MELPHALAN HYDROCHLORIDE

Search structure
Trade Names:
Synonyms:
Status: Approved (1992)
Entry Type: Small molecule
Molecule Category: Salt
UNII: 1VXP4V453T
Parent Compound: MELPHALAN

Structure
InChI Key OUUYBRCCFUEMLH-YDALLXLXSA-N
Smile Cl.N[C@@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O
InChI
InChI=1S/C13H18Cl2N2O2.ClH/c14-5-7-17(8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19;/h1-4,12H,5-9,16H2,(H,18,19);1H/t12-;/m0./s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C13H19Cl3N2O2
Molecular Weight 341.67
AlogP 1.93
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 8.0
Polar Surface Area 66.56
Molecular species ZWITTERION
Aromatic Rings 1.0
Heavy Atoms 19.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR DNA inhibitor DailyMed

Metabolites

visNetwork

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Lymphoma, Follicular 2 D008224 ClinicalTrials
Hodgkin Disease 2 D006689 ClinicalTrials
Multiple Myeloma 2 D009101 ClinicalTrials
Lymphoma, Non-Hodgkin 2 D008228 ClinicalTrials
Amyloidosis 2 D000686 ClinicalTrials
Retinoblastoma 2 D012175 ClinicalTrials
Leukemia, Lymphocytic, Chronic, B-Cell 2 D015451 ClinicalTrials
Myelodysplastic Syndromes 2 D009190 ClinicalTrials
Leukemia, Myeloid, Acute 2 D015470 ClinicalTrials
Leukemia, Myelogenous, Chronic, BCR-ABL Positive 2 D015464 ClinicalTrials
Lymphoma, Large B-Cell, Diffuse 2 D016403 ClinicalTrials
Lymphoma, Mantle-Cell 2 D020522 ClinicalTrials
Graft vs Host Disease 2 D006086 ClinicalTrials
Glioma 1 D005910 ClinicalTrials

Related Entries

Parent

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Eye disorders
11.32
Blood and lymphatic system disorders
11.06
General disorders and administration site conditions
9.42
Vascular disorders
8.56
Infections and infestations
7.81
Respiratory, thoracic and mediastinal disorders
6.46
Injury, poisoning and procedural complications
6.09
Gastrointestinal disorders
5.83
Nervous system disorders
5.0
Skin and subcutaneous tissue disorders
4.37
Immune system disorders
3.79
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
3.48
Investigations
2.87
Metabolism and nutrition disorders
2.76
Hepatobiliary disorders
2.1
Cardiac disorders
2.04

Cross References

Resources Reference
ChEMBL CHEMBL1200863
EPA CompTox DTXSID60872785
FDA SRS 1VXP4V453T
PubChem 9927978
SureChEMBL SCHEMBL41335
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