LENALIDOMIDE

Search structure
Trade Names:
Synonyms:
Status: Approved (2005)
Entry Type: Small molecule
Molecule Category: UNKNOWN
ATC: L04AX04
UNII: F0P408N6V4

Structure
InChI Key GOTYRUGSSMKFNF-UHFFFAOYSA-N
Smile Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O
InChI
InChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18)

Physicochemical Descriptors

Property Name Value
Molecular Formula C13H13N3O3
Molecular Weight 259.26
AlogP 0.03
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 1.0
Polar Surface Area 92.5
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 19.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR CRL4(CRBN) E3 ubiquitin ligase inhibitor PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Epigenetic regulator Reader Bromodomain
- 5190 - - -
Other cytosolic protein
- - - - 4-6
Transcription factor
- - - - 4-6
Unclassified protein
67 1500-37800 - 1490-16300 100

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Anemia 4 D000740 ClinicalTrials
Multiple Myeloma 4 D009101 ClinicalTrials
Melanoma 3 D008545 ClinicalTrials
Epstein-Barr Virus Infections 3 D020031 ClinicalTrials
Amyloidosis, Familial 3 D028226 ClinicalTrials
Leukemia, Myelomonocytic, Chronic 3 D015477 ClinicalTrials
Plasmacytoma 3 D010954 ClinicalTrials
Leukemia, Myeloid, Acute 3 D015470 ClinicalTrials
Lymphoma, Non-Hodgkin 3 D008228 ClinicalTrials
Smoldering Multiple Myeloma 3 D000075122 ClinicalTrials
Leukemia, Lymphocytic, Chronic, B-Cell 3 D015451 ClinicalTrials
Lymphoma, Large B-Cell, Diffuse 3 D016403 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 3 D064129 ClinicalTrials
Lymphoma 3 D008223 ClinicalTrials
Lymphoma, Follicular 3 D008224 ClinicalTrials
Neoplasm Metastasis 3 D009362 ClinicalTrials
Lymphoma, Follicular 3 D008224 ClinicalTrials
Polycythemia Vera 2 D011087 ClinicalTrials
Lymphoma, T-Cell, Cutaneous 2 D016410 ClinicalTrials
Histiocytosis, Sinus 2 D015618 ClinicalTrials
Hodgkin Disease 2 D006689 ClinicalTrials
Lymphoma, B-Cell, Marginal Zone 2 D018442 ClinicalTrials
Urinary Bladder Neoplasms 2 D001749 ClinicalTrials
Leukemia 2 D007938 ClinicalTrials
HIV Infections 2 D015658 ClinicalTrials
Leukemia, Biphenotypic, Acute 2 D015456 ClinicalTrials
Primary Myelofibrosis 2 D055728 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 2 D002289 ClinicalTrials
Pancreatic Neoplasms 2 D010190 ClinicalTrials
HIV Infections 2 D015658 ClinicalTrials
Thyroid Neoplasms 2 D013964 ClinicalTrials
Lymphoma, T-Cell, Peripheral 2 D016411 ClinicalTrials
Autistic Disorder 2 D001321 ClinicalTrials
Amyloidosis 2 D000686 ClinicalTrials
Prostatic Neoplasms 2 D011471 ClinicalTrials
Precursor Cell Lymphoblastic Leukemia-Lymphoma 2 D054198 ClinicalTrials
Crohn Disease 2 D003424 ClinicalTrials
Thrombocythemia, Essential 2 D013920 ClinicalTrials
Prostatic Neoplasms 2 D011471 ClinicalTrials
Carcinoma, Squamous Cell 2 D002294 ClinicalTrials
Lymphoma, B-Cell, Marginal Zone 2 D018442 ClinicalTrials
POEMS Syndrome 2 D016878 ClinicalTrials
Gliosarcoma 2 D018316 ClinicalTrials
Colorectal Neoplasms 2 D015179 ClinicalTrials
Hematologic Diseases 2 D006402 ClinicalTrials
Waldenstrom Macroglobulinemia 2 D008258 ClinicalTrials
Thyroid Neoplasms 2 D013964 ClinicalTrials
Colorectal Neoplasms 2 D015179 ClinicalTrials
Complex Regional Pain Syndromes 2 D020918 ClinicalTrials
Leukemia, Prolymphocytic 2 D015463 ClinicalTrials
Urinary Bladder Neoplasms 2 D001749 ClinicalTrials
Kidney Neoplasms 2 D007680 ClinicalTrials
Liver Neoplasms 2 D008113 ClinicalTrials
Radiculopathy 2 D011843 ClinicalTrials
Graft vs Host Disease 2 D006086 ClinicalTrials
Lymphoma, T-Cell 2 D016399 ClinicalTrials
Leukemia-Lymphoma, Adult T-Cell 2 D015459 ClinicalTrials
Hematologic Neoplasms 2 D019337 ClinicalTrials
Primary Myelofibrosis 2 D055728 ClinicalTrials
Glioma 2 D005910 ClinicalTrials
Myeloproliferative Disorders 2 D009196 ClinicalTrials
Leukemia, Plasma Cell 2 D007952 ClinicalTrials
Astrocytoma 1 D001254 ClinicalTrials
Ovarian Neoplasms 1 D010051 ClinicalTrials
Sarcoma, Kaposi 1 D012514 ClinicalTrials
Carcinoma, Renal Cell 1 D002292 ClinicalTrials
Colonic Neoplasms 1 D003110 ClinicalTrials
Peritoneal Neoplasms 1 D010534 ClinicalTrials
Fallopian Tube Neoplasms 1 D005185 ClinicalTrials
Neuroblastoma 1 D009447 ClinicalTrials
Cachexia 1 D002100 ClinicalTrials
Neoplasms 1 D009369 ClinicalTrials
Leukemia, Myelogenous, Chronic, BCR-ABL Positive 1 D015464 ClinicalTrials
Burkitt Lymphoma 1 D002051 ClinicalTrials
Carcinoma, Hepatocellular 1 D006528 ClinicalTrials
Carcinoma, Pancreatic Ductal 1 D021441 ClinicalTrials
Lymphoma, B-Cell 1 D016393 ClinicalTrials
Urethral Neoplasms 1 D014523 ClinicalTrials
Neoplasms 1 D009369 ClinicalTrials
Diffuse Intrinsic Pontine Glioma 1 D000080443 ClinicalTrials
Central Nervous System Neoplasms 1 D016543 ClinicalTrials
Rectal Neoplasms 1 D012004 ClinicalTrials

Related Entries

MCS

Side Effects from Label

Side effects Relative Frequency (%) Labels
Blood and lymphatic system disorders Neutropenia 79.0
Blood and lymphatic system disorders Neutropenia 76.8
Blood and lymphatic system disorders Neutropenia 74.6
Blood and lymphatic system disorders Thrombocytopenia 74.0
Blood and lymphatic system disorders Neutropenia 66.2
Blood and lymphatic system disorders Neutropenia 64.9
Blood and lymphatic system disorders Thrombocytopenia 64.9
Gastrointestinal disorders Diarrhoea 60.1
Blood and lymphatic system disorders Thrombocytopenia 54.7
Blood and lymphatic system disorders Neutropenia 53.4
Blood and lymphatic system disorders Thrombocytopenia 50.0
Blood and lymphatic system disorders Neutropenia 48.5
Blood and lymphatic system disorders Thrombocytopenia 46.4
Skin and subcutaneous tissue disorders Pruritus 44.6
General disorders and administration site conditions Asthenia 43.9
General disorders and administration site conditions Fatigue 43.9
Blood and lymphatic system disorders Neutropenia 43.3
General disorders and administration site conditions Asthenia 42.6
General disorders and administration site conditions Fatigue 42.6
Blood and lymphatic system disorders Neutropenia 42.2
General disorders and administration site conditions Asthenia
General disorders and administration site conditions Fatigue
Gastrointestinal disorders Constipation 40.5
Gastrointestinal disorders Diarrhoea 38.5
Skin and subcutaneous tissue disorders Dermatitis 37.8
Skin and subcutaneous tissue disorders Rash 37.8
Blood and lymphatic system disorders Thrombocytopenia 36.9
Blood and lymphatic system disorders Thrombocytopenia 35.8
Gastrointestinal disorders Diarrhoea 34.8
General disorders and administration site conditions Asthenia 33.6
General disorders and administration site conditions Fatigue 33.6
Musculoskeletal and connective tissue disorders Muscle spasms 33.4
Blood and lymphatic system disorders Neutropenia 33.4
Gastrointestinal disorders Diarrhoea 33.3
Blood and lymphatic system disorders Anaemia 31.4
Gastrointestinal disorders Diarrhoea 31.3
Blood and lymphatic system disorders Anaemia 30.6
Gastrointestinal disorders Nausea 29.9
Respiratory, thoracic and mediastinal disorders Cough 28.4
Blood and lymphatic system disorders Thrombocytopenia 27.6
Investigations Body temperature increased 27.5
Gastrointestinal disorders Diarrhoea
Gastrointestinal disorders Constipation 26.4
Cardiac disorders Oedema peripheral 26.3
Gastrointestinal disorders Nausea 26.1
Musculoskeletal and connective tissue disorders Back pain 25.8
Skin and subcutaneous tissue disorders Pruritus 25.4
Infections and infestations Upper respiratory tract infection 24.6
Skin and subcutaneous tissue disorders Pruritus 23.9
Blood and lymphatic system disorders Anaemia
Cardiac disorders Dyspnoea 23.5
Infections and infestations Nasopharyngitis 23.5
Investigations Body temperature increased
Cardiac disorders Dizziness 23.2
Investigations Body temperature increased 23.1
Skin and subcutaneous tissue disorders Dermatitis 22.4
Skin and subcutaneous tissue disorders Rash 22.4
Blood and lymphatic system disorders Thrombocytopenia 21.5
Gastrointestinal disorders Nausea
Skin and subcutaneous tissue disorders Dermatitis 21.2
Skin and subcutaneous tissue disorders Rash 21.2
Nervous system disorders Tremor 21.2
Gastrointestinal disorders Constipation
Musculoskeletal and connective tissue disorders Muscle spasms
Cardiac disorders Oedema peripheral
Gastrointestinal disorders Constipation 19.6
Gastrointestinal disorders Nausea 19.6
Investigations Weight decreased 19.5
Gastrointestinal disorders Diarrhoea
Musculoskeletal and connective tissue disorders Back pain
General disorders and administration site conditions Asthenia 18.1
Skin and subcutaneous tissue disorders Dermatitis 18.1
General disorders and administration site conditions Fatigue 18.1
Skin and subcutaneous tissue disorders Rash 18.1
Cardiac disorders Dyspnoea 17.9
Blood and lymphatic system disorders Neutropenia
Cardiac disorders Dyspnoea 17.6
Infections and infestations Nasopharyngitis 17.6
Eye disorders Vision blurred 17.3
Skin and subcutaneous tissue disorders Pruritus 17.2
Cardiac disorders Dyspnoea
Infections and infestations Nasopharyngitis
Cardiac disorders Dizziness
Musculoskeletal and connective tissue disorders Muscle spasms 16.7
Gastrointestinal disorders Constipation 15.7
Cardiac disorders Oedema peripheral 15.7
Infections and infestations Upper respiratory tract infection
General disorders and administration site conditions Decreased appetite 15.6
Gastrointestinal disorders Dysgeusia 15.3
Skin and subcutaneous tissue disorders Dermatitis 15.2
Musculoskeletal and connective tissue disorders Muscle spasms 15.2
Skin and subcutaneous tissue disorders Rash 15.2
Blood and lymphatic system disorders Leukopenia 14.9
Investigations Weight decreased
Nervous system disorders Headache 14.5
General disorders and administration site conditions Asthenia 14.2
General disorders and administration site conditions Decreased appetite 14.2
Infections and infestations Pneumonia 14.2
Investigations Body temperature increased 13.8
Cardiac disorders Oedema peripheral 13.8
Infections and infestations Respiratory tract infection 13.8
Musculoskeletal and connective tissue disorders Bone pain 13.6
Metabolism and nutrition disorders Hypokalaemia 13.6
Gastrointestinal disorders Pharyngitis 13.6
Infections and infestations Pneumonia 13.6
Musculoskeletal and connective tissue disorders Back pain 13.4
Metabolism and nutrition disorders Hypokalaemia 12.7
Musculoskeletal and connective tissue disorders Muscle spasms 12.7
Infections and infestations Upper respiratory tract infection 12.7
Investigations Weight decreased 12.7
Respiratory, thoracic and mediastinal disorders Cough 12.3
Blood and lymphatic system disorders Leukopenia 12.3
Blood and lymphatic system disorders Thrombocytopenia 12.2
Gastrointestinal disorders Vomiting 12.2
Musculoskeletal and connective tissue disorders Pain in extremity 11.9
Gastrointestinal disorders Vomiting 11.9
Infections and infestations Bronchitis 11.6
Infections and infestations Nasopharyngitis 11.6
Eye disorders Vision blurred
Infections and infestations Bronchitis 11.3
Blood and lymphatic system disorders Anaemia 11.2
Musculoskeletal and connective tissue disorders Bone pain
Infections and infestations Pneumonia 11.0
Gastrointestinal disorders Abdominal pain 10.9
Gastrointestinal disorders Gastrointestinal pain 10.9
Blood and lymphatic system disorders Thrombocytopenia
Nervous system disorders Hypoaesthesia 10.2
Cardiac disorders Dizziness 10.1
Skin and subcutaneous tissue disorders Dry skin 10.1
Skin and subcutaneous tissue disorders Dermatitis 10.0
Skin and subcutaneous tissue disorders Rash 10.0
Gastrointestinal disorders Abdominal pain 9.92
Blood and lymphatic system disorders Anaemia 9.92
Gastrointestinal disorders Gastrointestinal pain 9.92
General disorders and administration site conditions Hyperhidrosis 9.92
General disorders and administration site conditions Decreased appetite
Gastrointestinal disorders Dysgeusia
Gastrointestinal disorders Abdominal pain 9.7
General disorders and administration site conditions Decreased appetite
Gastrointestinal disorders Dysgeusia
Gastrointestinal disorders Gastrointestinal pain 9.7
Gastrointestinal disorders Oropharyngeal pain 9.7
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Tumour flare 9.7
Skin and subcutaneous tissue disorders Dermatitis
Gastrointestinal disorders Pharyngitis
Skin and subcutaneous tissue disorders Rash
Gastrointestinal disorders Vomiting
Skin and subcutaneous tissue disorders Dermatitis
Gastrointestinal disorders Pharyngitis
Skin and subcutaneous tissue disorders Rash
Gastrointestinal disorders Vomiting
Vascular disorders Deep vein thrombosis 9.35
Skin and subcutaneous tissue disorders Dry skin 9.35
Infections and infestations Pneumonia 9.35
Musculoskeletal and connective tissue disorders Pain in extremity
Musculoskeletal and connective tissue disorders Pain in extremity
Blood and lymphatic system disorders Anaemia 9.0
Gastrointestinal disorders Nausea
Infections and infestations Pneumonia 8.96
Cardiac disorders Dyspnoea
Infections and infestations Nasopharyngitis
Metabolism and nutrition disorders Hypocalcaemia 8.78
Infections and infestations Bronchitis
Infections and infestations Bronchitis
Infections and infestations Pneumonia 8.5
Infections and infestations Urinary tract infection 8.5
Infections and infestations Pneumonia
Infections and infestations Pneumonia
Cardiac disorders Chest pain 8.22
Vascular disorders Deep vein thrombosis 8.22
Musculoskeletal and connective tissue disorders Arthralgia 8.21
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 8.21
Investigations Alanine aminotransferase increased 8.11
Blood and lymphatic system disorders Leukopenia 8.0
Vascular disorders Hypertension 7.93
Blood and lymphatic system disorders Leukopenia 7.93
Skin and subcutaneous tissue disorders Pruritus 7.65
General disorders and administration site conditions Asthenia
Gastrointestinal disorders Constipation
General disorders and administration site conditions Fatigue
Nervous system disorders Headache
Infections and infestations Nasopharyngitis
Cardiac disorders Oedema peripheral
Metabolism and nutrition disorders Dehydration 7.46
Blood and lymphatic system disorders Lymphopenia 7.46
Respiratory, thoracic and mediastinal disorders Pleural effusion 7.46
Nervous system disorders Tremor
Infections and infestations Pneumonia 7.4
Nervous system disorders Tremor
Vascular disorders Deep vein thrombosis 7.37
Infections and infestations Sinusitis 7.37
General disorders and administration site conditions Hyperhidrosis
Nervous system disorders Hypoaesthesia
Nervous system disorders Hypoaesthesia
Gastrointestinal disorders Dry mouth 7.08
Vascular disorders Hypotension 7.08
General disorders and administration site conditions Asthenia 7.0
Musculoskeletal and connective tissue disorders Back pain 7.0
Cardiac disorders Dyspnoea 7.0
General disorders and administration site conditions Fatigue 7.0
General disorders and administration site conditions Decreased appetite 6.8
Skin and subcutaneous tissue disorders Dermatitis 6.8
Metabolism and nutrition disorders Hypomagnesaemia 6.8
General disorders and administration site conditions Lethargy 6.8
Skin and subcutaneous tissue disorders Rash 6.8
Renal and urinary disorders Dysuria 6.76
Endocrine disorders Endocrine disorder 6.76
Endocrine disorders Hypothyroidism 6.76
Endocrine disorders Primary hypothyroidism 6.76
Renal and urinary disorders Urethral disorder 6.76
Renal and urinary disorders Urinary tract disorder 6.76
General disorders and administration site conditions Asthenia 6.72
General disorders and administration site conditions Fatigue 6.72
Vascular disorders Hypotension 6.72
Blood and lymphatic system disorders Leukopenia 6.72
General disorders and administration site conditions Asthenia 6.52
Metabolism and nutrition disorders Dehydration 6.52
General disorders and administration site conditions Fatigue 6.52
Nervous system disorders Neuropathy peripheral 6.52
Blood and lymphatic system disorders Neutropenia
Gastrointestinal disorders Abdominal pain
Gastrointestinal disorders Gastrointestinal pain
Blood and lymphatic system disorders Neutropenia
Blood and lymphatic system disorders Thrombocytopenia
Blood and lymphatic system disorders Anaemia 6.1
Vascular disorders Angiopathy 6.08
Vascular disorders Hypertension 6.08
Gastrointestinal disorders Abdominal pain
Investigations Body temperature increased
Respiratory, thoracic and mediastinal disorders Cough
Blood and lymphatic system disorders Febrile neutropenia 6.0
Gastrointestinal disorders Gastrointestinal pain
Metabolism and nutrition disorders Hypokalaemia
Musculoskeletal and connective tissue disorders Muscle spasms
Infections and infestations Pneumonia
Gastrointestinal disorders Diarrhoea 5.97
Cardiac disorders Dyspnoea 5.97
Blood and lymphatic system disorders Febrile neutropenia 5.97
Nervous system disorders Muscular weakness 5.97
Blood and lymphatic system disorders Anaemia
Cardiac disorders Chest pain
Vascular disorders Hypertension
Nervous system disorders Muscular weakness 5.67
Infections and infestations Pneumonia
Infections and infestations Urinary tract infection
Cardiac disorders Cardiac disorder 5.41
Cardiac disorders Palpitations 5.41
Blood and lymphatic system disorders Leukopenia 5.4
Blood and lymphatic system disorders Lymphopenia 5.38
Skin and subcutaneous tissue disorders Pruritus
General disorders and administration site conditions Asthenia
General disorders and administration site conditions Fatigue
Metabolism and nutrition disorders Hypokalaemia 4.82
General disorders and administration site conditions Asthenia 4.7
Musculoskeletal and connective tissue disorders Back pain 4.7
Vascular disorders Deep vein thrombosis 4.7
Cardiac disorders Dyspnoea 4.7
General disorders and administration site conditions Fatigue 4.7
Infections and infestations Sinusitis
Infections and infestations Bronchitis
Cardiac disorders Dizziness
Skin and subcutaneous tissue disorders Pruritus
Vascular disorders Deep vein thrombosis
Metabolism and nutrition disorders Dehydration
Vascular disorders Hypotension
Blood and lymphatic system disorders Febrile neutropenia 4.1
General disorders and administration site conditions Decreased appetite
Skin and subcutaneous tissue disorders Dry skin
Blood and lymphatic system disorders Leukopenia 3.97
Respiratory, thoracic and mediastinal disorders Pulmonary embolism 3.97
Gastrointestinal disorders Abdominal pain 3.73
Vascular disorders Deep vein thrombosis 3.73
Gastrointestinal disorders Gastrointestinal pain 3.73
Blood and lymphatic system disorders Lymphopenia 3.73
Renal and urinary disorders Renal failure 3.73
Infections and infestations Urinary tract infection 3.73
Gastrointestinal disorders Dry mouth
Nervous system disorders Neuropathy peripheral
Cardiac disorders Atrial fibrillation 3.68
Metabolism and nutrition disorders Hypocalcaemia 3.68
Respiratory, thoracic and mediastinal disorders Pulmonary embolism 3.68
Vascular disorders Deep vein thrombosis
Blood and lymphatic system disorders Neutropenia
Vascular disorders Deep vein thrombosis
Cardiac disorders Atrial fibrillation 3.12
Gastrointestinal disorders Diarrhoea 3.12
Blood and lymphatic system disorders Leukopenia
Infections and infestations Respiratory tract infection
Blood and lymphatic system disorders Thrombocytopenia
General disorders and administration site conditions Asthenia 2.99
Metabolism and nutrition disorders Dehydration 2.99
Metabolism and nutrition disorders Hypocalcaemia 2.99
Vascular disorders Hypotension 2.99
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Squamous cell carcinoma of skin 2.99
Metabolism and nutrition disorders Hypocalcaemia
Metabolism and nutrition disorders Hypomagnesaemia
Nervous system disorders Muscular weakness
Psychiatric disorders Depression 2.83
Cardiac disorders Dizziness 2.83
Nervous system disorders Loss of consciousness 2.83
Blood and lymphatic system disorders Lymphopenia 2.83
Vascular disorders Shock 2.83
Cardiac disorders Syncope 2.83
Metabolism and nutrition disorders Hypophosphataemia 2.55
General disorders and administration site conditions Lethargy
Blood and lymphatic system disorders Febrile neutropenia 2.27
Investigations Body temperature increased 2.24
Infections and infestations Cellulitis 2.24
General disorders and administration site conditions General physical health deterioration 2.24
Metabolism and nutrition disorders Hypokalaemia 2.24
Metabolism and nutrition disorders Hyponatraemia 2.24
Respiratory, thoracic and mediastinal disorders Hypoxia 2.24
Respiratory, thoracic and mediastinal disorders Pulmonary embolism 2.24
Nervous system disorders Cerebrovascular accident 1.98
Gastrointestinal disorders Constipation 1.98
Cardiac disorders Dizziness 1.98
Psychiatric disorders Depression
Metabolism and nutrition disorders Hypocalcaemia
Eye disorders Cataract 1.7
Gastrointestinal disorders Diarrhoea 1.7
Blood and lymphatic system disorders Febrile neutropenia 1.7
Gastrointestinal disorders Nausea 1.7
Cardiac disorders Tachycardia 1.7
Skin and subcutaneous tissue disorders Dermatitis
Skin and subcutaneous tissue disorders Dry skin
Skin and subcutaneous tissue disorders Rash
Musculoskeletal and connective tissue disorders Arthralgia 1.49
Musculoskeletal and connective tissue disorders Back pain 1.49
Infections and infestations Bacteraemia 1.49
Infections and infestations Cellulitis 1.49
Skin and subcutaneous tissue disorders Dermatitis 1.49
General disorders and administration site conditions General physical health deterioration 1.49
Metabolism and nutrition disorders Hypocalcaemia 1.49
Respiratory, thoracic and mediastinal disorders Hypoxia 1.49
Nervous system disorders Muscular weakness 1.49
Musculoskeletal and connective tissue disorders Musculoskeletal discomfort 1.49
Respiratory, thoracic and mediastinal disorders Pleural effusion 1.49
Respiratory, thoracic and mediastinal disorders Pulmonary embolism 1.49
Skin and subcutaneous tissue disorders Rash 1.49
Renal and urinary disorders Renal failure 1.49
Respiratory, thoracic and mediastinal disorders Respiratory distress 1.49
Infections and infestations Staphylococcal bacteraemia 1.49
Infections and infestations Urinary tract infection 1.49
Metabolism and nutrition disorders Hypokalaemia
Blood and lymphatic system disorders Lymphopenia
Cardiac disorders Cardiac failure congestive 1.42
Eye disorders Cataract 1.42
Infections and infestations Urinary tract infection 1.42
Cardiac disorders Atrial fibrillation
Gastrointestinal disorders Diarrhoea
Blood and lymphatic system disorders Leukopenia
Blood and lymphatic system disorders Lymphopenia
Musculoskeletal and connective tissue disorders Bone pain 1.13
Respiratory, thoracic and mediastinal disorders Respiratory distress 1.13
Nervous system disorders Cerebrovascular accident
Cardiac disorders Dizziness
Nervous system disorders Loss of consciousness
Respiratory, thoracic and mediastinal disorders Pulmonary embolism
Vascular disorders Shock
Cardiac disorders Syncope
Gastrointestinal disorders Constipation 0.746
Respiratory, thoracic and mediastinal disorders Cough 0.746
General disorders and administration site conditions Decreased appetite 0.746
Musculoskeletal and connective tissue disorders Muscle spasms 0.746
Gastrointestinal disorders Nausea 0.746
Skin and subcutaneous tissue disorders Pruritus 0.746
Gastrointestinal disorders Vomiting 0.746
Cardiac disorders Atrial fibrillation
Gastrointestinal disorders Diarrhoea
Gastrointestinal disorders Nausea
Cardiac disorders Cardiac failure congestive
Eye disorders Cataract
Gastrointestinal disorders Constipation
Blood and lymphatic system disorders Leukopenia
Cardiac disorders Tachycardia
Infections and infestations Urinary tract infection

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
General disorders and administration site conditions
12.7
Gastrointestinal disorders
8.72
Investigations
8.34
Respiratory, thoracic and mediastinal disorders
8.22
Infections and infestations
7.36
Nervous system disorders
7.25
Skin and subcutaneous tissue disorders
5.87
Vascular disorders
5.82
Blood and lymphatic system disorders
5.56
Musculoskeletal and connective tissue disorders
5.2
Cardiac disorders
4.46
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
4.1
Injury, poisoning and procedural complications
3.63
Metabolism and nutrition disorders
2.73
Psychiatric disorders
2.71
Renal and urinary disorders
2.34

Cross References

Resources Reference
CAS NUMBER 191732-72-6
ChEBI 63791
ChEMBL CHEMBL848
DrugBank DB00480
DrugCentral 3317
EPA CompTox DTXSID8046664
FDA SRS F0P408N6V4
Human Metabolome Database HMDB0014623
Guide to Pharmacology 7331
PharmGKB PA162363968
PubChem 216326
SureChEMBL SCHEMBL32978
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