MEPHENYTOIN

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Trade Names:
Synonyms:
Status: Approved (1946)
Entry Type: Small molecule
Molecule Category: UNKNOWN
ATC: N03AB04
UNII: R420KW629U

Structure
InChI Key GMHKMTDVRCWUDX-UHFFFAOYSA-N
Smile CCC1(c2ccccc2)NC(=O)N(C)C1=O
InChI
InChI=1S/C12H14N2O2/c1-3-12(9-7-5-4-6-8-9)10(15)14(2)11(16)13-12/h4-8H,3H2,1-2H3,(H,13,16)

Physicochemical Descriptors

Property Name Value
Molecular Formula C12H14N2O2
Molecular Weight 218.26
AlogP 1.47
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 2.0
Polar Surface Area 49.41
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 16.0

Pharmacology

Action Mechanism of Action Reference
BLOCKER Sodium channel alpha subunit blocker PubMed PubMed DailyMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2C Cytochrome P450 2C19
- - - - 97
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference

Related Entries

Scaffolds

Cross References

Resources Reference
CAS NUMBER 50-12-4
ChEBI 6757
ChEMBL CHEMBL861
DrugBank DB00532
DrugCentral 1695
EPA CompTox DTXSID9023257
FDA SRS R420KW629U
Human Metabolome Database HMDB0014673
Guide to Pharmacology 7223
PharmGKB PA450373
PubChem 4060
SureChEMBL SCHEMBL21766
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