EVEROLIMUS

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Trade Names:
Synonyms:
Status: Approved (2009)
Entry Type: Small molecule
Molecule Category: UNKNOWN
ATC: L01EG02
UNII: 9HW64Q8G6G

Structure
InChI Key HKVAMNSJSFKALM-GKUWKFKPSA-N
Smile CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](OCCO)[C@H](OC)C2)CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C/1C
InChI
InChI=1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/b13-11+,16-12+,33-17+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C53H83NO14
Molecular Weight 958.24
AlogP 6.2
Hydrogen Bond Acceptor 14.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 9.0
Polar Surface Area 204.66
Molecular species NEUTRAL
Aromatic Rings 0.0
Heavy Atoms 68.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR FK506-binding protein 1A inhibitor DailyMed
Primary Target
mechanistic target of rapamycin kinase
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Auxiliary transport protein Slow voltage-gated potassium channel accessory protein family
- 100000 - - -
Enzyme Kinase Protein Kinase Atypical protein kinase group Atypical protein kinase PIKK family Atypical protein kinase FRAP subfamily
- 5 2 - -
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel
- 100000 - - -
Transporter Primary active transporter ATP-binding cassette ABCB subfamily
- 2000 - - -
Transporter Primary active transporter ATP-binding cassette ABCC subfamily
- 11300 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Breast Neoplasms 4 D001943 ClinicalTrials
Angiomyolipoma 4 D018207 ClinicalTrials
Neoplasms 4 D009369 ClinicalTrials
Breast Neoplasms 4 D001943 ClinicalTrials
Astrocytoma 4 D001254 ClinicalTrials
Astrocytoma 4 D001254 ClinicalTrials
Breast Neoplasms 4 D001943 ClinicalTrials
Neuroendocrine Tumors 4 D018358 ClinicalTrials
Neuroendocrine Tumors 4 D018358 ClinicalTrials
Carcinoma, Renal Cell 4 D002292 ClinicalTrials
Neoplasms 4 D009369 ClinicalTrials
Tuberous Sclerosis 4 D014402 ClinicalTrials
Neuroendocrine Tumors 4 D018358 ClinicalTrials
Kidney Neoplasms 3 D007680 ClinicalTrials
Endocardial Cushion Defects 3 D004694 ClinicalTrials
Stomach Neoplasms 3 D013274 ClinicalTrials
Renal Insufficiency, Chronic 3 D051436 ClinicalTrials
Carcinoid Tumor 3 D002276 ClinicalTrials
Malignant Carcinoid Syndrome 3 D008303 ClinicalTrials
Cytomegalovirus Infections 3 D003586 ClinicalTrials
Carcinoid Tumor 3 D002276 ClinicalTrials
Polycystic Kidney, Autosomal Dominant 3 D016891 ClinicalTrials
Carcinoma 3 D002277 ClinicalTrials
Graft vs Host Disease 3 D006086 ClinicalTrials
Lymphoma, Large B-Cell, Diffuse 3 D016403 ClinicalTrials
Infections 3 D007239 ClinicalTrials
Coronary Restenosis 3 D023903 ClinicalTrials
Skin Neoplasms 3 D012878 ClinicalTrials
Graft vs Host Disease 3 D006086 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 3 D064129 ClinicalTrials
Stomach Neoplasms 3 D013274 ClinicalTrials
Renal Insufficiency 3 D051437 ClinicalTrials
Oligodendroglioma 2 D009837 ClinicalTrials
Multiple Myeloma 2 D009101 ClinicalTrials
Melanoma 2 D008545 ClinicalTrials
Thymus Neoplasms 2 D013953 ClinicalTrials
Pancreatic Neoplasms 2 D010190 ClinicalTrials
Head and Neck Neoplasms 2 D006258 ClinicalTrials
Adenoma, Islet Cell 2 D007516 ClinicalTrials
Carcinoma, Transitional Cell 2 D002295 ClinicalTrials
Lymphoma, B-Cell, Marginal Zone 2 D018442 ClinicalTrials
Colorectal Neoplasms 2 D015179 ClinicalTrials
Sarcoma 2 D012509 ClinicalTrials
Meningioma 2 D008579 ClinicalTrials
Waldenstrom Macroglobulinemia 2 D008258 ClinicalTrials
Neurilemmoma 2 D009442 ClinicalTrials
Polycystic Kidney Diseases 2 D007690 ClinicalTrials
Diffuse Intrinsic Pontine Glioma 2 D000080443 ClinicalTrials
Osteosarcoma 2 D012516 ClinicalTrials
Carcinoma, Adenoid Cystic 2 D003528 ClinicalTrials
Colorectal Neoplasms 2 D015179 ClinicalTrials
Mesothelioma 2 D008654 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 2 D002289 ClinicalTrials
Sarcoma 2 D012509 ClinicalTrials
Small Cell Lung Carcinoma 2 D055752 ClinicalTrials
Cholangiocarcinoma 2 D018281 ClinicalTrials
Glioblastoma 2 D005909 ClinicalTrials
Carcinoma, Hepatocellular 2 D006528 ClinicalTrials
Kidney Diseases 2 D007674 ClinicalTrials
Lymphoma 2 D008223 ClinicalTrials
Mesothelioma 2 D008654 ClinicalTrials
Neurofibromatosis 2 2 D016518 ClinicalTrials
Pancreatic Neoplasms 2 D010190 ClinicalTrials
Lymphoma, T-Cell, Cutaneous 2 D016410 ClinicalTrials
Neoplasms, Germ Cell and Embryonal 2 D009373 ClinicalTrials
Lung Neoplasms 2 D008175 ClinicalTrials
Glioma 2 D005910 ClinicalTrials
Chondrosarcoma 2 D002813 ClinicalTrials
Hodgkin Disease 2 D006689 ClinicalTrials
Osteosarcoma 2 D012516 ClinicalTrials
Hepatitis C 2 D006526 ClinicalTrials
Peutz-Jeghers Syndrome 2 D010580 ClinicalTrials
Leukemia, Myeloid, Acute 2 D015470 ClinicalTrials
Brain Neoplasms 2 D001932 ClinicalTrials
Sarcoma, Kaposi 2 D012514 ClinicalTrials
Lymphangioleiomyomatosis 2 D018192 ClinicalTrials
Lymphoma, Mantle-Cell 2 D020522 ClinicalTrials
Myelodysplastic Syndromes 2 D009190 ClinicalTrials
Macular Degeneration 2 D008268 ClinicalTrials
Neurofibromatosis 1 2 D009456 ClinicalTrials
Tuberculosis 2 D014376 ClinicalTrials
Uveitis 2 D014605 ClinicalTrials
Carcinoma, Squamous Cell 2 D002294 ClinicalTrials
Melanoma 2 D008545 ClinicalTrials
Epilepsy 2 D004827 ClinicalTrials
Oligodendroglioma 2 D009837 ClinicalTrials
Urinary Bladder Neoplasms 2 D001749 ClinicalTrials
Hyperaldosteronism 2 D006929 ClinicalTrials
Thyroid Neoplasms 2 D013964 ClinicalTrials
Carcinoma, Neuroendocrine 2 D018278 ClinicalTrials
Liver Neoplasms 2 D008113 ClinicalTrials
Uterine Neoplasms 2 D014594 ClinicalTrials
Glioma 2 D005910 ClinicalTrials
Ependymoma 2 D004806 ClinicalTrials
Lung Neoplasms 2 D008175 ClinicalTrials
Hodgkin Disease 2 D006689 ClinicalTrials
Endometrial Neoplasms 2 D016889 ClinicalTrials
Carcinoma, Medullary 2 D018276 ClinicalTrials
Mastocytosis, Systemic 2 D034721 ClinicalTrials
Endometrial Hyperplasia 2 D004714 ClinicalTrials
Glioma 2 D005910 ClinicalTrials
Uterine Cervical Neoplasms 1 D002583 ClinicalTrials
Esophageal Neoplasms 1 D004938 ClinicalTrials
Neoplasm Metastasis 1 D009362 ClinicalTrials
Gallbladder Neoplasms 1 D005706 ClinicalTrials
Breast Neoplasms, Male 1 D018567 ClinicalTrials
Esophageal Neoplasms 1 D004938 ClinicalTrials
Ovarian Neoplasms 1 D010051 ClinicalTrials
Lymphoma, Non-Hodgkin 1 D008228 ClinicalTrials
Leukemia 1 D007938 ClinicalTrials
Leukemia, Myelogenous, Chronic, BCR-ABL Positive 1 D015464 ClinicalTrials
Acute Coronary Syndrome 1 D054058 ClinicalTrials
Leukemia, Lymphoid 1 D007945 ClinicalTrials
Central Nervous System Neoplasms 1 D016543 ClinicalTrials
Triple Negative Breast Neoplasms 1 D064726 ClinicalTrials
Gastrointestinal Stromal Tumors 1 D046152 ClinicalTrials
Precursor Cell Lymphoblastic Leukemia-Lymphoma 1 D054198 ClinicalTrials
Ovarian Neoplasms 1 D010051 ClinicalTrials
Adenocarcinoma 1 D000230 ClinicalTrials
Precursor Cell Lymphoblastic Leukemia-Lymphoma 1 D054198 ClinicalTrials
Peritoneal Neoplasms 1 D010534 ClinicalTrials
Nasopharyngeal Neoplasms 1 D009303 ClinicalTrials
Progeria 1 D011371 ClinicalTrials
Fallopian Tube Neoplasms 1 D005185 ClinicalTrials
Hamartoma Syndrome, Multiple 1 D006223 ClinicalTrials
Colonic Neoplasms 1 D003110 ClinicalTrials
Sarcoma, Synovial 1 D013584 ClinicalTrials
Hematologic Diseases 1 D006402 ClinicalTrials

Related Entries

Scaffolds

Side Effects from Label

Side effects Relative Frequency (%) Labels
Infections and infestations Infection 95.0
Investigations Haemoglobin decreased 92.0
Investigations Haemoglobin decreased 86.0
Metabolism and nutrition disorders Hypercholesterolaemia 85.0
Metabolism and nutrition disorders Hypercholesterolaemia 81.0
Investigations Haemoglobin decreased
Gastrointestinal disorders Stomatitis 78.0
Investigations Blood alkaline phosphatase increased 74.0
Gastrointestinal disorders Stomatitis 70.0
Investigations Blood alkaline phosphatase increased
Investigations Haemoglobin decreased
Gastrointestinal disorders Stomatitis 62.0
Blood and lymphatic system disorders Anaemia 61.0
Skin and subcutaneous tissue disorders Dermatitis 59.0
Skin and subcutaneous tissue disorders Rash 59.0
Investigations Blood glucose increased 57.0
Metabolism and nutrition disorders Hyperlipidaemia 52.2
Investigations Blood triglycerides increased 52.0
Metabolism and nutrition disorders Hypertriglyceridaemia 52.0
Investigations Lymphocyte count decreased 51.0
Gastrointestinal disorders Gastrointestinal disorder 50.2
Investigations Blood creatinine increased 50.0
Gastrointestinal disorders Diarrhoea 50.0
Blood and lymphatic system disorders Anaemia
Metabolism and nutrition disorders Hypophosphataemia 49.0
Vascular disorders Hypertension 47.4
Vascular disorders Hypertension 46.2
Metabolism and nutrition disorders Hypercholesterolaemia
Blood and lymphatic system disorders Neutropenia 46.0
General disorders and administration site conditions Asthenia 45.0
General disorders and administration site conditions Discomfort 45.0
General disorders and administration site conditions Fatigue 45.0
General disorders and administration site conditions Feeling abnormal 45.0
General disorders and administration site conditions Ill-defined disorder 45.0
Investigations Lymphocyte count decreased 45.0
General disorders and administration site conditions Malaise 45.0
Investigations Platelet count decreased 45.0
Cardiac disorders Oedema peripheral 44.9
Cardiac disorders Oedema peripheral 44.4
Infections and infestations Infection 43.6
Infections and infestations Infestation 43.6
Investigations White blood cell count decreased 43.0
Gastrointestinal disorders Constipation 42.9
Blood and lymphatic system disorders Anaemia 41.0
Blood and lymphatic system disorders Neutropenia
Investigations Blood phosphorus decreased 40.0
Cardiac disorders Pericardial effusion 39.8
Cardiac disorders Oedema peripheral 39.6
Metabolism and nutrition disorders Hypercholesterolaemia
General disorders and administration site conditions Oedema 39.0
Gastrointestinal disorders Constipation 38.7
Metabolism and nutrition disorders Hyperlipidaemia 38.5
Cardiac disorders Oedema peripheral 38.4
Investigations Blood calcium decreased 37.0
Investigations Blood phosphorus decreased 37.0
Blood and lymphatic system disorders Leukopenia 37.0
Gastrointestinal disorders Abdominal pain 36.0
Gastrointestinal disorders Gastrointestinal pain 36.0
Nervous system disorders Nervous system disorder 35.3
Investigations Blood creatinine increased
Gastrointestinal disorders Nausea
Vascular disorders Hypertension 32.6
Vascular disorders Hypertension 32.5
Gastrointestinal disorders Abdominal pain
Investigations Blood alkaline phosphatase increased 32.0
Gastrointestinal disorders Gastrointestinal pain
Gastrointestinal disorders Nausea 32.0
Gastrointestinal disorders Nausea 31.5
Investigations Body temperature increased 31.0
Infections and infestations Respiratory tract infection 31.0
General disorders and administration site conditions Decreased appetite 30.0
Nervous system disorders Headache 30.0
Nervous system disorders Migraine 30.0
Blood and lymphatic system disorders Neutropenia 30.0
Metabolism and nutrition disorders Hyperlipidaemia 29.7
Gastrointestinal disorders Nausea 29.6
Infections and infestations Cellulitis 29.0
Gastrointestinal disorders Vomiting 29.0
Nervous system disorders Headache 28.0
Investigations Lymphocyte count decreased
Investigations Weight decreased 28.0
Cardiac disorders Pericardial effusion 27.6
General disorders and administration site conditions Asthenia
Investigations Blood triglycerides increased 27.0
General disorders and administration site conditions Discomfort
General disorders and administration site conditions Fatigue
General disorders and administration site conditions Feeling abnormal
Metabolism and nutrition disorders Hypertriglyceridaemia 27.0
General disorders and administration site conditions Ill-defined disorder
General disorders and administration site conditions Malaise
Nervous system disorders Insomnia 26.9
Gastrointestinal disorders Nausea 26.5
Blood and lymphatic system disorders Neutropenia
Gastrointestinal disorders Stomatitis
Respiratory, thoracic and mediastinal disorders Pleural effusion 25.4
Investigations Blood glucose increased
Respiratory, thoracic and mediastinal disorders Cough 25.0
Gastrointestinal disorders Diarrhoea
Endocrine disorders Hyperglycaemia 25.0
Infections and infestations Nasopharyngitis 25.0
Blood and lymphatic system disorders Neutropenia 25.0
Respiratory, thoracic and mediastinal disorders Productive cough 25.0
Infections and infestations Rhinitis 25.0
Endocrine disorders Diabetes mellitus 24.9
Gastrointestinal disorders Constipation 24.7
Gastrointestinal disorders Abdominal pain 24.5
Gastrointestinal disorders Gastrointestinal pain 24.5
Vascular disorders Angiopathy 23.7
Metabolism and nutrition disorders Hyperlipidaemia 23.7
Gastrointestinal disorders Diarrhoea 23.5
Nervous system disorders Headache 23.5
Investigations Blood potassium decreased 23.0
Investigations Body temperature increased 23.0
Investigations Platelet count decreased 23.0
Infections and infestations Respiratory tract infection
Gastrointestinal disorders Stomatitis
Metabolism and nutrition disorders Hyperlipidaemia 22.4
Skin and subcutaneous tissue disorders Acne 22.0
Respiratory, thoracic and mediastinal disorders Epistaxis 22.0
Investigations Lymphocyte count decreased
Skin and subcutaneous tissue disorders Nail disorder 22.0
Gastrointestinal disorders Vomiting 22.0
Gastrointestinal disorders Constipation 21.6
Respiratory, thoracic and mediastinal disorders Pleural effusion 21.6
Endocrine disorders Diabetes mellitus 21.2
Psychiatric disorders Aggression 21.0
Blood and lymphatic system disorders Anaemia
Psychiatric disorders Anxiety 21.0
Skin and subcutaneous tissue disorders Dermatitis 21.0
Blood and lymphatic system disorders Leukopenia
Skin and subcutaneous tissue disorders Pruritus 21.0
Pruritus generalised 21.0
Skin and subcutaneous tissue disorders Rash 21.0
Gastrointestinal disorders Vomiting
Gastrointestinal disorders Nausea 20.8
Gastrointestinal disorders Diarrhoea 20.7
Respiratory, thoracic and mediastinal disorders Cough 20.4
Nervous system disorders Insomnia 20.1
General disorders and administration site conditions Asthenia
Respiratory, thoracic and mediastinal disorders Cough 20.0
Cardiac disorders Dyspnoea 20.0
Cardiac disorders Dyspnoea exertional 20.0
Blood and lymphatic system disorders Lymphopenia 20.0
Gastrointestinal disorders Stomatitis
Gastrointestinal disorders Diarrhoea 19.8
Endocrine disorders Diabetes mellitus 19.4
Gastrointestinal disorders Diarrhoea 19.2
Nervous system disorders Headache 19.2
Nervous system disorders Headache 19.1
General disorders and administration site conditions Asthenia 19.0
Investigations Blood creatinine increased 19.0
Skin and subcutaneous tissue disorders Dermatitis
Endocrine disorders Diabetes mellitus 19.0
Gastrointestinal disorders Dysgeusia 19.0
Skin and subcutaneous tissue disorders Rash
Blood and lymphatic system disorders Thrombocytopenia 19.0
Investigations Body temperature increased 18.6
Gastrointestinal disorders Diarrhoea 18.6
Gastrointestinal disorders Abdominal pain 18.4
Gastrointestinal disorders Gastrointestinal pain 18.4
Gastrointestinal disorders Diarrhoea 18.3
Gastrointestinal disorders Abdominal pain 18.2
Gastrointestinal disorders Gastrointestinal pain 18.2
Investigations Body temperature increased
General disorders and administration site conditions Decreased appetite
Vascular disorders Hypertension 18.0
Nervous system disorders Headache 17.9
Cardiac disorders Oedema peripheral 17.6
Nervous system disorders Insomnia 17.2
Gastrointestinal disorders Diarrhoea 17.0
Blood and lymphatic system disorders Neutropenia
Infections and infestations Pneumonia 17.0
Cardiac disorders Dyspnoea 16.8
Investigations Body temperature increased 16.5
Cardiac disorders Dyspnoea 16.0
Metabolism and nutrition disorders Hyponatraemia
Metabolism and nutrition disorders Hyponatraemia 16.0
Investigations Lymphocyte count decreased 16.0
Infections and infestations Urinary tract infection 16.0
Vascular disorders Hypertension 15.8
Nervous system disorders Insomnia 15.8
Respiratory, thoracic and mediastinal disorders Cough 15.7
Gastrointestinal disorders Vomiting 15.7
General disorders and administration site conditions Pain 15.4
Psychiatric disorders Anxiety 15.1
Musculoskeletal and connective tissue disorders Arthralgia 15.0
Musculoskeletal and connective tissue disorders Back pain 15.0
Investigations Blood glucose increased 15.0
Investigations Blood triglycerides increased
Investigations Body temperature increased 15.0
Investigations Haemoglobin decreased 15.0
Nervous system disorders Headache
Metabolism and nutrition disorders Hypertriglyceridaemia
Metabolism and nutrition disorders Hypophosphataemia
Nervous system disorders Migraine
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 15.0
Gastrointestinal disorders Vomiting 15.0
Investigations Body temperature increased 14.9
Nervous system disorders Headache 14.7
Gastrointestinal disorders Vomiting 14.6
Gastrointestinal disorders Abdominal pain 14.5
Gastrointestinal disorders Gastrointestinal pain 14.5
Gastrointestinal disorders Abdominal pain 14.2
Gastrointestinal disorders Gastrointestinal pain 14.2
General disorders and administration site conditions Asthenia 14.0
Investigations Blood bilirubin increased
Investigations Blood creatinine increased
Investigations Blood creatinine increased 14.0
Investigations Blood phosphorus decreased
Gastrointestinal disorders Constipation 14.0
Gastrointestinal disorders Diarrhoea 14.0
General disorders and administration site conditions Fatigue 14.0
Endocrine disorders Hyperglycaemia 14.0
Nervous system disorders Insomnia 14.0
Blood and lymphatic system disorders Neutropenia 14.0
Musculoskeletal and connective tissue disorders Pain in extremity 14.0
Gastrointestinal disorders Nausea 13.5
Investigations Body temperature increased 13.1
Musculoskeletal and connective tissue disorders Arthralgia 13.0
Investigations Blood albumin decreased 13.0
Investigations Body temperature increased
Gastrointestinal disorders Constipation
Respiratory, thoracic and mediastinal disorders Cough
Skin and subcutaneous tissue disorders Dry skin 13.0
Vascular disorders Hypertension 13.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 13.0
Infections and infestations Nasopharyngitis
Cardiac disorders Oedema peripheral 13.0
Respiratory, thoracic and mediastinal disorders Productive cough
Skin and subcutaneous tissue disorders Pruritus
Pruritus generalised
Infections and infestations Rhinitis
Gastrointestinal disorders Vomiting
Investigations White blood cell count decreased
Skin and subcutaneous tissue disorders Xeroderma 13.0
Metabolism and nutrition disorders Hypokalaemia 12.9
General disorders and administration site conditions Pain 12.3
Vascular disorders Embolism 12.2
Investigations Blood calcium decreased
Endocrine disorders Diabetes mellitus 12.0
Cardiac disorders Dizziness 12.0
Investigations Haemoglobin decreased 12.0
Metabolism and nutrition disorders Hypokalaemia 12.0
General disorders and administration site conditions Oedema
Nervous system disorders Tremor 12.0
Psychiatric disorders Anxiety 11.9
Metabolism and nutrition disorders Hypokalaemia 11.9
Metabolism and nutrition disorders Hypokalaemia 11.7
Gastrointestinal disorders Nausea 11.6
Gastrointestinal disorders Abdominal pain 11.5
Gastrointestinal disorders Gastrointestinal pain 11.5
Endocrine disorders Diabetes mellitus 11.4
Musculoskeletal and connective tissue disorders Back pain
Respiratory, thoracic and mediastinal disorders Cough 11.0
Gastrointestinal disorders Dry mouth 11.0
Gastrointestinal disorders Oropharyngeal pain 11.0
Investigations Platelet count decreased
Infections and infestations Upper respiratory tract infection 11.0
Investigations Weight decreased
General disorders and administration site conditions Asthenia 10.8
General disorders and administration site conditions Fatigue 10.8
Cardiac disorders Oedema peripheral 10.8
Skin and subcutaneous tissue disorders Acne 10.4
Investigations Body temperature increased 10.4
Gastrointestinal disorders Vomiting 10.4
Skin and subcutaneous tissue disorders Acne 10.0
Investigations Blood alkaline phosphatase increased
Investigations Blood bilirubin increased 10.0
Investigations Blood phosphorus decreased 10.0
Investigations Blood potassium increased
Investigations Blood triglycerides increased
Gastrointestinal disorders Constipation 10.0
Endocrine disorders Diabetes mellitus 10.0
Gastrointestinal disorders Gastroenteritis 10.0
Metabolism and nutrition disorders Hypertriglyceridaemia
Reproductive system and breast disorders Menorrhagia 10.0
Endocrine disorders Menstruation irregular 10.0
Musculoskeletal and connective tissue disorders Muscle spasms 10.0
Infections and infestations Pharyngitis streptococcal 10.0
Investigations Hepatic enzyme abnormal 9.96
Investigations Liver function test abnormal 9.96
General disorders and administration site conditions Pain 9.89
General disorders and administration site conditions Pain 9.85
Metabolism and nutrition disorders Hyperlipidaemia 9.54
Musculoskeletal and connective tissue disorders Arthralgia 9.52
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 9.52
Skin and subcutaneous tissue disorders Acne 9.49
Psychiatric disorders Anxiety 9.49
Gastrointestinal disorders Mouth ulceration 9.39
Gastrointestinal disorders Stomatitis 9.39
Gastrointestinal disorders Abdominal pain 9.13
Gastrointestinal disorders Gastrointestinal pain 9.13
Musculoskeletal and connective tissue disorders Arthralgia 9.12
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 9.12
Renal and urinary disorders Proteinuria 9.12
Investigations Protein urine present 9.12
Gastrointestinal disorders Abdominal pain 9.0
Respiratory, thoracic and mediastinal disorders Epistaxis 9.0
Gastrointestinal disorders Gastrointestinal pain 9.0
Metabolism and nutrition disorders Hypophosphataemia 9.0
Nervous system disorders Insomnia 9.0
Blood and lymphatic system disorders Neutropenia 9.0
Gastrointestinal disorders Stomatitis 9.0
Investigations Weight decreased 9.0
Cardiac disorders Dyspnoea 8.79
Gastrointestinal disorders Mouth ulceration 8.76
Gastrointestinal disorders Stomatitis 8.76
Musculoskeletal and connective tissue disorders Arthralgia 8.58
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 8.58
Skin and subcutaneous tissue disorders Acne 8.42
Gastrointestinal disorders Mouth ulceration 8.24
Gastrointestinal disorders Stomatitis 8.24
Vascular disorders Embolism 8.21
Investigations Blood albumin decreased
Investigations Blood alkaline phosphatase increased
Investigations Blood alkaline phosphatase increased 8.0
Investigations Blood phosphorus decreased
Skin and subcutaneous tissue disorders Dermatitis
Gastrointestinal disorders Dry mouth 8.0
Endocrine disorders Hyperglycaemia
Nervous system disorders Insomnia
Blood and lymphatic system disorders Lymphopenia
Gastrointestinal disorders Nausea 8.0
Cardiac disorders Oedema peripheral
Musculoskeletal and connective tissue disorders Pain in extremity 8.0
Skin and subcutaneous tissue disorders Rash
Reproductive system and breast disorders Vaginal haemorrhage 8.0
Hepatobiliary disorders Hepatitis C 7.88
Nervous system disorders Insomnia 7.88
Blood and lymphatic system disorders Lymphocele 7.66
Skin and subcutaneous tissue disorders Acne 7.53
Musculoskeletal and connective tissue disorders Arthralgia 7.47
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 7.47
Gastrointestinal disorders Vomiting 7.47
Renal and urinary disorders Proteinuria 7.33
Investigations Protein urine present 7.33
Respiratory, thoracic and mediastinal disorders Cough 7.3
Cardiac disorders Dyspnoea 7.3
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 7.17
Musculoskeletal and connective tissue disorders Myalgia 7.17
Cardiac disorders Tachycardia 7.09
Musculoskeletal and connective tissue disorders Arthralgia
Investigations Blood potassium increased 7.0
Cardiac disorders Dizziness
Cardiac disorders Dizziness 7.0
Cardiac disorders Dyspnoea
Cardiac disorders Dyspnoea exertional
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort
Respiratory, thoracic and mediastinal disorders Pleural effusion 7.0
Gastrointestinal disorders Stomatitis 7.0
Psychiatric disorders Anxiety 6.96
Musculoskeletal and connective tissue disorders Arthralgia 6.94
Gastrointestinal disorders Incisional hernia 6.94
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 6.94
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 6.72
Musculoskeletal and connective tissue disorders Myalgia 6.72
Gastrointestinal disorders Constipation 6.53
Investigations Hepatic enzyme abnormal 6.53
Cardiac disorders Tachycardia 6.45
Skin and subcutaneous tissue disorders Dermatitis 6.34
Skin and subcutaneous tissue disorders Rash 6.34
Skin and subcutaneous tissue disorders Dermatitis 6.23
Skin and subcutaneous tissue disorders Rash 6.23
Respiratory, thoracic and mediastinal disorders Cough 6.22
Respiratory, thoracic and mediastinal disorders Cough 6.12
Cardiac disorders Dyspnoea 6.12
Musculoskeletal and connective tissue disorders Arthralgia 6.09
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 6.09
Gastrointestinal disorders Oropharyngeal pain 6.09
Gastrointestinal disorders Abdominal pain
Investigations Blood phosphorus decreased 6.0
Investigations Body temperature increased 6.0
General disorders and administration site conditions Decreased appetite 6.0
Skin and subcutaneous tissue disorders Dry skin
Reproductive system and breast disorders Dysmenorrhoea 6.0
Gastrointestinal disorders Gastrointestinal pain
Vascular disorders Hypertension
Nervous system disorders Insomnia 6.0
Reproductive system and breast disorders Menorrhagia 6.0
Endocrine disorders Menstruation irregular 6.0
Reproductive system and breast disorders Metrorrhagia 6.0
Gastrointestinal disorders Oropharyngeal pain
Ear and labyrinth disorders Otitis media 6.0
Musculoskeletal and connective tissue disorders Pain in extremity
Infections and infestations Pneumonia 6.0
Gastrointestinal disorders Stomatitis 6.0
Infections and infestations Urinary tract infection
Skin and subcutaneous tissue disorders Xeroderma
Blood and lymphatic system disorders Lymphocele 5.86
Nervous system disorders Insomnia 5.71
Gastrointestinal disorders Vomiting 5.71
Vascular disorders Embolism 5.47
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 5.47
Musculoskeletal and connective tissue disorders Myalgia 5.47
Renal and urinary disorders Renal tubular necrosis 5.47
Gastrointestinal disorders Constipation 5.39
Gastrointestinal disorders Incisional hernia 5.39
Skin and subcutaneous tissue disorders Dermatitis 5.38
Respiratory, thoracic and mediastinal disorders Epistaxis 5.38
Psychiatric disorders Erectile dysfunction 5.38
Skin and subcutaneous tissue disorders Rash 5.38
Gastrointestinal disorders Oropharyngeal pain 5.31
Gastrointestinal disorders Oropharyngeal pain 5.11
Cardiac disorders Tachycardia 5.11
Immune system disorders Angioedema 5.02
Skin and subcutaneous tissue disorders Acne
Psychiatric disorders Aggression 5.0
Psychiatric disorders Anxiety 5.0
Musculoskeletal and connective tissue disorders Arthralgia
Investigations Blood potassium decreased
Cardiac disorders Chest pain 5.0
Gastrointestinal disorders Diarrhoea
Gastrointestinal disorders Diarrhoea 5.0
Gastrointestinal disorders Dysgeusia
Respiratory, thoracic and mediastinal disorders Epistaxis 5.0
Investigations Haemoglobin decreased
Gastrointestinal disorders Haemorrhoids 5.0
Metabolism and nutrition disorders Hypophosphataemia 5.0
Investigations Lymphocyte count decreased
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort
Skin and subcutaneous tissue disorders Nail disorder 5.0
Nervous system disorders Paraesthesia 5.0
Infections and infestations Upper respiratory tract infection
Gastrointestinal disorders Vomiting
Cardiac disorders Dyspnoea 4.98
Blood and lymphatic system disorders Leukopenia 4.98
Gastrointestinal disorders Mouth ulceration 4.85
Gastrointestinal disorders Stomatitis 4.85
Renal and urinary disorders Renal tubular necrosis 4.76
Skin and subcutaneous tissue disorders Dermatitis 4.74
Skin and subcutaneous tissue disorders Rash 4.74
Respiratory, thoracic and mediastinal disorders Pleural effusion 4.56
Psychiatric disorders Anxiety 4.49
Respiratory, thoracic and mediastinal disorders Pleural effusion 4.49
Investigations Hepatic enzyme abnormal 4.4
Blood and lymphatic system disorders Lymphocele 4.3
General disorders and administration site conditions Pain 4.15
Immune system disorders Angioedema 4.01
Gastrointestinal disorders Abdominal pain 4.0
Investigations Blood potassium decreased 4.0
General disorders and administration site conditions Chills 4.0
Gastrointestinal disorders Dry mouth
Gastrointestinal disorders Dysphagia 4.0
Skin and subcutaneous tissue disorders Erythema 4.0
Eye disorders Eyelid oedema 4.0
Gastrointestinal disorders Gastroenteritis 4.0
Gastrointestinal disorders Gastrointestinal pain 4.0
Vascular disorders Hypertension 4.0
Respiratory, thoracic and mediastinal disorders Laryngeal pain 4.0
Investigations Lymphocyte count decreased
Musculoskeletal and connective tissue disorders Muscle spasms
Blood and lymphatic system disorders Neutropenia
Blood and lymphatic system disorders Neutropenia 4.0
Skin and subcutaneous tissue disorders Onychoclasis 4.0
Skin and subcutaneous tissue disorders Skin lesion 4.0
Skin and subcutaneous tissue disorders Dermatitis 3.73
Gastrointestinal disorders Oropharyngeal pain 3.73
Skin and subcutaneous tissue disorders Rash 3.73
Skin and subcutaneous tissue disorders Dermatitis 3.67
Vascular disorders Embolism 3.67
Blood and lymphatic system disorders Pancytopenia 3.67
Skin and subcutaneous tissue disorders Rash 3.67
Immune system disorders Angioedema 3.66
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 3.66
Musculoskeletal and connective tissue disorders Myalgia 3.66
Gastrointestinal disorders Oropharyngeal pain 3.66
Psychiatric disorders Erectile dysfunction 3.65
Cardiac disorders Tachycardia 3.32
General disorders and administration site conditions Pain 3.27
Gastrointestinal disorders Incisional hernia 3.23
Renal and urinary disorders Proteinuria 3.23
Investigations Protein urine present 3.23
Psychiatric disorders Aggression
Psychiatric disorders Anxiety
General disorders and administration site conditions Asthenia
General disorders and administration site conditions Asthenia 3.0
Investigations Blood bilirubin increased 3.0
Investigations Blood phosphorus decreased
Investigations Body temperature increased
Gastrointestinal disorders Constipation
Skin and subcutaneous tissue disorders Dermatitis acneiform 3.0
Gastrointestinal disorders Diarrhoea
General disorders and administration site conditions Discomfort 3.0
General disorders and administration site conditions Fatigue
General disorders and administration site conditions Fatigue 3.0
General disorders and administration site conditions Feeling abnormal 3.0
Gastrointestinal disorders Gastroenteritis
Investigations Haemoglobin 3.0
Vascular disorders Haemorrhage 3.0
Immune system disorders Hypersensitivity 3.0
Metabolism and nutrition disorders Hypophosphataemia
General disorders and administration site conditions Ill-defined disorder 3.0
General disorders and administration site conditions Malaise 3.0
Infections and infestations Nasopharyngitis 3.0
Blood and lymphatic system disorders Neutropenia
Musculoskeletal and connective tissue disorders Pain in jaw 3.0
Infections and infestations Pharyngitis streptococcal
Investigations Platelet count decreased 3.0
Infections and infestations Pneumonia 3.0
Renal and urinary disorders Renal failure 3.0
Respiratory, thoracic and mediastinal disorders Rhinorrhoea 3.0
Gastrointestinal disorders Stomatitis
Cardiac disorders Tachycardia 3.0
Blood and lymphatic system disorders Thrombocytopenia
Vascular disorders Embolism 2.93
Cardiac disorders Tachycardia 2.93
Respiratory, thoracic and mediastinal disorders Pleural effusion 2.92
Metabolism and nutrition disorders Hypokalaemia 2.86
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 2.86
Musculoskeletal and connective tissue disorders Myalgia 2.86
Renal and urinary disorders Proteinuria 2.86
Investigations Protein urine present 2.86
Immune system disorders Angioedema 2.61
Respiratory, thoracic and mediastinal disorders Epistaxis 2.61
Psychiatric disorders Erectile dysfunction 2.61
Gastrointestinal disorders Mouth ulceration 2.56
Gastrointestinal disorders Stomatitis 2.56
Immune system disorders Interstitial lung disease 2.51
Blood and lymphatic system disorders Lymphocele 2.24
Respiratory, thoracic and mediastinal disorders Epistaxis 2.19
Investigations Hepatic enzyme abnormal 2.19
Infections and infestations Pyelonephritis 2.19
Vascular disorders Thrombosis 2.19
Investigations Hepatic enzyme abnormal 2.15
Psychiatric disorders Erectile dysfunction 2.07
Hepatobiliary disorders Hepatitis 2.07
Metabolism and nutrition disorders Hypokalaemia 2.07
Blood and lymphatic system disorders Jaundice 2.07
Gastrointestinal disorders Oropharyngeal pain 2.07
Respiratory, thoracic and mediastinal disorders Epistaxis 2.04
Hepatobiliary disorders Hepatitis 2.04
Cardiac disorders Tachycardia 2.04
General disorders and administration site conditions Asthenia
Investigations Blood bilirubin increased
Investigations Blood creatinine increased 2.0
Eye disorders Conjunctivitis 2.0
Endocrine disorders Diabetes mellitus 2.0
General disorders and administration site conditions Discomfort
Cardiac disorders Dyspnoea 2.0
Cardiac disorders Dyspnoea exertional 2.0
General disorders and administration site conditions Fatigue
General disorders and administration site conditions Feeling abnormal
General disorders and administration site conditions Ill-defined disorder
Investigations Lymphocyte count decreased 2.0
General disorders and administration site conditions Malaise
Skin and subcutaneous tissue disorders Nail disorder
Gastrointestinal disorders Nausea
Gastrointestinal disorders Nausea 2.0
Blood and lymphatic system disorders Neutropenia
Investigations Platelet count decreased
Gastrointestinal disorders Vomiting
Investigations White blood cell count decreased 2.0
Investigations Hepatic enzyme abnormal 1.87
Psychiatric disorders Erectile dysfunction 1.83
Respiratory, thoracic and mediastinal disorders Pleural effusion 1.83
Gastrointestinal disorders Incisional hernia 1.82
Psychiatric disorders Anxiety 1.66
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 1.66
Musculoskeletal and connective tissue disorders Myalgia 1.66
Skin and subcutaneous tissue disorders Acne 1.63
Gastrointestinal disorders Incisional hernia 1.49
Renal and urinary disorders Proteinuria 1.49
Investigations Protein urine present 1.49
Blood and lymphatic system disorders Pancytopenia 1.47
Renal and urinary disorders Azotaemia 1.46
Blood and lymphatic system disorders Thrombotic microangiopathy 1.46
Blood and lymphatic system disorders Thrombotic thrombocytopenic purpura 1.46
Gastrointestinal disorders Pancreatitis 1.43
Immune system disorders Angioedema 1.24
Vascular disorders Embolism 1.24
Gastrointestinal disorders Mouth ulceration 1.24
Gastrointestinal disorders Stomatitis 1.24
Immune system disorders Angioedema 1.22
Psychiatric disorders Erectile dysfunction 1.22
Respiratory, thoracic and mediastinal disorders Epistaxis 1.1
Gastrointestinal disorders Incisional hernia 1.1
Infections and infestations Pyelonephritis 1.1
Vascular disorders Thrombosis 1.1
Renal and urinary disorders Azotaemia 1.08
Blood and lymphatic system disorders Thrombotic microangiopathy 1.08
Blood and lymphatic system disorders Thrombotic thrombocytopenic purpura 1.08
Gastrointestinal disorders Abdominal pain
Musculoskeletal and connective tissue disorders Arthralgia 1.0
Musculoskeletal and connective tissue disorders Back pain
Musculoskeletal and connective tissue disorders Back pain 1.0
Investigations Blood albumin decreased 1.0
Investigations Blood alkaline phosphatase increased 1.0
Investigations Blood bilirubin increased 1.0
Investigations Blood creatinine increased 1.0
Investigations Blood glucose increased
Investigations Blood glucose increased 1.0
Cardiac disorders Cardiac failure congestive 1.0
General disorders and administration site conditions Decreased appetite
General disorders and administration site conditions Decreased appetite 1.0
Vascular disorders Deep vein thrombosis 1.0
Endocrine disorders Diabetes mellitus 1.0
Respiratory, thoracic and mediastinal disorders Epistaxis
Gastrointestinal disorders Gastroenteritis 1.0
Gastrointestinal disorders Gastrointestinal pain
Investigations Haemoglobin decreased
Investigations Haemoglobin decreased 1.0
Nervous system disorders Headache
Metabolism and nutrition disorders Hypercholesterolaemia 1.0
Vascular disorders Hypertension
Vascular disorders Hypertension 1.0
Metabolism and nutrition disorders Hyponatraemia
Metabolism and nutrition disorders Hyponatraemia 1.0
Metabolism and nutrition disorders Hypophosphataemia 1.0
General disorders and administration site conditions Impaired healing 1.0
Blood and lymphatic system disorders Lymphopenia 1.0
Nervous system disorders Migraine
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 1.0
Blood and lymphatic system disorders Neutropenia 1.0
General disorders and administration site conditions Oedema
General disorders and administration site conditions Oedema 1.0
Musculoskeletal and connective tissue disorders Pain in extremity
Investigations Platelet count decreased
Investigations Platelet count decreased 1.0
Infections and infestations Pneumonia 1.0
Infections and infestations Respiratory tract infection 1.0
Gastrointestinal disorders Vomiting 1.0
Gastrointestinal disorders Pancreatitis 0.83
Blood and lymphatic system disorders Pancytopenia 0.83
Cardiac disorders Pericardial effusion 0.83
Renal and urinary disorders Proteinuria 0.83
Investigations Protein urine present 0.83
Blood and lymphatic system disorders Jaundice 0.816
Gastrointestinal disorders Pancreatitis 0.816
Immune system disorders Interstitial lung disease 0.746
Blood and lymphatic system disorders Jaundice 0.746
Investigations Blood testosterone decreased 0.733
Blood and lymphatic system disorders Coagulopathy 0.733
Endocrine disorders Hypogonadism male 0.733
Immune system disorders Interstitial lung disease 0.733
Immune system disorders Interstitial lung disease 0.73
Blood and lymphatic system disorders Pancytopenia 0.73
Renal and urinary disorders Renal tubular necrosis 0.717
Metabolism and nutrition disorders Acute respiratory failure 0.7
Infections and infestations Infection 0.7
Renal failure acute 0.7
Musculoskeletal and connective tissue disorders Arthralgia
Musculoskeletal and connective tissue disorders Arthralgia 0.5
General disorders and administration site conditions Asthenia
General disorders and administration site conditions Asthenia 0.5
Investigations Blood calcium decreased 0.5
Investigations Blood potassium increased
Investigations Body temperature increased
Investigations Body temperature increased 0.5
Gastrointestinal disorders Constipation
Respiratory, thoracic and mediastinal disorders Cough 0.5
Skin and subcutaneous tissue disorders Dermatitis 0.5
Endocrine disorders Diabetes mellitus
Gastrointestinal disorders Diarrhoea 0.5
General disorders and administration site conditions Discomfort
General disorders and administration site conditions Discomfort 0.5
Cardiac disorders Dizziness 0.5
Cardiac disorders Dyspnoea
Cardiac disorders Dyspnoea 0.5
Cardiac disorders Dyspnoea exertional
Cardiac disorders Dyspnoea exertional 0.5
General disorders and administration site conditions Fatigue
General disorders and administration site conditions Fatigue 0.5
General disorders and administration site conditions Feeling abnormal
General disorders and administration site conditions Feeling abnormal 0.5
Nervous system disorders Headache 0.5
General disorders and administration site conditions Ill-defined disorder
General disorders and administration site conditions Ill-defined disorder 0.5
General disorders and administration site conditions Malaise
General disorders and administration site conditions Malaise 0.5
Nervous system disorders Migraine 0.5
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 0.5
Skin and subcutaneous tissue disorders Nail disorder 0.5
General disorders and administration site conditions Oedema 0.5
Musculoskeletal and connective tissue disorders Pain in extremity 0.5
Infections and infestations Pneumonia 0.5
Respiratory, thoracic and mediastinal disorders Productive cough 0.5
Skin and subcutaneous tissue disorders Rash 0.5
Infections and infestations Urinary tract infection
Investigations Weight decreased 0.5
Blood and lymphatic system disorders Coagulopathy 0.415
Respiratory, thoracic and mediastinal disorders Epistaxis 0.415
Immune system disorders Interstitial lung disease 0.415
Blood and lymphatic system disorders Lymphocele 0.415
Investigations Blood testosterone decreased 0.408
Endocrine disorders Hypogonadism male 0.408
Immune system disorders Interstitial lung disease 0.408
Cardiac disorders Pericardial effusion 0.408
Renal failure acute 0.4
Hepatobiliary disorders Hepatitis 0.373
Renal and urinary disorders Renal tubular necrosis 0.373
Injury, poisoning and procedural complications Wound complication 0.373
Hepatobiliary disorders Hepatitis 0.366
Gastrointestinal disorders Pancreatitis 0.366
Cardiac disorders Pericardial effusion 0.366
Injury, poisoning and procedural complications Wound complication 0.366
Blood and lymphatic system disorders Coagulopathy 0.365
Hepatobiliary disorders Hepatitis 0.365
Gastrointestinal disorders Pancreatitis 0.365
Cardiac disorders Pericardial effusion 0.365
Injury, poisoning and procedural complications Wound complication 0.365
Blood and lymphatic system disorders Coagulopathy 0.358
Hepatobiliary disorders Hepatitis 0.358
Blood and lymphatic system disorders Jaundice 0.358
Injury, poisoning and procedural complications Wound complication 0.358

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
12.25
Gastrointestinal disorders
11.86
Investigations
10.25
Respiratory, thoracic and mediastinal disorders
9.23
Infections and infestations
5.6
Nervous system disorders
5.2
Cardiac disorders
5.2
Skin and subcutaneous tissue disorders
5.0
Metabolism and nutrition disorders
4.59
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
4.5
Vascular disorders
4.28
Musculoskeletal and connective tissue disorders
3.6
Injury, poisoning and procedural complications
3.39
Psychiatric disorders
2.76
Renal and urinary disorders
2.57
Blood and lymphatic system disorders
2.16

Cross References

Resources Reference
CAS NUMBER 159351-69-6
ChEBI 68478
ChEMBL CHEMBL1908360
DrugBank DB01590
DrugCentral 1118
EPA CompTox DTXSID0040599
FDA SRS 9HW64Q8G6G
Guide to Pharmacology 5889
PharmGKB PA164746311
PubChem 6442177
SureChEMBL SCHEMBL20973097
ZINC ZINC000169677008
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