GABAPENTIN

Search structure
Trade Names:
Synonyms:
Status: Approved (1993)
Entry Type: Small molecule
Molecule Category: Parent
ATC: N03AX12
UNII: 6CW7F3G59X

Structure
InChI Key UGJMXCAKCUNAIE-UHFFFAOYSA-N
Smile NCC1(CC(=O)O)CCCCC1
InChI
InChI=1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12)

Physicochemical Descriptors

Property Name Value
Molecular Formula C9H17NO2
Molecular Weight 171.24
AlogP 1.37
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 3.0
Polar Surface Area 63.32
Molecular species ZWITTERION
Aromatic Rings 0.0
Heavy Atoms 12.0

Pharmacology

Action Mechanism of Action Reference
MODULATOR Voltage-gated calcium channel modulator FDA ISBN PubMed Wikipedia
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Auxiliary transport protein Calcium channel auxiliary subunit alpha2delta family
- 70-140 - 120-120 -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters
- - - - 15

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Neuralgia, Postherpetic 4 D051474 ClinicalTrials
Carpal Tunnel Syndrome 3 D002349 ClinicalTrials
Neuralgia 3 D009437 ClinicalTrials
Fibromyalgia 3 D005356 ClinicalTrials
Epilepsies, Partial 3 D004828 ClinicalTrials
Liver Cirrhosis 3 D008103 ClinicalTrials
Sleep Initiation and Maintenance Disorders 3 D007319 ClinicalTrials
Pain 3 D010146 ClinicalTrials
Pruritus 3 D011537 ClinicalTrials
Scoliosis 3 D012600 ClinicalTrials
Alcoholism 3 D000437 ClinicalTrials
Postoperative Nausea and Vomiting 3 D020250 ClinicalTrials
Diabetic Neuropathies 3 D003929 ClinicalTrials
Schizophrenia 3 D012559 ClinicalTrials
Alcohol Drinking 3 D000428 ClinicalTrials
Pelvic Organ Prolapse 3 D056887 ClinicalTrials
Anxiety 3 D001007 ClinicalTrials
Oropharyngeal Neoplasms 3 D009959 ClinicalTrials
Dementia 3 D003704 ClinicalTrials
Head and Neck Neoplasms 3 D006258 ClinicalTrials
Dyspepsia 3 D004415 ClinicalTrials
Chronic Pain 3 D059350 ClinicalTrials
Azoospermia 3 D053713 ClinicalTrials
Tremor 3 D014202 ClinicalTrials
Vomiting 3 D014839 ClinicalTrials
Intervertebral Disc Degeneration 3 D055959 ClinicalTrials
Hot Flashes 3 D019584 ClinicalTrials
Herpes Zoster 3 D006562 ClinicalTrials
Delirium 3 D003693 ClinicalTrials
Depressive Disorder 3 D003866 ClinicalTrials
Substance Withdrawal Syndrome 2 D013375 ClinicalTrials
Wounds and Injuries 2 D014947 ClinicalTrials
Intervertebral Disc Displacement 2 D007405 ClinicalTrials
Mucositis 2 D052016 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 2 D064129 ClinicalTrials
Tobacco Use Disorder 2 D014029 ClinicalTrials
Low Back Pain 2 D017116 ClinicalTrials
Marijuana Abuse 2 D002189 ClinicalTrials
Substance-Related Disorders 2 D019966 ClinicalTrials
Opioid-Related Disorders 2 D009293 ClinicalTrials
Rotator Cuff Injuries 2 D000070636 ClinicalTrials
Urinary Bladder Neoplasms 2 D001749 ClinicalTrials
Neoplasms 2 D009369 ClinicalTrials
Paget Disease, Extramammary 2 D010145 ClinicalTrials
Tinnitus 2 D014012 ClinicalTrials
Multiple Sclerosis 2 D009103 ClinicalTrials
Anemia, Sickle Cell 2 D000755 ClinicalTrials
Breast Neoplasms 2 D001943 ClinicalTrials
Abortion, Spontaneous 2 D000022 ClinicalTrials
Postoperative Complications 2 D011183 ClinicalTrials
Hyperemesis Gravidarum 2 D006939 ClinicalTrials
Psychotic Disorders 1 D011618 ClinicalTrials
Premature Birth 1 D047928 ClinicalTrials
Child Development Disorders, Pervasive 0 D002659 ClinicalTrials
Alopecia 0 D000505 ClinicalTrials

Side Effects from Label

Side effects Relative Frequency (%) Labels
Gastrointestinal disorders Diarrhoea 46.0
Nervous system disorders Headache 45.0
Gastrointestinal disorders Nausea 45.0
Cardiac disorders Oedema peripheral 44.0
General disorders and administration site conditions Asthenia 41.0
Infections and infestations Infection 38.0
Injury, poisoning and procedural complications Injury 32.0
Cardiac disorders Dizziness 30.0
General disorders and administration site conditions Pain 30.0
Cardiac disorders Dizziness 28.0
Gastrointestinal disorders Dry mouth 27.0
Nervous system disorders Somnolence 27.0
Cardiac disorders Dizziness 26.0
Gastrointestinal disorders Abdominal pain 23.0
Gastrointestinal disorders Gastrointestinal pain 23.0
Cardiac disorders Dizziness 22.0
Nervous system disorders Somnolence 21.4
Infections and infestations Influenza 21.0
Nervous system disorders Somnolence 21.0
Eye disorders Nystagmus 20.4
Nervous system disorders Somnolence 20.0
Nervous system disorders Somnolence 19.3
Musculoskeletal and connective tissue disorders Back pain 19.0
Gastrointestinal disorders Constipation 19.0
Nervous system disorders Somnolence 19.0
Cardiac disorders Dizziness 17.1
Cardiac disorders Dizziness 17.0
Gastrointestinal disorders Dyspepsia 16.0
Gastrointestinal disorders Vomiting 16.0
Cardiac disorders Dizziness
Nervous system disorders Headache 15.0
Nervous system disorders Tremor 14.8
Gastrointestinal disorders Flatulence 14.0
Nervous system disorders Somnolence 14.0
Investigations Weight increased 14.0
Nervous system disorders Ataxia 13.0
Cardiac disorders Dizziness 13.0
Infections and infestations Rhinitis 13.0
Nervous system disorders Ataxia 12.5
Nervous system disorders Headache 12.0
General disorders and administration site conditions Asthenia 11.0
General disorders and administration site conditions Fatigue 11.0
Nervous system disorders Headache
Nervous system disorders Somnolence 11.0
Infections and infestations Viral infection 11.0
Cardiac disorders Dizziness 10.9
Infections and infestations Viral infection 10.9
Investigations Body temperature increased 10.1
General disorders and administration site conditions Asthenia 10.0
Investigations Body temperature increased 10.0
General disorders and administration site conditions Fatigue 10.0
Nervous system disorders Headache 10.0
Nervous system disorders Somnolence 10.0
General disorders and administration site conditions Gait disturbance 9.0
Nervous system disorders Headache
Gastrointestinal disorders Nausea 9.0
Nervous system disorders Somnolence
Nervous system disorders Somnolence
Nervous system disorders Somnolence 8.7
Gastrointestinal disorders Nausea 8.4
Nervous system disorders Somnolence 8.4
Gastrointestinal disorders Vomiting 8.4
Metabolism and nutrition disorders Malnutrition 8.3
Eye disorders Nystagmus 8.3
Cardiac disorders Oedema peripheral 8.3
Nervous system disorders Headache 8.1
Cardiac disorders Dizziness
Psychiatric disorders Erectile dysfunction 8.0
Psychiatric disorders Hostility 8.0
Gastrointestinal disorders Nausea 8.0
Eye disorders Nystagmus 8.0
Cardiac disorders Oedema peripheral 8.0
Nervous system disorders Somnolence
Nervous system disorders Somnolence 8.0
Gastrointestinal disorders Vomiting 8.0
Psychiatric disorders Hostility 7.6
Cardiac disorders Dizziness
Cardiac disorders Dizziness 7.5
Cardiac disorders Oedema peripheral 7.4
Gastrointestinal disorders Nausea
Gastrointestinal disorders Vomiting
General disorders and administration site conditions Asthenia 7.0
Cardiac disorders Dizziness
General disorders and administration site conditions Fatigue 7.0
Nervous system disorders Headache 7.0
Nervous system disorders Insomnia 7.0
Gastrointestinal disorders Nausea
Gastrointestinal disorders Nausea 7.0
Cardiac disorders Oedema peripheral 7.0
Nervous system disorders Tremor 7.0
Gastrointestinal disorders Vomiting
Gastrointestinal disorders Vomiting 7.0
Cardiac disorders Dizziness
Cardiac disorders Dizziness 6.9
Nervous system disorders Tremor 6.8
Gastrointestinal disorders Nausea 6.1
Gastrointestinal disorders Vomiting 6.1
General disorders and administration site conditions Asthenia 6.0
Nervous system disorders Ataxia
Gastrointestinal disorders Diarrhoea 6.0
Eye disorders Diplopia 6.0
General disorders and administration site conditions Fatigue 6.0
Gastrointestinal disorders Nausea 6.0
Cardiac disorders Oedema peripheral 6.0
Nervous system disorders Somnolence
Eye disorders Diplopia 5.9
General disorders and administration site conditions Asthenia 5.7
Gastrointestinal disorders Diarrhoea 5.7
Nervous system disorders Ataxia
Nervous system disorders Ataxia 5.6
Gastrointestinal disorders Diarrhoea 5.6
Nervous system disorders Headache 5.5
Gastrointestinal disorders Nausea 5.5
Cardiac disorders Oedema peripheral 5.4
Nervous system disorders Somnolence
Nervous system disorders Somnolence 5.3
Infections and infestations Infection 5.1
General disorders and administration site conditions Asthenia
General disorders and administration site conditions Asthenia 5.0
Gastrointestinal disorders Dry mouth 5.0
General disorders and administration site conditions Fatigue
General disorders and administration site conditions Fatigue 5.0
Infections and infestations Infection 5.0
Nervous system disorders Insomnia 5.0
Gastrointestinal disorders Nausea
Nervous system disorders Somnolence
Eye disorders Vision blurred 5.0
Investigations Weight increased 5.0
General disorders and administration site conditions Asthenia
General disorders and administration site conditions Asthenia 4.8
Gastrointestinal disorders Dry mouth 4.8
Nervous system disorders Somnolence
Nervous system disorders Somnolence 4.7
Infections and infestations Infection 4.6
Nervous system disorders Somnolence 4.5
Cardiac disorders Dizziness 4.4
Psychiatric disorders Affect lability 4.2
Eye disorders Amblyopia 4.2
Nervous system disorders Headache 4.2
Psychiatric disorders Mood swings 4.2
Nervous system disorders Headache
Infections and infestations Rhinitis 4.1
Psychiatric disorders Affect lability 4.0
Eye disorders Amblyopia 4.0
General disorders and administration site conditions Asthenia
General disorders and administration site conditions Asthenia 4.0
Gastrointestinal disorders Constipation 4.0
Cardiac disorders Dizziness
Gastrointestinal disorders Dry mouth 4.0
General disorders and administration site conditions Fatigue
General disorders and administration site conditions Fatigue 4.0
Infections and infestations Infection
General disorders and administration site conditions Irritability 4.0
Psychiatric disorders Mood swings 4.0
Gastrointestinal disorders Nausea 4.0
Eye disorders Nystagmus
Eye disorders Nystagmus 4.0
Gastrointestinal disorders Constipation 3.9
Injury, poisoning and procedural complications Injury 3.9
Gastrointestinal disorders Nausea 3.9
Cardiac disorders Oedema peripheral 3.9
General disorders and administration site conditions Pain 3.7
Infections and infestations Rhinitis
Infections and infestations Rhinitis 3.7
Infections and infestations Infection
Infections and infestations Infection 3.5
General disorders and administration site conditions Asthenia 3.4
Infections and infestations Bronchitis 3.4
General disorders and administration site conditions Fatigue 3.4
Investigations Weight increased 3.4
Nervous system disorders Ataxia 3.3
Gastrointestinal disorders Diarrhoea 3.3
Gastrointestinal disorders Dry mouth 3.3
Nervous system disorders Headache 3.3
Injury, poisoning and procedural complications Injury 3.3
Gastrointestinal disorders Vomiting 3.3
Nervous system disorders Tremor
Nervous system disorders Tremor 3.2
Investigations Body temperature increased
Investigations Body temperature increased 3.1
Gastrointestinal disorders Diarrhoea
Gastrointestinal disorders Diarrhoea 3.1
Nervous system disorders Headache
Nervous system disorders Headache 3.1
Gastrointestinal disorders Nausea
Gastrointestinal disorders Nausea 3.1
Infections and infestations Viral infection
Infections and infestations Viral infection 3.1
Nervous system disorders Agitation 3.0
Eye disorders Amblyopia 3.0
General disorders and administration site conditions Asthenia 3.0
Nervous system disorders Ataxia 3.0
Investigations Body temperature increased
Infections and infestations Bronchitis 3.0
Psychiatric disorders Depression 3.0
Gastrointestinal disorders Diarrhoea
Cardiac disorders Dizziness 3.0
Gastrointestinal disorders Dry mouth 3.0
General disorders and administration site conditions Fatigue 3.0
General disorders and administration site conditions Feeling abnormal 3.0
General disorders and administration site conditions Feeling drunk 3.0
Gastrointestinal disorders Flatulence 3.0
Nervous system disorders Hyperkinesia 3.0
Injury, poisoning and procedural complications Injury 3.0
Nervous system disorders Insomnia 3.0
Social circumstances Mental disability 3.0
Gastrointestinal disorders Nausea
Cardiac disorders Oedema peripheral 3.0
Gastrointestinal disorders Pharyngitis 3.0
Infections and infestations Respiratory tract infection 3.0
Nervous system disorders Thinking abnormal 3.0
Nervous system disorders Tremor
Ear and labyrinth disorders Vertigo 3.0
Infections and infestations Viral infection
Gastrointestinal disorders Vomiting 3.0
Investigations Weight increased 3.0
Nervous system disorders Somnolence 2.9
Investigations Weight increased 2.9
Gastrointestinal disorders Abdominal pain 2.8
Gastrointestinal disorders Dry mouth 2.8
Gastrointestinal disorders Gastrointestinal pain 2.8
Gastrointestinal disorders Pharyngitis 2.8
Gastrointestinal disorders Abdominal pain 2.7
Eye disorders Amblyopia 2.7
Gastrointestinal disorders Diarrhoea
Gastrointestinal disorders Gastrointestinal pain 2.7
Social circumstances Mental disability 2.7
Nervous system disorders Somnolence
Nervous system disorders Thinking abnormal 2.7
Gastrointestinal disorders Abdominal pain
Gastrointestinal disorders Abdominal pain 2.6
Gastrointestinal disorders Gastrointestinal pain
Gastrointestinal disorders Gastrointestinal pain 2.6
Infections and infestations Influenza 2.6
Nervous system disorders Agitation 2.5
Cardiac disorders Dizziness 2.5
Nervous system disorders Hyperkinesia 2.5
Infections and infestations Nasopharyngitis 2.5
Infections and infestations Respiratory tract infection 2.5
Gastrointestinal disorders Abdominal pain
Nervous system disorders Dysarthria 2.4
Gastrointestinal disorders Gastrointestinal pain
Psychiatric disorders Nervousness 2.4
Musculoskeletal and connective tissue disorders Osteoarthritis 2.4
Psychiatric disorders Tension 2.4
Musculoskeletal and connective tissue disorders Back pain 2.3
Gastrointestinal disorders Constipation 2.3
Psychiatric disorders Hostility
Psychiatric disorders Hostility 2.3
Nervous system disorders Amnesia 2.2
Cardiac disorders Dizziness
Gastrointestinal disorders Dyspepsia 2.2
Metabolism and nutrition disorders Malnutrition
Infections and infestations Nasopharyngitis
Cardiac disorders Oedema peripheral
Cardiac disorders Oedema peripheral 2.2
Gastrointestinal disorders Diarrhoea
Gastrointestinal disorders Flatulence 2.1
Infections and infestations Viral infection
Psychiatric disorders Affect lability
Nervous system disorders Amnesia 2.0
General disorders and administration site conditions Asthenia
Musculoskeletal and connective tissue disorders Back pain 2.0
Gastrointestinal disorders Constipation
Gastrointestinal disorders Constipation 2.0
Nervous system disorders Coordination abnormal 2.0
Respiratory, thoracic and mediastinal disorders Cough 2.0
Psychiatric disorders Depression 2.0
Eye disorders Diplopia
Psychiatric disorders Disturbance in sexual arousal 2.0
Cardiac disorders Dizziness
Gastrointestinal disorders Dry mouth
Gastrointestinal disorders Dry throat 2.0
Nervous system disorders Dysarthria 2.0
Gastrointestinal disorders Dyspepsia 2.0
Psychiatric disorders Erectile dysfunction 2.0
General disorders and administration site conditions Fatigue
Gastrointestinal disorders Flatulence 2.0
General disorders and administration site conditions Gait disturbance 2.0
Psychiatric disorders Hostility
General disorders and administration site conditions Increased appetite 2.0
Nervous system disorders Insomnia
Psychiatric disorders Libido decreased 2.0
Social circumstances Mental disability 2.0
Psychiatric disorders Mood swings
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 2.0
Musculoskeletal and connective tissue disorders Myalgia 2.0
Cardiac disorders Oedema peripheral
Cardiac disorders Oedema peripheral 2.0
Musculoskeletal and connective tissue disorders Osteoarthritis 2.0
Gastrointestinal disorders Pharyngitis
Nervous system disorders Thinking abnormal 2.0
Eye disorders Vision blurred 2.0
Gastrointestinal disorders Vomiting
Investigations Weight increased
Investigations Weight increased 2.0
Nervous system disorders Confusional state
Eye disorders Diplopia
Eye disorders Diplopia 1.9
Gastrointestinal disorders Dyspepsia 1.9
General disorders and administration site conditions Feeling abnormal
Nervous system disorders Insomnia
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 1.9
Musculoskeletal and connective tissue disorders Myalgia
Musculoskeletal and connective tissue disorders Myalgia 1.9
Psychiatric disorders Nervousness
Psychiatric disorders Nervousness 1.9
Musculoskeletal and connective tissue disorders Pain in extremity 1.9
Psychiatric disorders Tension
Psychiatric disorders Tension 1.9
Gastrointestinal disorders Vomiting 1.9
Investigations Weight increased 1.9
Gastrointestinal disorders Abdominal pain 1.8
Musculoskeletal and connective tissue disorders Back pain 1.8
Gastrointestinal disorders Constipation
Gastrointestinal disorders Constipation 1.8
Respiratory, thoracic and mediastinal disorders Cough 1.8
Psychiatric disorders Depression
Psychiatric disorders Depression 1.8
Gastrointestinal disorders Flatulence
Gastrointestinal disorders Flatulence 1.8
Gastrointestinal disorders Gastrointestinal pain 1.8
Gastrointestinal disorders Vomiting
Gastrointestinal disorders Vomiting 1.8
Investigations Weight increased 1.8
Musculoskeletal and connective tissue disorders Back pain 1.7
Nervous system disorders Confusional state 1.7
Gastrointestinal disorders Dry throat 1.7
General disorders and administration site conditions Feeling abnormal 1.7
Gastrointestinal disorders Flatulence 1.7
Social circumstances Mental disability 1.7
Cardiac disorders Oedema peripheral 1.7
Nervous system disorders Thinking abnormal 1.7
Infections and infestations Urinary tract infection 1.7
Investigations Weight increased 1.7
Psychiatric disorders Affect lability
Psychiatric disorders Affect lability 1.6
General disorders and administration site conditions Asthenia
General disorders and administration site conditions Asthenia 1.6
Skin and subcutaneous tissue disorders Dermatitis
Cardiac disorders Dizziness
Cardiac disorders Dizziness 1.6
General disorders and administration site conditions Fatigue
General disorders and administration site conditions Fatigue 1.6
Psychiatric disorders Mood swings
Psychiatric disorders Mood swings 1.6
Gastrointestinal disorders Pharyngitis
Gastrointestinal disorders Pharyngitis 1.6
Skin and subcutaneous tissue disorders Rash
Investigations Weight increased
Investigations Weight increased 1.6
Gastrointestinal disorders Constipation 1.5
Nervous system disorders Coordination abnormal 1.5
Skin and subcutaneous tissue disorders Dermatitis 1.5
Psychiatric disorders Erectile dysfunction 1.5
General disorders and administration site conditions Gait disturbance 1.5
Skin and subcutaneous tissue disorders Rash 1.5
Gastrointestinal disorders Constipation 1.4
Gastrointestinal disorders Dry mouth
Gastrointestinal disorders Dyspepsia 1.4
Nervous system disorders Somnolence 1.4
Ear and labyrinth disorders Vertigo 1.4
Skin and subcutaneous tissue disorders Acne
Psychiatric disorders Affect lability
Investigations Body temperature increased
Investigations Body temperature increased 1.3
Respiratory, thoracic and mediastinal disorders Cough
Respiratory, thoracic and mediastinal disorders Cough 1.3
Gastrointestinal disorders Diarrhoea 1.3
Gastrointestinal disorders Dry mouth
Gastrointestinal disorders Dry mouth 1.3
Excoriation 1.3
Psychiatric disorders Hostility 1.3
Injury, poisoning and procedural complications Injury
Injury, poisoning and procedural complications Injury 1.3
Social circumstances Mental disability
Social circumstances Mental disability 1.3
Psychiatric disorders Mood swings
Musculoskeletal and connective tissue disorders Muscle twitching 1.3
Gastrointestinal disorders Nausea 1.3
Skin and subcutaneous tissue disorders Pruritus 1.3
Nervous system disorders Thinking abnormal
Nervous system disorders Thinking abnormal 1.3
Infections and infestations Viral infection 1.3
Nervous system disorders Amnesia 1.2
Eye disorders Conjunctivitis 1.2
Skin and subcutaneous tissue disorders Dermatitis 1.2
Eye disorders Diplopia 1.2
Endocrine disorders Hyperglycaemia 1.2
Nervous system disorders Hypoaesthesia 1.2
Ear and labyrinth disorders Otitis media 1.2
Gastrointestinal disorders Pharyngitis 1.2
Skin and subcutaneous tissue disorders Rash 1.2
Nervous system disorders Somnolence 1.2
Skin and subcutaneous tissue disorders Acne 1.1
Psychiatric disorders Affect lability 1.1
Nervous system disorders Agitation 1.1
Eye disorders Amblyopia
Musculoskeletal and connective tissue disorders Back pain
Nervous system disorders Coordination abnormal 1.1
Psychiatric disorders Depression
Psychiatric disorders Depression 1.1
Psychiatric disorders Erectile dysfunction
Psychiatric disorders Erectile dysfunction 1.1
Musculoskeletal and connective tissue disorders Fracture 1.1
General disorders and administration site conditions Gait disturbance 1.1
Nervous system disorders Hyperkinesia 1.1
General disorders and administration site conditions Increased appetite 1.1
Nervous system disorders Insomnia 1.1
General disorders and administration site conditions Lethargy 1.1
Blood and lymphatic system disorders Leukopenia 1.1
Psychiatric disorders Mood swings 1.1
Injury, poisoning and procedural complications Multiple fractures 1.1
General disorders and administration site conditions Pain 1.1
Surgical and medical procedures Vasodilation procedure 1.1
Investigations White blood cell count decreased 1.1
Nervous system disorders Agitation
Nervous system disorders Agitation 1.0
Eye disorders Amblyopia
General disorders and administration site conditions Asthenia
Nervous system disorders Ataxia 1.0
Musculoskeletal and connective tissue disorders Back pain
Infections and infestations Bronchitis
Eye disorders Conjunctivitis 1.0
Gastrointestinal disorders Constipation
Nervous system disorders Coordination abnormal 1.0
Respiratory, thoracic and mediastinal disorders Cough
Psychiatric disorders Depression
Psychiatric disorders Depression 1.0
Eye disorders Diplopia 1.0
Psychiatric disorders Disturbance in sexual arousal
Psychiatric disorders Disturbance in sexual arousal 1.0
Gastrointestinal disorders Dry mouth
Gastrointestinal disorders Dry throat
Nervous system disorders Dysarthria
Gastrointestinal disorders Dyspepsia
Psychiatric disorders Erectile dysfunction
Excoriation 1.0
General disorders and administration site conditions Fatigue
General disorders and administration site conditions Feeling abnormal
General disorders and administration site conditions Feeling abnormal 1.0
General disorders and administration site conditions Feeling drunk 1.0
Gastrointestinal disorders Flatulence
Psychiatric disorders Hostility 1.0
Endocrine disorders Hyperglycaemia 1.0
Nervous system disorders Hyperkinesia
Nervous system disorders Hyperkinesia 1.0
General disorders and administration site conditions Increased appetite
Injury, poisoning and procedural complications Injury
General disorders and administration site conditions Irritability
Psychiatric disorders Libido decreased
Psychiatric disorders Libido decreased 1.0
Social circumstances Mental disability
Cardiac disorders Oedema peripheral
Cardiac disorders Oedema peripheral 1.0
Musculoskeletal and connective tissue disorders Osteoarthritis
Ear and labyrinth disorders Otitis media 1.0
Gastrointestinal disorders Pharyngitis 1.0
Infections and infestations Respiratory tract infection
Nervous system disorders Thinking abnormal
Ear and labyrinth disorders Vertigo 1.0
Investigations Weight increased
Eye disorders Amblyopia
Eye disorders Amblyopia 0.9
Nervous system disorders Amnesia
Nervous system disorders Amnesia 0.9
Skin and subcutaneous tissue disorders Dermatitis
Skin and subcutaneous tissue disorders Dermatitis 0.9
Nervous system disorders Hypoaesthesia
Nervous system disorders Hypoaesthesia 0.9
Skin and subcutaneous tissue disorders Rash
Skin and subcutaneous tissue disorders Rash 0.9
Nervous system disorders Agitation
Nervous system disorders Agitation 0.8
Nervous system disorders Ataxia 0.8
Infections and infestations Bronchitis
Infections and infestations Bronchitis 0.8
Gastrointestinal disorders Constipation
Gastrointestinal disorders Constipation 0.8
Gastrointestinal disorders Dyspepsia
Musculoskeletal and connective tissue disorders Fracture
Musculoskeletal and connective tissue disorders Fracture 0.8
Nervous system disorders Hyperkinesia
Nervous system disorders Hyperkinesia 0.8
General disorders and administration site conditions Increased appetite
General disorders and administration site conditions Increased appetite 0.8
Blood and lymphatic system disorders Leukopenia
Injury, poisoning and procedural complications Multiple fractures
Injury, poisoning and procedural complications Multiple fractures 0.8
Infections and infestations Respiratory tract infection
Infections and infestations Respiratory tract infection 0.8
Investigations Weight increased
Investigations Weight increased 0.8
General disorders and administration site conditions Asthenia 0.6
Cardiac disorders Dizziness 0.6
General disorders and administration site conditions Fatigue 0.6
Gastrointestinal disorders Vomiting 0.6
Musculoskeletal and connective tissue disorders Back pain
Musculoskeletal and connective tissue disorders Back pain 0.5
Gastrointestinal disorders Dry throat
Gastrointestinal disorders Dry throat 0.5
Nervous system disorders Dysarthria
Nervous system disorders Dysarthria 0.5
Gastrointestinal disorders Dyspepsia
Gastrointestinal disorders Dyspepsia 0.5
Blood and lymphatic system disorders Leukopenia
Blood and lymphatic system disorders Leukopenia 0.5
Musculoskeletal and connective tissue disorders Muscle twitching
Musculoskeletal and connective tissue disorders Muscle twitching 0.5
Cardiac disorders Oedema peripheral
Cardiac disorders Oedema peripheral 0.5
Musculoskeletal and connective tissue disorders Osteoarthritis
Musculoskeletal and connective tissue disorders Osteoarthritis 0.5
General disorders and administration site conditions Pain
Musculoskeletal and connective tissue disorders Pain in extremity
Skin and subcutaneous tissue disorders Pruritus
Skin and subcutaneous tissue disorders Pruritus 0.5
Infections and infestations Urinary tract infection
Ear and labyrinth disorders Vertigo
Investigations Weight increased
Investigations White blood cell count decreased
Investigations White blood cell count decreased 0.5
Endocrine disorders Hyperglycaemia
Endocrine disorders Hyperglycaemia 0.4
Gastrointestinal disorders Pharyngitis
Gastrointestinal disorders Pharyngitis 0.4
Gastrointestinal disorders Constipation
Nervous system disorders Coordination abnormal
Nervous system disorders Coordination abnormal 0.3
General disorders and administration site conditions Lethargy
Cardiac disorders Oedema peripheral
Surgical and medical procedures Vasodilation procedure
Surgical and medical procedures Vasodilation procedure 0.3

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
19.74
Nervous system disorders
16.0
Psychiatric disorders
11.84
Injury, poisoning and procedural complications
11.56
Musculoskeletal and connective tissue disorders
5.49
Immune system disorders
5.11
Gastrointestinal disorders
5.08
Skin and subcutaneous tissue disorders
3.92
Cardiac disorders
3.56
Vascular disorders
3.22
Respiratory, thoracic and mediastinal disorders
2.88
Investigations
2.48

Cross References

Resources Reference
CAS NUMBER 60142-96-3
ChEBI 42797
ChEMBL CHEMBL940
DrugBank DB00996
DrugCentral 1264
EPA CompTox DTXSID0020074
FDA SRS 6CW7F3G59X
Human Metabolome Database HMDB0005015
Guide to Pharmacology 5483
KEGG D00332
PDB GBN
PharmGKB PA449720
PubChem 3446
SureChEMBL SCHEMBL8343
ZINC ZINC000000004949
CONTENTS