Trade Names: | |
Synonyms: | |
Status: | Approved (1984) |
Entry Type: | Small molecule |
Molecule Category: | Salt |
UNII: | Z6375YW9SF |
Parent Compound: | NALTREXONE |
InChI Key | RHBRMCOKKKZVRY-ITLPAZOVSA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C20H24ClNO4 |
Molecular Weight | 377.87 |
AlogP | 1.53 |
Hydrogen Bond Acceptor | 5.0 |
Hydrogen Bond Donor | 2.0 |
Number of Rotational Bond | 2.0 |
Polar Surface Area | 70.0 |
Molecular species | BASE |
Aromatic Rings | 1.0 |
Heavy Atoms | 25.0 |
Action | Mechanism of Action | Reference |
---|---|---|
ANTAGONIST | Opioid receptors; mu/kappa/delta antagonist | DailyMed |
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
---|---|---|---|---|---|---|
Membrane receptor
Family A G protein-coupled receptor
Peptide receptor (family A GPCR)
Short peptide receptor (family A GPCR)
Opioid receptor
|
- | 1-1 | - | - | - | |
Transporter
Electrochemical transporter
SLC superfamily of solute carriers
SLC21/SLCO family of organic anion transporting polypeptides
|
- | - | - | - | 72 |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Chronic Pain | 3 | D059350 | ClinicalTrials |
Charcot-Marie-Tooth Disease | 3 | D002607 | ClinicalTrials |
Amphetamine-Related Disorders | 2 | D019969 | ClinicalTrials |
Feeding and Eating Disorders | 2 | D001068 | ClinicalTrials |
Severe Acute Respiratory Syndrome | 2 | D045169 | ClinicalTrials |
Opioid-Related Disorders | 1 | D009293 | ClinicalTrials |
Resources | Reference |
---|---|
ChEBI | 134687 |
ChEMBL | CHEMBL1201149 |
FDA SRS | Z6375YW9SF |
PubChem | 5388998 |
SureChEMBL | SCHEMBL37713 |