Trade Names: | |
Synonyms: | |
Status: | Approved (1998) |
Entry Type: | Protein |
Molecule Category: | Parent |
ATC: | H04AA01 |
UNII: | 76LA80IG2G |
InChI Key | MASNOZXLGMXCHN-ZLPAWPGGSA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C153H225N43O49S |
Molecular Weight | 3482.8 |
AlogP | None |
Hydrogen Bond Acceptor | None |
Hydrogen Bond Donor | None |
Number of Rotational Bond | None |
Polar Surface Area | None |
Molecular species | None |
Aromatic Rings | None |
Heavy Atoms | None |
Action | Mechanism of Action | Reference |
---|---|---|
AGONIST | Glucagon receptor agonist | PubMed |
Primary Target | |
---|---|
glucagon receptor |
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
---|---|---|---|---|---|---|
Enzyme
Lyase
|
6-8 | - | - | - | - | |
Enzyme
|
6-8 | - | - | - | - | |
Membrane receptor
Family B G protein-coupled receptor
Peptide receptor (family B GPCR)
Glucagon-like receptor
Glucagon-like peptide receptor
|
0-41 | - | - | - | - | |
Membrane receptor
Family B G protein-coupled receptor
Peptide receptor (family B GPCR)
Glucagon-like receptor
Glucagon receptor
|
0-1 | 2-2 | - | - | - | |
Unclassified protein
|
0 | - | - | - | - |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Diabetes Mellitus, Type 1 | 3 | D003922 | ClinicalTrials |
Nesidioblastosis | 2 | D046768 | ClinicalTrials |
Obesity | 2 | D009765 | ClinicalTrials |
Congenital Hyperinsulinism | 2 | D044903 | ClinicalTrials |
Common Cold | 1 | D003139 | ClinicalTrials |
Diabetes Mellitus, Type 2 | 1 | D003924 | ClinicalTrials |
Resources | Reference |
---|---|
CAS NUMBER | 16941-32-5 |
ChEBI | 5391 |
ChEMBL | CHEMBL266481 |
DrugCentral | 2994 |
FDA SRS | 76LA80IG2G |
Guide to Pharmacology | 1136 |
PubChem | 16132283 |
SureChEMBL | SCHEMBL23721788 |