General disorders and administration site conditions
Chills
|
75.3
|
|
|
Investigations
Body temperature increased
|
69.7
|
|
|
Gastrointestinal disorders
Gastrointestinal disorder
|
55.0
|
|
|
Infections and infestations
Infection
|
54.0
|
|
|
Infections and infestations
Infestation
|
54.0
|
|
|
Respiratory, thoracic and mediastinal disorders
Mediastinal disorder
|
54.0
|
|
|
Gastrointestinal disorders
Gastrointestinal disorder
|
53.0
|
|
|
Gastrointestinal disorders
Gastrointestinal disorder
|
50.0
|
|
|
Gastrointestinal disorders
Gastrointestinal disorder
|
49.0
|
|
|
Respiratory, thoracic and mediastinal disorders
Mediastinal disorder
|
49.0
|
|
|
Infections and infestations
Infection
|
48.0
|
|
|
Infections and infestations
Infestation
|
48.0
|
|
|
Respiratory, thoracic and mediastinal disorders
Mediastinal disorder
|
47.0
|
|
|
Infections and infestations
Infection
|
45.0
|
|
|
Infections and infestations
Infestation
|
45.0
|
|
|
Respiratory, thoracic and mediastinal disorders
Mediastinal disorder
|
43.0
|
|
|
Gastrointestinal disorders
Gastrointestinal disorder
|
42.0
|
|
|
Infections and infestations
Infection
|
42.0
|
|
|
Infections and infestations
Infestation
|
42.0
|
|
|
Skin and subcutaneous tissue disorders
Skin disorder
|
42.0
|
|
|
Gastrointestinal disorders
Gastrointestinal disorder
|
41.0
|
|
|
Skin and subcutaneous tissue disorders
Skin disorder
|
41.0
|
|
|
Infections and infestations
Infection
|
40.0
|
|
|
Infections and infestations
Infestation
|
40.0
|
|
|
Respiratory, thoracic and mediastinal disorders
Mediastinal disorder
|
40.0
|
|
|
Skin and subcutaneous tissue disorders
Skin disorder
|
39.0
|
|
|
Vascular disorders
Angiopathy
|
38.0
|
|
|
Investigations
Haemoglobin decreased
|
37.1
|
|
|
Skin and subcutaneous tissue disorders
Skin disorder
|
37.0
|
|
|
Gastrointestinal disorders
Gastrointestinal disorder
|
35.0
|
|
|
Infections and infestations
Infection
|
35.0
|
|
|
Infections and infestations
Infestation
|
35.0
|
|
|
Cardiac disorders
Cardiac disorder
|
34.0
|
|
|
Investigations
Body temperature increased
|
33.0
|
|
|
Gastrointestinal disorders
Gastrointestinal disorder
|
33.0
|
|
|
Skin and subcutaneous tissue disorders
Skin disorder
|
33.0
|
|
|
Investigations
Haematocrit decreased
|
32.6
|
|
|
Investigations
Blood alkaline phosphatase increased
|
32.0
|
|
|
Investigations
Blood potassium decreased
|
32.0
|
|
|
Respiratory, thoracic and mediastinal disorders
Mediastinal disorder
|
32.0
|
|
|
Investigations
Blood potassium decreased
|
31.5
|
|
|
General disorders and administration site conditions
Chills
|
31.0
|
|
|
Investigations
Body temperature increased
|
30.0
|
|
|
General disorders and administration site conditions
Chills
|
30.0
|
|
|
Gastrointestinal disorders
Gastrointestinal disorder
|
30.0
|
|
|
Infections and infestations
Infection
|
30.0
|
|
|
Infections and infestations
Infestation
|
30.0
|
|
|
Investigations
Body temperature increased
|
29.0
|
|
|
Investigations
Body temperature increased
|
28.6
|
|
|
Investigations
Blood creatinine increased
|
28.1
|
|
|
Investigations
Blood creatinine increased
|
28.0
|
|
|
Skin and subcutaneous tissue disorders
Skin disorder
|
28.0
|
|
|
Investigations
Blood potassium decreased
|
27.0
|
|
|
Investigations
Body temperature increased
|
27.0
|
|
|
Gastrointestinal disorders
Diarrhoea
|
27.0
|
|
|
Respiratory, thoracic and mediastinal disorders
Mediastinal disorder
|
27.0
|
|
|
Nervous system disorders
Nervous system disorder
|
27.0
|
|
|
General disorders and administration site conditions
Chills
|
26.4
|
|
|
Investigations
Body temperature increased
|
26.2
|
|
|
Cardiac disorders
Cardiac disorder
|
26.0
|
|
|
Respiratory, thoracic and mediastinal disorders
Mediastinal disorder
|
26.0
|
|
|
Vascular disorders
Angiopathy
|
25.0
|
|
|
Nervous system disorders
Nervous system disorder
|
25.0
|
|
|
Skin and subcutaneous tissue disorders
Skin disorder
|
25.0
|
|
|
General disorders and administration site conditions
Chills
|
24.7
|
|
|
Vascular disorders
Angiopathy
|
24.0
|
|
|
Metabolism and nutrition disorders
Malnutrition
|
24.0
|
|
|
Investigations
Blood potassium decreased
|
23.4
|
|
|
Investigations
Body temperature increased
|
23.2
|
|
|
Investigations
Body temperature increased
|
23.1
|
|
|
Vascular disorders
Angiopathy
|
23.0
|
|
|
Investigations
Blood alkaline phosphatase increased
|
23.0
|
|
|
Investigations
Blood potassium decreased
|
23.0
|
|
|
Investigations
Blood urea increased
|
23.0
|
|
|
Investigations
Body temperature increased
|
23.0
|
|
|
General disorders and administration site conditions
Chills
|
23.0
|
|
|
Skin and subcutaneous tissue disorders
Dermatitis
|
23.0
|
|
|
Investigations
Haemoglobin decreased
|
23.0
|
|
|
Metabolism and nutrition disorders
Malnutrition
|
23.0
|
|
|
Respiratory, thoracic and mediastinal disorders
Mediastinal disorder
|
23.0
|
|
|
Skin and subcutaneous tissue disorders
Rash
|
23.0
|
|
|
Investigations
Alanine aminotransferase increased
|
22.7
|
|
|
Investigations
Aspartate aminotransferase increased
|
22.7
|
|
|
Investigations
Blood creatinine increased
|
22.6
|
|
|
Investigations
Aspartate aminotransferase increased
|
22.5
|
|
|
Vascular disorders
Phlebitis
|
22.5
|
|
|
Vascular disorders
Thrombophlebitis
|
22.5
|
|
|
Investigations
Blood alkaline phosphatase increased
|
22.0
|
|
|
Metabolism and nutrition disorders
Malnutrition
|
22.0
|
|
|
Investigations
Body temperature increased
|
21.3
|
|
|
Gastrointestinal disorders
Nausea
|
21.3
|
|
|
Vascular disorders
Angiopathy
|
21.0
|
|
|
Investigations
Blood alkaline phosphatase increased
|
21.0
|
|
|
Investigations
Body temperature increased
|
21.0
|
|
|
Investigations
Haemoglobin decreased
|
21.0
|
|
|
Metabolism and nutrition disorders
Malnutrition
|
21.0
|
|
|
Investigations
Alanine aminotransferase increased
|
20.0
|
|
|
Vascular disorders
Angiopathy
|
20.0
|
|
|
Gastrointestinal disorders
Diarrhoea
|
20.0
|
|
|
Vascular disorders
Hypotension
|
20.0
|
|
|
Gastrointestinal disorders
Nausea
|
20.0
|
|
|
Metabolism and nutrition disorders
Respiratory failure
|
20.0
|
|
|
Investigations
Body temperature increased
|
19.4
|
|
|
Investigations
Blood alkaline phosphatase increased
|
19.3
|
|
|
Nervous system disorders
Headache
|
19.1
|
|
|
Vascular disorders
Angiopathy
|
19.0
|
|
|
Investigations
Aspartate aminotransferase increased
|
19.0
|
|
|
Cardiac disorders
Cardiac disorder
|
19.0
|
|
|
Cardiac disorders
Tachycardia
|
19.0
|
|
|
Investigations
White blood cell count decreased
|
19.0
|
|
|
Investigations
Alanine aminotransferase increased
|
18.0
|
|
|
Vascular disorders
Angiopathy
|
18.0
|
|
|
Investigations
Blood potassium decreased
|
18.0
|
|
|
Gastrointestinal disorders
Diarrhoea
|
18.0
|
|
|
Investigations
Haematocrit decreased
|
18.0
|
|
|
Investigations
Haemoglobin decreased
|
18.0
|
|
|
Nervous system disorders
Nervous system disorder
|
18.0
|
|
|
Vascular disorders
Phlebitis
|
18.0
|
|
|
Investigations
Alanine aminotransferase increased
|
17.0
|
|
|
Investigations
Aspartate aminotransferase increased
|
17.0
|
|
|
Investigations
Blood alkaline phosphatase increased
|
17.0
|
|
|
Investigations
Blood bilirubin increased
|
17.0
|
|
|
Investigations
Body temperature increased
|
17.0
|
|
|
Cardiac disorders
Cardiac disorder
|
17.0
|
|
|
Gastrointestinal disorders
Diarrhoea
|
17.0
|
|
|
Gastrointestinal disorders
Nausea
|
17.0
|
|
|
Nervous system disorders
Nervous system disorder
|
17.0
|
|
|
Gastrointestinal disorders
Vomiting
|
17.0
|
|
|
Investigations
Alanine aminotransferase increased
|
16.0
|
|
|
Investigations
Aspartate aminotransferase increased
|
16.0
|
|
|
Cardiac disorders
Cardiac disorder
|
16.0
|
|
|
Skin and subcutaneous tissue disorders
Dermatitis
|
16.0
|
|
|
Gastrointestinal disorders
Diarrhoea
|
16.0
|
|
|
Investigations
Haematocrit decreased
|
16.0
|
|
|
Investigations
Haemoglobin decreased
|
16.0
|
|
|
Vascular disorders
Hypotension
|
16.0
|
|
|
Nervous system disorders
Nervous system disorder
|
16.0
|
|
|
Skin and subcutaneous tissue disorders
Rash
|
16.0
|
|
|
Gastrointestinal disorders
Vomiting
|
16.0
|
|
|
Investigations
Blood urea increased
|
15.8
|
|
|
Vascular disorders
Phlebitis
|
15.7
|
|
|
Vascular disorders
Thrombophlebitis
|
15.7
|
|
|
Investigations
Blood alkaline phosphatase increased
|
15.6
|
|
|
Investigations
Alanine aminotransferase increased
|
15.0
|
|
|
Vascular disorders
Angiopathy
|
15.0
|
|
|
Investigations
Blood alkaline phosphatase increased
|
15.0
|
|
|
Investigations
Blood potassium decreased
|
15.0
|
|
|
Gastrointestinal disorders
Diarrhoea
|
15.0
|
|
|
Nervous system disorders
Headache
|
15.0
|
|
|
Gastrointestinal disorders
Nausea
|
15.0
|
|
|
Skin and subcutaneous tissue disorders
Skin disorder
|
15.0
|
|
|
Investigations
Blood albumin decreased
|
14.9
|
|
|
Investigations
Alanine aminotransferase increased
|
14.0
|
|
|
Investigations
Aspartate aminotransferase increased
|
14.0
|
|
|
Investigations
Bilirubin conjugated increased
|
14.0
|
|
|
Investigations
Blood bilirubin increased
|
14.0
|
|
|
Musculoskeletal and connective tissue disorders
Connective tissue disorder
|
14.0
|
|
|
Skin and subcutaneous tissue disorders
Dermatitis
|
14.0
|
|
|
Gastrointestinal disorders
Diarrhoea
|
14.0
|
|
|
Respiratory, thoracic and mediastinal disorders
Pleural effusion
|
14.0
|
|
|
Skin and subcutaneous tissue disorders
Rash
|
14.0
|
|
|
Infections and infestations
Septic shock
|
14.0
|
|
|
General disorders and administration site conditions
Chills
|
13.8
|
|
|
Vascular disorders
Phlebitis
|
13.8
|
|
|
Vascular disorders
Thrombophlebitis
|
13.8
|
|
|
Gastrointestinal disorders
Vomiting
|
13.5
|
|
|
Investigations
Alanine aminotransferase increased
|
13.0
|
|
|
Investigations
Aspartate aminotransferase increased
|
13.0
|
|
|
Infections and infestations
Aspergillus infection
|
13.0
|
|
|
Investigations
Blood alkaline phosphatase increased
|
13.0
|
|
|
Investigations
Blood bilirubin increased
|
13.0
|
|
|
Investigations
Blood potassium decreased
|
13.0
|
|
|
Investigations
Body temperature increased
|
13.0
|
|
|
Cardiac disorders
Cardiac disorder
|
13.0
|
|
|
General disorders and administration site conditions
Chills
|
13.0
|
|
|
Skin and subcutaneous tissue disorders
Dermatitis
|
13.0
|
|
|
Investigations
Haematocrit decreased
|
13.0
|
|
|
Nervous system disorders
Nervous system disorder
|
13.0
|
|
|
Skin and subcutaneous tissue disorders
Rash
|
13.0
|
|
|
Infections and infestations
Septic shock
|
13.0
|
|
|
Investigations
Aspartate aminotransferase increased
|
12.9
|
|
|
Investigations
Haemoglobin decreased
|
12.3
|
|
|
Gastrointestinal disorders
Abdominal pain
|
12.0
|
|
|
Investigations
Alanine aminotransferase increased
|
12.0
|
|
|
Investigations
Aspartate aminotransferase increased
|
12.0
|
|
|
Investigations
Blood alkaline phosphatase increased
|
12.0
|
|
|
Musculoskeletal and connective tissue disorders
Connective tissue disorder
|
12.0
|
|
|
Gastrointestinal disorders
Gastrointestinal pain
|
12.0
|
|
|
Nervous system disorders
Headache
|
12.0
|
|
|
Vascular disorders
Hypotension
|
12.0
|
|
|
Immune system disorders
Immune system disorder
|
12.0
|
|
|
Cardiac disorders
Oedema peripheral
|
12.0
|
|
|
Metabolism and nutrition disorders
Respiratory failure
|
12.0
|
|
|
Cardiac disorders
Tachycardia
|
12.0
|
|
|
Gastrointestinal disorders
Vomiting
|
12.0
|
|
|
Investigations
White blood cell count decreased
|
12.0
|
|
|
Investigations
Alanine aminotransferase increased
|
11.8
|
|
|
Investigations
Blood alkaline phosphatase increased
|
11.8
|
|
|
Metabolism and nutrition disorders
Hypokalaemia
|
11.8
|
|
|
Investigations
Body temperature increased
|
11.7
|
|
|
Investigations
Blood potassium decreased
|
11.5
|
|
|
Cardiac disorders
Tachycardia
|
11.5
|
|
|
Nervous system disorders
Headache
|
11.3
|
|
|
Gastrointestinal disorders
Nausea
|
11.3
|
|
|
Vascular disorders
Phlebitis
|
11.3
|
|
|
Vascular disorders
Thrombophlebitis
|
11.3
|
|
|
Gastrointestinal disorders
Diarrhoea
|
11.2
|
|
|
Investigations
Haematocrit decreased
|
11.1
|
|
|
Gastrointestinal disorders
Abdominal pain
|
11.0
|
|
|
Blood and lymphatic system disorders
Anaemia
|
11.0
|
|
|
Investigations
Blood creatinine increased
|
11.0
|
|
|
Musculoskeletal and connective tissue disorders
Connective tissue disorder
|
11.0
|
|
|
Respiratory, thoracic and mediastinal disorders
Cough
|
11.0
|
|
|
Gastrointestinal disorders
Gastrointestinal pain
|
11.0
|
|
|
Nervous system disorders
Headache
|
11.0
|
|
|
Metabolism and nutrition disorders
Malnutrition
|
11.0
|
|
|
Gastrointestinal disorders
Nausea
|
11.0
|
|
|
Cardiac disorders
Oedema peripheral
|
11.0
|
|
|
Vascular disorders
Phlebitis
|
11.0
|
|
|
Infections and infestations
Pneumonia
|
11.0
|
|
|
Metabolism and nutrition disorders
Respiratory failure
|
11.0
|
|
|
Infections and infestations
Septic shock
|
11.0
|
|
|
Cardiac disorders
Tachycardia
|
11.0
|
|
|
Respiratory, thoracic and mediastinal disorders
Tachypnoea
|
11.0
|
|
|
Gastrointestinal disorders
Vomiting
|
11.0
|
|
|
Investigations
Alanine aminotransferase increased
|
10.8
|
|
|
Investigations
Aspartate aminotransferase increased
|
10.8
|
|
|
Investigations
Blood potassium decreased
|
10.8
|
|
|
Investigations
Alanine aminotransferase increased
|
10.6
|
|
|
Investigations
Blood alkaline phosphatase increased
|
10.5
|
|
|
Investigations
Haemoglobin decreased
|
10.5
|
|
|
Cardiac disorders
Tachycardia
|
10.4
|
|
|
Respiratory, thoracic and mediastinal disorders
Tachypnoea
|
10.4
|
|
|
Investigations
Blood urea increased
|
10.3
|
|
|
Investigations
Blood bilirubin increased
|
10.0
|
|
|
Investigations
Blood urine
|
10.0
|
|
|
Investigations
Blood urine present
|
10.0
|
|
|
General disorders and administration site conditions
Chills
|
10.0
|
|
|
Respiratory, thoracic and mediastinal disorders
Cough
|
10.0
|
|
|
Skin and subcutaneous tissue disorders
Dermatitis
|
10.0
|
|
|
Gastrointestinal disorders
Diarrhoea
|
10.0
|
|
|
Cardiac disorders
Dyspnoea
|
10.0
|
|
|
Renal and urinary disorders
Haematuria
|
10.0
|
|
|
Vascular disorders
Hypertension
|
10.0
|
|
|
Vascular disorders
Hypotension
|
10.0
|
|
|
General disorders and administration site conditions
Mucosal inflammation
|
10.0
|
|
|
Infections and infestations
Pneumonia
|
10.0
|
|
|
Skin and subcutaneous tissue disorders
Rash
|
10.0
|
|
|
Investigations
Blood potassium decreased
|
9.9
|
|
|
Gastrointestinal disorders
Abdominal pain
|
9.0
|
|
|
Blood and lymphatic system disorders
Anaemia
|
9.0
|
|
|
Investigations
Aspartate aminotransferase increased
|
9.0
|
|
|
Investigations
Bilirubin conjugated increased
|
9.0
|
|
|
Investigations
Blood alkaline phosphatase increased
|
9.0
|
|
|
Investigations
Blood glucose increased
|
9.0
|
|
|
Investigations
Blood magnesium decreased
|
9.0
|
|
|
Investigations
Blood potassium decreased
|
9.0
|
|
|
Investigations
Blood urea increased
|
9.0
|
|
|
General disorders and administration site conditions
Chills
|
9.0
|
|
|
Respiratory, thoracic and mediastinal disorders
Cough
|
9.0
|
|
|
General disorders and administration site conditions
Device related infection
|
9.0
|
|
|
Cardiac disorders
Dyspnoea
|
9.0
|
|
|
Skin and subcutaneous tissue disorders
Erythema
|
9.0
|
|
|
Gastrointestinal disorders
Gastrointestinal pain
|
9.0
|
|
|
Nervous system disorders
Headache
|
9.0
|
|
|
Vascular disorders
Hypertension
|
9.0
|
|
|
Vascular disorders
Hypotension
|
9.0
|
|
|
Gastrointestinal disorders
Nausea
|
9.0
|
|
|
General disorders and administration site conditions
Pain
|
9.0
|
|
|
Respiratory, thoracic and mediastinal disorders
Pleural effusion
|
9.0
|
|
|
Infections and infestations
Septic shock
|
9.0
|
|
|
Cardiac disorders
Tachycardia
|
9.0
|
|
|
Gastrointestinal disorders
Vomiting
|
9.0
|
|
|
Investigations
Alanine aminotransferase increased
|
8.9
|
|
|
Investigations
Blood bilirubin increased
|
8.9
|
|
|
Skin and subcutaneous tissue disorders
Dermatitis
|
8.9
|
|
|
Nervous system disorders
Headache
|
8.9
|
|
|
Skin and subcutaneous tissue disorders
Rash
|
8.9
|
|
|
Investigations
Alanine aminotransferase increased
|
8.7
|
|
|
Investigations
Blood albumin decreased
|
8.6
|
|
|
Gastrointestinal disorders
Vomiting
|
8.6
|
|
|
Investigations
White blood cell count decreased
|
8.6
|
|
|
Vascular disorders
Phlebitis
|
8.5
|
|
|
Vascular disorders
Thrombophlebitis
|
8.5
|
|
|
Investigations
Blood bilirubin increased
|
8.4
|
|
|
Investigations
Blood alkaline phosphatase increased
|
8.3
|
|
|
Investigations
Alanine aminotransferase increased
|
8.1
|
|
|
Blood and lymphatic system disorders
Anaemia
|
8.0
|
|
|
Musculoskeletal and connective tissue disorders
Back pain
|
8.0
|
|
|
Investigations
Bilirubin conjugated increased
|
8.0
|
|
|
Investigations
Blood albumin decreased
|
8.0
|
|
|
Investigations
Blood potassium decreased
|
8.0
|
|
|
Investigations
Blood potassium increased
|
8.0
|
|
|
Investigations
Blood urea increased
|
8.0
|
|
|
General disorders and administration site conditions
Chills
|
8.0
|
|
|
Respiratory, thoracic and mediastinal disorders
Cough
|
8.0
|
|
|
Skin and subcutaneous tissue disorders
Dermatitis
|
8.0
|
|
|
Immune system disorders
Graft versus host disease
|
8.0
|
|
|
Metabolism and nutrition disorders
Hypokalaemia
|
8.0
|
|
|
Vascular disorders
Hypotension
|
8.0
|
|
|
General disorders and administration site conditions
Mucosal inflammation
|
8.0
|
|
|
Gastrointestinal disorders
Nausea
|
8.0
|
|
|
Nervous system disorders
Nervous system disorder
|
8.0
|
|
|
General disorders and administration site conditions
Oedema
|
8.0
|
|
|
Investigations
Protein total decreased
|
8.0
|
|
|
Skin and subcutaneous tissue disorders
Pruritus
|
8.0
|
|
|
Respiratory, thoracic and mediastinal disorders
Rales
|
8.0
|
|
|
Skin and subcutaneous tissue disorders
Rash
|
8.0
|
|
|
Respiratory, thoracic and mediastinal disorders
Respiratory distress
|
8.0
|
|
|
Cardiac disorders
Tachycardia
|
8.0
|
|
|
Gastrointestinal disorders
Vomiting
|
8.0
|
|
|
Skin and subcutaneous tissue disorders
Erythema
|
7.9
|
|
|
Nervous system disorders
Tremor
|
7.9
|
|
|
Investigations
White blood cell count decreased
|
7.9
|
|
|
Investigations
Blood alkaline phosphatase increased
|
7.7
|
|
|
General disorders and administration site conditions
Chills
|
7.7
|
|
|
Nervous system disorders
Headache
|
7.7
|
|
|
Gastrointestinal disorders
Vomiting
|
7.7
|
|
|
Investigations
Blood alkaline phosphatase increased
|
7.69
|
|
|
Investigations
Aspartate aminotransferase increased
|
7.6
|
|
|
Investigations
Haematocrit decreased
|
7.3
|
|
|
Metabolism and nutrition disorders
Hypokalaemia
|
7.3
|
|
|
Gastrointestinal disorders
Abdominal pain
|
7.0
|
|
|
Investigations
Alanine aminotransferase increased
|
7.0
|
|
|
Investigations
Aspartate aminotransferase increased
|
7.0
|
|
|
Investigations
Blood albumin decreased
|
7.0
|
|
|
Investigations
Blood alkaline phosphatase increased
|
7.0
|
|
|
Investigations
Blood magnesium decreased
|
7.0
|
|
|
Investigations
Body temperature increased
|
7.0
|
|
|
Gastrointestinal disorders
Diarrhoea
|
7.0
|
|
|
Gastrointestinal disorders
Gastrointestinal pain
|
7.0
|
|
|
Vascular disorders
Hypotension
|
7.0
|
|
|
Immune system disorders
Immune system disorder
|
7.0
|
|
|
Gastrointestinal disorders
Nausea
|
7.0
|
|
|
Infections and infestations
Pneumonia
|
7.0
|
|
|
Skin and subcutaneous tissue disorders
Pruritus
|
7.0
|
|
|
Respiratory, thoracic and mediastinal disorders
Rales
|
7.0
|
|
|
Infections and infestations
Sepsis
|
7.0
|
|
|
Cardiac disorders
Tachycardia
|
7.0
|
|
|
Investigations
Blood alkaline phosphatase increased
|
6.9
|
|
|
General disorders and administration site conditions
Asthenia
|
6.7
|
|
|
General disorders and administration site conditions
Fatigue
|
6.7
|
|
|
General disorders and administration site conditions
Induration
|
6.7
|
|
|
Investigations
Blood bicarbonate decreased
|
6.6
|
|
|
Investigations
Alanine aminotransferase increased
|
6.5
|
|
|
Vascular disorders
Hypertension
|
6.4
|
|
|
Gastrointestinal disorders
Nausea
|
6.4
|
|
|
Investigations
Bilirubin conjugated increased
|
6.3
|
|
|
Skin and subcutaneous tissue disorders
Dermatitis
|
6.2
|
|
|
Skin and subcutaneous tissue disorders
Rash
|
6.2
|
|
|
Investigations
White blood cell count decreased
|
6.2
|
|
|
Investigations
Aspartate aminotransferase increased
|
6.0
|
|
|
Investigations
Blood glucose increased
|
6.0
|
|
|
Investigations
Blood potassium decreased
|
6.0
|
|
|
Investigations
Body temperature increased
|
6.0
|
|
|
Respiratory, thoracic and mediastinal disorders
Cough
|
6.0
|
|
|
Skin and subcutaneous tissue disorders
Dermatitis
|
6.0
|
|
|
Gastrointestinal disorders
Diarrhoea
|
6.0
|
|
|
Nervous system disorders
Headache
|
6.0
|
|
|
Vascular disorders
Hypertension
|
6.0
|
|
|
Metabolism and nutrition disorders
Hypokalaemia
|
6.0
|
|
|
Vascular disorders
Hypotension
|
6.0
|
|
|
General disorders and administration site conditions
Mucosal inflammation
|
6.0
|
|
|
Gastrointestinal disorders
Nausea
|
6.0
|
|
|
Skin and subcutaneous tissue disorders
Pruritus
|
6.0
|
|
|
Skin and subcutaneous tissue disorders
Rash
|
6.0
|
|
|
Metabolism and nutrition disorders
Respiratory failure
|
6.0
|
|
|
Gastrointestinal disorders
Vomiting
|
6.0
|
|
|
Nervous system disorders
Headache
|
5.7
|
|
|
General disorders and administration site conditions
Discomfort
|
5.6
|
|
|
General disorders and administration site conditions
Feeling abnormal
|
5.6
|
|
|
Metabolism and nutrition disorders
Hypokalaemia
|
5.6
|
|
|
General disorders and administration site conditions
Ill-defined disorder
|
5.6
|
|
|
General disorders and administration site conditions
Malaise
|
5.6
|
|
|
Gastrointestinal disorders
Nausea
|
5.6
|
|
|
General disorders and administration site conditions
Oedema
|
5.6
|
|
|
General disorders and administration site conditions
Pain
|
5.6
|
|
|
Renal and urinary disorders
Renal failure
|
5.6
|
|
|
Renal and urinary disorders
Renal impairment
|
5.6
|
|
|
General disorders and administration site conditions
Swelling
|
5.6
|
|
|
Investigations
Blood creatinine increased
|
5.5
|
|
|
Investigations
Blood albumin decreased
|
5.4
|
|
|
Investigations
Haematocrit decreased
|
5.4
|
|
|
Investigations
Haemoglobin decreased
|
5.4
|
|
|
General disorders and administration site conditions
Chills
|
5.3
|
|
|
Skin and subcutaneous tissue disorders
Dermatitis
|
5.3
|
|
|
Skin and subcutaneous tissue disorders
Rash
|
5.3
|
|
|
Investigations
Blood bilirubin increased
|
5.2
|
|
|
Investigations
Alanine aminotransferase increased
|
5.0
|
|
|
Investigations
Bilirubin conjugated increased
|
5.0
|
|
|
Skin and subcutaneous tissue disorders
Decubitus ulcer
|
5.0
|
|
|
Nervous system disorders
Headache
|
5.0
|
|
|
Vascular disorders
Hypertension
|
5.0
|
|
|
Metabolism and nutrition disorders
Hypokalaemia
|
5.0
|
|
|
Gastrointestinal disorders
Nausea
|
5.0
|
|
|
Infections and infestations
Pneumonia
|
5.0
|
|
|
Infections and infestations
Sepsis
|
5.0
|
|
|
Investigations
Protein urine present
|
4.9
|
|
|
Vascular disorders
Phlebitis
|
4.8
|
|
|
Vascular disorders
Thrombophlebitis
|
4.8
|
|
|
Skin and subcutaneous tissue disorders
Dermatitis
|
4.7
|
|
|
Skin and subcutaneous tissue disorders
Rash
|
4.7
|
|
|
Investigations
Blood albumin decreased
|
4.6
|
|
|
Skin and subcutaneous tissue disorders
Dermatitis
|
4.6
|
|
|
General disorders and administration site conditions
Pain
|
4.6
|
|
|
Skin and subcutaneous tissue disorders
Rash
|
4.6
|
|
|
Investigations
White blood cell count decreased
|
4.6
|
|
|
Investigations
Blood bilirubin increased
|
4.5
|
|
|
General disorders and administration site conditions
Pain
|
4.5
|
|
|
Investigations
Protein urine present
|
4.5
|
|
|
Cardiac disorders
Tachycardia
|
4.5
|
|
|
Respiratory, thoracic and mediastinal disorders
Tachypnoea
|
4.5
|
|
|
Investigations
Blood potassium decreased
|
4.3
|
|
|
Nervous system disorders
Headache
|
4.3
|
|
|
Cardiac disorders
Dyspnoea
|
4.2
|
|
|
General disorders and administration site conditions
Flushing
|
4.2
|
|
|
Metabolism and nutrition disorders
Hypokalaemia
|
4.2
|
|
|
Gastrointestinal disorders
Abdominal pain
|
4.0
|
|
|
Investigations
Alanine aminotransferase increased
|
4.0
|
|
|
Investigations
Aspartate aminotransferase increased
|
4.0
|
|
|
Musculoskeletal and connective tissue disorders
Back pain
|
4.0
|
|
|
Investigations
Blood bilirubin increased
|
4.0
|
|
|
Investigations
Blood urea increased
|
4.0
|
|
|
Skin and subcutaneous tissue disorders
Dermatitis
|
4.0
|
|
|
Skin and subcutaneous tissue disorders
Erythema
|
4.0
|
|
|
Gastrointestinal disorders
Gastrointestinal pain
|
4.0
|
|
|
Immune system disorders
Graft versus host disease
|
4.0
|
|
|
Renal and urinary disorders
Haematuria
|
4.0
|
|
|
Nervous system disorders
Headache
|
4.0
|
|
|
Vascular disorders
Hypertension
|
4.0
|
|
|
Metabolism and nutrition disorders
Hypokalaemia
|
4.0
|
|
|
General disorders and administration site conditions
Mucosal inflammation
|
4.0
|
|
|
Gastrointestinal disorders
Nausea
|
4.0
|
|
|
General disorders and administration site conditions
Oedema
|
4.0
|
|
|
Infections and infestations
Pneumonia
|
4.0
|
|
|
Skin and subcutaneous tissue disorders
Rash
|
4.0
|
|
|
Respiratory, thoracic and mediastinal disorders
Respiratory distress
|
4.0
|
|
|
Cardiac disorders
Tachycardia
|
4.0
|
|
|
Blood and lymphatic system disorders
Anaemia
|
3.8
|
|
|
Immune system disorders
Angioedema
|
3.8
|
|
|
Investigations
Blood bilirubin increased
|
3.8
|
|
|
Immune system disorders
Circumoral oedema
|
3.8
|
|
|
Cardiac disorders
Dyspnoea
|
3.8
|
|
|
Hepatobiliary disorders
Hepatitis
|
3.8
|
|
|
Blood and lymphatic system disorders
Hyperbilirubinaemia
|
3.8
|
|
|
Metabolism and nutrition disorders
Hypokalaemia
|
3.8
|
|
|
Metabolism and nutrition disorders
Hyponatraemia
|
3.8
|
|
|
Vascular disorders
Hypotension
|
3.8
|
|
|
General disorders and administration site conditions
Injection site phlebitis
|
3.8
|
|
|
Blood and lymphatic system disorders
Jaundice
|
3.8
|
|
|
Respiratory, thoracic and mediastinal disorders
Laryngospasm
|
3.8
|
|
|
Gastrointestinal disorders
Nausea
|
3.8
|
|
|
Investigations
Alanine aminotransferase increased
|
3.7
|
|
|
Investigations
Blood creatinine increased
|
3.7
|
|
|
Investigations
Blood potassium decreased
|
3.7
|
|
|
Metabolism and nutrition disorders
Hypokalaemia
|
3.7
|
|
|
Investigations
Protein urine present
|
3.7
|
|
|
Investigations
Blood bicarbonate decreased
|
3.6
|
|
|
Investigations
Blood potassium decreased
|
3.6
|
|
|
Investigations
Body temperature increased
|
3.6
|
|
|
General disorders and administration site conditions
Catheter site pain
|
3.6
|
|
|
Gastrointestinal disorders
Diarrhoea
|
3.6
|
|
|
General disorders and administration site conditions
Flushing
|
3.6
|
|
|
Vascular disorders
Hypotension
|
3.6
|
|
|
General disorders and administration site conditions
Pain
|
3.6
|
|
|
Investigations
pH urine increased
|
3.6
|
|
|
Skin and subcutaneous tissue disorders
Pruritus
|
3.6
|
|
|
Investigations
Blood potassium decreased
|
3.5
|
|
|
Gastrointestinal disorders
Nausea
|
3.5
|
|
|
Vascular disorders
Phlebitis
|
3.5
|
|
|
Vascular disorders
Thrombophlebitis
|
3.5
|
|
|
Gastrointestinal disorders
Vomiting
|
3.5
|
|
|
Investigations
Blood uric acid increased
|
3.4
|
|
|
General disorders and administration site conditions
Decreased appetite
|
3.4
|
|
|
Skin and subcutaneous tissue disorders
Dermatitis
|
3.4
|
|
|
General disorders and administration site conditions
Hyperhidrosis
|
3.4
|
|
|
Investigations
Platelet count decreased
|
3.4
|
|
|
Investigations
Protein total decreased
|
3.4
|
|
|
Skin and subcutaneous tissue disorders
Rash
|
3.4
|
|
|
Immune system disorders
Vasculitis
|
3.4
|
|
|
Investigations
Blood bilirubin increased
|
3.3
|
|
|
Investigations
Protein urine present
|
3.3
|
|
|
Investigations
Blood bilirubin increased
|
3.2
|
|
|
Investigations
Blood calcium decreased
|
3.2
|
|
|
Skin and subcutaneous tissue disorders
Dermatitis
|
3.2
|
|
|
Blood and lymphatic system disorders
Eosinophilia
|
3.2
|
|
|
General disorders and administration site conditions
Hyperhidrosis
|
3.2
|
|
|
Metabolism and nutrition disorders
Hyponatraemia
|
3.2
|
|
|
Blood and lymphatic system disorders
Jaundice
|
3.2
|
|
|
Blood and lymphatic system disorders
Neutropenia
|
3.2
|
|
|
Investigations
Protein total decreased
|
3.2
|
|
|
Skin and subcutaneous tissue disorders
Rash
|
3.2
|
|
|
Gastrointestinal disorders
Vomiting
|
3.2
|
|
|
Gastrointestinal disorders
Diarrhoea
|
3.1
|
|
|
Blood and lymphatic system disorders
Eosinophilia
|
3.1
|
|
|
Investigations
Haemoglobin decreased
|
3.1
|
|
|
General disorders and administration site conditions
Induration
|
3.1
|
|
|
General disorders and administration site conditions
Influenza like illness
|
3.1
|
|
|
Musculoskeletal and connective tissue disorders
Musculoskeletal discomfort
|
3.1
|
|
|
Musculoskeletal and connective tissue disorders
Myalgia
|
3.1
|
|
|
Gastrointestinal disorders
Nausea
|
3.1
|
|
|
Blood and lymphatic system disorders
Neutropenia
|
3.1
|
|
|
General disorders and administration site conditions
Oedema
|
3.1
|
|
|
Nervous system disorders
Paraesthesia
|
3.1
|
|
|
Investigations
Platelet count decreased
|
3.1
|
|
|
Investigations
Protein total decreased
|
3.1
|
|
|
Gastrointestinal disorders
Vomiting
|
3.1
|
|
|
Blood and lymphatic system disorders
Eosinophilia
|
3.08
|
|
|
Investigations
Haemoglobin decreased
|
3.08
|
|
|
Blood and lymphatic system disorders
Neutropenia
|
3.08
|
|
|
Blood and lymphatic system disorders
Eosinophilia
|
3.07
|
|
|
Investigations
Protein total decreased
|
3.07
|
|
|
Investigations
Blood bilirubin increased
|
3.0
|
|
|
Investigations
Blood creatinine increased
|
3.0
|
|
|
Investigations
Blood potassium increased
|
3.0
|
|
|
Skin and subcutaneous tissue disorders
Decubitus ulcer
|
3.0
|
|
|
Vascular disorders
Hypotension
|
3.0
|
|
|
General disorders and administration site conditions
Oedema
|
3.0
|
|
|
Investigations
Blood alkaline phosphatase increased
|
2.9
|
|
|
Investigations
Blood potassium decreased
|
2.9
|
|
|
Investigations
Body temperature increased
|
2.9
|
|
|
General disorders and administration site conditions
Flushing
|
2.9
|
|
|
Nervous system disorders
Headache
|
2.9
|
|
|
Gastrointestinal disorders
Nausea
|
2.9
|
|
|
Gastrointestinal disorders
Vomiting
|
2.9
|
|
|
Investigations
Blood bilirubin increased
|
2.8
|
|
|
General disorders and administration site conditions
Hyperhidrosis
|
2.8
|
|
|
Musculoskeletal and connective tissue disorders
Back pain
|
2.7
|
|
|
Investigations
Blood phosphorus increased
|
2.7
|
|
|
Gastrointestinal disorders
Diarrhoea
|
2.7
|
|
|
Investigations
Blood bilirubin increased
|
2.6
|
|
|
Gastrointestinal disorders
Diarrhoea
|
2.6
|
|
|
Metabolism and nutrition disorders
Hypomagnesaemia
|
2.6
|
|
|
Investigations
Blood bilirubin increased
|
2.5
|
|
|
General disorders and administration site conditions
Chills
|
2.5
|
|
|
Gastrointestinal disorders
Nausea
|
2.5
|
|
|
General disorders and administration site conditions
Pain
|
2.5
|
|
|
Skin and subcutaneous tissue disorders
Pruritus
|
2.5
|
|
|
Gastrointestinal disorders
Abdominal pain
|
2.4
|
|
|
Investigations
Blood potassium increased
|
2.4
|
|
|
Gastrointestinal disorders
Diarrhoea
|
2.4
|
|
|
Skin and subcutaneous tissue disorders
Erythema
|
2.4
|
|
|
Gastrointestinal disorders
Gastrointestinal pain
|
2.4
|
|
|
Vascular disorders
Hypotension
|
2.4
|
|
|
Cardiac disorders
Tachycardia
|
2.4
|
|
|
Nervous system disorders
Tremor
|
2.4
|
|
|
Metabolism and nutrition disorders
Hypomagnesaemia
|
2.3
|
|
|
Investigations
Prothrombin level increased
|
2.3
|
|
|
Immune system disorders
Anaphylactic shock
|
2.2
|
|
|
Investigations
Blood creatinine increased
|
2.2
|
|
|
Investigations
Blood potassium increased
|
2.2
|
|
|
General disorders and administration site conditions
Hyperhidrosis
|
2.2
|
|
|
Nervous system disorders
Insomnia
|
2.2
|
|
|
Investigations
Lymphocyte count increased
|
2.2
|
|
|
Musculoskeletal and connective tissue disorders
Musculoskeletal discomfort
|
2.2
|
|
|
Musculoskeletal and connective tissue disorders
Myalgia
|
2.2
|
|
|
General disorders and administration site conditions
Pain
|
2.2
|
|
|
Investigations
Platelet count decreased
|
2.2
|
|
|
Cardiac disorders
Dizziness
|
2.13
|
|
|
Investigations
Platelet count decreased
|
2.13
|
|
|
Gastrointestinal disorders
Diarrhoea
|
2.1
|
|
|
Cardiac disorders
Dizziness
|
2.1
|
|
|
Gastrointestinal disorders
Gastritis
|
2.1
|
|
|
General disorders and administration site conditions
Pain
|
2.1
|
|
|
Investigations
Alanine aminotransferase increased
|
2.0
|
|
|
Blood and lymphatic system disorders
Anaemia
|
2.0
|
|
|
Investigations
Aspartate aminotransferase increased
|
2.0
|
|
|
Investigations
Blood alkaline phosphatase increased
|
2.0
|
|
|
Investigations
Blood phosphorus decreased
|
2.0
|
|
|
Cardiac disorders
Dyspnoea
|
2.0
|
|
|
Nervous system disorders
Headache
|
2.0
|
|
|
Vascular disorders
Hypertension
|
2.0
|
|
|
Metabolism and nutrition disorders
Hypokalaemia
|
2.0
|
|
|
General disorders and administration site conditions
Injection site erythema
|
2.0
|
|
|
General disorders and administration site conditions
Injection site phlebitis
|
2.0
|
|
|
General disorders and administration site conditions
Injection site swelling
|
2.0
|
|
|
Metabolism and nutrition disorders
Malnutrition
|
2.0
|
|
|
Nervous system disorders
Nervous system disorder
|
2.0
|
|
|
Metabolism and nutrition disorders
Respiratory failure
|
2.0
|
|
|
Respiratory, thoracic and mediastinal disorders
Tachypnoea
|
2.0
|
|
|
Investigations
Aspartate aminotransferase increased
|
1.9
|
|
|
Investigations
Blood calcium decreased
|
1.9
|
|
|
Investigations
Blood urea increased
|
1.9
|
|
|
Metabolism and nutrition disorders
Hyponatraemia
|
1.9
|
|
|
Metabolism and nutrition disorders
Malnutrition
|
1.9
|
|
|
Blood and lymphatic system disorders
Neutropenia
|
1.9
|
|
|
Investigations
Blood bilirubin increased
|
1.8
|
|
|
Investigations
Blood phosphorus decreased
|
1.8
|
|
|
General disorders and administration site conditions
Chills
|
1.8
|
|
|
General disorders and administration site conditions
Flushing
|
1.8
|
|
|
Vascular disorders
Hypertension
|
1.8
|
|
|
Vascular disorders
Hypotension
|
1.8
|
|
|
Gastrointestinal disorders
Nausea
|
1.8
|
|
|
Skin and subcutaneous tissue disorders
Pruritus
|
1.8
|
|
|
Cardiac disorders
Tachycardia
|
1.8
|
|
|
Nervous system disorders
Tremor
|
1.8
|
|
|
Gastrointestinal disorders
Vomiting
|
1.8
|
|
|
Investigations
Lymphocyte count increased
|
1.6
|
|
|
Investigations
Haematocrit decreased
|
1.54
|
|
|
Investigations
Blood creatinine increased
|
1.5
|
|
|
General disorders and administration site conditions
Chills
|
1.5
|
|
|
Cardiac disorders
Dizziness
|
1.5
|
|
|
Skin and subcutaneous tissue disorders
Erythema
|
1.5
|
|
|
Investigations
Haematocrit decreased
|
1.5
|
|
|
Metabolism and nutrition disorders
Hyponatraemia
|
1.5
|
|
|
Investigations
Platelet count decreased
|
1.5
|
|
|
Investigations
Prothrombin level increased
|
1.5
|
|
|
Skin and subcutaneous tissue disorders
Pruritus
|
1.5
|
|
|
Gastrointestinal disorders
Abdominal pain
|
1.4
|
|
|
Gastrointestinal disorders
Gastrointestinal pain
|
1.4
|
|
|
Cardiac disorders
Tachycardia
|
1.4
|
|
|
General disorders and administration site conditions
Decreased appetite
|
1.3
|
|
|
Skin and subcutaneous tissue disorders
Dermatitis
|
1.3
|
|
|
Gastrointestinal disorders
Diarrhoea
|
1.3
|
|
|
Skin and subcutaneous tissue disorders
Erythema
|
1.3
|
|
|
General disorders and administration site conditions
Hyperhidrosis
|
1.3
|
|
|
General disorders and administration site conditions
Pain
|
1.3
|
|
|
Nervous system disorders
Paraesthesia
|
1.3
|
|
|
Investigations
Prothrombin level increased
|
1.3
|
|
|
Skin and subcutaneous tissue disorders
Rash
|
1.3
|
|
|
Cardiac disorders
Tachycardia
|
1.3
|
|
|
Respiratory, thoracic and mediastinal disorders
Tachypnoea
|
1.3
|
|
|
Gastrointestinal disorders
Vomiting
|
1.3
|
|
|
Investigations
Blood creatinine increased
|
1.2
|
|
|
Investigations
Blood urea increased
|
1.2
|
|
|
General disorders and administration site conditions
Catheter site pain
|
1.2
|
|
|
Skin and subcutaneous tissue disorders
Erythema
|
1.2
|
|
|
Nervous system disorders
Insomnia
|
1.2
|
|
|
Musculoskeletal and connective tissue disorders
Musculoskeletal discomfort
|
1.2
|
|
|
Musculoskeletal and connective tissue disorders
Myalgia
|
1.2
|
|
|
Investigations
Protein urine present
|
1.2
|
|
|
Skin and subcutaneous tissue disorders
Pruritus
|
1.2
|
|
|
Cardiac disorders
Tachycardia
|
1.2
|
|
|
Gastrointestinal disorders
Vomiting
|
1.2
|
|
|
Investigations
Blood calcium decreased
|
1.1
|
|
|
Investigations
Blood potassium increased
|
1.1
|
|
|
Investigations
Body temperature increased
|
1.1
|
|
|
Cardiac disorders
Dizziness
|
1.1
|
|
|
Blood and lymphatic system disorders
Eosinophilia
|
1.1
|
|
|
Nervous system disorders
Headache
|
1.1
|
|
|
Vascular disorders
Hypertension
|
1.1
|
|
|
Metabolism and nutrition disorders
Hyponatraemia
|
1.1
|
|
|
Blood and lymphatic system disorders
Neutropenia
|
1.1
|
|
|
Nervous system disorders
Paraesthesia
|
1.1
|
|
|
General disorders and administration site conditions
Device related infection
|
1.0
|
|
|
Immune system disorders
Graft versus host disease
|
1.0
|
|
|
Metabolism and nutrition disorders
Hypokalaemia
|
1.0
|
|
|
General disorders and administration site conditions
Injection site swelling
|
1.0
|
|
|
Respiratory, thoracic and mediastinal disorders
Tachypnoea
|
1.0
|
|
|
Investigations
Blood bicarbonate decreased
|
0.9
|
|
|
Investigations
Blood potassium increased
|
0.9
|
|
|
Skin and subcutaneous tissue disorders
Dermatitis
|
0.9
|
|
|
Investigations
Haematocrit decreased
|
0.9
|
|
|
Investigations
Haemoglobin decreased
|
0.9
|
|
|
General disorders and administration site conditions
Hyperhidrosis
|
0.9
|
|
|
Metabolism and nutrition disorders
Hypokalaemia
|
0.9
|
|
|
Vascular disorders
Hypotension
|
0.9
|
|
|
Blood and lymphatic system disorders
Jaundice
|
0.9
|
|
|
Skin and subcutaneous tissue disorders
Rash
|
0.9
|
|
|
Renal and urinary disorders
Renal failure
|
0.9
|
|
|
Renal and urinary disorders
Renal impairment
|
0.9
|
|
|
Gastrointestinal disorders
Diarrhoea
|
0.8
|
|
|
Investigations
pH urine increased
|
0.8
|
|
|
Musculoskeletal and connective tissue disorders
Back pain
|
0.7
|
|
|
Investigations
Blood bilirubin increased
|
0.6
|
|
|
Investigations
Blood potassium increased
|
0.6
|
|
|
Investigations
Blood uric acid increased
|
0.6
|
|
|
Metabolism and nutrition disorders
Hypokalaemia
|
0.6
|
|
|
Gastrointestinal disorders
Vomiting
|
0.6
|
|
|
Respiratory, thoracic and mediastinal disorders
Tachypnoea
|
0.4
|
|
|