DOCETAXEL

Search structure
Trade Names:
Synonyms:
Status: Approved (1996)
Entry Type: Small molecule
Molecule Category: Parent
ATC: L01CD02
UNII: 699121PHCA

Structure
InChI Key ZDZOTLJHXYCWBA-VCVYQWHSSA-N
Smile CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C
InChI
InChI=1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C43H53NO14
Molecular Weight 807.89
AlogP 3.26
Hydrogen Bond Acceptor 14.0
Hydrogen Bond Donor 5.0
Number of Rotational Bond 8.0
Polar Surface Area 224.45
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 58.0

Experimental and Estimated Properties

Property Name Value Unit Method
log P (octanol-water) 2.830 - EST
Henry's Law Constant 8.10E-24 atm-m3/mole EST
Atmospheric OH Rate Constant 2.20E-10 cm3/molecule-sec EST
Melting Point 232 deg C EXP
Water Solubility 0.025 mg/L EST
Vapor Pressure 1.90E-28 mm Hg EST

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Tubulin inhibitor Wikipedia FDA
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase EGFR family
- - 1 - -
Membrane receptor Family B G protein-coupled receptor Peptide receptor (family B GPCR) Glucagon-like receptor Growth hormone-releasing hormone receptor
- 0 - - -
Structural protein
- 500 - - -
Transporter Primary active transporter ATP-binding cassette ABCB subfamily
- 41000 - - -
Unclassified protein
- 5012 - - 98

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Neoplasms 4 D009369 ClinicalTrials
Breast Neoplasms 4 D001943 ClinicalTrials
Breast Neoplasms 4 D001943 ClinicalTrials
Neoplasms 4 D009369 ClinicalTrials
Carcinoma, Squamous Cell 3 D002294 ClinicalTrials
Head and Neck Neoplasms 3 D006258 ClinicalTrials
Urinary Bladder Neoplasms 3 D001749 ClinicalTrials
Esophageal Neoplasms 3 D004938 ClinicalTrials
Carcinoma, Squamous Cell 3 D002294 ClinicalTrials
Ovarian Neoplasms 3 D010051 ClinicalTrials
Carcinoma 3 D002277 ClinicalTrials
Stomach Neoplasms 3 D013274 ClinicalTrials
Nasopharyngeal Neoplasms 3 D009303 ClinicalTrials
Prostatic Neoplasms 3 D011471 ClinicalTrials
Prostatic Neoplasms 3 D011471 ClinicalTrials
Prostatic Neoplasms 3 D011471 ClinicalTrials
Stomach Neoplasms 3 D013274 ClinicalTrials
Sarcoma 3 D012509 ClinicalTrials
Uterine Cervical Neoplasms 3 D002583 ClinicalTrials
Hypersensitivity 3 D006967 ClinicalTrials
Laryngeal Neoplasms 3 D007822 ClinicalTrials
Urogenital Neoplasms 3 D014565 ClinicalTrials
Ovarian Neoplasms 3 D010051 ClinicalTrials
Pharyngeal Neoplasms 3 D010610 ClinicalTrials
Esophageal Neoplasms 3 D004938 ClinicalTrials
Head and Neck Neoplasms 3 D006258 ClinicalTrials
Inflammatory Breast Neoplasms 3 D058922 ClinicalTrials
Peritoneal Neoplasms 3 D010534 ClinicalTrials
Oropharyngeal Neoplasms 3 D009959 ClinicalTrials
Sarcoma 3 D012509 ClinicalTrials
Ovarian Neoplasms 3 D010051 ClinicalTrials
Adenocarcinoma of Lung 3 D000077192 ClinicalTrials
Urinary Bladder Neoplasms 3 D001749 ClinicalTrials
Neoplasm Metastasis 3 D009362 ClinicalTrials
Hypopharyngeal Neoplasms 3 D007012 ClinicalTrials
Kidney Neoplasms 3 D007680 ClinicalTrials
Genital Neoplasms, Male 3 D005834 ClinicalTrials
Anorexia 3 D000855 ClinicalTrials
Cachexia 3 D002100 ClinicalTrials
Fatigue 3 D005221 ClinicalTrials
Stomach Neoplasms 3 D013274 ClinicalTrials
Urinary Bladder Neoplasms 3 D001749 ClinicalTrials
Neutropenia 3 D009503 ClinicalTrials
Head and Neck Neoplasms 3 D006258 ClinicalTrials
Peritoneal Neoplasms 3 D010534 ClinicalTrials
Fallopian Tube Neoplasms 3 D005185 ClinicalTrials
Laryngeal Neoplasms 3 D007822 ClinicalTrials
Kidney Neoplasms 3 D007680 ClinicalTrials
Uterine Cervical Neoplasms 3 D002583 ClinicalTrials
Urethral Neoplasms 3 D014523 ClinicalTrials
Esophageal Neoplasms 3 D004938 ClinicalTrials
Ovarian Neoplasms 3 D010051 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 3 D064129 ClinicalTrials
Lung Neoplasms 3 D008175 ClinicalTrials
Endometrial Neoplasms 3 D016889 ClinicalTrials
Lung Neoplasms 3 D008175 ClinicalTrials
Head and Neck Neoplasms 3 D006258 ClinicalTrials
Esophageal Neoplasms 3 D004938 ClinicalTrials
Paranasal Sinus Neoplasms 3 D010255 ClinicalTrials
Endometrial Neoplasms 3 D016889 ClinicalTrials
Mouth Neoplasms 3 D009062 ClinicalTrials
Stomach Neoplasms 3 D013274 ClinicalTrials
Carcinoma, Squamous Cell 3 D002294 ClinicalTrials
Leukemia 2 D007938 ClinicalTrials
Carcinoma, Intraductal, Noninfiltrating 2 D002285 ClinicalTrials
Retroviridae Infections 2 D012192 ClinicalTrials
Tonsillar Neoplasms 2 D014067 ClinicalTrials
Pancreatic Neoplasms 2 D010190 ClinicalTrials
Mediastinal Neoplasms 2 D008479 ClinicalTrials
Carcinoma, Transitional Cell 2 D002295 ClinicalTrials
Squamous Cell Carcinoma of Head and Neck 2 D000077195 ClinicalTrials
Liver Neoplasms 2 D008113 ClinicalTrials
Colorectal Neoplasms 2 D015179 ClinicalTrials
Gastrointestinal Stromal Tumors 2 D046152 ClinicalTrials
Hereditary Breast and Ovarian Cancer Syndrome 2 D061325 ClinicalTrials
Penile Neoplasms 2 D010412 ClinicalTrials
Uterine Neoplasms 2 D014594 ClinicalTrials
Colorectal Neoplasms 2 D015179 ClinicalTrials
Biliary Tract Neoplasms 2 D001661 ClinicalTrials
Carcinoma, Hepatocellular 2 D006528 ClinicalTrials
Adenocarcinoma 2 D000230 ClinicalTrials
Leiomyosarcoma 2 D007890 ClinicalTrials
Osteosarcoma 2 D012516 ClinicalTrials
Anus Neoplasms 2 D001005 ClinicalTrials
Small Cell Lung Carcinoma 2 D055752 ClinicalTrials
Melanoma 2 D008545 ClinicalTrials
Squamous Cell Carcinoma of Head and Neck 2 D000077195 ClinicalTrials
Melanoma 2 D008545 ClinicalTrials
Carcinoma, Neuroendocrine 2 D018278 ClinicalTrials
Pancreatic Neoplasms 2 D010190 ClinicalTrials
Biliary Tract Neoplasms 2 D001661 ClinicalTrials
Thyroid Carcinoma, Anaplastic 2 D065646 ClinicalTrials
Testicular Neoplasms 2 D013736 ClinicalTrials
Testicular Neoplasms 2 D013736 ClinicalTrials
Triple Negative Breast Neoplasms 2 D064726 ClinicalTrials
Carcinoma, Renal Cell 1 D002292 ClinicalTrials
Sarcoma, Synovial 1 D013584 ClinicalTrials
Nausea 1 D009325 ClinicalTrials
Carcinoma, Endometrioid 1 D018269 ClinicalTrials
Myelodysplastic Syndromes 1 D009190 ClinicalTrials
Colonic Neoplasms 1 D003110 ClinicalTrials
Myeloproliferative Disorders 1 D009196 ClinicalTrials
Breast Neoplasms, Male 1 D018567 ClinicalTrials
Lymphoma 1 D008223 ClinicalTrials
Digestive System Diseases 1 D004066 ClinicalTrials
Vaginal Neoplasms 1 D014625 ClinicalTrials
Cystadenoma, Serous 1 D018293 ClinicalTrials
Vulvar Neoplasms 1 D014846 ClinicalTrials
Multiple Myeloma 1 D009101 ClinicalTrials

Related Entries

Scaffolds

Side Effects from Label

Side effects Relative Frequency (%) Labels
Skin and subcutaneous tissue disorders Alopecia 98.0
Blood and lymphatic system disorders Lymphopenia 98.0
Blood and lymphatic system disorders Anaemia 96.8
Skin and subcutaneous tissue disorders Alopecia 95.8
Blood and lymphatic system disorders Neutropenia 95.5
Blood and lymphatic system disorders Anaemia 95.0
Blood and lymphatic system disorders Neutropenia 95.0
Blood and lymphatic system disorders Anaemia 94.0
Blood and lymphatic system disorders Neutropenia 93.7
Blood and lymphatic system disorders Anaemia 93.3
Blood and lymphatic system disorders Neutropenia 93.0
Skin and subcutaneous tissue disorders Alopecia 92.3
Skin and subcutaneous tissue disorders Alopecia 92.0
Blood and lymphatic system disorders Anaemia 90.0
Blood and lymphatic system disorders Anaemia 89.1
Blood and lymphatic system disorders Anaemia 89.0
Blood and lymphatic system disorders Anaemia 88.0
Gastrointestinal disorders Nausea 87.2
Blood and lymphatic system disorders Agranulocytosis 87.0
Blood and lymphatic system disorders Neutropenia 87.0
Blood and lymphatic system disorders Anaemia 86.0
Blood and lymphatic system disorders Neutropenia 84.0
Blood and lymphatic system disorders Neutropenia 83.3
Blood and lymphatic system disorders Anaemia 83.0
Blood and lymphatic system disorders Neutropenia 82.3
Blood and lymphatic system disorders Neutropenia 82.0
General disorders and administration site conditions Asthenia 81.3
General disorders and administration site conditions Fatigue 81.3
Skin and subcutaneous tissue disorders Alopecia 81.0
Gastrointestinal disorders Nausea 80.8
General disorders and administration site conditions Asthenia 80.4
General disorders and administration site conditions Fatigue 80.4
Gastrointestinal disorders Nausea 80.0
Skin and subcutaneous tissue disorders Alopecia 79.9
Gastrointestinal disorders Diarrhoea 77.8
Gastrointestinal disorders Nausea 77.0
Gastrointestinal disorders Nausea 76.3
Skin and subcutaneous tissue disorders Alopecia 76.0
Blood and lymphatic system disorders Neutropenia 76.0
Skin and subcutaneous tissue disorders Alopecia 75.8
Gastrointestinal disorders Nausea 75.7
Skin and subcutaneous tissue disorders Alopecia 74.0
Gastrointestinal disorders Nausea 73.3
Gastrointestinal disorders Vomiting 73.2
Skin and subcutaneous tissue disorders Alopecia 68.0
Gastrointestinal disorders Stomatitis 68.0
Skin and subcutaneous tissue disorders Alopecia 67.7
Skin and subcutaneous tissue disorders Alopecia 66.5
Blood and lymphatic system disorders Anaemia 66.5
Gastrointestinal disorders Vomiting 66.5
Blood and lymphatic system disorders Agranulocytosis 66.0
Blood and lymphatic system disorders Neutropenia 66.0
Gastrointestinal disorders Stomatitis 66.0
Skin and subcutaneous tissue disorders Alopecia 65.1
Blood and lymphatic system disorders Anaemia 65.0
Gastrointestinal disorders Pharyngitis 65.0
Gastrointestinal disorders Stomatitis 65.0
Gastrointestinal disorders Stomatitis 64.5
Gastrointestinal disorders Pharyngitis 63.1
Gastrointestinal disorders Stomatitis 63.1
Gastrointestinal disorders Vomiting 63.0
General disorders and administration site conditions Lethargy 62.9
Skin and subcutaneous tissue disorders Alopecia 62.3
Skin and subcutaneous tissue disorders Alopecia 62.0
Gastrointestinal disorders Stomatitis 61.2
General disorders and administration site conditions Lethargy 61.0
Endocrine disorders Amenorrhoea 59.9
Gastrointestinal disorders Stomatitis 59.3
General disorders and administration site conditions Lethargy 58.6
General disorders and administration site conditions Lethargy 58.0
Blood and lymphatic system disorders Anaemia 57.8
Blood and lymphatic system disorders Neutropenia 57.0
Gastrointestinal disorders Vomiting 56.2
Skin and subcutaneous tissue disorders Alopecia 56.0
General disorders and administration site conditions Lethargy 56.0
Blood and lymphatic system disorders Neutropenia 56.0
Gastrointestinal disorders Vomiting 56.0
Gastrointestinal disorders Diarrhoea 55.8
Gastrointestinal disorders Vomiting 55.3
Blood and lymphatic system disorders Lymphoedema 54.5
Gastrointestinal disorders Vomiting 54.4
General disorders and administration site conditions Decreased appetite 54.0
Blood and lymphatic system disorders Neutropenia 53.0
Metabolism and nutrition disorders Fluid retention 52.2
Gastrointestinal disorders Pharyngitis 51.8
Gastrointestinal disorders Stomatitis 51.8
Investigations Blood alkaline phosphatase increased 51.0
Metabolism and nutrition disorders Fluid retention 51.0
Gastrointestinal disorders Nausea 51.0
Blood and lymphatic system disorders Neutropenia 51.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 50.9
Musculoskeletal and connective tissue disorders Myalgia 50.9
Metabolism and nutrition disorders Fluid retention 50.8
General disorders and administration site conditions Decreased appetite 50.7
Skin and subcutaneous tissue disorders Nail disorder 50.0
Gastrointestinal disorders Diarrhoea 49.6
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 49.0
Musculoskeletal and connective tissue disorders Myalgia 49.0
Blood and lymphatic system disorders Neutropenia 49.0
Investigations Blood alkaline phosphatase increased 48.0
Gastrointestinal disorders Diarrhoea 48.0
Gastrointestinal disorders Nausea 47.0
Gastrointestinal disorders Stomatitis 47.0
Blood and lymphatic system disorders Thrombocytopenia 47.0
Skin and subcutaneous tissue disorders Nail disorder 46.4
Gastrointestinal disorders Diarrhoea 45.3
Gastrointestinal disorders Diarrhoea 45.0
Gastrointestinal disorders Gastrointestinal disorder 45.0
Nervous system disorders Neuropathy peripheral 44.8
Nervous system disorders Neuropathy peripheral 44.2
Skin and subcutaneous tissue disorders Alopecia 44.0
Blood and lymphatic system disorders Lymphopenia 44.0
Gastrointestinal disorders Nausea 44.0
Gastrointestinal disorders Nausea 43.7
Skin and subcutaneous tissue disorders Alopecia 43.0
General disorders and administration site conditions Asthenia 43.0
Gastrointestinal disorders Diarrhoea 43.0
Gastrointestinal disorders Nausea 43.0
Blood and lymphatic system disorders Neutropenia 43.0
Gastrointestinal disorders Stomatitis 43.0
General disorders and administration site conditions Asthenia 42.8
General disorders and administration site conditions Fatigue 42.8
Gastrointestinal disorders Diarrhoea 42.2
Skin and subcutaneous tissue disorders Alopecia 42.0
Investigations Aspartate aminotransferase increased 42.0
General disorders and administration site conditions Asthenia 42.0
Gastrointestinal disorders Nausea 42.0
Gastrointestinal disorders Stomatitis 42.0
Skin and subcutaneous tissue disorders Alopecia 41.1
General disorders and administration site conditions Lethargy 41.0
General disorders and administration site conditions Decreased appetite 40.0
Gastrointestinal disorders Diarrhoea 40.0
Metabolism and nutrition disorders Fluid retention 40.0
Blood and lymphatic system disorders Lymphopenia 40.0
General disorders and administration site conditions Mucosal inflammation 40.0
Musculoskeletal and connective tissue disorders Arthralgia 39.7
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 39.7
Skin and subcutaneous tissue disorders Nail disorder 39.6
Gastrointestinal disorders Vomiting 39.4
Gastrointestinal disorders Diarrhoea 39.0
Gastrointestinal disorders Nausea 39.0
Blood and lymphatic system disorders Thrombocytopenia 39.0
Gastrointestinal disorders Vomiting 39.0
Gastrointestinal disorders Nausea 38.9
Gastrointestinal disorders Diarrhoea 38.7
Gastrointestinal disorders Constipation 38.0
General disorders and administration site conditions Lethargy 38.0
Gastrointestinal disorders Nausea 38.0
General disorders and administration site conditions Lethargy 37.9
General disorders and administration site conditions Decreased appetite 37.8
Gastrointestinal disorders Nausea 37.7
Gastrointestinal disorders Diarrhoea 37.6
Investigations Aspartate aminotransferase increased 37.0
Investigations Body temperature increased 37.0
Infections and infestations Infection 37.0
Investigations Body temperature increased 35.7
Infections and infestations Infection 35.7
Gastrointestinal disorders Nausea 35.5
Musculoskeletal and connective tissue disorders Arthralgia 35.4
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 35.4
Skin and subcutaneous tissue disorders Alopecia 35.0
Gastrointestinal disorders Nausea 35.0
General disorders and administration site conditions Decreased appetite 34.0
Gastrointestinal disorders Constipation 33.9
Endocrine disorders Menstruation irregular 33.6
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 33.4
Musculoskeletal and connective tissue disorders Myalgia 33.4
Gastrointestinal disorders Diarrhoea 33.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 33.0
Musculoskeletal and connective tissue disorders Myalgia 33.0
Gastrointestinal disorders Diarrhoea 32.8
Endocrine disorders Menstruation irregular 32.2
Blood and lymphatic system disorders Neutropenia 32.1
General disorders and administration site conditions Asthenia 32.0
Investigations Body temperature increased 32.0
Infections and infestations Infection 32.0
Gastrointestinal disorders Nausea 32.0
Nervous system disorders Nervous system disorder 32.0
Blood and lymphatic system disorders Neutropenia 32.0
General disorders and administration site conditions Asthenia 31.7
General disorders and administration site conditions Asthenia 31.0
Blood and lymphatic system disorders Thrombocytopenia 31.0
Skin and subcutaneous tissue disorders Nail disorder 30.6
Investigations Body temperature increased 30.0
Infections and infestations Infection 30.0
Nervous system disorders Neuropathy peripheral 29.9
Gastrointestinal disorders Dysgeusia 29.5
Infections and infestations Infection 29.4
Gastrointestinal disorders Diarrhoea 29.3
Endocrine disorders Menstruation irregular 29.1
Investigations Body temperature increased 29.0
Gastrointestinal disorders Stomatitis 29.0
Gastrointestinal disorders Nausea 28.7
Gastrointestinal disorders Dysgeusia 28.3
Skin and subcutaneous tissue disorders Nail disorder 28.3
Investigations Body temperature increased 28.0
Gastrointestinal disorders Diarrhoea 28.0
Infections and infestations Infection 28.0
Blood and lymphatic system disorders Thrombocytopenia 28.0
Nervous system disorders Neuropathy peripheral 27.4
Endocrine disorders Amenorrhoea 27.2
Gastrointestinal disorders Dysgeusia 27.2
Gastrointestinal disorders Constipation 27.1
Musculoskeletal and connective tissue disorders Connective tissue disorder 27.0
Gastrointestinal disorders Constipation 27.0
Infections and infestations Infection 27.0
General disorders and administration site conditions Oedema 27.0
Gastrointestinal disorders Stomatitis 27.0
Investigations Weight decreased 27.0
General disorders and administration site conditions Asthenia 26.6
General disorders and administration site conditions Fatigue 26.6
Investigations Body temperature increased 26.3
Gastrointestinal disorders Constipation 26.3
Infections and infestations Infection 26.3
Blood and lymphatic system disorders Anaemia 26.0
Gastrointestinal disorders Dysphagia 26.0
Blood and lymphatic system disorders Febrile neutropenia 26.0
Infections and infestations Infection 26.0
Gastrointestinal disorders Odynophagia 26.0
Gastrointestinal disorders Oesophagitis 26.0
Gastrointestinal disorders Vomiting 26.0
Skin and subcutaneous tissue disorders Dermatitis 25.9
Skin and subcutaneous tissue disorders Rash 25.9
Skin and subcutaneous tissue disorders Skin exfoliation 25.9
Gastrointestinal disorders Vomiting 25.9
Blood and lymphatic system disorders Thrombocytopenia 25.5
Gastrointestinal disorders Constipation 25.3
Blood and lymphatic system disorders Febrile neutropenia 25.2
General disorders and administration site conditions Asthenia 25.0
General disorders and administration site conditions Decreased appetite 25.0
Gastrointestinal disorders Dysphagia 25.0
General disorders and administration site conditions Fatigue 25.0
Gastrointestinal disorders Odynophagia 25.0
Gastrointestinal disorders Oesophagitis 25.0
Metabolism and nutrition disorders Fluid retention 24.4
Gastrointestinal disorders Diarrhoea 24.1
Gastrointestinal disorders Diarrhoea 24.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 24.0
Musculoskeletal and connective tissue disorders Myalgia 24.0
Blood and lymphatic system disorders Thrombocytopenia 24.0
Endocrine disorders Menstruation irregular 23.6
Skin and subcutaneous tissue disorders Nail disorder 23.3
Investigations Blood bilirubin increased 23.0
Infections and infestations Infection 23.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 23.0
Musculoskeletal and connective tissue disorders Myalgia 23.0
Skin and subcutaneous tissue disorders Nail disorder 23.0
Gastrointestinal disorders Stomatitis 23.0
Blood and lymphatic system disorders Thrombocytopenia 23.0
Gastrointestinal disorders Vomiting 23.0
Investigations Body temperature increased 22.8
Skin and subcutaneous tissue disorders Dermatitis 22.8
Infections and infestations Infection 22.8
Skin and subcutaneous tissue disorders Rash 22.8
Skin and subcutaneous tissue disorders Skin exfoliation 22.8
Gastrointestinal disorders Vomiting 22.3
General disorders and administration site conditions Asthenia 22.0
Gastrointestinal disorders Constipation 22.0
Metabolism and nutrition disorders Malnutrition 22.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 22.0
Musculoskeletal and connective tissue disorders Myalgia 22.0
Blood and lymphatic system disorders Neutropenia 22.0
Infections and infestations Pneumonia 22.0
Gastrointestinal disorders Vomiting 22.0
Gastrointestinal disorders Dysphagia 21.9
Gastrointestinal disorders Odynophagia 21.9
Gastrointestinal disorders Oesophagitis 21.9
Musculoskeletal and connective tissue disorders Arthralgia 21.8
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 21.8
Endocrine disorders Menstruation irregular 21.4
Skin and subcutaneous tissue disorders Dermatitis 21.3
General disorders and administration site conditions Lethargy 21.3
Skin and subcutaneous tissue disorders Rash 21.3
Skin and subcutaneous tissue disorders Skin exfoliation 21.3
Investigations Body temperature increased 21.0
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Cancer pain 21.0
Eye disorders Eye disorder 21.0
Blood and lymphatic system disorders Febrile neutropenia 21.0
General disorders and administration site conditions Lethargy 21.0
Gastrointestinal disorders Stomatitis 21.0
Gastrointestinal disorders Vomiting 21.0
Investigations Weight decreased 21.0
Gastrointestinal disorders Stomatitis 20.8
Gastrointestinal disorders Stomatitis 20.7
Gastrointestinal disorders Diarrhoea 20.4
Metabolism and nutrition disorders Fluid retention 20.1
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Cancer pain 20.0
Skin and subcutaneous tissue disorders Dermatitis 20.0
Gastrointestinal disorders Diarrhoea 20.0
Metabolism and nutrition disorders Fluid retention 20.0
Respiratory, thoracic and mediastinal disorders Mediastinal disorder 20.0
Nervous system disorders Parosmia 20.0
Skin and subcutaneous tissue disorders Rash 20.0
Endocrine disorders Menstruation irregular 19.9
Nervous system disorders Parosmia 19.5
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 19.0
Musculoskeletal and connective tissue disorders Myalgia 19.0
Gastrointestinal disorders Nausea 19.0
Gastrointestinal disorders Vomiting 19.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 18.9
Musculoskeletal and connective tissue disorders Myalgia 18.9
Blood and lymphatic system disorders Anaemia 18.2
Blood and lymphatic system disorders Anaemia 18.0
Musculoskeletal and connective tissue disorders Arthralgia 18.0
Gastrointestinal disorders Dysphagia 18.0
General disorders and administration site conditions Lethargy 18.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 18.0
Gastrointestinal disorders Odynophagia 18.0
Gastrointestinal disorders Oesophagitis 18.0
Blood and lymphatic system disorders Thrombocytopenia 18.0
Gastrointestinal disorders Pharyngitis 17.8
Gastrointestinal disorders Stomatitis 17.8
Gastrointestinal disorders Dysgeusia 17.5
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Cancer pain 17.0
Gastrointestinal disorders Constipation 17.0
General disorders and administration site conditions Oedema 17.0
Nervous system disorders Parosmia 17.0
Blood and lymphatic system disorders Febrile neutropenia 16.4
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 16.4
Musculoskeletal and connective tissue disorders Myalgia 16.4
Gastrointestinal disorders Dysphagia 16.3
Infections and infestations Infection 16.3
Gastrointestinal disorders Odynophagia 16.3
Gastrointestinal disorders Oesophagitis 16.3
Investigations Body temperature increased 16.0
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Cancer pain 16.0
Gastrointestinal disorders Constipation 16.0
General disorders and administration site conditions Decreased appetite 16.0
Skin and subcutaneous tissue disorders Dermatitis 16.0
Cardiac disorders Dizziness 16.0
Infections and infestations Infection 16.0
Gastrointestinal disorders Nausea 16.0
Skin and subcutaneous tissue disorders Rash 16.0
Gastrointestinal disorders Vomiting 16.0
Blood and lymphatic system disorders Neutropenic infection 15.9
Cardiac disorders Dizziness 15.8
Gastrointestinal disorders Nausea 15.8
General disorders and administration site conditions Decreased appetite 15.5
Infections and infestations Infection 15.5
Cardiac disorders Dizziness 15.0
Gastrointestinal disorders Gastrointestinal pain 15.0
Musculoskeletal and connective tissue disorders Muscle spasms 15.0
Skin and subcutaneous tissue disorders Nail disorder 15.0
Nervous system disorders Paraesthesia 15.0
Gastrointestinal disorders Stomatitis 15.0
Gastrointestinal disorders Vomiting 15.0
Metabolism and nutrition disorders Fluid retention 14.9
Gastrointestinal disorders Vomiting 14.9
Investigations Body temperature increased 14.4
Infections and infestations Infection 14.4
Blood and lymphatic system disorders Anaemia 14.0
Investigations Body temperature increased 14.0
Gastrointestinal disorders Dysgeusia 14.0
Metabolism and nutrition disorders Fluid retention 14.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 14.0
Musculoskeletal and connective tissue disorders Myalgia 14.0
Gastrointestinal disorders Nausea 14.0
Blood and lymphatic system disorders Neutropenic infection 14.0
Cardiac disorders Oedema peripheral 14.0
Blood and lymphatic system disorders Thrombocytopenia 14.0
Investigations Weight decreased 14.0
Gastrointestinal disorders Constipation 13.9
Gastrointestinal disorders Nausea 13.9
Gastrointestinal disorders Dysphagia 13.8
Gastrointestinal disorders Odynophagia 13.8
Gastrointestinal disorders Oesophagitis 13.8
Gastrointestinal disorders Vomiting 13.3
General disorders and administration site conditions Decreased appetite 13.1
Metabolism and nutrition disorders Fluid retention 13.1
Infections and infestations Infection 13.1
General disorders and administration site conditions Oedema 13.1
General disorders and administration site conditions Decreased appetite 13.0
Gastrointestinal disorders Dyspepsia 13.0
Gastrointestinal disorders Dysphagia 13.0
Metabolism and nutrition disorders Fluid retention 13.0
Investigations Haemoglobin decreased 13.0
Gastrointestinal disorders Nausea 13.0
Gastrointestinal disorders Odynophagia 13.0
General disorders and administration site conditions Oedema 13.0
Gastrointestinal disorders Oesophagitis 13.0
General disorders and administration site conditions Decreased appetite 12.7
Skin and subcutaneous tissue disorders Dermatitis 12.7
Skin and subcutaneous tissue disorders Rash 12.7
Blood and lymphatic system disorders Neutropenic infection 12.6
General disorders and administration site conditions Oedema 12.6
Skin and subcutaneous tissue disorders Alopecia 12.5
Blood and lymphatic system disorders Anaemia 12.4
Investigations Body temperature increased 12.1
Blood and lymphatic system disorders Anaemia 12.0
Gastrointestinal disorders Constipation 12.0
General disorders and administration site conditions Decreased appetite 12.0
Skin and subcutaneous tissue disorders Dermatitis 12.0
Gastrointestinal disorders Dysphagia 12.0
Blood and lymphatic system disorders Febrile neutropenia 12.0
Infections and infestations Infection 12.0
Eye disorders Lacrimation increased 12.0
Psychiatric disorders Mental disorder 12.0
Blood and lymphatic system disorders Neutropenia 12.0
Blood and lymphatic system disorders Neutropenic infection 12.0
Gastrointestinal disorders Odynophagia 12.0
General disorders and administration site conditions Oedema 12.0
Cardiac disorders Oedema peripheral 12.0
Gastrointestinal disorders Oesophagitis 12.0
Skin and subcutaneous tissue disorders Rash 12.0
Skin and subcutaneous tissue disorders Dermatitis 11.8
Skin and subcutaneous tissue disorders Rash 11.8
General disorders and administration site conditions Decreased appetite 11.6
Gastrointestinal disorders Gastrointestinal pain 11.3
Musculoskeletal and connective tissue disorders Muscle spasms 11.3
Investigations Weight decreased 11.2
Skin and subcutaneous tissue disorders Alopecia 11.0
Musculoskeletal and connective tissue disorders Arthralgia 11.0
General disorders and administration site conditions Asthenia 11.0
Investigations Body temperature increased 11.0
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Cancer pain 11.0
Blood and lymphatic system disorders Febrile neutropenia 11.0
Investigations Haemoglobin decreased 11.0
Infections and infestations Infection 11.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 11.0
Musculoskeletal and connective tissue disorders Myalgia 11.0
Gastrointestinal disorders Oropharyngeal discomfort 11.0
Gastrointestinal disorders Oropharyngeal pain 11.0
Gastrointestinal disorders Stomatitis 11.0
Blood and lymphatic system disorders Thrombocytopenia 11.0
Skin and subcutaneous tissue disorders Alopecia 10.9
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 10.7
Musculoskeletal and connective tissue disorders Myalgia 10.7
Immune system disorders Hypersensitivity 10.4
Blood and lymphatic system disorders Neutropenic infection 10.4
Nervous system disorders Parosmia 10.3
Blood and lymphatic system disorders Agranulocytosis 10.0
Blood and lymphatic system disorders Anaemia 10.0
General disorders and administration site conditions Decreased appetite 10.0
Gastrointestinal disorders Dysphagia 10.0
Gastrointestinal disorders Gastrointestinal pain 10.0
Infections and infestations Infection 10.0
General disorders and administration site conditions Lethargy 10.0
Musculoskeletal and connective tissue disorders Muscle spasms 10.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 10.0
Musculoskeletal and connective tissue disorders Myalgia 10.0
Gastrointestinal disorders Nausea 10.0
Nervous system disorders Neuropathy peripheral 10.0
Blood and lymphatic system disorders Neutropenia 10.0
Gastrointestinal disorders Odynophagia 10.0
Gastrointestinal disorders Oesophagitis 10.0
Nervous system disorders Parosmia 10.0
Gastrointestinal disorders Stomatitis 10.0
Gastrointestinal disorders Vomiting 10.0
Investigations Weight decreased 9.8
Eye disorders Lacrimation increased 9.3
Blood and lymphatic system disorders Anaemia 9.2
Musculoskeletal and connective tissue disorders Arthralgia 9.2
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 9.2
Gastrointestinal disorders Abdominal pain 9.0
Blood and lymphatic system disorders Anaemia 9.0
Musculoskeletal and connective tissue disorders Arthralgia 9.0
General disorders and administration site conditions Asthenia 9.0
Investigations Blood bilirubin increased 9.0
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Cancer pain 9.0
Respiratory, thoracic and mediastinal disorders Cough 9.0
Skin and subcutaneous tissue disorders Dermatitis 9.0
Cardiac disorders Dyspnoea 9.0
Gastrointestinal disorders Gastrointestinal pain 9.0
Infections and infestations Infection 9.0
Musculoskeletal and connective tissue disorders Muscle spasms 9.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 9.0
Gastrointestinal disorders Vomiting 9.0
Gastrointestinal disorders Dyspepsia 8.8
Skin and subcutaneous tissue disorders Dermatitis 8.6
Skin and subcutaneous tissue disorders Rash 8.6
Skin and subcutaneous tissue disorders Dermatitis 8.5
Skin and subcutaneous tissue disorders Rash 8.5
Gastrointestinal disorders Vomiting 8.4
Eye disorders Lacrimation increased 8.1
Skin and subcutaneous tissue disorders Nail disorder 8.1
Musculoskeletal and connective tissue disorders Arthralgia 8.0
Metabolism and nutrition disorders Dehydration 8.0
Gastrointestinal disorders Diarrhoea 8.0
Cardiac disorders Dizziness 8.0
Gastrointestinal disorders Gastrointestinal pain 8.0
Nervous system disorders Headache 8.0
Infections and infestations Infection 8.0
Musculoskeletal and connective tissue disorders Muscle spasms 8.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 8.0
Blood and lymphatic system disorders Neutropenic infection 8.0
Musculoskeletal and connective tissue disorders Pain in extremity 8.0
Vascular disorders Phlebitis 8.0
Blood and lymphatic system disorders Thrombocytopenia 8.0
Gastrointestinal disorders Vomiting 8.0
Gastrointestinal disorders Pharyngitis 7.8
Gastrointestinal disorders Stomatitis 7.8
Blood and lymphatic system disorders Thrombocytopenia 7.7
Gastrointestinal disorders Vomiting 7.2
Gastrointestinal disorders Gastrointestinal pain 7.1
Musculoskeletal and connective tissue disorders Muscle spasms 7.1
Skin and subcutaneous tissue disorders Alopecia 7.0
Musculoskeletal and connective tissue disorders Arthralgia 7.0
Musculoskeletal and connective tissue disorders Back pain 7.0
Infections and infestations Candida infection 7.0
Gastrointestinal disorders Diarrhoea 7.0
Cardiac disorders Dyspnoea 7.0
Blood and lymphatic system disorders Febrile neutropenia 7.0
Metabolism and nutrition disorders Fluid retention 7.0
Infections and infestations Infection 7.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 7.0
Musculoskeletal and connective tissue disorders Myalgia 7.0
Gastrointestinal disorders Nausea 7.0
General disorders and administration site conditions Oedema 7.0
Gastrointestinal disorders Oral candidiasis 7.0
Gastrointestinal disorders Oropharyngeal discomfort 7.0
Gastrointestinal disorders Oropharyngeal pain 7.0
Gastrointestinal disorders Stomatitis 7.0
Gastrointestinal disorders Vomiting 7.0
General disorders and administration site conditions Asthenia 6.91
General disorders and administration site conditions Fatigue 6.91
Gastrointestinal disorders Constipation 6.9
Immune system disorders Hypersensitivity 6.9
Gastrointestinal disorders Diarrhoea 6.8
General disorders and administration site conditions Asthenia 6.76
General disorders and administration site conditions Fatigue 6.76
General disorders and administration site conditions Asthenia 6.65
General disorders and administration site conditions Fatigue 6.65
Musculoskeletal and connective tissue disorders Arthralgia 6.6
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 6.6
Skin and subcutaneous tissue disorders Nail disorder 6.6
Infections and infestations Infection 6.5
Gastrointestinal disorders Vomiting 6.37
Gastrointestinal disorders Dysgeusia 6.3
Infections and infestations Infection 6.3
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 6.3
Musculoskeletal and connective tissue disorders Myalgia 6.3
Gastrointestinal disorders Abdominal pain upper 6.0
Cardiac disorders Arrhythmia 6.0
General disorders and administration site conditions Asthenia 6.0
Musculoskeletal and connective tissue disorders Back pain 6.0
Investigations Blood bilirubin increased 6.0
Infections and infestations Candida infection 6.0
Respiratory, thoracic and mediastinal disorders Cough 6.0
Skin and subcutaneous tissue disorders Dermatitis 6.0
Cardiac disorders Dizziness 6.0
Skin and subcutaneous tissue disorders Dry skin 6.0
Gastrointestinal disorders Dyspepsia 6.0
Blood and lymphatic system disorders Febrile neutropenia 6.0
Gastrointestinal disorders Gastrointestinal pain 6.0
Blood and lymphatic system disorders Hyperbilirubinaemia 6.0
Immune system disorders Hypersensitivity 6.0
Infections and infestations Infection 6.0
General disorders and administration site conditions Injection site reaction 6.0
Musculoskeletal and connective tissue disorders Muscle spasms 6.0
Blood and lymphatic system disorders Neutropenia 6.0
General disorders and administration site conditions Oedema 6.0
Gastrointestinal disorders Oral candidiasis 6.0
Skin and subcutaneous tissue disorders Rash 6.0
Skin and subcutaneous tissue disorders Skin exfoliation 6.0
Investigations Weight decreased 6.0
Investigations Weight increased 6.0
Gastrointestinal disorders Nausea 5.81
Gastrointestinal disorders Vomiting 5.81
Immune system disorders Hypersensitivity 5.8
Gastrointestinal disorders Dysphagia 5.7
Gastrointestinal disorders Odynophagia 5.7
Gastrointestinal disorders Oesophagitis 5.7
Investigations Weight increased 5.7
Skin and subcutaneous tissue disorders Erythema 5.6
General disorders and administration site conditions Extravasation 5.6
General disorders and administration site conditions Inflammation 5.6
Vascular disorders Phlebitis 5.6
Skin and subcutaneous tissue disorders Skin hyperpigmentation 5.6
General disorders and administration site conditions Swelling 5.6
Blood and lymphatic system disorders Febrile neutropenia 5.46
Gastrointestinal disorders Nausea 5.34
Investigations Body temperature increased 5.2
Skin and subcutaneous tissue disorders Dry skin 5.2
Gastrointestinal disorders Gastrointestinal pain 5.2
Musculoskeletal and connective tissue disorders Muscle spasms 5.2
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 5.2
Musculoskeletal and connective tissue disorders Myalgia 5.2
Gastrointestinal disorders Diarrhoea 5.15
Skin and subcutaneous tissue disorders Alopecia 5.0
Blood and lymphatic system disorders Anaemia 5.0
Cardiac disorders Arrhythmia 5.0
General disorders and administration site conditions Asthenia 5.0
Investigations Blood bilirubin increased 5.0
Investigations Body temperature increased 5.0
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Cancer pain 5.0
Metabolism and nutrition disorders Dehydration 5.0
Gastrointestinal disorders Diarrhoea 5.0
Cardiac disorders Dizziness 5.0
Skin and subcutaneous tissue disorders Dry skin 5.0
Gastrointestinal disorders Dyspepsia 5.0
Gastrointestinal disorders Dysphagia 5.0
Respiratory, thoracic and mediastinal disorders Epistaxis 5.0
General disorders and administration site conditions Fatigue 5.0
Blood and lymphatic system disorders Febrile neutropenia 5.0
Gastrointestinal disorders Gastrointestinal haemorrhage 5.0
Gastrointestinal disorders Gastrointestinal pain 5.0
Infections and infestations Infection 5.0
Eye disorders Lacrimation increased 5.0
General disorders and administration site conditions Lethargy 5.0
Musculoskeletal and connective tissue disorders Muscle spasms 5.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 5.0
Musculoskeletal and connective tissue disorders Myalgia 5.0
Gastrointestinal disorders Nausea 5.0
Nervous system disorders Neuropathy peripheral 5.0
Gastrointestinal disorders Odynophagia 5.0
Gastrointestinal disorders Oesophagitis 5.0
Skin and subcutaneous tissue disorders Onycholysis 5.0
Nervous system disorders Parosmia 5.0
Skin and subcutaneous tissue disorders Skin exfoliation 5.0
Gastrointestinal disorders Stomatitis 5.0
Blood and lymphatic system disorders Thrombocytopenia 5.0
Gastrointestinal disorders Vomiting 5.0
Blood and lymphatic system disorders Neutropenic infection 4.99
Gastrointestinal disorders Diarrhoea 4.92
Blood and lymphatic system disorders Anaemia 4.9
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 4.87
Musculoskeletal and connective tissue disorders Myalgia 4.87
Infections and infestations Infection 4.8
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 4.67
Musculoskeletal and connective tissue disorders Myalgia 4.67
Gastrointestinal disorders Nausea 4.64
Cardiac disorders Dizziness 4.5
Cardiac disorders Dyspnoea 4.5
Blood and lymphatic system disorders Febrile neutropenia 4.5
Metabolism and nutrition disorders Fluid retention 4.5
Skin and subcutaneous tissue disorders Erythema 4.4
General disorders and administration site conditions Extravasation 4.4
General disorders and administration site conditions Inflammation 4.4
Vascular disorders Phlebitis 4.4
Skin and subcutaneous tissue disorders Skin hyperpigmentation 4.4
General disorders and administration site conditions Swelling 4.4
Gastrointestinal disorders Diarrhoea 4.2
Skin and subcutaneous tissue disorders Alopecia 4.0
Blood and lymphatic system disorders Anaemia 4.0
Investigations Aspartate aminotransferase increased 4.0
General disorders and administration site conditions Asthenia 4.0
Investigations Blood alkaline phosphatase increased 4.0
Investigations Body temperature increased 4.0
General disorders and administration site conditions Decreased appetite 4.0
Gastrointestinal disorders Diarrhoea 4.0
Cardiac disorders Dizziness 4.0
Gastrointestinal disorders Dry mouth 4.0
Gastrointestinal disorders Dyspepsia 4.0
Metabolism and nutrition disorders Fluid retention 4.0
Gastrointestinal disorders Gastrointestinal haemorrhage 4.0
Investigations Haemoglobin decreased 4.0
Infections and infestations Infection 4.0
General disorders and administration site conditions Lethargy 4.0
Skin and subcutaneous tissue disorders Nail discolouration 4.0
Skin and subcutaneous tissue disorders Rash erythematous 4.0
Skin and subcutaneous tissue disorders Skin exfoliation 4.0
Gastrointestinal disorders Stomatitis 4.0
Blood and lymphatic system disorders Thrombocytopenia 4.0
Gastrointestinal disorders Vomiting 4.0
Investigations Weight decreased 4.0
General disorders and administration site conditions Asthenia 3.9
General disorders and administration site conditions Fatigue 3.9
Nervous system disorders Neuropathy peripheral 3.9
Gastrointestinal disorders Pharyngitis 3.62
Gastrointestinal disorders Stomatitis 3.62
Investigations Body temperature increased 3.6
Infections and infestations Infection 3.6
General disorders and administration site conditions Lethargy 3.4
Skin and subcutaneous tissue disorders Dermatitis 3.3
Cardiac disorders Dyspnoea 3.3
Skin and subcutaneous tissue disorders Erythema 3.3
General disorders and administration site conditions Extravasation 3.3
Infections and infestations Infection 3.3
General disorders and administration site conditions Inflammation 3.3
Vascular disorders Phlebitis 3.3
Skin and subcutaneous tissue disorders Rash 3.3
Skin and subcutaneous tissue disorders Skin exfoliation 3.3
Skin and subcutaneous tissue disorders Skin hyperpigmentation 3.3
General disorders and administration site conditions Swelling 3.3
Cardiac disorders Arrhythmia 3.2
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Cancer pain 3.2
Respiratory, thoracic and mediastinal disorders Cough 3.1
General disorders and administration site conditions Oedema 3.1
Gastrointestinal disorders Vomiting 3.03
Blood and lymphatic system disorders Anaemia 3.0
Cardiac disorders Arrhythmia 3.0
Musculoskeletal and connective tissue disorders Arthralgia 3.0
Investigations Aspartate aminotransferase increased 3.0
General disorders and administration site conditions Asthenia 3.0
Investigations Blood bilirubin increased 3.0
Investigations Body temperature increased 3.0
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Cancer pain 3.0
Gastrointestinal disorders Constipation 3.0
General disorders and administration site conditions Decreased appetite 3.0
Gastrointestinal disorders Diarrhoea 3.0
Skin and subcutaneous tissue disorders Dry skin 3.0
Gastrointestinal disorders Dysphagia 3.0
Cardiac disorders Dyspnoea 3.0
Respiratory, thoracic and mediastinal disorders Epistaxis 3.0
Gastrointestinal disorders Gastrointestinal pain 3.0
Immune system disorders Hypersensitivity 3.0
Infections and infestations Infection 3.0
General disorders and administration site conditions Lethargy 3.0
Blood and lymphatic system disorders Leukopenia 3.0
Musculoskeletal and connective tissue disorders Muscle spasms 3.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 3.0
Musculoskeletal and connective tissue disorders Myalgia 3.0
Gastrointestinal disorders Nausea 3.0
Gastrointestinal disorders Odynophagia 3.0
General disorders and administration site conditions Oedema 3.0
Gastrointestinal disorders Oesophagitis 3.0
Gastrointestinal disorders Pharyngitis 3.0
Vascular disorders Phlebitis 3.0
Gastrointestinal disorders Stomatitis 3.0
Gastrointestinal disorders Diarrhoea 2.95
Gastrointestinal disorders Diarrhoea 2.9
Immune system disorders Hypersensitivity 2.9
Musculoskeletal and connective tissue disorders Arthralgia 2.86
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 2.86
Skin and subcutaneous tissue disorders Dry skin 2.8
General disorders and administration site conditions Asthenia 2.7
Investigations Body temperature increased 2.7
General disorders and administration site conditions Fatigue 2.7
Cardiac disorders Myocardial ischaemia 2.7
Gastrointestinal disorders Nausea 2.4
Respiratory, thoracic and mediastinal disorders Cough 2.2
Eye disorders Lacrimation increased 2.2
Nervous system disorders Neuropathy peripheral 2.19
Cardiac disorders Cardiac failure 2.17
Investigations Blood bilirubin increased 2.1
Infections and infestations Infection 2.1
Nervous system disorders Neuropathy peripheral 2.1
Investigations Alanine aminotransferase increased 2.0
Blood and lymphatic system disorders Anaemia 2.0
Cardiac disorders Arrhythmia 2.0
Musculoskeletal and connective tissue disorders Arthralgia 2.0
General disorders and administration site conditions Asthenia 2.0
Investigations Blood alkaline phosphatase increased 2.0
Investigations Blood bilirubin increased 2.0
Investigations Body temperature increased 2.0
Gastrointestinal disorders Constipation 2.0
General disorders and administration site conditions Decreased appetite 2.0
Metabolism and nutrition disorders Dehydration 2.0
Gastrointestinal disorders Diarrhoea 2.0
Cardiac disorders Dizziness 2.0
Skin and subcutaneous tissue disorders Dry skin 2.0
Gastrointestinal disorders Dyspepsia 2.0
Gastrointestinal disorders Dysphagia 2.0
Blood and lymphatic system disorders Febrile neutropenia 2.0
Metabolism and nutrition disorders Fluid retention 2.0
Gastrointestinal disorders Gastrointestinal haemorrhage 2.0
Gastrointestinal disorders Gastrointestinal pain 2.0
Blood and lymphatic system disorders Hyperbilirubinaemia 2.0
Immune system disorders Hypersensitivity 2.0
Vascular disorders Hypertension 2.0
Infections and infestations Infection 2.0
Eye disorders Lacrimation increased 2.0
Blood and lymphatic system disorders Leukopenia 2.0
Musculoskeletal and connective tissue disorders Muscle spasms 2.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 2.0
Musculoskeletal and connective tissue disorders Myalgia 2.0
Cardiac disorders Myocardial ischaemia 2.0
Gastrointestinal disorders Nausea 2.0
Nervous system disorders Neuropathy peripheral 2.0
Blood and lymphatic system disorders Neutropenia 2.0
Gastrointestinal disorders Odynophagia 2.0
Gastrointestinal disorders Oesophagitis 2.0
Gastrointestinal disorders Oropharyngeal discomfort 2.0
Gastrointestinal disorders Oropharyngeal pain 2.0
General disorders and administration site conditions Pain 2.0
Skin and subcutaneous tissue disorders Skin exfoliation 2.0
Gastrointestinal disorders Stomatitis 2.0
Blood and lymphatic system disorders Thrombocytopenia 2.0
Gastrointestinal disorders Vomiting 2.0
Investigations Weight decreased 2.0
Nervous system disorders Neuropathy peripheral 1.87
Blood and lymphatic system disorders Anaemia 1.8
Investigations Body temperature increased 1.8
Gastrointestinal disorders Constipation 1.8
Gastrointestinal disorders Dysphagia 1.8
Gastrointestinal disorders Gastrointestinal pain 1.8
Immune system disorders Hypersensitivity 1.8
Infections and infestations Infection 1.8
Musculoskeletal and connective tissue disorders Muscle spasms 1.8
Blood and lymphatic system disorders Neutropenic infection 1.8
Gastrointestinal disorders Odynophagia 1.8
Gastrointestinal disorders Oesophagitis 1.8
Skin and subcutaneous tissue disorders Skin exfoliation 1.8
Eye disorders Lacrimation increased 1.7
Cardiac disorders Myocardial ischaemia 1.7
Vascular disorders Hypertension 1.6
Eye disorders Lacrimation increased 1.6
Skin and subcutaneous tissue disorders Dermatitis 1.52
Skin and subcutaneous tissue disorders Rash 1.52
Skin and subcutaneous tissue disorders Skin exfoliation 1.52
Metabolism and nutrition disorders Fluid retention 1.5
Eye disorders Lacrimation increased 1.5
Metabolism and nutrition disorders Fluid retention 1.42
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 1.42
Musculoskeletal and connective tissue disorders Myalgia 1.42
Gastrointestinal disorders Pharyngitis 1.42
Gastrointestinal disorders Stomatitis 1.42
Cardiac disorders Tachycardia 1.4
Metabolism and nutrition disorders Fluid retention 1.33
Skin and subcutaneous tissue disorders Dermatitis 1.31
Skin and subcutaneous tissue disorders Rash 1.31
Skin and subcutaneous tissue disorders Skin exfoliation 1.31
Investigations Alanine aminotransferase increased 1.3
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Cancer pain 1.2
Respiratory, thoracic and mediastinal disorders Cough 1.2
Gastrointestinal disorders Diarrhoea 1.2
Metabolism and nutrition disorders Fluid retention 1.2
Gastrointestinal disorders Gastrointestinal pain 1.2
Musculoskeletal and connective tissue disorders Muscle spasms 1.2
Nervous system disorders Neuropathy peripheral 1.2
General disorders and administration site conditions Oedema 1.2
Gastrointestinal disorders Vomiting 1.2
Blood and lymphatic system disorders Neutropenic infection 1.19
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Cancer pain 1.1
Eye disorders Conjunctivitis 1.1
Gastrointestinal disorders Gastrointestinal haemorrhage 1.1
Musculoskeletal and connective tissue disorders Arthralgia 1.04
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 1.04
Gastrointestinal disorders Abdominal pain 1.0
Gastrointestinal disorders Abdominal pain upper 1.0
Skin and subcutaneous tissue disorders Alopecia 1.0
Blood and lymphatic system disorders Anaemia 1.0
Cardiac disorders Arrhythmia 1.0
Musculoskeletal and connective tissue disorders Arthralgia 1.0
General disorders and administration site conditions Asthenia 1.0
Musculoskeletal and connective tissue disorders Back pain 1.0
Investigations Blood alkaline phosphatase increased 1.0
Investigations Body temperature increased 1.0
Infections and infestations Candida infection 1.0
Eye disorders Conjunctivitis 1.0
Gastrointestinal disorders Constipation 1.0
Respiratory, thoracic and mediastinal disorders Cough 1.0
General disorders and administration site conditions Decreased appetite 1.0
Metabolism and nutrition disorders Dehydration 1.0
Skin and subcutaneous tissue disorders Dermatitis 1.0
Gastrointestinal disorders Diarrhoea 1.0
Cardiac disorders Dizziness 1.0
Gastrointestinal disorders Dysgeusia 1.0
Gastrointestinal disorders Dyspepsia 1.0
Gastrointestinal disorders Dysphagia 1.0
Cardiac disorders Dyspnoea 1.0
Respiratory, thoracic and mediastinal disorders Epistaxis 1.0
Metabolism and nutrition disorders Fluid retention 1.0
Gastrointestinal disorders Gastrointestinal haemorrhage 1.0
Gastrointestinal disorders Gastrointestinal pain 1.0
Nervous system disorders Headache 1.0
Immune system disorders Hypersensitivity 1.0
Infections and infestations Infection 1.0
Eye disorders Lacrimation increased 1.0
General disorders and administration site conditions Lethargy 1.0
Nervous system disorders Loss of consciousness 1.0
Musculoskeletal and connective tissue disorders Muscle spasms 1.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 1.0
Musculoskeletal and connective tissue disorders Myalgia 1.0
Cardiac disorders Myocardial ischaemia 1.0
Skin and subcutaneous tissue disorders Nail discolouration 1.0
Gastrointestinal disorders Nausea 1.0
Nervous system disorders Neuropathy peripheral 1.0
Blood and lymphatic system disorders Neutropenia 1.0
Gastrointestinal disorders Odynophagia 1.0
General disorders and administration site conditions Oedema 1.0
Cardiac disorders Oedema peripheral 1.0
Gastrointestinal disorders Oesophagitis 1.0
Skin and subcutaneous tissue disorders Onycholysis 1.0
Gastrointestinal disorders Oral candidiasis 1.0
Gastrointestinal disorders Oropharyngeal discomfort 1.0
Gastrointestinal disorders Oropharyngeal pain 1.0
Musculoskeletal and connective tissue disorders Pain in extremity 1.0
Nervous system disorders Paraesthesia 1.0
Nervous system disorders Parosmia 1.0
Gastrointestinal disorders Pharyngitis 1.0
Vascular disorders Phlebitis 1.0
Skin and subcutaneous tissue disorders Rash 1.0
Vascular disorders Shock 1.0
Skin and subcutaneous tissue disorders Skin exfoliation 1.0
Injury, poisoning and procedural complications Skin toxicity 1.0
Gastrointestinal disorders Stomatitis 1.0
Cardiac disorders Syncope 1.0
Cardiac disorders Tachycardia 1.0
Blood and lymphatic system disorders Thrombocytopenia 1.0
Gastrointestinal disorders Vomiting 1.0
Investigations Weight decreased 1.0
Investigations Weight increased 1.0
Gastrointestinal disorders Constipation 0.936
Respiratory, thoracic and mediastinal disorders Cough 0.9
Skin and subcutaneous tissue disorders Dermatitis 0.9
Gastrointestinal disorders Diarrhoea 0.9
Cardiac disorders Myocardial ischaemia 0.9
Gastrointestinal disorders Nausea 0.9
Nervous system disorders Neuropathy peripheral 0.9
Gastrointestinal disorders Pharyngitis 0.9
Skin and subcutaneous tissue disorders Rash 0.9
Skin and subcutaneous tissue disorders Skin exfoliation 0.9
Gastrointestinal disorders Stomatitis 0.9
Eye disorders Conjunctivitis 0.8
Gastrointestinal disorders Dyspepsia 0.8
Cardiac disorders Myocardial ischaemia 0.8
Cardiac disorders Arrhythmia 0.6
Investigations Body temperature increased 0.6
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Cancer pain 0.6
General disorders and administration site conditions Decreased appetite 0.6
Gastrointestinal disorders Dysphagia 0.6
Cardiac disorders Dyspnoea 0.6
Respiratory, thoracic and mediastinal disorders Epistaxis 0.6
Metabolism and nutrition disorders Fluid retention 0.6
Gastrointestinal disorders Gastrointestinal haemorrhage 0.6
Immune system disorders Hypersensitivity 0.6
Infections and infestations Infection 0.6
Eye disorders Lacrimation increased 0.6
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 0.6
Musculoskeletal and connective tissue disorders Myalgia 0.6
Gastrointestinal disorders Nausea 0.6
Gastrointestinal disorders Odynophagia 0.6
Gastrointestinal disorders Oesophagitis 0.6
Skin and subcutaneous tissue disorders Skin exfoliation 0.6
Gastrointestinal disorders Vomiting 0.6
Gastrointestinal disorders Constipation 0.571
Gastrointestinal disorders Constipation 0.568
Nervous system disorders Neuropathy peripheral 0.568
Investigations Aspartate aminotransferase increased 0.5
Eye disorders Conjunctivitis 0.4
Gastrointestinal disorders Constipation 0.4
Skin and subcutaneous tissue disorders Dry skin 0.4
Gastrointestinal disorders Gastrointestinal haemorrhage 0.4
Immune system disorders Hypersensitivity 0.4
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 0.4
Musculoskeletal and connective tissue disorders Myalgia 0.4
Nervous system disorders Parosmia 0.4
Skin and subcutaneous tissue disorders Skin exfoliation 0.4
Investigations Weight increased 0.4
Skin and subcutaneous tissue disorders Dermatitis 0.379
Skin and subcutaneous tissue disorders Rash 0.379
Skin and subcutaneous tissue disorders Skin exfoliation 0.379
Investigations Blood alkaline phosphatase increased 0.3
Cardiac disorders Cardiac failure 0.3
Skin and subcutaneous tissue disorders Dermatitis 0.3
Cardiac disorders Dyspnoea 0.3
Metabolism and nutrition disorders Fluid retention 0.3
Immune system disorders Hypersensitivity 0.3
Skin and subcutaneous tissue disorders Rash 0.3
Skin and subcutaneous tissue disorders Skin exfoliation 0.3
Cardiac disorders Arrhythmia 0.2
Respiratory, thoracic and mediastinal disorders Cough 0.1
Blood and lymphatic system disorders Thrombocytopenia 0.1

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Skin and subcutaneous tissue disorders
46.64
Psychiatric disorders
17.24
General disorders and administration site conditions
7.27
Eye disorders
6.02
Social circumstances
3.23
Gastrointestinal disorders
2.74
Nervous system disorders
2.07

Cross References

Resources Reference
CAS NUMBER 114977-28-5
ChEBI 4672
ChEMBL CHEMBL92
DrugBank DB01248
DrugCentral 939
EPA CompTox DTXSID0040464
FDA SRS 699121PHCA
Human Metabolome Database HMDB0015378
Guide to Pharmacology 6809
KEGG C11231
PDB TXL
PharmGKB PA449383
PubChem 148123
SureChEMBL SCHEMBL4419
ZINC ZINC000085537053
CAS NUMBER 114977-28-5
ChEBI 59809
ChEMBL CHEMBL3545252
DrugBank DB01248
EPA CompTox DTXSID80872444
FDA SRS 15H5577CQD
Guide to Pharmacology 6809
KEGG C11231
PDB TXL
PubChem 148123
SureChEMBL SCHEMBL189599
ZINC ZINC85537053
CONTENTS