CHLORHEXIDINE GLUCONATE

Search structure


Trade Names:	BIOSCRUB BRIAN CARE CHG SCRUB CHLORHEXIDINE GLUCONATE CIDA-STAT EXIDINE E-Z SCRUB HIBICLENS HIBISTAT MICRODERM PAROEX PERIDEX PERIOCHIP PERIOGARD PHARMASEAL SCRUB CARE PREVACARE R READYPREP CHG STERI-STAT
Synonyms:	Acriflex Aerocide 1 Bacticlens Bioscrub Brian care Cepton Cetriclens Cetriclens fte Chg scrub Chlohexidine gluconate Chloraprep Chlorhex glucon Chlorhexidine d-digluconate Chlorhexidine digluconate Chlorhexidine gluconate Cida-stat Clinivex Corsodyl Corsodyl daily Corsodyl daily defence Curasept Cx 1 Cyteal Dispray 1 Dispray 2 Dyna-hex Eczmol Exidine E-z scrub Gppe soln Gppe tinct Gppe wsh Hibi Hibicet Hibiclens Hibidil Hibiscrub Hibispray Hibistat Hibitane plus Hydrex Microderm NSC-753971 Paroex Peridex Periochip Periogard Perio-kin Pharmaseal scrub care Phiso-med Prevacare Prevacare r Primahex Readyprep chg Rotersept Savloclens Savlodil Savlon hc Savlon jnr Sterets tisept Sterets uniscrub Sterets unisept Sterexidine Steri-stat Tarodent Tisept Uriflex-c
Status:	Approved (1976)
Entry Type:	Small molecule
Molecule Category:	Salt
UNII:	MOR84MUD8E
Parent Compound:	CHLORHEXIDINE

Structure


InChI Key	KUXUALPOSMRJSW-IFWQJVLJSA-N
Smile	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1.O=C(O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
InChI	InChI=1S/C22H30Cl2N10.C6H12O7/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;7-1-2(8)3(9)4(10)5(11)6(12)13/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2-5,7-11H,1H2,(H,12,13)/t;2-,3-,4+,5-/m.1/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C34H54Cl2N10O14
Molecular Weight	897.77
AlogP	4.18
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	10.0
Number of Rotational Bond	9.0
Polar Surface Area	167.58
Molecular species	BASE
Aromatic Rings	2.0
Heavy Atoms	34.0

Pharmacology

Action	Mechanism of Action	Reference
INHIBITOR	Cell membrane inhibitor	PubMed Wikipedia

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference
Pharyngitis	4	D010612	ClinicalTrials
Dental Caries	3	D003731	ClinicalTrials
Peri-Implantitis	3	D057873	ClinicalTrials
Infections	3	D007239	ClinicalTrials
Pneumonia	3	D011014	ClinicalTrials
Cystic Fibrosis	2	D003550	ClinicalTrials
Radiodermatitis	2	D011855	ClinicalTrials
Severe Acute Respiratory Syndrome	2	D045169	ClinicalTrials
HIV Infections	2	D015658	ClinicalTrials
Abscess	2	D000038	ClinicalTrials
Clostridium Infections	2	D003015	ClinicalTrials
Mucositis	2	D052016	ClinicalTrials
Stomatitis	2	D013280	ClinicalTrials
Sepsis	2	D018805	ClinicalTrials
Head and Neck Neoplasms	1	D006258	ClinicalTrials

Related Entries

Parent

Mixture

Mixture

Adverse Reactions

SOC By Demographic Distribution

System Organ Classification (SOC)

	Relative Frequency (%)
Gastrointestinal disorders	14.49
Skin and subcutaneous tissue disorders	13.57
General disorders and administration site conditions	13.25
Injury, poisoning and procedural complications	10.28
Nervous system disorders	7.88
Immune system disorders	7.08
Respiratory, thoracic and mediastinal disorders	5.24
Infections and infestations	4.04
Musculoskeletal and connective tissue disorders	3.88
Vascular disorders	3.52
Cardiac disorders	3.08
Investigations	2.92
Psychiatric disorders	2.92
Pregnancy, puerperium and perinatal conditions	2.52

Cross References

Resources	Reference
ChEBI	28312
ChEMBL	CHEMBL4297088
EPA CompTox	DTXSID5034519
FDA SRS	MOR84MUD8E
KEGG	C08038
PubChem	29089
SureChEMBL	SCHEMBL34468

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