DrugMapper


Trade Names:	DICLOFENAC ZORVOLEX
Synonyms:	Arthrotec Cambia Cataflam Diclofenac Diclofenac free acid Las41007 LAS-41007 LAS41007 Solaraze Voltaren Voltaren Ophthalmic Voltaren Xr Voltaren-XR Zorvolex Zorvolex capsules
Status:	Approved (1988)
Entry Type:	Small molecule
Molecule Category:	Parent
ATC:	D11AX18
UNII:	144O8QL0L1


InChI Key	DCOPUUMXTXDBNB-UHFFFAOYSA-N
Smile	O=C(O)Cc1ccccc1Nc1c(Cl)cccc1Cl
InChI	InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19)

Property Name	Value
Molecular Formula	C14H11Cl2NO2
Molecular Weight	296.15
AlogP	4.36
Hydrogen Bond Acceptor	2.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	4.0
Polar Surface Area	49.33
Molecular species	ACID
Aromatic Rings	2.0
Heavy Atoms	19.0

Property Name	Value	Unit	Method
log P (octanol-water)	4.51	-	EXP
pKa Dissociation Constant	4.15	-	EXP
Henry's Law Constant	4.73E-12	atm-m3/mole	EST
Atmospheric OH Rate Constant	1.65E-10	cm3/molecule-sec	EST
Water Solubility	2.37	mg/L	EXP
Vapor Pressure	6.14E-08	mm Hg	EST

Action	Mechanism of Action	Reference
INHIBITOR	Cyclooxygenase inhibitor	FDA PubMed PubMed PubMed

	Primary Target
COX-1
COX-2

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Auxiliary transport protein Fatty acid binding protein family	-	-	-	3220-35400	-
Enzyme Oxidoreductase	-	5-23620	-	-	90-100
Enzyme Protease Aspartic protease Aspartic protease AD clan Aspartic protease A22A subfamily Aspartic protease A22A regulatory subfamily	-	-	-	-	17
Enzyme Transferase	-	-	-	11000	0
Enzyme	-	5-23620	-	11000	90-100
Ion channel Other ion channel Miscellaneous ion channel Presenilin ER Ca2+ leak channel family	-	-	-	-	17
Ion channel Voltage-gated ion channel Transient receptor potential channel	56000-63096	-	-	-	-
Ion channel Voltage-gated ion channel Voltage-gated calcium channel	-	12890	-	-	-
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Chemokine receptor CXC chemokine receptor	-	12	-	-	-
Secreted protein	-	8	60-1000	-	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	20
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters	-	-	-	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC47 family of multidrug and toxin extrusion transporters	-	-	-	-	12
Transporter Primary active transporter ATP-binding cassette ABCB subfamily	-	44000-64970	-	-	-
Transporter Primary active transporter Oxidoreduction-driven transporters	-	10050	-	-	-

Mesh Heading	Maximum Phase	Mesh ID	Reference
Pain	4	D010146	ClinicalTrials
Keratosis, Actinic	4	D055623	ClinicalTrials
Infertility	3	D007246	ClinicalTrials
Osteoarthritis, Hip	3	D015207	ClinicalTrials
Osteoarthritis, Knee	3	D020370	ClinicalTrials
Renal Colic	3	D056844	ClinicalTrials
Stomach Ulcer	3	D013276	ClinicalTrials
Toothache	3	D014098	ClinicalTrials
Spondylitis, Ankylosing	3	D013167	ClinicalTrials
Carcinoma	2	D002277	ClinicalTrials
Mastodynia	2	D059373	ClinicalTrials
Pulmonary Embolism	2	D011655	ClinicalTrials
Carcinoma, Basal Cell	2	D002280	ClinicalTrials
Neoplasms	1	D009369	ClinicalTrials
Aging	1	D000375	ClinicalTrials
Depressive Disorder	1	D003866	ClinicalTrials
Periodontitis	1	D010518	ClinicalTrials

Side Effects (PT)

Side effects	Relative Frequency (%)	Labels
General disorders and administration site conditions Application site reaction	84.0
General disorders and administration site conditions Application site reaction	75.0
General disorders and administration site conditions Application site reaction	71.0
General disorders and administration site conditions Application site reaction	70.0
Skin and subcutaneous tissue disorders Pruritus	59.0
Skin and subcutaneous tissue disorders Pruritus	52.0
Skin and subcutaneous tissue disorders Dermatitis	46.0
Skin and subcutaneous tissue disorders Rash	46.0
Skin and subcutaneous tissue disorders Pruritus	45.0
Skin and subcutaneous tissue disorders Dry skin	41.9
Musculoskeletal and connective tissue disorders Arthralgia	40.4
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort	40.4
Musculoskeletal and connective tissue disorders Arthralgia
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort
Gastrointestinal disorders Nausea
Skin and subcutaneous tissue disorders Dermatitis	35.0
Skin and subcutaneous tissue disorders Rash	35.0
Immune system disorders Dermatitis contact	33.0
General disorders and administration site conditions Oedema	33.0
Nervous system disorders Headache	32.7
Skin and subcutaneous tissue disorders Dry skin	32.1
Skin and subcutaneous tissue disorders Dry skin	32.0
General disorders and administration site conditions Oedema
Skin and subcutaneous tissue disorders Pruritus	31.0
General disorders and administration site conditions Pain	30.0
Skin and subcutaneous tissue disorders Dry skin	27.0
Gastrointestinal disorders Nausea	27.0
Nervous system disorders Headache
General disorders and administration site conditions Pain	26.0
Skin and subcutaneous tissue disorders Dry skin	25.0
Skin and subcutaneous tissue disorders Skin exfoliation	24.0
Skin and subcutaneous tissue disorders Dry skin	23.3
Skin and subcutaneous tissue disorders Dry skin	23.1
General disorders and administration site conditions Pain	22.0
Gastrointestinal disorders Nausea
Skin and subcutaneous tissue disorders Dermatitis	20.0
Nervous system disorders Paraesthesia	20.0
Skin and subcutaneous tissue disorders Rash	20.0
Immune system disorders Dermatitis contact	19.0
General disorders and administration site conditions Pain	17.3
Nervous system disorders Headache
Skin and subcutaneous tissue disorders Dermatitis	17.0
Skin and subcutaneous tissue disorders Dry skin	17.0
Skin and subcutaneous tissue disorders Rash	17.0
Musculoskeletal and connective tissue disorders Arthralgia	16.8
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort	16.8
Musculoskeletal and connective tissue disorders Arthralgia	16.5
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort	16.5
Cardiac disorders Dizziness
Musculoskeletal and connective tissue disorders Arthropathy
Musculoskeletal and connective tissue disorders Back pain	15.4
Musculoskeletal and connective tissue disorders Osteoarthritis
Nervous system disorders Headache
General disorders and administration site conditions Pain	15.0
Nervous system disorders Headache	13.1
Nervous system disorders Headache	13.0
Skin and subcutaneous tissue disorders Skin exfoliation	13.0
Nervous system disorders Headache	12.1
Musculoskeletal and connective tissue disorders Arthropathy
Skin and subcutaneous tissue disorders Dry skin	12.0
Musculoskeletal and connective tissue disorders Osteoarthritis
Gastrointestinal disorders Vomiting
Infections and infestations Infection	11.5
General disorders and administration site conditions Pain
Nervous system disorders Paraesthesia
Skin and subcutaneous tissue disorders Dermatitis	10.0
Cardiac disorders Dizziness	10.0
Infections and infestations Influenza	10.0
Skin and subcutaneous tissue disorders Rash	10.0
Skin and subcutaneous tissue disorders Dermatitis	9.64
Skin and subcutaneous tissue disorders Rash	9.64
Gastrointestinal disorders Dyspepsia	9.62
Immune system disorders Dermatitis contact	9.11
Nervous system disorders Paraesthesia	9.05
Gastrointestinal disorders Gastrointestinal disorder	9.0
General disorders and administration site conditions Induration	9.0
Gastrointestinal disorders Vomiting	9.0
Gastrointestinal disorders Constipation	8.0
Nervous system disorders Headache	8.0
Metabolism and nutrition disorders Malnutrition	8.0
Nervous system disorders Paraesthesia	8.0
Gastrointestinal disorders Pharyngitis	8.0
Skin and subcutaneous tissue disorders Pruritus
Skin and subcutaneous tissue disorders Pruritus	8.0
Infections and infestations Upper respiratory tract infection	8.0
Gastrointestinal disorders Vomiting
Gastrointestinal disorders Dyspepsia	7.9
Nervous system disorders Paraesthesia	7.85
Musculoskeletal and connective tissue disorders Arthropathy	7.69
Skin and subcutaneous tissue disorders Dermatitis	7.69
Musculoskeletal and connective tissue disorders Osteoarthritis	7.69
Nervous system disorders Paraesthesia	7.69
Skin and subcutaneous tissue disorders Rash	7.69
Musculoskeletal and connective tissue disorders Back pain
Nervous system disorders Headache	7.0
Metabolism and nutrition disorders Malnutrition	7.0
Gastrointestinal disorders Nausea	7.0
Skin and subcutaneous tissue disorders Pruritus	7.0
Skin and subcutaneous tissue disorders Skin exfoliation	7.0
Infections and infestations Urinary tract infection	7.0
Skin and subcutaneous tissue disorders Dry skin
Gastrointestinal disorders Pharyngitis
General disorders and administration site conditions Application site reaction	6.79
Musculoskeletal and connective tissue disorders Back pain	6.5
General disorders and administration site conditions Pain	6.33
General disorders and administration site conditions Pain	6.05
Gastrointestinal disorders Diarrhoea	6.0
Gastrointestinal disorders Gastrointestinal disorder
Gastrointestinal disorders Gastrointestinal disorder	6.0
Nervous system disorders Headache	6.0
Infections and infestations Infection	6.0
Infections and infestations Influenza	6.0
Infections and infestations Nasopharyngitis	6.0
Gastrointestinal disorders Nausea	6.0
Skin and subcutaneous tissue disorders Pruritus
Skin and subcutaneous tissue disorders Pruritus	6.0
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Skin cancer	6.0
Skin and subcutaneous tissue disorders Skin exfoliation	6.0
Gastrointestinal disorders Abdominal pain	5.93
Gastrointestinal disorders Gastrointestinal pain	5.93
General disorders and administration site conditions Application site reaction	5.77
Gastrointestinal disorders Pharyngitis	5.77
Musculoskeletal and connective tissue disorders Back pain	5.66
Musculoskeletal and connective tissue disorders Arthropathy	5.43
Musculoskeletal and connective tissue disorders Osteoarthritis	5.43
Gastrointestinal disorders Pharyngitis	5.38
Cardiac disorders Dizziness
Gastrointestinal disorders Abdominal pain
Gastrointestinal disorders Gastrointestinal pain
Skin and subcutaneous tissue disorders Dry skin
Gastrointestinal disorders Constipation	5.0
Infections and infestations Infection	5.0
Musculoskeletal and connective tissue disorders Osteoarthritis	5.0
Skin and subcutaneous tissue disorders Pruritus	5.0
Infections and infestations Sinusitis	5.0
Skin and subcutaneous tissue disorders Dermatitis	4.98
Skin and subcutaneous tissue disorders Rash	4.98
Musculoskeletal and connective tissue disorders Arthropathy	4.71
Musculoskeletal and connective tissue disorders Osteoarthritis	4.71
Gastrointestinal disorders Dysgeusia
Infections and infestations Infection
Infections and infestations Influenza
Skin and subcutaneous tissue disorders Pruritus	4.52
Gastrointestinal disorders Dyspepsia	4.48
Gastrointestinal disorders Pharyngitis	4.39
Infections and infestations Influenza	4.07
Musculoskeletal and connective tissue disorders Arthropathy	4.04
Infections and infestations Influenza	4.04
Musculoskeletal and connective tissue disorders Osteoarthritis	4.04
Skin and subcutaneous tissue disorders Acne	4.0
Investigations Alanine aminotransferase increased	4.0
Musculoskeletal and connective tissue disorders Back pain	4.0
Investigations Blood creatine phosphokinase increased	4.0
Eye disorders Conjunctivitis	4.0
Gastrointestinal disorders Constipation
Respiratory, thoracic and mediastinal disorders Cough	4.0
Skin and subcutaneous tissue disorders Dermatitis	4.0
Skin and subcutaneous tissue disorders Dermatitis bullous	4.0
Immune system disorders Dermatitis contact	4.0
Cardiac disorders Dizziness	4.0
Skin and subcutaneous tissue disorders Dry skin	4.0
Gastrointestinal disorders Dyspepsia
Gastrointestinal disorders Dyspepsia	4.0
Skin and subcutaneous tissue disorders Erythema	4.0
Nervous system disorders Headache	4.0
Infections and infestations Infection	4.0
Infections and infestations Influenza	4.0
Injury, poisoning and procedural complications Injury	4.0
General disorders and administration site conditions Oedema	4.0
Nervous system disorders Paraesthesia	4.0
Gastrointestinal disorders Pharyngitis	4.0
Skin and subcutaneous tissue disorders Pruritus
Skin and subcutaneous tissue disorders Pruritus	4.0
Skin and subcutaneous tissue disorders Rash	4.0
Infections and infestations Rash pustular	4.0
Skin and subcutaneous tissue disorders Skin exfoliation	4.0
Gastrointestinal disorders Dyspepsia
Gastrointestinal disorders Pharyngitis
Musculoskeletal and connective tissue disorders Arthropathy	3.85
Skin and subcutaneous tissue disorders Dermatitis	3.85
Gastrointestinal disorders Dyspepsia	3.85
Gastrointestinal disorders Nausea	3.85
Musculoskeletal and connective tissue disorders Osteoarthritis	3.85
Skin and subcutaneous tissue disorders Pruritus	3.85
Skin and subcutaneous tissue disorders Rash	3.85
Gastrointestinal disorders Flatulence	3.84
Gastrointestinal disorders Dysgeusia	3.81
Skin and subcutaneous tissue disorders Pruritus	3.73
Gastrointestinal disorders Diarrhoea	3.62
Gastrointestinal disorders Dysgeusia	3.62
Gastrointestinal disorders Nausea	3.62
General disorders and administration site conditions Application site rash	3.5
Gastrointestinal disorders Abdominal pain
Gastrointestinal disorders Gastrointestinal pain
Gastrointestinal disorders Constipation	3.18
Gastrointestinal disorders Abdominal pain	3.14
Gastrointestinal disorders Gastrointestinal pain	3.14
Infections and infestations Infection	3.14
Infections and infestations Urinary tract infection	3.08
Gastrointestinal disorders Abdominal pain
Gastrointestinal disorders Gastrointestinal pain
Gastrointestinal disorders Abdominal pain upper	3.0
Musculoskeletal and connective tissue disorders Arthralgia	3.0
Investigations Aspartate aminotransferase increased	3.0
Musculoskeletal and connective tissue disorders Back pain	3.0
Infections and infestations Bronchitis	3.0
Injury, poisoning and procedural complications Contusion	3.0
Gastrointestinal disorders Diarrhoea
Gastrointestinal disorders Diarrhoea	3.0
Cardiac disorders Dizziness	3.0
Skin and subcutaneous tissue disorders Dry skin	3.0
Gastrointestinal disorders Dyspepsia	3.0
Gastrointestinal disorders Flatulence	3.0
Nervous system disorders Headache
Skin and subcutaneous tissue disorders Hyperaesthesia	3.0
Immune system disorders Hypersensitivity	3.0
Vascular disorders Hypertension	3.0
Infections and infestations Influenza	3.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort	3.0
Musculoskeletal and connective tissue disorders Myalgia	3.0
Gastrointestinal disorders Nausea	3.0
Nervous system disorders Nervous system disorder	3.0
General disorders and administration site conditions Oedema	3.0
Musculoskeletal and connective tissue disorders Pain in extremity	3.0
Skin and subcutaneous tissue disorders Photosensitivity reaction	3.0
General disorders and administration site conditions Procedural pain	3.0
Infections and infestations Sinusitis	3.0
Gastrointestinal disorders Vomiting	3.0
Skin and subcutaneous tissue disorders Pruritus	2.91
Skin and subcutaneous tissue disorders Dermatitis
Skin and subcutaneous tissue disorders Rash
General disorders and administration site conditions Oedema	2.85
Gastrointestinal disorders Constipation
Gastrointestinal disorders Diarrhoea
Skin and subcutaneous tissue disorders Dermatitis	2.74
Infections and infestations Infection	2.74
Skin and subcutaneous tissue disorders Rash	2.74
Infections and infestations Infection	2.71
Gastrointestinal disorders Pharyngitis	2.71
Musculoskeletal and connective tissue disorders Osteoarthritis	2.6
General disorders and administration site conditions Application site reaction	2.47
Gastrointestinal disorders Dyspepsia
Infections and infestations Infection
Injury, poisoning and procedural complications Injury	2.41
Gastrointestinal disorders Nausea	2.26
General disorders and administration site conditions Application site reaction
Gastrointestinal disorders Diarrhoea
Injury, poisoning and procedural complications Injury
Skin and subcutaneous tissue disorders Pruritus
Skin and subcutaneous tissue disorders Dry skin	2.09
Blood and lymphatic system disorders Ecchymosis	2.09
Skin and subcutaneous tissue disorders Dermatitis	2.02
Gastrointestinal disorders Nausea	2.02
Nervous system disorders Paraesthesia	2.02
Skin and subcutaneous tissue disorders Rash	2.02
Gastrointestinal disorders Abdominal discomfort	2.0
Gastrointestinal disorders Abdominal pain	2.0
Skin and subcutaneous tissue disorders Acne	2.0
Investigations Alanine aminotransferase increased	2.0
Skin and subcutaneous tissue disorders Alopecia	2.0
Psychiatric disorders Anxiety	2.0
Musculoskeletal and connective tissue disorders Arthralgia	2.0
Musculoskeletal and connective tissue disorders Arthropathy	2.0
Investigations Aspartate aminotransferase increased	2.0
General disorders and administration site conditions Asthenia	2.0
Immune system disorders Asthma	2.0
Musculoskeletal and connective tissue disorders Back pain	2.0
Investigations Blood creatinine increased	2.0
Cardiac disorders Chest pain	2.0
General disorders and administration site conditions Chills	2.0
Eye disorders Conjunctivitis	2.0
Gastrointestinal disorders Constipation	2.0
Skin and subcutaneous tissue disorders Dermatitis	2.0
Immune system disorders Dermatitis contact	2.0
Gastrointestinal disorders Diarrhoea	2.0
Cardiac disorders Dizziness	2.0
Gastrointestinal disorders Dysgeusia	2.0
Gastrointestinal disorders Dyspepsia	2.0
Cardiac disorders Dyspnoea	2.0
Eye disorders Eye pain	2.0
Gastrointestinal disorders Flatulence
Gastrointestinal disorders Flatulence	2.0
Gastrointestinal disorders Gastrointestinal pain	2.0
Renal and urinary disorders Haematuria	2.0
Nervous system disorders Headache
Nervous system disorders Headache	2.0
Infections and infestations Herpes simplex	2.0
Metabolism and nutrition disorders Hypercholesterolaemia	2.0
Endocrine disorders Hyperglycaemia	2.0
Vascular disorders Hypertension	2.0
Nervous system disorders Hypokinesia	2.0
General disorders and administration site conditions Induration	2.0
Injury, poisoning and procedural complications Injury	2.0
Metabolism and nutrition disorders Malnutrition	2.0
Nervous system disorders Migraine	2.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort	2.0
Musculoskeletal and connective tissue disorders Myalgia	2.0
Gastrointestinal disorders Nausea
Gastrointestinal disorders Nausea	2.0
Musculoskeletal and connective tissue disorders Neck pain	2.0
Nervous system disorders Nervous system disorder	2.0
General disorders and administration site conditions Oedema	2.0
Musculoskeletal and connective tissue disorders Osteoarthritis	2.0
General disorders and administration site conditions Pain	2.0
Gastrointestinal disorders Pharyngitis	2.0
Vascular disorders Phlebitis	2.0
Skin and subcutaneous tissue disorders Photosensitivity reaction	2.0
Infections and infestations Pneumonia	2.0
Skin and subcutaneous tissue disorders Pruritus	2.0
Skin and subcutaneous tissue disorders Rash	2.0
Skin and subcutaneous tissue disorders Rash maculo-papular	2.0
Infections and infestations Rhinitis	2.0
Infections and infestations Sinusitis	2.0
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Skin cancer	2.0
Skin and subcutaneous tissue disorders Skin mass	2.0
Skin and subcutaneous tissue disorders Skin ulcer	2.0
Immune system disorders Dermatitis contact	1.98
Skin and subcutaneous tissue disorders Pruritus
Nervous system disorders Somnolence
Skin and subcutaneous tissue disorders Dermatitis	1.81
Immune system disorders Dermatitis contact
Skin and subcutaneous tissue disorders Rash	1.81
General disorders and administration site conditions Application site reaction
Gastrointestinal disorders Nausea
Skin and subcutaneous tissue disorders Pruritus	1.65
Gastrointestinal disorders Abdominal pain	1.58
Gastrointestinal disorders Gastrointestinal pain	1.58
Nervous system disorders Paraesthesia	1.58
General disorders and administration site conditions Application site induration	1.54
Injury, poisoning and procedural complications Contusion	1.54
Gastrointestinal disorders Nausea	1.54
Nervous system disorders Paraesthesia	1.54
Respiratory, thoracic and mediastinal disorders Sinus congestion	1.54
Skin and subcutaneous tissue disorders Dermatitis
Skin and subcutaneous tissue disorders Rash
General disorders and administration site conditions Application site reaction	1.21
Gastrointestinal disorders Breath odour	1.21
Nervous system disorders Paraesthesia
General disorders and administration site conditions Application site reaction	1.13
Infections and infestations Sinusitis	1.1
Gastrointestinal disorders Abdominal pain	1.0
Gastrointestinal disorders Abdominal pain upper
Skin and subcutaneous tissue disorders Acne	1.0
Skin and subcutaneous tissue disorders Alopecia	1.0
Psychiatric disorders Anxiety	1.0
Investigations Blood creatine phosphokinase increased	1.0
Investigations Blood creatinine increased	1.0
Cardiac disorders Chest pain	1.0
Eye disorders Conjunctivitis	1.0
Skin and subcutaneous tissue disorders Dermatitis	1.0
Skin and subcutaneous tissue disorders Dermatitis bullous	1.0
Cardiac disorders Dizziness	1.0
Gastrointestinal disorders Dysgeusia	1.0
Gastrointestinal disorders Dyspepsia
Gastrointestinal disorders Dyspepsia	1.0
Gastrointestinal disorders Gastrointestinal pain	1.0
Renal and urinary disorders Haematuria	1.0
Nervous system disorders Headache	1.0
Skin and subcutaneous tissue disorders Hyperaesthesia	1.0
Metabolism and nutrition disorders Hypercholesterolaemia	1.0
Endocrine disorders Hyperglycaemia	1.0
Immune system disorders Hypersensitivity	1.0
Vascular disorders Hypertension
Vascular disorders Hypertension	1.0
Infections and infestations Influenza	1.0
Nervous system disorders Migraine	1.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort	1.0
Musculoskeletal and connective tissue disorders Myalgia	1.0
General disorders and administration site conditions Pain	1.0
Musculoskeletal and connective tissue disorders Pain in extremity
Nervous system disorders Paraesthesia
Nervous system disorders Paraesthesia	1.0
Infections and infestations Pneumonia	1.0
Skin and subcutaneous tissue disorders Pruritus	1.0
Infections and infestations Rash pustular	1.0
Skin and subcutaneous tissue disorders Scab	1.0
Infections and infestations Sinusitis
Skin and subcutaneous tissue disorders Skin ulcer	1.0
Nervous system disorders Somnolence
Nervous system disorders Somnolence	1.0
Gastrointestinal disorders Vomiting
General disorders and administration site conditions Application site reaction
Gastrointestinal disorders Nausea
Nervous system disorders Paraesthesia
General disorders and administration site conditions Application site induration	0.775
Injury, poisoning and procedural complications Contusion	0.775
Respiratory, thoracic and mediastinal disorders Sinus congestion	0.775
Infections and infestations Urinary tract infection	0.775
General disorders and administration site conditions Application site pruritus	0.767
Musculoskeletal and connective tissue disorders Arthritis	0.7
Immune system disorders Rheumatoid arthritis	0.7
General disorders and administration site conditions Application site rash
General disorders and administration site conditions Application site erythema	0.657
General disorders and administration site conditions Hyperhidrosis
Skin and subcutaneous tissue disorders Pruritus
Infections and infestations Sinusitis
General disorders and administration site conditions Application site paraesthesia	0.548
Cardiac disorders Dizziness
General disorders and administration site conditions Application site dryness	0.438
General disorders and administration site conditions Application site dryness
General disorders and administration site conditions Application site erythema
General disorders and administration site conditions Application site paraesthesia
General disorders and administration site conditions Application site vesicles	0.329
Gastrointestinal disorders Breath odour
Gastrointestinal disorders Constipation
Skin and subcutaneous tissue disorders Dry skin
Blood and lymphatic system disorders Ecchymosis
Gastrointestinal disorders Flatulence
General disorders and administration site conditions Application site irritation	0.219
General disorders and administration site conditions Flushing	0.2
Immune system disorders Urticaria	0.2
General disorders and administration site conditions Application site pruritus
General disorders and administration site conditions Application site papules	0.11

Resources	Reference
CAS NUMBER	15307-86-5
ChEBI	47381
ChEMBL	CHEMBL139
DrugBank	DB00586
DrugCentral	865
EPA CompTox	DTXSID6022923
FDA SRS	144O8QL0L1
Human Metabolome Database	HMDB0014724
Guide to Pharmacology	2714
KEGG	C01690
PDB	DIF
PharmGKB	PA449293
PubChem	3033
SureChEMBL	SCHEMBL2799
ZINC	ZINC000000001281

DICLOFENAC

Structure

Physicochemical Descriptors

Experimental and Estimated Properties

Pharmacology

Metabolites

Indications

Related Entries

MCS

Scaffolds

Side Effects from Label

Adverse Reactions

Cross References

	Relative Frequency (%)
Gastrointestinal disorders	24.68
General disorders and administration site conditions	14.29
Skin and subcutaneous tissue disorders	9.81
Vascular disorders	8.23
Nervous system disorders	7.94
Immune system disorders	5.77
Injury, poisoning and procedural complications	5.77
Cardiac disorders	5.05
Musculoskeletal and connective tissue disorders	3.32
Hepatobiliary disorders	2.6
Respiratory, thoracic and mediastinal disorders	2.6


Active Pharmaceutical Ingredients (APIs) Scaffolds	Exact Similarity SubStructure	Threshold (%) >= 70