DEXMEDETOMIDINE HYDROCHLORIDE

Search structure
Trade Names:
Synonyms:
Status: Approved (1999)
Entry Type: Small molecule
Molecule Category: Salt
UNII: 1018WH7F9I
Parent Compound: DEXMEDETOMIDINE

Structure
InChI Key VPNGEIHDPSLNMU-MERQFXBCSA-N
Smile Cc1cccc([C@H](C)c2c[nH]cn2)c1C.Cl
InChI
InChI=1S/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H/t11-;/m0./s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C13H17ClN2
Molecular Weight 236.75
AlogP 3.18
Hydrogen Bond Acceptor 1.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 2.0
Polar Surface Area 28.68
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 15.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Adrenergic receptor alpha-2 agonist DailyMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Pain 2 D010146 ClinicalTrials
Schizophrenia 2 D012559 ClinicalTrials
Psychotic Disorders 2 D011618 ClinicalTrials
Brain Injuries 2 D001930 ClinicalTrials
Amnesia 1 D000647 ClinicalTrials
Delirium 1 D003693 ClinicalTrials

Related Entries

Parent

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Cardiac disorders
16.44
Respiratory, thoracic and mediastinal disorders
11.85
Nervous system disorders
10.7
Injury, poisoning and procedural complications
10.33
General disorders and administration site conditions
9.88
Vascular disorders
9.12
Investigations
6.79
Psychiatric disorders
5.41
Metabolism and nutrition disorders
3.21
Pregnancy, puerperium and perinatal conditions
2.97
Gastrointestinal disorders
2.43

Cross References

Resources Reference
ChEBI 31472
ChEMBL CHEMBL2106195
EPA CompTox DTXSID40873215
FDA SRS 1018WH7F9I
KEGG C07450
PubChem 6918081
SureChEMBL SCHEMBL406837
ZINC ZINC04632106
CONTENTS