Trade Names: | |
Synonyms: | |
Status: | Approved (2018) |
Entry Type: | Small molecule |
Molecule Category: | UNKNOWN |
ATC: | L01ED05 |
UNII: | OSP71S83EU |
InChI Key | IIXWYSCJSQVBQM-LLVKDONJSA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C21H19FN6O2 |
Molecular Weight | 406.42 |
AlogP | 2.8 |
Hydrogen Bond Acceptor | 7.0 |
Hydrogen Bond Donor | 1.0 |
Number of Rotational Bond | 0.0 |
Polar Surface Area | 110.06 |
Molecular species | NEUTRAL |
Aromatic Rings | 3.0 |
Heavy Atoms | 30.0 |
Action | Mechanism of Action | Reference |
---|---|---|
INHIBITOR | ALK tyrosine kinase receptor inhibitor | FDA |
Primary Target | |
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ALK receptor tyrosine kinase | |
c-ros oncogene 1, receptor tyrosine kinase |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Neoplasms | 4 | D009369 | ClinicalTrials |
Lymphoma, Large-Cell, Anaplastic | 2 | D017728 | ClinicalTrials |
Neuroblastoma | 1 | D009447 | ClinicalTrials |
Kidney Diseases | 1 | D007674 | ClinicalTrials |
Resources | Reference |
---|---|
CAS NUMBER | 1454846-35-5 |
ChEBI | 143117 |
ChEMBL | CHEMBL3286830 |
DrugBank | DB12130 |
DrugCentral | 5302 |
FDA SRS | OSP71S83EU |
Guide to Pharmacology | 7476 |
PDB | 5P8 |
PubChem | 71731823 |
SureChEMBL | SCHEMBL15261807 |
ZINC | ZINC000098208524 |