CHLOROQUINE HYDROCHLORIDE

Search structure
Trade Names:
Synonyms:
Status: Approved (1949)
Entry Type: Small molecule
Molecule Category: Salt
UNII: NT0J0815S5
Parent Compound: CHLOROQUINE

Structure
InChI Key PTGMKRAMUHJZFD-UHFFFAOYSA-N
Smile CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12.Cl
InChI
InChI=1S/C18H26ClN3.ClH/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);1H

Physicochemical Descriptors

Property Name Value
Molecular Formula C18H28Cl3N3
Molecular Weight 392.8
AlogP 4.81
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 8.0
Polar Surface Area 28.16
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 22.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Ferriprotoporphyrin IX inhibitor PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Arthritis, Rheumatoid 3 D001172 ClinicalTrials
Lupus Erythematosus, Systemic 2 D008180 ClinicalTrials

Related Entries

Scaffolds

Parent

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
9.52
Nervous system disorders
9.27
Investigations
8.86
Cardiac disorders
7.7
Respiratory, thoracic and mediastinal disorders
7.62
Psychiatric disorders
7.28
Musculoskeletal and connective tissue disorders
6.21
Eye disorders
5.79
Injury, poisoning and procedural complications
5.46
Vascular disorders
4.72
Metabolism and nutrition disorders
3.97
Immune system disorders
3.64
Skin and subcutaneous tissue disorders
3.31
Gastrointestinal disorders
3.15
Infections and infestations
3.15
Blood and lymphatic system disorders
2.9

Cross References

Resources Reference
ChEMBL CHEMBL4297165
FDA SRS NT0J0815S5
PubChem 83820
SureChEMBL SCHEMBL9862220
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