GANCICLOVIR SODIUM

Search structure
Trade Names:
Synonyms:
Status: Approved (1989)
Entry Type: Small molecule
Molecule Category: Salt Prodrug
UNII: 02L083W284
Parent Compound: GANCICLOVIR

Structure
InChI Key JJICLMJFIKGAAU-UHFFFAOYSA-M
Smile Nc1nc([O-])c2ncn(COC(CO)CO)c2n1.[Na+]
InChI
InChI=1S/C9H13N5O4.Na/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16;/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17);/q;+1/p-1

Physicochemical Descriptors

Property Name Value
Molecular Formula C9H12N5NaO4
Molecular Weight 277.22
AlogP -1.56
Hydrogen Bond Acceptor 9.0
Hydrogen Bond Donor 4.0
Number of Rotational Bond 5.0
Polar Surface Area 139.54
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 18.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Human herpesvirus 1 DNA polymerase inhibitor DailyMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Uveitis, Anterior 2 D014606 ClinicalTrials
Brain Neoplasms 1 D001932 ClinicalTrials
Neoplasm Metastasis 1 D009362 ClinicalTrials

Related Entries

Scaffolds

Parent

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Infections and infestations
17.16
Blood and lymphatic system disorders
11.83
General disorders and administration site conditions
11.52
Injury, poisoning and procedural complications
8.49
Respiratory, thoracic and mediastinal disorders
6.97
Investigations
6.44
Nervous system disorders
5.73
Gastrointestinal disorders
4.03
Vascular disorders
3.47
Renal and urinary disorders
3.28
Eye disorders
3.13
Hepatobiliary disorders
3.03
Immune system disorders
2.97
Metabolism and nutrition disorders
2.66
Skin and subcutaneous tissue disorders
2.45
Cardiac disorders
2.01

Cross References

Resources Reference
ChEMBL CHEMBL1200850
EPA CompTox DTXSID20883175
FDA SRS 02L083W284
KEGG D00333
PubChem 23700083
SureChEMBL SCHEMBL149822
ZINC ZINC00001505
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