Trade Names: | |
Synonyms: | |
Status: | Approved (1988) |
Entry Type: | Small molecule |
Molecule Category: | UNKNOWN |
UNII: | GV0O7ES0R3 |
InChI Key | LZFZMUMEGBBDTC-QEJZJMRPSA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C18H28N2O7 |
Molecular Weight | 384.43 |
AlogP | 1.13 |
Hydrogen Bond Acceptor | 4.0 |
Hydrogen Bond Donor | 3.0 |
Number of Rotational Bond | 8.0 |
Polar Surface Area | 106.94 |
Molecular species | ACID |
Aromatic Rings | 1.0 |
Heavy Atoms | 25.0 |
Action | Mechanism of Action | Reference |
---|---|---|
INHIBITOR | Angiotensin-converting enzyme inhibitor | FDA |
Primary Target | |
---|---|
Angiotensin-converting enzyme |
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
---|---|---|---|---|---|---|
Enzyme
Protease
Metallo protease
Metallo protease MAE clan
Metallo protease M2 family
|
- | 1-3100 | - | 1 | 74 |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Cardiomyopathy, Dilated | 3 | D002311 | ClinicalTrials |
Hypertension | 3 | D006973 | ClinicalTrials |
Resources | Reference |
---|---|
CAS NUMBER | 76420-72-9 |
ChEBI | 59877 |
ChEMBL | CHEMBL3989406 |
FDA SRS | GV0O7ES0R3 |
Guide to Pharmacology | 6332 |
KEGG | C11720 |
PDB | EAL |
PubChem | 6917719 |
SureChEMBL | SCHEMBL37288 |
ZINC | ZINC03812851 |
CAS NUMBER | 76420-72-9 |
ChEBI | 4786 |
ChEMBL | CHEMBL577 |
DrugBank | DB09477 |
DrugCentral | 1006 |
EPA CompTox | DTXSID0048975 |
FDA SRS | Q508Q118JM |
Human Metabolome Database | HMDB0041886 |
Guide to Pharmacology | 6332 |
KEGG | C11720 |
PDB | EAL |
PubChem | 6917719 |
SureChEMBL | SCHEMBL37289 |
ZINC | ZINC000003812851 |