Trade Names: | |
Synonyms: | |
Status: | Approved (1985) |
Entry Type: | Small molecule |
Molecule Category: | Parent Prodrug |
UNII: | 9O25354EPJ |
InChI Key | OYFJQPXVCSSHAI-QFPUQLAESA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C24H32N2O9 |
Molecular Weight | 492.53 |
AlogP | 1.6 |
Hydrogen Bond Acceptor | 5.0 |
Hydrogen Bond Donor | 2.0 |
Number of Rotational Bond | 9.0 |
Polar Surface Area | 95.94 |
Molecular species | ACID |
Aromatic Rings | 1.0 |
Heavy Atoms | 27.0 |
Action | Mechanism of Action | Reference |
---|---|---|
INHIBITOR | Angiotensin-converting enzyme inhibitor | FDA |
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
---|---|---|---|---|---|---|
Transporter
Electrochemical transporter
SLC superfamily of solute carriers
SLC21/SLCO family of organic anion transporting polypeptides
|
- | - | - | - | 111 |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Proteinuria | 3 | D011507 | ClinicalTrials |
Arthritis, Rheumatoid | 2 | D001172 | ClinicalTrials |
Cerebral Hemorrhage | 2 | D002543 | ClinicalTrials |
Pre-Eclampsia | 2 | D011225 | ClinicalTrials |
Resources | Reference |
---|---|
ChEBI | 4785 |
ChEMBL | CHEMBL1200659 |
EPA CompTox | DTXSID30896796 |
FDA SRS | 9O25354EPJ |
Guide to Pharmacology | 6322 |
KEGG | C06977 |
PubChem | 5388961 |
SureChEMBL | SCHEMBL9 |