Structure

InChI Key PCHPORCSPXIHLZ-UHFFFAOYSA-N
Smile CN(C)CCOC(c1ccccc1)c1ccccc1.Cl
InChI
InChI=1S/C17H21NO.ClH/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;/h3-12,17H,13-14H2,1-2H3;1H

Physicochemical Descriptors

Property Name Value
Molecular Formula C17H22ClNO
Molecular Weight 291.82
AlogP 3.35
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 6.0
Polar Surface Area 12.47
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 19.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Histamine H1 receptor antagonist PubMed PubMed Wikipedia

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Lupus Erythematosus, Systemic 3 D008180 ClinicalTrials
Headache 3 D006261 ClinicalTrials
Breast Neoplasms 2 D001943 ClinicalTrials
Diabetic Neuropathies 2 D003929 ClinicalTrials
Lymphoma, Large B-Cell, Diffuse 2 D016403 ClinicalTrials
Kidney Neoplasms 2 D007680 ClinicalTrials
Leukemia, Lymphocytic, Chronic, B-Cell 1 D015451 ClinicalTrials
Pain 1 D010146 ClinicalTrials
Rhinitis, Allergic, Seasonal 1 D006255 ClinicalTrials
Hypotension, Orthostatic 1 D007024 ClinicalTrials
Rectal Neoplasms 1 D012004 ClinicalTrials
Hypersensitivity 1 D006967 ClinicalTrials

Related Entries

Parent
Mixture
Mixture
Mixture

Adverse Reactions

System Organ Classification (SOC)
Relative Frequency (%)
Injury, poisoning and procedural complications
19.39
Psychiatric disorders
15.3
General disorders and administration site conditions
13.18
Nervous system disorders
12.72
Cardiac disorders
6.14
Respiratory, thoracic and mediastinal disorders
4.68
Investigations
4.52
Immune system disorders
4.5
Vascular disorders
4.2
Gastrointestinal disorders
3.24
Skin and subcutaneous tissue disorders
2.95
Musculoskeletal and connective tissue disorders
2.39

Cross References

Resources Reference
ChEBI 4637
ChEMBL CHEMBL1620
EPA CompTox DTXSID4020537
FDA SRS TC2D6JAD40
KEGG C07784
PubChem 8980
SureChEMBL SCHEMBL17071