ELTROMBOPAG OLAMINE

Search structure
Trade Names:
Synonyms:
Status: Approved (2008)
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 4U07F515LG

Structure
InChI Key LQQUHOUXABUDJA-OUFJFOJPSA-N
Smile CC1=NN(c2ccc(C)c(C)c2)C(=O)/C1=N\Nc1cccc(-c2cccc(C(=O)O)c2)c1O.NCCO
InChI
InChI=1S/C25H22N4O4.C2H7NO/c1-14-10-11-19(12-15(14)2)29-24(31)22(16(3)28-29)27-26-21-9-5-8-20(23(21)30)17-6-4-7-18(13-17)25(32)33;3-1-2-4/h4-13,26,30H,1-3H3,(H,32,33);4H,1-3H2/b27-22-;

Physicochemical Descriptors

Property Name Value
Molecular Formula C29H36N6O6
Molecular Weight 564.64
AlogP 4.56
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 5.0
Polar Surface Area 114.59
Molecular species ACID
Aromatic Rings 3.0
Heavy Atoms 33.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Thrombopoietin receptor agonist DailyMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Thrombocytopenia 4 D013921 ClinicalTrials
Myelodysplastic Syndromes 2 D009190 ClinicalTrials

Related Entries

MCS

Scaffolds

Side Effects from Label

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
14.12
Investigations
11.34
Vascular disorders
9.8
Nervous system disorders
8.19
Gastrointestinal disorders
6.72
Respiratory, thoracic and mediastinal disorders
5.8
Musculoskeletal and connective tissue disorders
5.42
Skin and subcutaneous tissue disorders
5.37
Blood and lymphatic system disorders
4.45
Injury, poisoning and procedural complications
4.34
Infections and infestations
4.1
Cardiac disorders
4.06
Psychiatric disorders
3.07

Cross References

Resources Reference
ChEMBL CHEMBL3989691
FDA SRS 4U07F515LG
ZINC ZINC11679756
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