Trade Names:
Synonyms:
Status: Approved (2017)
Entry Type: Antibody
Molecule Category: UNKNOWN
ATC: L01XC28
UNII: 28X28X9OKV

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Programmed cell death 1 ligand 1 inhibitor PubMed PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Urinary Bladder Neoplasms 4 D001749 ClinicalTrials
Lung Neoplasms 4 D008175 ClinicalTrials
Urinary Bladder Neoplasms 4 D001749 FDA
Urinary Bladder Neoplasms 4 D001749 ClinicalTrials
Neoplasms 4 D009369 ClinicalTrials
Neoplasms 4 D009369 ClinicalTrials
Urinary Bladder Neoplasms 4 D001749 ClinicalTrials
Small Cell Lung Carcinoma 4 D055752 ClinicalTrials
Lung Neoplasms 4 D008175 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 4 D002289 ClinicalTrials
Oropharyngeal Neoplasms 3 D009959 ClinicalTrials
Biliary Tract Neoplasms 3 D001661 ClinicalTrials
Carcinoma, Squamous Cell 3 D002294 ClinicalTrials
Ovarian Neoplasms 3 D010051 ClinicalTrials
Carcinoma, Renal Cell 3 D002292 ClinicalTrials
Endometrial Neoplasms 3 D016889 ClinicalTrials
Mesothelioma 3 D008654 ClinicalTrials
Carcinoma, Squamous Cell 3 D002294 ClinicalTrials
Carcinoma, Renal Cell 3 D002292 ClinicalTrials
Carcinoma, Squamous Cell 3 D002294 ClinicalTrials
Ovarian Neoplasms 3 D010051 ClinicalTrials
Esophageal Neoplasms 3 D004938 ClinicalTrials
Urogenital Neoplasms 3 D014565 ClinicalTrials
Biliary Tract Neoplasms 3 D001661 ClinicalTrials
Esophageal Neoplasms 3 D004938 ClinicalTrials
Mesothelioma 3 D008654 ClinicalTrials
Uterine Cervical Neoplasms 3 D002583 ClinicalTrials
Carcinoma, Hepatocellular 3 D006528 ClinicalTrials
Fallopian Tube Neoplasms 2 D005185 ClinicalTrials
Colorectal Neoplasms 2 D015179 ClinicalTrials
Breast Neoplasms 2 D001943 ClinicalTrials
Stomach Neoplasms 2 D013274 ClinicalTrials
Breast Neoplasms 2 D001943 ClinicalTrials
Lymphoma, Large B-Cell, Diffuse 2 D016403 ClinicalTrials
Glioblastoma 2 D005909 ClinicalTrials
Multiple Myeloma 2 D009101 ClinicalTrials
Carcinoma, Pancreatic Ductal 2 D021441 ClinicalTrials
Colorectal Neoplasms 2 D015179 ClinicalTrials
Pancreatic Neoplasms 2 D010190 ClinicalTrials
Myelodysplastic Syndromes 2 D009190 ClinicalTrials
Leukemia, Myeloid, Acute 2 D015470 ClinicalTrials
Adenocarcinoma 2 D000230 ClinicalTrials
Adenocarcinoma, Clear Cell 2 D018262 ClinicalTrials
Neoplasms, Germ Cell and Embryonal 2 D009373 ClinicalTrials
Lymphoma 2 D008223 ClinicalTrials
Sarcoma 2 D012509 ClinicalTrials
Carcinoma, Large Cell 2 D018287 ClinicalTrials
Head and Neck Neoplasms 2 D006258 ClinicalTrials
Lymphoma, Non-Hodgkin 2 D008228 ClinicalTrials
Head and Neck Neoplasms 2 D006258 ClinicalTrials
Rectal Neoplasms 2 D012004 ClinicalTrials
Colorectal Neoplasms 2 D015179 ClinicalTrials
Carcinoma 2 D002277 ClinicalTrials
Adenocarcinoma, Follicular 2 D018263 ClinicalTrials
Adenocarcinoma of Lung 2 D000077192 ClinicalTrials
Thyroid Neoplasms 2 D013964 ClinicalTrials
Prostatic Neoplasms 2 D011471 ClinicalTrials
Mouth Neoplasms 2 D009062 ClinicalTrials
Stomach Neoplasms 2 D013274 ClinicalTrials
Thyroid Neoplasms 2 D013964 ClinicalTrials
Seminoma 2 D018239 ClinicalTrials
Dysgerminoma 2 D004407 ClinicalTrials
Bile Duct Neoplasms 2 D001650 ClinicalTrials
Anus Neoplasms 2 D001005 ClinicalTrials
Breast Neoplasms 2 D001943 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 2 D064129 ClinicalTrials
Squamous Cell Carcinoma of Head and Neck 2 D000077195 ClinicalTrials
Squamous Cell Carcinoma of Head and Neck 2 D000077195 ClinicalTrials
Stomach Neoplasms 2 D013274 ClinicalTrials
Genital Neoplasms, Female 2 D005833 ClinicalTrials
Hemangiosarcoma 2 D006394 ClinicalTrials
Neuroendocrine Tumors 2 D018358 ClinicalTrials
Cholangiocarcinoma 2 D018281 ClinicalTrials
Cholangiocarcinoma 2 D018281 ClinicalTrials
Sarcoma 2 D012509 ClinicalTrials
Neoplasm Metastasis 1 D009362 ClinicalTrials
Lymphoma, Follicular 1 D008224 ClinicalTrials
Triple Negative Breast Neoplasms 1 D064726 ClinicalTrials
Primary Myelofibrosis 1 D055728 ClinicalTrials
Primary Myelofibrosis 1 D055728 ClinicalTrials
Skin Neoplasms 1 D012878 ClinicalTrials
Lymphoma, T-Cell, Cutaneous 1 D016410 ClinicalTrials
Polycythemia Vera 1 D011087 ClinicalTrials
Hematologic Neoplasms 1 D019337 ClinicalTrials
Melanoma 1 D008545 ClinicalTrials
Plasmacytoma 1 D010954 ClinicalTrials
Leukemia, Lymphocytic, Chronic, B-Cell 1 D015451 ClinicalTrials

Adverse Reactions

System Organ Classification (SOC)
Relative Frequency (%)
Respiratory, thoracic and mediastinal disorders
17.88
General disorders and administration site conditions
9.73
Injury, poisoning and procedural complications
7.48
Nervous system disorders
7.04
Gastrointestinal disorders
6.97
Vascular disorders
6.29
Cardiac disorders
5.07
Infections and infestations
4.79
Musculoskeletal and connective tissue disorders
4.79
Investigations
4.32
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
4.32
Immune system disorders
3.98
Metabolism and nutrition disorders
3.49
Blood and lymphatic system disorders
2.93
Skin and subcutaneous tissue disorders
2.22
Endocrine disorders
2.12

Cross References

Resources Reference
CAS NUMBER 1428935-60-7
ChEMBL CHEMBL3301587
FDA SRS 28X28X9OKV
Guide to Pharmacology 7985