Trade Names: | |
Synonyms: | |
Status: | Approved (1958) |
Entry Type: | Small molecule |
Molecule Category: | Parent |
ATC: | C03AA04 |
UNII: | 77W477J15H |
InChI Key | JBMKAUGHUNFTOL-UHFFFAOYSA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C7H6ClN3O4S2 |
Molecular Weight | 295.73 |
AlogP | -0.06 |
Hydrogen Bond Acceptor | 5.0 |
Hydrogen Bond Donor | 2.0 |
Number of Rotational Bond | 1.0 |
Polar Surface Area | 118.69 |
Molecular species | ACID |
Aromatic Rings | 1.0 |
Heavy Atoms | 17.0 |
Action | Mechanism of Action | Reference |
---|---|---|
INHIBITOR | Thiazide-sensitive sodium-chloride cotransporter inhibitor | DOI |
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
---|---|---|---|---|---|---|
Transporter
Electrochemical transporter
SLC superfamily of solute carriers
SLC21/SLCO family of organic anion transporting polypeptides
|
- | - | - | - | 70 |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Coronary Disease | 3 | D003327 | ClinicalTrials |
Heart Diseases | 3 | D006331 | ClinicalTrials |
Diabetes Mellitus, Type 2 | 3 | D003924 | ClinicalTrials |
Atherosclerosis | 3 | D050197 | ClinicalTrials |
Hypercholesterolemia | 3 | D006937 | ClinicalTrials |
Resources | Reference |
---|---|
CAS NUMBER | 58-94-6 |
ChEBI | 3640 |
ChEMBL | CHEMBL842 |
DrugBank | DB00880 |
DrugCentral | 609 |
EPA CompTox | DTXSID0022800 |
FDA SRS | 77W477J15H |
Human Metabolome Database | HMDB0015018 |
Guide to Pharmacology | 4835 |
KEGG | C07461 |
PharmGKB | PA448953 |
PubChem | 2720 |
SureChEMBL | SCHEMBL22329 |
ZINC | ZINC000003872055 |