Trade Names:
Synonyms:
Status: Approved (2015)
Entry Type: Antibody
Molecule Category: UNKNOWN
ATC: C10AX13
UNII: LKC0U3A8NJ

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Subtilisin/kexin type 9 inhibitor DailyMed
Primary Target
proprotein convertase subtilisin/kexin type 9

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Coronary Disease 4 D003327 ClinicalTrials
Hyperlipoproteinemia Type II 4 D006938 ClinicalTrials
Severe Acute Respiratory Syndrome 3 D045169 ClinicalTrials
Hyperlipidemias 3 D006949 ClinicalTrials
Hypercholesterolemia 3 D006937 ClinicalTrials
Lipid Metabolism Disorders 3 D052439 ClinicalTrials
Acute Coronary Syndrome 3 D054058 ClinicalTrials
Hyperlipidemia, Familial Combined 3 D006950 ClinicalTrials
ST Elevation Myocardial Infarction 2 D000072657 ClinicalTrials
Sepsis 2 D018805 ClinicalTrials
Heart Failure 2 D006333 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 1 D002289 ClinicalTrials
Glioblastoma 0 D005909 ClinicalTrials

Adverse Reactions

System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
18.93
Injury, poisoning and procedural complications
17.08
Musculoskeletal and connective tissue disorders
11.51
Respiratory, thoracic and mediastinal disorders
8.64
Skin and subcutaneous tissue disorders
6.89
Nervous system disorders
6.63
Gastrointestinal disorders
5.29
Vascular disorders
4.97
Investigations
4.17
Infections and infestations
3.23
Cardiac disorders
2.93
Psychiatric disorders
2.92

Cross References

Resources Reference
CAS NUMBER 1256937-27-5
ChEMBL CHEMBL2364655
FDA SRS LKC0U3A8NJ
Guide to Pharmacology 7343