| Trade Names: | |
| Synonyms: | |
| Status: | Approved (2007) |
| Entry Type: | Small molecule |
| Molecule Category: | Salt |
| UNII: | SOD6A38AGA |
| Parent Compound: | LEVOCETIRIZINE |
Structure
| InChI Key | PGLIUCLTXOYQMV-GHVWMZMZSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C21H27Cl3N2O3 |
| Molecular Weight | 461.82 |
| AlogP | 3.15 |
| Hydrogen Bond Acceptor | 4.0 |
| Hydrogen Bond Donor | 1.0 |
| Number of Rotational Bond | 8.0 |
| Polar Surface Area | 53.01 |
| Molecular species | ACID |
| Aromatic Rings | 2.0 |
| Heavy Atoms | 27.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| ANTAGONIST | Histamine H1 receptor antagonist | DailyMed |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Membrane receptor
Family A G protein-coupled receptor
Small molecule receptor (family A GPCR)
Monoamine receptor
Histamine receptor
|
- | - | - | 50 | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Rhinitis | 3 | D012220 | ClinicalTrials |
| Cough | 2 | D003371 | ClinicalTrials |
| Lecithin Cholesterol Acyltransferase Deficiency | 1 | D007863 | ClinicalTrials |
Related Entries
Scaffolds
Adverse Reactions
System Organ Classification (SOC)
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL1201190 |
| FDA SRS | SOD6A38AGA |
| PubChem | 9955977 |
| SureChEMBL | SCHEMBL144375 |
CONTENTS