IMIPRAMINE HYDROCHLORIDE

Search structure
Trade Names:
Synonyms:
Status: Approved (1959)
Entry Type: Small molecule
Molecule Category: Salt
UNII: BKE5Q1J60U
Parent Compound: IMIPRAMINE

Structure
InChI Key XZZXIYZZBJDEEP-UHFFFAOYSA-N
Smile CN(C)CCCN1c2ccccc2CCc2ccccc21.Cl
InChI
InChI=1S/C19H24N2.ClH/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21;/h3-6,8-11H,7,12-15H2,1-2H3;1H

Physicochemical Descriptors

Property Name Value
Molecular Formula C19H25ClN2
Molecular Weight 316.88
AlogP 3.88
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 4.0
Polar Surface Area 6.48
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 21.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Norepinephrine transporter inhibitor DailyMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC06 neurotransmitter transporter family
- 3 - 12 -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 62

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Depressive Disorder 2 D003866 ClinicalTrials
Glioblastoma 2 D005909 ClinicalTrials

Related Entries

Scaffolds

Parent

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Nervous system disorders
18.36
General disorders and administration site conditions
17.67
Injury, poisoning and procedural complications
10.88
Psychiatric disorders
10.59
Cardiac disorders
8.29
Musculoskeletal and connective tissue disorders
5.81
Respiratory, thoracic and mediastinal disorders
5.35
Investigations
5.24
Skin and subcutaneous tissue disorders
3.17
Gastrointestinal disorders
2.88
Vascular disorders
2.59

Cross References

Resources Reference
ChEBI 5882
ChEMBL CHEMBL1692
EPA CompTox DTXSID7040738
FDA SRS BKE5Q1J60U
Guide to Pharmacology 357
KEGG C07982
PDB IXX
PubChem 8228
SureChEMBL SCHEMBL41765
ZINC ZINC00020245
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