IMIQUIMOD

Search structure
Trade Names:
Synonyms:
Status: Approved (1997)
Entry Type: Small molecule
Molecule Category: UNKNOWN
ATC: D06BB10
UNII: P1QW714R7M

Structure
InChI Key DOUYETYNHWVLEO-UHFFFAOYSA-N
Smile CC(C)Cn1cnc2c(N)nc3ccccc3c21
InChI
InChI=1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17)

Physicochemical Descriptors

Property Name Value
Molecular Formula C14H16N4
Molecular Weight 240.31
AlogP 2.82
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 2.0
Polar Surface Area 56.73
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 18.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Toll-like receptor 7 agonist FDA PubMed
Primary Target
TLR7
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- 646 - - -
Membrane receptor Toll-like and Il-1 receptors
2120-12100 - - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Keratosis 4 D007642 ClinicalTrials
Carcinoma, Basal Cell 4 D002280 ClinicalTrials
Scleroderma, Localized 3 D012594 ClinicalTrials
Anus Neoplasms 3 D001005 ClinicalTrials
Squamous Intraepithelial Lesions 3 D000081483 ClinicalTrials
Cervical Intraepithelial Neoplasia 3 D018290 ClinicalTrials
Lentigo 3 D007911 ClinicalTrials
Leishmaniasis, Cutaneous 3 D016773 ClinicalTrials
Condylomata Acuminata 3 D003218 ClinicalTrials
Influenza, Human 3 D007251 ClinicalTrials
Paget Disease, Extramammary 3 D010145 ClinicalTrials
Vulvar Neoplasms 3 D014846 ClinicalTrials
Papillomavirus Infections 2 D030361 ClinicalTrials
Melanoma 2 D008545 ClinicalTrials
Uterine Cervical Neoplasms 2 D002583 ClinicalTrials
Leukemia, Lymphocytic, Chronic, B-Cell 2 D015451 ClinicalTrials
Melanoma 2 D008545 ClinicalTrials
Leukemia 2 D007938 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 2 D002289 ClinicalTrials
Hepatitis B, Chronic 2 D019694 ClinicalTrials
Hemangioma 2 D006391 ClinicalTrials
Keloid 2 D007627 ClinicalTrials
Renal Insufficiency 2 D051437 ClinicalTrials
Cheilitis 2 D002613 ClinicalTrials
Fallopian Tube Neoplasms 2 D005185 ClinicalTrials
Uterine Cervical Neoplasms 2 D002583 ClinicalTrials
Breast Neoplasms 2 D001943 ClinicalTrials
Ovarian Neoplasms 2 D010051 ClinicalTrials
Carcinoma in Situ 2 D002278 ClinicalTrials
Port-Wine Stain 2 D019339 ClinicalTrials
Diffuse Intrinsic Pontine Glioma 1 D000080443 ClinicalTrials
Carcinoma, Squamous Cell 1 D002294 ClinicalTrials
Glioma 1 D005910 ClinicalTrials
Osteosarcoma 1 D012516 ClinicalTrials
Ependymoma 1 D004806 ClinicalTrials
Brain Neoplasms 1 D001932 ClinicalTrials
Prostatic Neoplasms 1 D011471 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 1 D064129 ClinicalTrials
Medulloblastoma 1 D008527 ClinicalTrials
Sarcoma 1 D012509 ClinicalTrials
Precursor Cell Lymphoblastic Leukemia-Lymphoma 1 D054198 ClinicalTrials
Neoplasms 1 D009369 ClinicalTrials
Glioblastoma 1 D005909 ClinicalTrials
Astrocytoma 1 D001254 ClinicalTrials
Colorectal Neoplasms 1 D015179 ClinicalTrials
Influenza in Birds 1 D005585 ClinicalTrials
Mouth Neoplasms 0 D009062 ClinicalTrials
Lymphoma, T-Cell, Cutaneous 0 D016410 ClinicalTrials

Related Entries

Scaffolds

Side Effects from Label

Side effects Relative Frequency (%) Labels
Skin and subcutaneous tissue disorders Erythema 100.0
Skin and subcutaneous tissue disorders Erythema 97.2
Skin and subcutaneous tissue disorders Erythema 97.0
Skin and subcutaneous tissue disorders Erythema 95.0
Skin and subcutaneous tissue disorders Erythema 93.6
Skin and subcutaneous tissue disorders Erythema 93.0
General disorders and administration site conditions Induration 84.0
Skin and subcutaneous tissue disorders Scab 83.0
Skin and subcutaneous tissue disorders Scab 79.0
Skin and subcutaneous tissue disorders Scab 78.6
General disorders and administration site conditions Induration 78.0
General disorders and administration site conditions Oedema 78.0
General disorders and administration site conditions Oedema 71.0
Skin and subcutaneous tissue disorders Erythema 69.0
Skin and subcutaneous tissue disorders Erythema 65.0
Skin and subcutaneous tissue disorders Erythema 64.9
Skin and subcutaneous tissue disorders Scab 64.0
Skin and subcutaneous tissue disorders Erythema 61.0
Skin and subcutaneous tissue disorders Erythema 60.7
Skin and subcutaneous tissue disorders Erythema 58.0
Skin and subcutaneous tissue disorders Erythema 57.7
Skin and subcutaneous tissue disorders Erythema 54.0
General disorders and administration site conditions Induration 53.0
General disorders and administration site conditions Oedema 49.3
General disorders and administration site conditions Oedema 49.0
General disorders and administration site conditions Ulcer 48.0
General disorders and administration site conditions Ulcer 47.9
Skin and subcutaneous tissue disorders Erythema 44.1
Skin and subcutaneous tissue disorders Erythema 44.0
Skin and subcutaneous tissue disorders Scab 42.0
Skin and subcutaneous tissue disorders Scab 41.8
General disorders and administration site conditions Ulcer 40.0
General disorders and administration site conditions Oedema 36.0
Skin and subcutaneous tissue disorders Scab 34.0
General disorders and administration site conditions Ulcer 34.0
General disorders and administration site conditions Application site reaction 33.0
Skin and subcutaneous tissue disorders Pruritus 32.5
Skin and subcutaneous tissue disorders Pruritus 32.0
Skin and subcutaneous tissue disorders Erythema 31.0
General disorders and administration site conditions Application site reaction 28.1
General disorders and administration site conditions Application site reaction 28.0
Skin and subcutaneous tissue disorders Erythema 28.0
Skin and subcutaneous tissue disorders Pruritus 26.4
Excoriation 26.0
Excoriation 25.6
Excoriation 25.0
Skin and subcutaneous tissue disorders Erythema 24.0
Excoriation 22.6
General disorders and administration site conditions Crying 22.0
Skin and subcutaneous tissue disorders Erythema 22.0
Skin and subcutaneous tissue disorders Pruritus 22.0
Psychiatric disorders Tearfulness 22.0
Skin and subcutaneous tissue disorders Pruritus 21.8
Skin and subcutaneous tissue disorders Erythema 21.7
Skin and subcutaneous tissue disorders Erythema 21.5
Skin and subcutaneous tissue disorders Erythema 21.2
Skin and subcutaneous tissue disorders Erythema 21.0
General disorders and administration site conditions Crying 20.9
Psychiatric disorders Tearfulness 20.9
Skin and subcutaneous tissue disorders Pruritus 20.5
Skin and subcutaneous tissue disorders Pruritus 20.4
Skin and subcutaneous tissue disorders Pruritus 20.0
Skin and subcutaneous tissue disorders Scab 20.0
Skin and subcutaneous tissue disorders Scab 19.0
Excoriation 18.4
Skin and subcutaneous tissue disorders Erythema 18.0
Excoriation 18.0
General disorders and administration site conditions Oedema 18.0
Skin and subcutaneous tissue disorders Erythema 17.7
General disorders and administration site conditions Oedema 17.5
General disorders and administration site conditions Oedema 17.0
Skin and subcutaneous tissue disorders Pruritus 16.8
Skin and subcutaneous tissue disorders Pruritus 16.2
Excoriation 15.9
Infections and infestations Upper respiratory tract infection 15.3
General disorders and administration site conditions Application site reaction 14.5
General disorders and administration site conditions Oedema 14.4
Skin and subcutaneous tissue disorders Pruritus 14.2
General disorders and administration site conditions Oedema 14.0
Skin and subcutaneous tissue disorders Pruritus 13.9
Skin and subcutaneous tissue disorders Scab 13.0
Skin and subcutaneous tissue disorders Scab 12.8
General disorders and administration site conditions Oedema 12.2
Infections and infestations Upper respiratory tract infection 12.2
General disorders and administration site conditions Oedema 12.0
Infections and infestations Fungal infection 11.1
Infections and infestations Fungal infection 11.0
Skin and subcutaneous tissue disorders Pruritus 10.1
General disorders and administration site conditions Oedema 10.0
Skin and subcutaneous tissue disorders Pruritus 10.0
Skin and subcutaneous tissue disorders Erythema 9.8
General disorders and administration site conditions Ulcer 9.09
General disorders and administration site conditions Ulcer 9.0
Skin and subcutaneous tissue disorders Scab 8.9
Skin and subcutaneous tissue disorders Scab 8.37
Excoriation 8.08
Excoriation 8.0
Nervous system disorders Headache 8.0
General disorders and administration site conditions Oedema 8.0
General disorders and administration site conditions Pain 8.0
Skin and subcutaneous tissue disorders Scab 8.0
General disorders and administration site conditions Ulcer 8.0
General disorders and administration site conditions Ulcer 7.89
Excoriation 7.8
General disorders and administration site conditions Oedema 7.8
General disorders and administration site conditions Pain 7.69
Skin and subcutaneous tissue disorders Pruritus 7.69
Excoriation 7.64
Nervous system disorders Headache 7.6
Nervous system disorders Headache 7.57
Infections and infestations Sinusitis 7.44
General disorders and administration site conditions Induration 7.05
General disorders and administration site conditions Application site pain 7.0
General disorders and administration site conditions Induration 7.0
General disorders and administration site conditions Instillation site pain 7.0
General disorders and administration site conditions Oedema 7.0
Infections and infestations Sinusitis 6.33
General disorders and administration site conditions Induration 6.3
Skin and subcutaneous tissue disorders Scab 6.3
Nervous system disorders Headache 6.25
General disorders and administration site conditions Application site irritation 6.0
General disorders and administration site conditions Induration 6.0
General disorders and administration site conditions Ulcer 6.0
General disorders and administration site conditions Ulcer 5.9
General disorders and administration site conditions Induration 5.26
Nervous system disorders Headache 5.13
Nervous system disorders Headache 5.12
Nervous system disorders Headache 5.1
General disorders and administration site conditions Oedema 5.05
Nervous system disorders Headache 5.0
General disorders and administration site conditions Induration 5.0
General disorders and administration site conditions Oedema 5.0
Skin and subcutaneous tissue disorders Scab 5.0
General disorders and administration site conditions Ulcer 5.0
General disorders and administration site conditions Ulcer 4.49
General disorders and administration site conditions Pain 4.4
Skin and subcutaneous tissue disorders Pruritus 4.4
General disorders and administration site conditions Application site pruritus 4.38
General disorders and administration site conditions Asthenia 4.38
General disorders and administration site conditions Fatigue 4.38
General disorders and administration site conditions Pain 4.3
Nervous system disorders Headache 4.27
Musculoskeletal and connective tissue disorders Back pain 4.0
Skin and subcutaneous tissue disorders Erythema 4.0
Nervous system disorders Headache 4.0
Skin and subcutaneous tissue disorders Scab 4.0
General disorders and administration site conditions Tenderness 4.0
General disorders and administration site conditions Ulcer 4.0
Skin and subcutaneous tissue disorders Erythema 3.85
Musculoskeletal and connective tissue disorders Back pain 3.78
General disorders and administration site conditions Application site pruritus 3.75
General disorders and administration site conditions Influenza like illness 3.75
Gastrointestinal disorders Nausea 3.75
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Squamous cell carcinoma 3.72
Nervous system disorders Headache 3.7
Skin and subcutaneous tissue disorders Erythema 3.51
Skin and subcutaneous tissue disorders Scab 3.51
General disorders and administration site conditions Influenza like illness 3.42
Investigations Haemoglobin 3.26
Vascular disorders Haemorrhage 3.26
General disorders and administration site conditions Pain 3.24
Infections and infestations Upper respiratory tract infection 3.24
General disorders and administration site conditions Pain 3.2
Nervous system disorders Headache 3.17
Nervous system disorders Headache 3.14
General disorders and administration site conditions Application site irritation 3.12
General disorders and administration site conditions Application site pain 3.12
Investigations Body temperature increased 3.12
General disorders and administration site conditions Instillation site pain 3.12
General disorders and administration site conditions Application site reaction 3.0
Skin and subcutaneous tissue disorders Erythema 3.0
Infections and infestations Fungal infection 3.0
Nervous system disorders Headache 3.0
General disorders and administration site conditions Influenza like illness 3.0
Blood and lymphatic system disorders Lymphadenopathy 3.0
Infections and infestations Rhinitis 3.0
Skin and subcutaneous tissue disorders Scab 3.0
General disorders and administration site conditions Tenderness 3.0
General disorders and administration site conditions Ulcer 3.0
Infections and infestations Upper respiratory tract infection 3.0
Infections and infestations Fungal infection 2.91
Nervous system disorders Headache 2.91
General disorders and administration site conditions Application site reaction 2.79
Gastrointestinal disorders Diarrhoea 2.79
General disorders and administration site conditions Pain 2.79
General disorders and administration site conditions Application site pruritus 2.75
Blood and lymphatic system disorders Lymphadenopathy 2.7
Infections and infestations Rhinitis 2.7
General disorders and administration site conditions Ulcer 2.63
General disorders and administration site conditions Induration 2.6
General disorders and administration site conditions Tenderness 2.56
Skin and subcutaneous tissue disorders Scab 2.55
General disorders and administration site conditions Application site irritation 2.5
Musculoskeletal and connective tissue disorders Arthralgia 2.5
General disorders and administration site conditions Decreased appetite 2.5
Cardiac disorders Dizziness 2.5
Infections and infestations Herpes simplex 2.5
Blood and lymphatic system disorders Lymphadenopathy 2.5
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 2.5
Gastrointestinal disorders Oral herpes 2.5
General disorders and administration site conditions Induration 2.33
General disorders and administration site conditions Ulcer 2.33
Excoriation 2.3
Nervous system disorders Headache 2.3
General disorders and administration site conditions Oedema 2.3
Skin and subcutaneous tissue disorders Erythema 2.27
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Squamous cell carcinoma 2.26
Nervous system disorders Headache 2.23
General disorders and administration site conditions Asthenia 2.2
General disorders and administration site conditions Fatigue 2.2
Investigations Haemoglobin 2.2
Vascular disorders Haemorrhage 2.2
Nervous system disorders Headache 2.2
General disorders and administration site conditions Pain 2.2
General disorders and administration site conditions Asthenia 2.16
General disorders and administration site conditions Fatigue 2.16
Investigations Haemoglobin 2.16
Vascular disorders Haemorrhage 2.16
Infections and infestations Sinusitis 2.16
Nervous system disorders Headache 2.1
General disorders and administration site conditions Induration 2.02
General disorders and administration site conditions Asthenia 2.0
Investigations Body temperature increased 2.0
Respiratory, thoracic and mediastinal disorders Cough 2.0
Gastrointestinal disorders Dyspepsia 2.0
Skin and subcutaneous tissue disorders Erythema 2.0
General disorders and administration site conditions Fatigue 2.0
Infections and infestations Fungal infection 2.0
Nervous system disorders Headache 2.0
General disorders and administration site conditions Induration 2.0
General disorders and administration site conditions Influenza like illness 2.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 2.0
Musculoskeletal and connective tissue disorders Myalgia 2.0
General disorders and administration site conditions Pain 2.0
Skin and subcutaneous tissue disorders Scab 2.0
Infections and infestations Sinusitis 2.0
General disorders and administration site conditions Ulcer 2.0
General disorders and administration site conditions Influenza like illness 1.94
General disorders and administration site conditions Pain 1.94
Infections and infestations Fungal infection 1.92
General disorders and administration site conditions Pain 1.92
General disorders and administration site conditions Induration 1.91
Nervous system disorders Headache 1.9
General disorders and administration site conditions Influenza like illness 1.9
Skin and subcutaneous tissue disorders Pruritus 1.9
Gastrointestinal disorders Cheilitis 1.88
Gastrointestinal disorders Diarrhoea 1.88
Nervous system disorders Headache 1.88
Blood and lymphatic system disorders Lymphadenopathy 1.88
Skin and subcutaneous tissue disorders Eczema 1.86
General disorders and administration site conditions Tenderness 1.86
Skin and subcutaneous tissue disorders Scab 1.82
Nervous system disorders Paraesthesia 1.7
Investigations Body temperature increased 1.62
Musculoskeletal and connective tissue disorders Bone pain 1.62
Respiratory, thoracic and mediastinal disorders Cough 1.62
Gastrointestinal disorders Dyspepsia 1.62
Skin and subcutaneous tissue disorders Erythema 1.62
Skin and subcutaneous tissue disorders Papule 1.62
Investigations Body temperature increased 1.6
Skin and subcutaneous tissue disorders Erythema 1.6
Nervous system disorders Headache 1.6
Blood and lymphatic system disorders Lymphadenopathy 1.6
Skin and subcutaneous tissue disorders Papule 1.6
Skin and subcutaneous tissue disorders Scab 1.6
General disorders and administration site conditions Ulcer 1.6
Investigations Body temperature increased 1.5
Nervous system disorders Headache 1.5
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 1.5
Musculoskeletal and connective tissue disorders Myalgia 1.5
Infections and infestations Vaginal infection 1.5
Vaginitis bacterial 1.5
Skin and subcutaneous tissue disorders Alopecia 1.4
General disorders and administration site conditions Asthenia 1.4
Cardiac disorders Atrial fibrillation 1.4
Musculoskeletal and connective tissue disorders Back pain 1.4
Investigations Body temperature increased 1.4
General disorders and administration site conditions Chills 1.4
Cardiac disorders Dizziness 1.4
General disorders and administration site conditions Fatigue 1.4
Vascular disorders Hypertension 1.4
Infections and infestations Infection 1.4
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 1.4
Musculoskeletal and connective tissue disorders Myalgia 1.4
General disorders and administration site conditions Pain 1.4
Infections and infestations Urinary tract infection 1.4
Infections and infestations Viral infection 1.4
Gastrointestinal disorders Vomiting 1.4
General disorders and administration site conditions Crying 1.36
Skin and subcutaneous tissue disorders Eczema 1.36
General disorders and administration site conditions Induration 1.36
Psychiatric disorders Tearfulness 1.36
General disorders and administration site conditions Tenderness 1.36
General disorders and administration site conditions Influenza like illness 1.28
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 1.28
Musculoskeletal and connective tissue disorders Myalgia 1.28
Gastrointestinal disorders Nausea 1.26
General disorders and administration site conditions Application site pain 1.25
Musculoskeletal and connective tissue disorders Arthralgia 1.25
General disorders and administration site conditions Asthenia 1.25
Gastrointestinal disorders Diarrhoea 1.25
General disorders and administration site conditions Fatigue 1.25
General disorders and administration site conditions Instillation site pain 1.25
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 1.25
Musculoskeletal and connective tissue disorders Arthralgia 1.2
General disorders and administration site conditions Asthenia 1.2
General disorders and administration site conditions Decreased appetite 1.2
Skin and subcutaneous tissue disorders Erythema 1.2
General disorders and administration site conditions Fatigue 1.2
General disorders and administration site conditions Induration 1.2
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 1.2
Gastrointestinal disorders Nausea 1.2
General disorders and administration site conditions Pain 1.2
Gastrointestinal disorders Abdominal pain 1.12
General disorders and administration site conditions Asthenia 1.12
Musculoskeletal and connective tissue disorders Bone pain 1.12
Gastrointestinal disorders Diarrhoea 1.12
Gastrointestinal disorders Dyspepsia 1.12
General disorders and administration site conditions Fatigue 1.12
Gastrointestinal disorders Gastrointestinal pain 1.12
Gastrointestinal disorders Tooth disorder 1.12
Infections and infestations Upper respiratory tract infection 1.12
Psychiatric disorders Anxiety 1.1
General disorders and administration site conditions Asthenia 1.1
Musculoskeletal and connective tissue disorders Back pain 1.1
Skin and subcutaneous tissue disorders Dermatitis 1.1
General disorders and administration site conditions Fatigue 1.1
Investigations Haemoglobin 1.1
Vascular disorders Haemorrhage 1.1
Infections and infestations Infection 1.1
General disorders and administration site conditions Influenza like illness 1.1
Skin and subcutaneous tissue disorders Leukoderma 1.1
Gastrointestinal disorders Nausea 1.1
General disorders and administration site conditions Pain 1.1
Nervous system disorders Paraesthesia 1.1
Skin and subcutaneous tissue disorders Rash 1.1
Infections and infestations Rash pustular 1.1
General disorders and administration site conditions Tenderness 1.1
Psychiatric disorders Anxiety 1.08
Cardiac disorders Chest pain 1.08
Cardiac disorders Dizziness 1.08
Metabolism and nutrition disorders Gout 1.08
Immune system disorders Hypersensitivity 1.08
Infections and infestations Infection 1.08
Metabolism and nutrition disorders Malnutrition 1.08
Gastrointestinal disorders Nausea 1.08
Gastrointestinal disorders Pharyngitis 1.08
General disorders and administration site conditions Tenderness 1.08
General disorders and administration site conditions Ulcer 1.01
Psychiatric disorders Anxiety 1.0
General disorders and administration site conditions Asthenia 1.0
Musculoskeletal and connective tissue disorders Back pain 1.0
Cardiac disorders Chest pain 1.0
Respiratory, thoracic and mediastinal disorders Cough 1.0
General disorders and administration site conditions Crying 1.0
Cardiac disorders Dizziness 1.0
Gastrointestinal disorders Dyspepsia 1.0
Excoriation 1.0
General disorders and administration site conditions Fatigue 1.0
Infections and infestations Fungal infection 1.0
General disorders and administration site conditions Influenza like illness 1.0
Blood and lymphatic system disorders Lymphadenopathy 1.0
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 1.0
Musculoskeletal and connective tissue disorders Myalgia 1.0
Gastrointestinal disorders Nausea 1.0
General disorders and administration site conditions Oedema 1.0
General disorders and administration site conditions Pain 1.0
Gastrointestinal disorders Pharyngitis 1.0
Infections and infestations Rhinitis 1.0
Infections and infestations Sinusitis 1.0
Psychiatric disorders Tearfulness 1.0
General disorders and administration site conditions Tenderness 1.0
General disorders and administration site conditions Ulcer 1.0
Infections and infestations Upper respiratory tract infection 1.0
General disorders and administration site conditions Application site irritation 0.99
General disorders and administration site conditions Application site pruritus 0.99
Infections and infestations Vaginal infection 0.99
Vaginitis bacterial 0.99
General disorders and administration site conditions Asthenia 0.905
Cardiac disorders Atrial fibrillation 0.905
Musculoskeletal and connective tissue disorders Back pain 0.905
Gastrointestinal disorders Diarrhoea 0.905
General disorders and administration site conditions Fatigue 0.905
General disorders and administration site conditions Pain 0.905
Infections and infestations Viral infection 0.905
General disorders and administration site conditions Oedema 0.877
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 0.855
Musculoskeletal and connective tissue disorders Myalgia 0.855
General disorders and administration site conditions Asthenia 0.8
Investigations Body temperature increased 0.8
General disorders and administration site conditions Chills 0.8
Psychiatric disorders Depression 0.8
Gastrointestinal disorders Diarrhoea 0.8
General disorders and administration site conditions Discomfort 0.8
Skin and subcutaneous tissue disorders Erythema 0.8
General disorders and administration site conditions Flushing 0.8
Skin and subcutaneous tissue disorders Hyperaesthesia 0.8
Infections and infestations Infection 0.8
General disorders and administration site conditions Oedema 0.8
Nervous system disorders Paraesthesia 0.8
Skin and subcutaneous tissue disorders Pruritus 0.8
General disorders and administration site conditions Ulcer 0.8
Excoriation 0.641
General disorders and administration site conditions Oedema 0.637
General disorders and administration site conditions Ulcer 0.637
Infections and infestations Fungal infection 0.633
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 0.633
Musculoskeletal and connective tissue disorders Myalgia 0.633
General disorders and administration site conditions Pain 0.633
General disorders and administration site conditions Tenderness 0.633
General disorders and administration site conditions Application site pruritus 0.629
Infections and infestations Herpes simplex 0.629
Cardiac disorders Dizziness 0.625
General disorders and administration site conditions Influenza like illness 0.625
Gastrointestinal disorders Nausea 0.625
General disorders and administration site conditions Pain 0.6
Skin and subcutaneous tissue disorders Pruritus 0.6
Psychiatric disorders Anxiety 0.559
Musculoskeletal and connective tissue disorders Back pain 0.559
Respiratory, thoracic and mediastinal disorders Cough 0.559
Cardiac disorders Dizziness 0.559
Immune system disorders Hypersensitivity 0.559
Blood and lymphatic system disorders Lymphadenopathy 0.559
Gastrointestinal disorders Pharyngitis 0.559
Skin and subcutaneous tissue disorders Pruritus 0.559
Infections and infestations Rhinitis 0.559
Infections and infestations Sinusitis 0.559
Gastrointestinal disorders Abdominal pain 0.541
Gastrointestinal disorders Diarrhoea 0.541
Gastrointestinal disorders Gastrointestinal pain 0.541
Cardiac disorders Chest pain 0.5
Skin and subcutaneous tissue disorders Dermatitis 0.5
Gastrointestinal disorders Dry mouth 0.5
General disorders and administration site conditions Inflammation 0.5
General disorders and administration site conditions Influenza like illness 0.5
General disorders and administration site conditions Irritability 0.5
General disorders and administration site conditions Lethargy 0.5
Gastrointestinal disorders Nausea 0.5
General disorders and administration site conditions Oedema 0.5
Skin and subcutaneous tissue disorders Pruritus 0.5
Skin and subcutaneous tissue disorders Scab 0.5
Skin and subcutaneous tissue disorders Skin disorder 0.5
General disorders and administration site conditions Swelling 0.5
General disorders and administration site conditions Application site pain 0.495
Nervous system disorders Headache 0.495
General disorders and administration site conditions Instillation site pain 0.495
Cardiac disorders Dizziness 0.452
Investigations Haemoglobin 0.452
Vascular disorders Haemorrhage 0.452
Infections and infestations Urinary tract infection 0.452
Gastrointestinal disorders Vomiting 0.452
Skin and subcutaneous tissue disorders Actinic keratosis 0.4
Musculoskeletal and connective tissue disorders Arthralgia 0.4
Investigations Body temperature increased 0.4
General disorders and administration site conditions Chills 0.4
Eye disorders Conjunctival irritation 0.4
Skin and subcutaneous tissue disorders Dermatitis 0.4
Renal and urinary disorders Dysuria 0.4
Eye disorders Eyelid oedema 0.4
General disorders and administration site conditions Face oedema 0.4
General disorders and administration site conditions Feeling hot 0.4
Investigations Haemoglobin 0.4
Vascular disorders Haemorrhage 0.4
Nervous system disorders Headache 0.4
General disorders and administration site conditions Inflammation 0.4
Infections and infestations Influenza 0.4
Nervous system disorders Insomnia 0.4
Respiratory, thoracic and mediastinal disorders Laryngeal pain 0.4
Blood and lymphatic system disorders Lymphadenopathy 0.4
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 0.4
Musculoskeletal and connective tissue disorders Myalgia 0.4
Respiratory, thoracic and mediastinal disorders Nasal congestion 0.4
General disorders and administration site conditions Oedema 0.4
Musculoskeletal and connective tissue disorders Pain in extremity 0.4
Skin and subcutaneous tissue disorders Papule 0.4
Nervous system disorders Paraesthesia 0.4
Gastrointestinal disorders Pharyngitis 0.4
Skin and subcutaneous tissue disorders Pruritus 0.4
Skin and subcutaneous tissue disorders Rash 0.4
Infections and infestations Rash pustular 0.4
Infections and infestations Rhinitis 0.4
Skin and subcutaneous tissue disorders Scab 0.4
Injury, poisoning and procedural complications Scar 0.4
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Seborrhoeic keratosis 0.4
Skin and subcutaneous tissue disorders Skin ulcer 0.4
General disorders and administration site conditions Swelling 0.4
General disorders and administration site conditions Ulcer 0.4
Immune system disorders Urticaria 0.4
Gastrointestinal disorders Abdominal pain 0.3
Gastrointestinal disorders Diarrhoea 0.3
Cardiac disorders Dizziness 0.3
Gastrointestinal disorders Gastrointestinal pain 0.3
Infections and infestations Herpes simplex 0.3
General disorders and administration site conditions Influenza like illness 0.3
General disorders and administration site conditions Pain 0.3
Musculoskeletal and connective tissue disorders Arthralgia 0.2
General disorders and administration site conditions Asthenia 0.2
Musculoskeletal and connective tissue disorders Back pain 0.2
General disorders and administration site conditions Decreased appetite 0.2
Skin and subcutaneous tissue disorders Dermatitis 0.2
General disorders and administration site conditions Discomfort 0.2
General disorders and administration site conditions Feeling abnormal 0.2
Infections and infestations Genital candidiasis 0.2
Reproductive system and breast disorders Genital pain 0.2
General disorders and administration site conditions Ill-defined disorder 0.2
Nervous system disorders Insomnia 0.2
Blood and lymphatic system disorders Lymphadenopathy 0.2
General disorders and administration site conditions Malaise 0.2
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 0.2
Reproductive system and breast disorders Penis disorder 0.2
Infections and infestations Vaginal infection 0.2
Vaginal inflammation 0.2
Gastrointestinal disorders Vomiting 0.2
Gastrointestinal disorders Anorectal discomfort 0.1
Gastrointestinal disorders Anorectal disorder 0.1
Reproductive system and breast disorders Atrophic vulvovaginitis 0.1
Infections and infestations Bacterial infection 0.1
General disorders and administration site conditions Chills 0.1
Psychiatric disorders Depression 0.1
Skin and subcutaneous tissue disorders Dermatitis 0.1
Psychiatric disorders Dyspareunia 0.1
Skin and subcutaneous tissue disorders Eczema 0.1
Psychiatric disorders Erectile dysfunction 0.1
General disorders and administration site conditions Flushing 0.1
Infections and infestations Folliculitis 0.1
Infections and infestations Fungal infection 0.1
General disorders and administration site conditions Hyperhidrosis 0.1
Nervous system disorders Migraine 0.1
Gastrointestinal disorders Pharyngitis 0.1
Gastrointestinal disorders Proctalgia 0.1
Skin and subcutaneous tissue disorders Rash 0.1
Skin and subcutaneous tissue disorders Rash erythematous 0.1
Gastrointestinal disorders Rectal tenesmus 0.1
Infections and infestations Rhinitis 0.1
Nervous system disorders Somnolence 0.1
Ear and labyrinth disorders Tinnitus 0.1
Infections and infestations Upper respiratory tract infection 0.1
Immune system disorders Urticaria 0.1
Reproductive system and breast disorders Uterovaginal prolapse 0.1
Reproductive system and breast disorders Vulval disorder 0.1
Infections and infestations Vulvitis 0.1
Reproductive system and breast disorders Vulvovaginal pain 0.1

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
21.69
Skin and subcutaneous tissue disorders
18.24
Injury, poisoning and procedural complications
14.99
Nervous system disorders
7.19
Gastrointestinal disorders
7.04
Musculoskeletal and connective tissue disorders
4.61
Immune system disorders
3.2
Psychiatric disorders
3.16
Vascular disorders
2.75
Eye disorders
2.57
Infections and infestations
2.51

Cross References

Resources Reference
CAS NUMBER 99011-02-6
ChEBI 36704
ChEMBL CHEMBL1282
DrugBank DB00724
DrugCentral 1429
EPA CompTox DTXSID7041047
FDA SRS P1QW714R7M
Human Metabolome Database HMDB0014862
Guide to Pharmacology 5003
KEGG D02500
PDB 6T0
PharmGKB PA449972
PubChem 57469
SureChEMBL SCHEMBL26136
ZINC ZINC000019632912
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