| Trade Names: | |
| Synonyms: | |
| Status: | Approved (1985) |
| Entry Type: | Small molecule |
| Molecule Category: | Salt |
| UNII: | W7TTW573JJ |
| Parent Compound: | MIDAZOLAM |
Structure
| InChI Key | PLYSCVSCYOQVRP-UHFFFAOYSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C18H14Cl2FN3 |
| Molecular Weight | 362.24 |
| AlogP | 4.32 |
| Hydrogen Bond Acceptor | 3.0 |
| Hydrogen Bond Donor | 0.0 |
| Number of Rotational Bond | 1.0 |
| Polar Surface Area | 30.18 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 3.0 |
| Heavy Atoms | 23.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Nervous System Diseases | 3 | D009422 | ClinicalTrials |
| Depressive Disorder | 2 | D003866 | ClinicalTrials |
| Adenomatous Polyposis Coli | 2 | D011125 | ClinicalTrials |
| Depressive Disorder, Major | 2 | D003865 | ClinicalTrials |
| Dental Anxiety | 2 | D016854 | ClinicalTrials |
| Bipolar Disorder | 2 | D001714 | ClinicalTrials |
| Diabetes Mellitus, Type 2 | 1 | D003924 | ClinicalTrials |
| Tuberculosis | 1 | D014376 | ClinicalTrials |
| Dermatitis, Atopic | 1 | D003876 | ClinicalTrials |
| Pain | 1 | D010146 | ClinicalTrials |
| Burns | 1 | D002056 | ClinicalTrials |
| Status Epilepticus | 1 | D013226 | ClinicalTrials |
| Neoplasms | 1 | D009369 | ClinicalTrials |
Related Entries
Scaffolds
Adverse Reactions
System Organ Classification (SOC)
Cross References
| Resources | Reference |
|---|---|
| ChEBI | 6932 |
| ChEMBL | CHEMBL1200420 |
| EPA CompTox | DTXSID8047846 |
| FDA SRS | W7TTW573JJ |
| Guide to Pharmacology | 3342 |
| KEGG | C07524 |
| PDB | 08J |
| PubChem | 43032 |
| SureChEMBL | SCHEMBL41265 |
| ZINC | ZINC00001732 |
CONTENTS