General disorders and administration site conditions
Decreased appetite
|
54.8
|
|
|
Nervous system disorders
Somnolence
|
48.4
|
|
|
Infections and infestations
Upper respiratory tract infection
|
45.2
|
|
|
Gastrointestinal disorders
Vomiting
|
38.7
|
|
|
Nervous system disorders
Headache
|
36.8
|
|
|
Gastrointestinal disorders
Nausea
|
34.2
|
|
|
Infections and infestations
Upper respiratory tract infection
|
|
|
|
Investigations
Body temperature increased
|
22.6
|
|
|
General disorders and administration site conditions
Decreased appetite
|
19.3
|
|
|
Nervous system disorders
Somnolence
|
19.3
|
|
|
Nervous system disorders
Headache
|
|
|
|
Psychiatric disorders
Nervousness
|
|
|
|
Psychiatric disorders
Tension
|
|
|
|
Cardiac disorders
Dizziness
|
18.4
|
|
|
Nervous system disorders
Headache
|
18.0
|
|
|
Nervous system disorders
Insomnia
|
17.5
|
|
|
General disorders and administration site conditions
Asthenia
|
16.8
|
|
|
General disorders and administration site conditions
Fatigue
|
16.8
|
|
|
Gastrointestinal disorders
Vomiting
|
16.7
|
|
|
Nervous system disorders
Insomnia
|
16.1
|
|
|
Psychiatric disorders
Nervousness
|
16.1
|
|
|
Psychiatric disorders
Tension
|
16.1
|
|
|
General disorders and administration site conditions
Decreased appetite
|
|
|
|
Nervous system disorders
Insomnia
|
|
|
|
Gastrointestinal disorders
Vomiting
|
|
|
|
Cardiac disorders
Dizziness
|
|
|
|
Gastrointestinal disorders
Constipation
|
12.9
|
|
|
Blood and lymphatic system disorders
Purpura
|
12.9
|
|
|
Blood and lymphatic system disorders
Vascular purpura
|
12.9
|
|
|
Gastrointestinal disorders
Dyspepsia
|
12.3
|
|
|
Gastrointestinal disorders
Constipation
|
11.4
|
|
|
Investigations
Body temperature increased
|
|
|
|
Nervous system disorders
Somnolence
|
|
|
|
General disorders and administration site conditions
Asthenia
|
9.7
|
|
|
Skin and subcutaneous tissue disorders
Dermatitis
|
9.7
|
|
|
General disorders and administration site conditions
Fatigue
|
9.7
|
|
|
General disorders and administration site conditions
Gait disturbance
|
9.7
|
|
|
Gastrointestinal disorders
Hiccups
|
9.7
|
|
|
Ear and labyrinth disorders
Otitis media
|
9.7
|
|
|
Gastrointestinal disorders
Pharyngitis
|
9.7
|
|
|
Skin and subcutaneous tissue disorders
Rash
|
9.7
|
|
|
Nervous system disorders
Headache
|
|
|
|
Gastrointestinal disorders
Dyspepsia
|
8.6
|
|
|
Nervous system disorders
Insomnia
|
8.6
|
|
|
Infections and infestations
Upper respiratory tract infection
|
8.6
|
|
|
Gastrointestinal disorders
Vomiting
|
8.6
|
|
|
Skin and subcutaneous tissue disorders
Dermatitis
|
|
|
|
Blood and lymphatic system disorders
Purpura
|
|
|
|
Skin and subcutaneous tissue disorders
Rash
|
|
|
|
Nervous system disorders
Urinary incontinence
|
|
|
|
Blood and lymphatic system disorders
Vascular purpura
|
|
|
|
General disorders and administration site conditions
Asthenia
|
|
|
|
Gastrointestinal disorders
Dyspepsia
|
|
|
|
General disorders and administration site conditions
Fatigue
|
|
|
|
Nervous system disorders
Insomnia
|
|
|
|
Psychiatric disorders
Nervousness
|
7.0
|
|
|
Nervous system disorders
Somnolence
|
|
|
|
Psychiatric disorders
Tension
|
7.0
|
|
|
Infections and infestations
Upper respiratory tract infection
|
|
|
|
General disorders and administration site conditions
Asthenia
|
6.9
|
|
|
Gastrointestinal disorders
Constipation
|
6.9
|
|
|
General disorders and administration site conditions
Fatigue
|
6.9
|
|
|
Nervous system disorders
Headache
|
6.9
|
|
|
Infections and infestations
Rhinitis
|
6.9
|
|
|
Psychiatric disorders
Affect lability
|
6.5
|
|
|
Nervous system disorders
Ataxia
|
6.5
|
|
|
Respiratory, thoracic and mediastinal disorders
Cough
|
6.5
|
|
|
Gastrointestinal disorders
Dyspepsia
|
6.5
|
|
|
Nervous system disorders
Headache
|
6.5
|
|
|
Blood and lymphatic system disorders
Leukopenia
|
6.5
|
|
|
Social circumstances
Mental disability
|
6.5
|
|
|
Eye disorders
Miosis
|
6.5
|
|
|
Psychiatric disorders
Mood swings
|
6.5
|
|
|
Gastrointestinal disorders
Nausea
|
6.5
|
|
|
General disorders and administration site conditions
Pain
|
6.5
|
|
|
Nervous system disorders
Thinking abnormal
|
6.5
|
|
|
Nervous system disorders
Urinary incontinence
|
6.5
|
|
|
Investigations
Weight decreased
|
6.5
|
|
|
Eye disorders
Diplopia
|
6.1
|
|
|
Gastrointestinal disorders
Dysgeusia
|
6.1
|
|
|
Nervous system disorders
Tremor
|
6.1
|
|
|
Gastrointestinal disorders
Abdominal pain
|
5.3
|
|
|
Psychiatric disorders
Anxiety
|
5.3
|
|
|
Psychiatric disorders
Depression
|
5.3
|
|
|
Gastrointestinal disorders
Diarrhoea
|
5.3
|
|
|
General disorders and administration site conditions
Gait disturbance
|
5.3
|
|
|
Gastrointestinal disorders
Gastrointestinal pain
|
5.3
|
|
|
Infections and infestations
Upper respiratory tract infection
|
5.3
|
|
|
Eye disorders
Visual impairment
|
5.3
|
|
|
Investigations
Alanine aminotransferase increased
|
5.2
|
|
|
Psychiatric disorders
Anxiety
|
5.2
|
|
|
Gastrointestinal disorders
Diarrhoea
|
5.2
|
|
|
Psychiatric disorders
Anxiety
|
|
|
|
Investigations
Body temperature increased
|
|
|
|
Skin and subcutaneous tissue disorders
Dermatitis
|
|
|
|
Skin and subcutaneous tissue disorders
Rash
|
|
|
|
Gastrointestinal disorders
Vomiting
|
|
|
|
General disorders and administration site conditions
Asthenia
|
4.0
|
|
|
Eye disorders
Diplopia
|
4.0
|
|
|
General disorders and administration site conditions
Fatigue
|
4.0
|
|
|
Nervous system disorders
Insomnia
|
4.0
|
|
|
Infections and infestations
Upper respiratory tract infection
|
4.0
|
|
|
General disorders and administration site conditions
Asthenia
|
|
|
|
Nervous system disorders
Ataxia
|
|
|
|
Gastrointestinal disorders
Dyspepsia
|
|
|
|
General disorders and administration site conditions
Fatigue
|
|
|
|
Gastrointestinal disorders
Hiccups
|
|
|
|
Social circumstances
Mental disability
|
|
|
|
Gastrointestinal disorders
Pharyngitis
|
|
|
|
Nervous system disorders
Thinking abnormal
|
|
|
|
Investigations
Alanine aminotransferase increased
|
3.5
|
|
|
Nervous system disorders
Ataxia
|
3.5
|
|
|
Skin and subcutaneous tissue disorders
Dermatitis
|
3.5
|
|
|
Nervous system disorders
Paraesthesia
|
3.5
|
|
|
Skin and subcutaneous tissue disorders
Rash
|
3.5
|
|
|
Infections and infestations
Sinusitis
|
3.5
|
|
|
Skin and subcutaneous tissue disorders
Acne
|
3.4
|
|
|
Skin and subcutaneous tissue disorders
Dermatitis
|
3.4
|
|
|
Eye disorders
Diplopia
|
3.4
|
|
|
General disorders and administration site conditions
Face oedema
|
3.4
|
|
|
Investigations
Haemoglobin
|
3.4
|
|
|
Vascular disorders
Haemorrhage
|
3.4
|
|
|
Metabolism and nutrition disorders
Hypophosphataemia
|
3.4
|
|
|
Ear and labyrinth disorders
Otitis media
|
3.4
|
|
|
Skin and subcutaneous tissue disorders
Rash
|
3.4
|
|
|
Infections and infestations
Urinary tract infection
|
3.4
|
|
|
Investigations
Weight decreased
|
3.4
|
|
|
Investigations
Body temperature increased
|
2.6
|
|
|
Cardiac disorders
Chest pain
|
2.6
|
|
|
Nervous system disorders
Depressed level of consciousness
|
2.6
|
|
|
Gastrointestinal disorders
Dry mouth
|
2.6
|
|
|
Musculoskeletal and connective tissue disorders
Musculoskeletal discomfort
|
2.6
|
|
|
Musculoskeletal and connective tissue disorders
Myalgia
|
2.6
|
|
|
Gastrointestinal disorders
Pharyngitis
|
2.6
|
|
|
Nervous system disorders
Stupor
|
2.6
|
|
|
Gastrointestinal disorders
Constipation
|
|
|
|
General disorders and administration site conditions
Decreased appetite
|
|
|
|
Gastrointestinal disorders
Diarrhoea
|
|
|
|
Gastrointestinal disorders
Nausea
|
|
|
|
Psychiatric disorders
Nervousness
|
|
|
|
Nervous system disorders
Paraesthesia
|
|
|
|
Psychiatric disorders
Tension
|
|
|
|
Nervous system disorders
Tremor
|
|
|
|
Eye disorders
Visual impairment
|
|
|
|
Investigations
Alanine aminotransferase increased
|
2.0
|
|
|
Psychiatric disorders
Anxiety
|
2.0
|
|
|
Gastrointestinal disorders
Constipation
|
2.0
|
|
|
Gastrointestinal disorders
Dyspepsia
|
2.0
|
|
|
Infections and infestations
Urinary tract infection
|
2.0
|
|
|
Gastrointestinal disorders
Vomiting
|
2.0
|
|
|
General disorders and administration site conditions
Decreased appetite
|
1.6
|
|
|
Gastrointestinal disorders
Nausea
|
1.4
|
|
|
Skin and subcutaneous tissue disorders
Dermatitis
|
1.2
|
|
|
Skin and subcutaneous tissue disorders
Rash
|
1.2
|
|
|
Skin and subcutaneous tissue disorders
Dermatitis
|
1.1
|
|
|
Skin and subcutaneous tissue disorders
Rash
|
1.1
|
|
|
Investigations
Weight decreased
|
1.1
|
|
|