| Trade Names: | |
| Synonyms: | |
| Status: | Approved (1996) |
| Entry Type: | Small molecule |
| Molecule Category: | Parent |
| ATC: | J01MA12 |
| UNII: | RIX4E89Y14 |
Structure
| InChI Key | GSDSWSVVBLHKDQ-JTQLQIEISA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C18H20FN3O4 |
| Molecular Weight | 361.37 |
| AlogP | 1.54 |
| Hydrogen Bond Acceptor | 6.0 |
| Hydrogen Bond Donor | 1.0 |
| Number of Rotational Bond | 2.0 |
| Polar Surface Area | 75.01 |
| Molecular species | ACID |
| Aromatic Rings | 2.0 |
| Heavy Atoms | 26.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | DNA gyrase inhibitor | DailyMed |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Isomerase
|
- | 52000 | - | - | - | |
|
Ion channel
Voltage-gated ion channel
Potassium channels
Voltage-gated potassium channel
|
- | - | - | - | -1-10 | |
|
Transporter
Electrochemical transporter
SLC superfamily of solute carriers
SLC21/SLCO family of organic anion transporting polypeptides
|
- | - | - | - | 117 | |
|
Transporter
Electrochemical transporter
SLC superfamily of solute carriers
SLC47 family of multidrug and toxin extrusion transporters
|
- | 17900 | - | - | 26 |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Sinusitis | 4 | D012852 | ClinicalTrials |
| Conjunctivitis, Bacterial | 4 | D003234 | ClinicalTrials |
| Bronchitis, Chronic | 4 | D029481 | ClinicalTrials |
| Pneumonia, Bacterial | 3 | D018410 | ClinicalTrials |
| Pelvic Inflammatory Disease | 3 | D000292 | ClinicalTrials |
| Dyspepsia | 3 | D004415 | ClinicalTrials |
| Pyelonephritis | 3 | D011704 | ClinicalTrials |
| Prostatic Hyperplasia | 3 | D011470 | ClinicalTrials |
| Fever | 3 | D005334 | ClinicalTrials |
| Hot Flashes | 3 | D019584 | ClinicalTrials |
| Cataract | 3 | D002386 | ClinicalTrials |
| Endocarditis | 3 | D004696 | ClinicalTrials |
| Pulmonary Disease, Chronic Obstructive | 3 | D029424 | ClinicalTrials |
| Tuberculosis | 3 | D014376 | ClinicalTrials |
| Cystic Fibrosis | 3 | D003550 | ClinicalTrials |
| Prostatitis | 3 | D011472 | ClinicalTrials |
| Neutropenia | 3 | D009503 | ClinicalTrials |
| Skin Diseases | 3 | D012871 | ClinicalTrials |
| Otitis Media | 3 | D010033 | ClinicalTrials |
| Staphylococcal Infections | 3 | D013203 | ClinicalTrials |
| Maxillary Sinusitis | 3 | D015523 | ClinicalTrials |
| Helicobacter Infections | 3 | D016481 | ClinicalTrials |
| Diabetic Foot | 2 | D017719 | ClinicalTrials |
| Neoplasms | 2 | D009369 | ClinicalTrials |
| Cellulitis | 2 | D002481 | ClinicalTrials |
| Sarcoidosis | 2 | D012507 | ClinicalTrials |
| Lymphoma, Non-Hodgkin | 2 | D008228 | ClinicalTrials |
| Appendicitis | 2 | D001064 | ClinicalTrials |
| Tuberculosis, Multidrug-Resistant | 2 | D018088 | ClinicalTrials |
| Endophthalmitis | 1 | D009877 | ClinicalTrials |
| Urinary Bladder, Overactive | 1 | D053201 | ClinicalTrials |
| HIV Infections | 1 | D015658 | ClinicalTrials |
| Escherichia coli Infections | 1 | D004927 | ClinicalTrials |
| Kidney Diseases | 1 | D007674 | ClinicalTrials |
| Osteomyelitis | 0 | D010019 | ClinicalTrials |
Related Entries
Adverse Reactions
System Organ Classification (SOC)
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 100986-85-4 |
| ChEBI | 63598 |
| ChEMBL | CHEMBL33 |
| DrugBank | DB01137 |
| DrugCentral | 1569 |
| EPA CompTox | DTXSID0041060 |
| FDA SRS | RIX4E89Y14 |
| Human Metabolome Database | HMDB0001929 |
| Guide to Pharmacology | 10911 |
| KEGG | C07660 |
| PDB | LFX |
| PharmGKB | PA450214 |
| PubChem | 3033924 |
| SureChEMBL | SCHEMBL15397 |
| ZINC | ZINC000000538273 |
CONTENTS