LIDOCAINE HYDROCHLORIDE

Search structure


Trade Names:	AKTEN ALPHACAINE HYDROCHLORIDE ANESTACON GLYDO LARYNG-O-JET KIT LARYNGOTRACHEAL ANESTHESIA KIT LIDOCAINE HYDROCHLORIDE LIDOCAINE HYDROCHLORIDE 0.1% AND DEXTROSE 5% IN PLASTIC CONTAINER LIDOCAINE HYDROCHLORIDE 0.2% AND DEXTROSE 5% IN PLASTIC CONTAINER LIDOCAINE HYDROCHLORIDE 0.2% IN DEXTROSE 5% LIDOCAINE HYDROCHLORIDE 0.2% IN DEXTROSE 5% IN PLASTIC CONTAINER LIDOCAINE HYDROCHLORIDE 0.4% AND DEXTROSE 5% IN PLASTIC CONTAINER LIDOCAINE HYDROCHLORIDE 0.4% IN DEXTROSE 5% LIDOCAINE HYDROCHLORIDE 0.4% IN DEXTROSE 5% IN PLASTIC CONTAINER LIDOCAINE HYDROCHLORIDE 0.8% AND DEXTROSE 5% IN PLASTIC CONTAINER LIDOCAINE HYDROCHLORIDE 0.8% IN DEXTROSE 5% IN PLASTIC CONTAINER LIDOCAINE HYDROCHLORIDE 5% AND DEXTROSE 7.5% LIDOCAINE HYDROCHLORIDE IN PLASTIC CONTAINER LIDOCAINE HYDROCHLORIDE PRESERVATIVE FREE LIDOCAINE HYDROCHLORIDE PRESERVATIVE FREE IN PLASTIC CONTAINER LIDOCAINE HYDROCHLORIDE VISCOUS LIDOCAINE VISCOUS LIDOCATON LIDOPEN LTA II KIT PEDIATRIC LTA KIT XYLOCAINE XYLOCAINE 1.5% W/ DEXTROSE 7.5% XYLOCAINE 4% PRESERVATIVE FREE XYLOCAINE 5% W/ GLUCOSE 7.5% XYLOCAINE DENTAL XYLOCAINE PRESERVATIVE FREE XYLOCAINE VISCOUS ZINGO
Synonyms:	Akten Alphacaine hydrochloride Anestacon Anodesyn Bismodyne Bradosol plus Calgel Co-phenylcaine fte Denela Dequaspray Emla Germoloids Germoloids complete Glydo Hemocane Iglu Instillagel Laryngojet Laryng-o-jet kit Laryngotracheal anesthesia kit Lidocaine hcl Lidocaine hydrochloride Lidocaine hydrochloride monohydrate Lidocaine hydrochloride preservative free Lidocaine hydrochloride usp Lidocaine hydrochloride viscous Lidocaine viscous Lidocaini hydrochloridum Lidocaton Lido hcl Lidopen Lignocaine (as hydrochloride) Lignocaine hydrochloride Lignokent Lignospan special Lignostab Lignostab-a Lignostab a 100 Lignostab n Lta ii kit Medijel NSC-757420 Oragard Pediatric lta kit Preparation h Rexocaine Versatis Xylocaine Xylocaine dental Xylocaine hydrochloride Xylocaine preservative free Xylocaine viscous Xylotox e80 Zingo
Status:	Approved (1948)
Entry Type:	Small molecule
Molecule Category:	Salt
UNII:	V13007Z41A
Parent Compound:	LIDOCAINE

Structure


InChI Key	IYBQHJMYDGVZRY-UHFFFAOYSA-N
Smile	CCN(CC)CC(=O)Nc1c(C)cccc1C.Cl
InChI	InChI=1S/C14H22N2O.ClH/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C14H25ClN2O2
Molecular Weight	288.82
AlogP	2.58
Hydrogen Bond Acceptor	2.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	5.0
Polar Surface Area	32.34
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	17.0

Pharmacology

Action	Mechanism of Action	Reference
BLOCKER	Sodium channel alpha subunit blocker	PubMed PubMed

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference
Pregnancy	3	D011247	ClinicalTrials
Diabetes Mellitus	3	D003920	ClinicalTrials
Pruritus	2	D011537	ClinicalTrials
Liver Neoplasms	2	D008113	ClinicalTrials
Hemorrhoids	2	D006484	ClinicalTrials
Rotator Cuff Injuries	2	D000070636	ClinicalTrials
Headache	2	D006261	ClinicalTrials
Neoplasms	2	D009369	ClinicalTrials
Wounds and Injuries	2	D014947	ClinicalTrials
Mucositis	2	D052016	ClinicalTrials
Hypertension	1	D006973	ClinicalTrials
Pancreatic Neoplasms	0	D010190	ClinicalTrials

Related Entries

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Adverse Reactions

SOC By Demographic Distribution

System Organ Classification (SOC)

	Relative Frequency (%)
Nervous system disorders	16.42
General disorders and administration site conditions	16.18
Injury, poisoning and procedural complications	12.93
Cardiac disorders	8.44
Vascular disorders	7.42
Immune system disorders	5.23
Psychiatric disorders	5.12
Respiratory, thoracic and mediastinal disorders	4.32
Skin and subcutaneous tissue disorders	4.11
Musculoskeletal and connective tissue disorders	3.87
Gastrointestinal disorders	3.1
Investigations	2.97
Eye disorders	2.76
Infections and infestations	2.23

Cross References

Resources	Reference
ChEBI	60791
ChEMBL	CHEMBL1200409
EPA CompTox	DTXSID80209953
FDA SRS	V13007Z41A
Guide to Pharmacology	2623
KEGG	C07073
PDB	LQZ
PubChem	22483
SureChEMBL	SCHEMBL29128
ZINC	ZINC00020237

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