Trade Names: | |
Synonyms: | |
Status: | Approved (2014) |
Entry Type: | Small molecule |
Molecule Category: | Parent |
ATC: | A10BK03 |
UNII: | HDC1R2M35U |
InChI Key | OBWASQILIWPZMG-QZMOQZSNSA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C23H27ClO7 |
Molecular Weight | 450.92 |
AlogP | 1.61 |
Hydrogen Bond Acceptor | 7.0 |
Hydrogen Bond Donor | 4.0 |
Number of Rotational Bond | 6.0 |
Polar Surface Area | 108.61 |
Molecular species | NEUTRAL |
Aromatic Rings | 2.0 |
Heavy Atoms | 31.0 |
Action | Mechanism of Action | Reference |
---|---|---|
INHIBITOR | Sodium/glucose cotransporter 2 inhibitor | FDA |
Primary Target | |
---|---|
Sodium/glucose cotransporter 2 |
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
---|---|---|---|---|---|---|
Transporter
Electrochemical transporter
SLC superfamily of solute carriers
SLC05 family of sodium-dependent glucose transporters
|
3 | 3-3 | - | - | - |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Myocardial Infarction | 3 | D009203 | ClinicalTrials |
Diabetes Mellitus, Type 1 | 3 | D003922 | ClinicalTrials |
Heart Failure | 3 | D006333 | ClinicalTrials |
Diabetes, Gestational | 3 | D016640 | ClinicalTrials |
Diabetic Nephropathies | 3 | D003928 | ClinicalTrials |
Renal Insufficiency, Chronic | 3 | D051436 | ClinicalTrials |
Insulin Resistance | 3 | D007333 | ClinicalTrials |
Myocardial Infarction | 3 | D009203 | ClinicalTrials |
Kidney Calculi | 2 | D007669 | ClinicalTrials |
Non-alcoholic Fatty Liver Disease | 2 | D065626 | ClinicalTrials |
Kidney Diseases | 2 | D007674 | ClinicalTrials |
Polycystic Ovary Syndrome | 2 | D011085 | ClinicalTrials |
Glycogen Storage Disease Type I | 2 | D005953 | ClinicalTrials |
Inappropriate ADH Syndrome | 2 | D007177 | ClinicalTrials |
Prediabetic State | 2 | D011236 | ClinicalTrials |
Hyponatremia | 2 | D007010 | ClinicalTrials |
Resources | Reference |
---|---|
CAS NUMBER | 864070-44-0 |
ChEBI | 82720 |
ChEMBL | CHEMBL2107830 |
DrugBank | DB09038 |
DrugCentral | 4830 |
FDA SRS | HDC1R2M35U |
Guide to Pharmacology | 4754 |
PharmGKB | PA166163327 |
PubChem | 11949646 |
SureChEMBL | SCHEMBL899986 |
ZINC | ZINC000036520252 |