.1
Endocrine disorders Hypoglycaemia 0.1
Respiratory, thoracic and mediastinal disorders Lung disorder 0.1
Gastrointestinal disorders Nausea
Cardiac disorders Oedema peripheral
Cardiac disorders Oedema peripheral 0.1
Nervous system disorders Orthostatic hypotension
Nervous system disorders Orthostatic hypotension 0.1
Cardiac disorders Palpitations
Nervous system disorders Paraesthesia 0.1
Renal and urinary disorders Renal failure 0.1
Blood and lymphatic system disorders Thrombocytopenia 0.1
Infections and infestations Upper respiratory tract infection 0.1
Eye disorders Vision blurred
Eye disorders Visual impairment 0.1
Gastrointestinal disorders Vomiting 0.1
Investigations Weight increased
Investigations Weight increased 0.1

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Cardiac disorders
15.01
General disorders and administration site conditions
13.62
Vascular disorders
9.18
Nervous system disorders
9.14
Respiratory, thoracic and mediastinal disorders
6.8
Investigations
6.41
Injury, poisoning and procedural complications
6.19
Gastrointestinal disorders
4.9
Psychiatric disorders
4.1
Metabolism and nutrition disorders
4.08
Skin and subcutaneous tissue disorders
3.43
Musculoskeletal and connective tissue disorders
3.22

Cross References

Resources Reference
CAS NUMBER 72956-09-3
ChEBI 3441
ChEMBL CHEMBL723
DrugBank DB01136
DrugCentral 522
EPA CompTox DTXSID8022747
FDA SRS 0K47UL67F2
Human Metabolome Database HMDB0015267
Guide to Pharmacology 551
KEGG C06875
PharmGKB PA448817
PubChem 2585
SureChEMBL SCHEMBL22293
ZINC ZINC01530580
CONTENTS