| Trade Names: | |
| Synonyms: | |
| Status: | Approved (1952) |
| Entry Type: | Small molecule |
| Molecule Category: | Parent |
| ATC: | A01AC03 |
| UNII: | WI4X0X7BPJ |
Structure
| InChI Key | JYGXADMDTFJGBT-VWUMJDOOSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C21H30O5 |
| Molecular Weight | 362.47 |
| AlogP | 1.78 |
| Hydrogen Bond Acceptor | 5.0 |
| Hydrogen Bond Donor | 3.0 |
| Number of Rotational Bond | 2.0 |
| Polar Surface Area | 94.83 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 0.0 |
| Heavy Atoms | 26.0 |
Experimental and Estimated Properties
| Property Name | Value | Unit | Method |
|---|---|---|---|
| log P (octanol-water) | 1.61 | - | EXP |
| Henry's Law Constant | 5.77E-08 | atm-m3/mole | EST |
| Atmospheric OH Rate Constant | 1.14E-10 | cm3/molecule-sec | EST |
| Melting Point | 220 | deg C | EXP |
| Water Solubility | 320 | mg/L | EXP |
| Vapor Pressure | 1.35E-13 | mm Hg | EST |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| AGONIST | Glucocorticoid receptor agonist |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Adrenal Hyperplasia, Congenital | 4 | D000312 | ClinicalTrials |
| Herpes Labialis | 4 | D006560 | ClinicalTrials |
| Psoriasis | 4 | D011565 | ClinicalTrials |
| Precursor Cell Lymphoblastic Leukemia-Lymphoma | 3 | D054198 | ClinicalTrials |
| Leukemia, Lymphoid | 3 | D007945 | ClinicalTrials |
| Precursor Cell Lymphoblastic Leukemia-Lymphoma | 3 | D054198 | ClinicalTrials |
| Alcoholism | 3 | D000437 | ClinicalTrials |
| Alopecia Areata | 3 | D000506 | ClinicalTrials |
| Prostatic Neoplasms, Castration-Resistant | 3 | D064129 | ClinicalTrials |
| Severe Acute Respiratory Syndrome | 3 | D045169 | ClinicalTrials |
| Bronchopulmonary Dysplasia | 3 | D001997 | ClinicalTrials |
| Heart Arrest | 3 | D006323 | ClinicalTrials |
| Leukemia, Biphenotypic, Acute | 3 | D015456 | ClinicalTrials |
| Myelodysplastic Syndromes | 3 | D009190 | ClinicalTrials |
| Leukemia, Biphenotypic, Acute | 3 | D015456 | ClinicalTrials |
| Leukemia, Biphenotypic, Acute | 3 | D015456 | ClinicalTrials |
| Leukemia, Erythroblastic, Acute | 3 | D004915 | ClinicalTrials |
| Pain | 3 | D010146 | ClinicalTrials |
| Leukemia, Monocytic, Acute | 3 | D007948 | ClinicalTrials |
| Leukemia, Myelomonocytic, Acute | 3 | D015479 | ClinicalTrials |
| Leukemia, Megakaryoblastic, Acute | 3 | D007947 | ClinicalTrials |
| Leukemia, Myeloid, Acute | 3 | D015470 | ClinicalTrials |
| Anemia, Refractory | 3 | D000753 | ClinicalTrials |
| Anemia, Refractory, with Excess of Blasts | 3 | D000754 | ClinicalTrials |
| Prostatic Neoplasms | 3 | D011471 | ClinicalTrials |
| Influenza, Human | 3 | D007251 | ClinicalTrials |
| Prostatic Neoplasms | 3 | D011471 | ClinicalTrials |
| Pneumonia, Viral | 3 | D011024 | ClinicalTrials |
| Myeloproliferative Disorders | 3 | D009196 | ClinicalTrials |
| Hypotension | 3 | D007022 | ClinicalTrials |
| Shock, Septic | 3 | D012772 | ClinicalTrials |
| Hypoxia | 3 | D000860 | ClinicalTrials |
| Prostatic Neoplasms | 3 | D011471 | ClinicalTrials |
| Leukemia, Myeloid, Acute | 3 | D015470 | ClinicalTrials |
| Oral Submucous Fibrosis | 3 | D009914 | ClinicalTrials |
| Liver Cirrhosis | 3 | D008103 | ClinicalTrials |
| Eczema | 3 | D004485 | ClinicalTrials |
| Precursor Cell Lymphoblastic Leukemia-Lymphoma | 3 | D054198 | ClinicalTrials |
| Sepsis | 3 | D018805 | ClinicalTrials |
| Leukemia, Myelomonocytic, Chronic | 3 | D015477 | ClinicalTrials |
| Lymphohistiocytosis, Hemophagocytic | 2 | D051359 | ClinicalTrials |
| Wounds and Injuries | 2 | D014947 | ClinicalTrials |
| Myocardial Infarction | 2 | D009203 | ClinicalTrials |
| Melanoma | 2 | D008545 | ClinicalTrials |
| Multiple Myeloma | 2 | D009101 | ClinicalTrials |
| Opioid-Related Disorders | 2 | D009293 | ClinicalTrials |
| Leukemia, Mast-Cell | 2 | D007946 | ClinicalTrials |
| Phobic Disorders | 2 | D010698 | ClinicalTrials |
| Borderline Personality Disorder | 2 | D001883 | ClinicalTrials |
| Atrial Fibrillation | 2 | D001281 | ClinicalTrials |
| Lymphoma, Large B-Cell, Diffuse | 2 | D016403 | ClinicalTrials |
| Memory Disorders | 2 | D008569 | ClinicalTrials |
| Adrenal Cortex Neoplasms | 2 | D000306 | ClinicalTrials |
| Central Nervous System Neoplasms | 2 | D016543 | ClinicalTrials |
| Addison Disease | 2 | D000224 | ClinicalTrials |
| Heart Failure | 2 | D006333 | ClinicalTrials |
| Opioid-Related Disorders | 2 | D009293 | ClinicalTrials |
| Pancreatitis | 2 | D010195 | ClinicalTrials |
| Addison Disease | 2 | D000224 | ClinicalTrials |
| Granuloma, Pyogenic | 2 | D017789 | ClinicalTrials |
| Neoplasms, Plasma Cell | 2 | D054219 | ClinicalTrials |
| Inflammatory Bowel Diseases | 2 | D015212 | ClinicalTrials |
| Aging | 2 | D000375 | ClinicalTrials |
| Infections | 1 | D007239 | ClinicalTrials |
| Insulin Resistance | 1 | D007333 | ClinicalTrials |
| Obesity | 1 | D009765 | ClinicalTrials |
| HIV Infections | 1 | D015658 | ClinicalTrials |
| Diabetes Mellitus, Type 1 | 1 | D003922 | ClinicalTrials |
| Tobacco Use Disorder | 1 | D014029 | ClinicalTrials |
| Fibromyalgia | 1 | D005356 | ClinicalTrials |
| Lymphoma, Large-Cell, Anaplastic | 1 | D017728 | ClinicalTrials |
Related Entries
Adverse Reactions
System Organ Classification (SOC)
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 50-23-7 |
| ChEBI | 17650 |
| ChEMBL | CHEMBL389621 |
| DrugBank | DB00741 |
| DrugCentral | 1388 |
| EPA CompTox | DTXSID7020714 |
| FDA SRS | WI4X0X7BPJ |
| Human Metabolome Database | HMDB14879 |
| Guide to Pharmacology | 2868 |
| KEGG | C08176 |
| PDB | HCY |
| PharmGKB | PA449905 |
| PubChem | 5754 |
| SureChEMBL | SCHEMBL4148 |
| ZINC | ZINC000013540519 |
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