FIDAXOMICIN

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Trade Names:
Synonyms:
Status: Approved (2011)
Entry Type: Small molecule
Molecule Category: UNKNOWN
ATC: A07AA12
UNII: Z5N076G8YQ

Structure
InChI Key ZVGNESXIJDCBKN-UUEYKCAUSA-N
Smile CCc1c(Cl)c(O)c(Cl)c(O)c1C(=O)O[C@H]1[C@H](O)[C@H](OC)[C@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@@H]3OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]3O)/C(C)=C/C(C)=C/C[C@@H]([C@@H](C)O)OC2=O)O[C@@H]1C
InChI
InChI=1S/C52H74Cl2O18/c1-13-30-22-26(6)33(56)18-16-15-17-31(23-66-51-45(65-12)42(61)44(29(9)67-51)69-49(64)35-32(14-2)36(53)39(58)37(54)38(35)57)48(63)68-34(28(8)55)20-19-25(5)21-27(7)43(30)70-50-41(60)40(59)46(52(10,11)72-50)71-47(62)24(3)4/h15-17,19,21-22,24,28-30,33-34,40-46,50-51,55-61H,13-14,18,20,23H2,1-12H3/b16-15+,25-19+,26-22+,27-21+,31-17+/t28-,29-,30+,33+,34+,40-,41+,42+,43+,44-,45+,46+,50-,51-/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C52H74Cl2O18
Molecular Weight 1058.05
AlogP None
Hydrogen Bond Acceptor None
Hydrogen Bond Donor None
Number of Rotational Bond None
Polar Surface Area None
Molecular species None
Aromatic Rings None
Heavy Atoms None

Pharmacology

Action Mechanism of Action Reference
INHIBITOR DNA-directed RNA polymerase inhibitor DailyMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Clostridium Infections 3 D003015 ClinicalTrials
Clostridium Infections 3 D003015 ClinicalTrials

Related Entries

Scaffolds

Side Effects from Label

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
25.03
Gastrointestinal disorders
24.47
Infections and infestations
14.34
Injury, poisoning and procedural complications
4.78
Investigations
4.45
Skin and subcutaneous tissue disorders
3.4
Nervous system disorders
3.36
Respiratory, thoracic and mediastinal disorders
2.73
Vascular disorders
2.2
Cardiac disorders
2.13
Musculoskeletal and connective tissue disorders
2.05

Cross References

Resources Reference
CAS NUMBER 873857-62-6
ChEMBL CHEMBL1255800
DrugBank DB08874
DrugCentral 4180
FDA SRS Z5N076G8YQ
Guide to Pharmacology 10909
PDB FI8
PubChem 10034073
SureChEMBL SCHEMBL10000818
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